|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Everolimus and zoledronic acid——a potential synergistic treatment for lung adenocarcinoma bone metastasis显示文摘Non-small-cell 肺癌症(NSCLC ) 经常转移到骨头。zoledronic 酸是到肿瘤,和 everolimus 的 cytostatic,这被知道,为 rapamycin 的哺乳动物的目标的禁止者,能禁止癌症的许多类型。此处,我们在在 vitro 并且在 vivo 对待肺腺癌骨头转移上与 everolimus 独自并且在联合评估了 zoledronic 酸的效果。与 everolimus 在联合与 zoledronic 酸对待的老鼠有更多的 apoptotic 肺癌症房间,更多的房间在 G1/G0 阶段被逮捕。p70S6K 的 phosphorylation 在联合治疗组被禁止。肺癌症房间侵略显著地也在 vitro 与联合治疗在这个组被禁止。骨头原子扫描在联合治疗组与那些相比在控制揭示了更变形的损害。骨头扫描和 X 光线照相术的图象显示那联合治疗显著地减少了骨头转移。中等幸存率建议药联合是 synergistic,它能推迟 NSCLC 骨头转移并且在 vivo 延长幸存。 | Yongfeng Yu Zhengbo Song Shunfang Yang Xiaohua Yang Jie Zhang Shun Lu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 5 |
| 2 | INVESTIGATION OF BUOYANT TRAJECTORY OF THERMAL WAKE BEHIND A SLENDER STREAMLINED HEATED BODY OF REVOLUTION IN STRATIFIED FLUID显示文摘In this paper, the buoyant trajectories of laminar far thermal wakes behind slenderstreamlined heated bodies of revolution in stable stratified fluid have been investigated in theoryand experiment. It has been found that the buoyant trajectories of thermal wakes in stratifiedfluid are different from that in homogeneous fluid. The buoyant trajectories of thermal wakes instratified fluid are wavy. The factors influencing the buoyant trajectories of axisymmetric lami-nar thermal wakes in stratified fluid are Richardson number, Nusselt number and number.The validity of theoretical analysis has been proved by the results of measurements and visualiza-tions. The buoyant trajectories of thermal wakes after underwater bodies can be estimated by re-sults herein presented. | Yang, Li Hua, Shunfang Du, Xianzhi | 1992 | Journal of Hydrodynamics1992，4，2： | 4 |
| 3 | Plasmon-mediated photodecomposition of NH3 via intramolecular charge transfer显示文摘As an excellent clean medium for hydrogen storage and fuel cell applications,the photolysis of ammonia via localized surface plasmon could be invoked as a promising route towards significantly reducing the temperature for conventional thermolysis.Here,we explore the underlying microscopic mechanism of ultrafast carrier dynamics in plasmon-mediated NH3 photodecomposition at the single-molecular level using real-time time-dependent density functional theory.The NH_(3)molecule adsorbed on the tip of archetypal magic metal clusters represented by tetrahedral Ag_(2)0 and icosahedral Ag147,splits within a hundred femtoseconds upon laser pulse illumination.We found that the splitting of the first N-H bond is dominated by the intramolecular charge transfer driven by localized surface plasmon.Surprisingly,the phase of laser pulse could modulate the dynamics of charge transfer and thus affect the plasmon-induced bond breaking.These findings offer a new avenue for NH3 decomposition and provide in-depth insights in designing highly efficient plasmon-mediated photocatalysts. | Yimin Zhang Weite Meng Daqiang Chen Lili Zhang Shunfang Li Sheng Meng | 2022 | Nano Research2022，15，5： | 2 |
| 4 | Statistical inference of risk difference in K correlated 2 x 2 tables with structural zero显示文摘 | Wang Shunfang Tang Niansheng Zhang Bo Wang Xueren | 2009 | Pharmaceutical Statistics2009，8，： | 1 |
| 5 | The pinhole SPECT for animal model of bone metastasis with SPC-A-1BM human pulmonary adenocarcinoma bone metastasis cell line显示文摘The study was to investigate the role of pinhole single photon emission computed tomography (SPECT), the human pulmonary adenocarcinoma bone-seeking metastasis cell line SPC-A-1BM was used.These cells form typical osteolytic bone metastases when inoculated into the arterial circulation of NIH-Beige-Nude-XD (BNX) mice via the left ventricle.In order to evaluate the irradiation impact of ^(99m)Tc-MDP versus X-ray on cells growth,we used six groups of SPC-A-1BM cells in our imaging scheme and irradiated by various doses of ^(99m)Tc-MDP (37,74,111, 370,740 MBq) and X-ray(40 kV,2 mA,6 s) respectively.The cell's number of each group was well recorded in different exposure time(4,8,12,24,48,72,96 hours).After that,SPC-A-1BM cells(1×106) were inoculated into the mice via left ventricle.We compared the results obtained with those different doses of ^(99m)Tc-MDP using pinhole SPECT and conventional X-ray skeletal surveys.The data show that the cell-survival number of 111 MBq group has insignificant difference with that of X-ray and the dose is adequate to have an ideal image.Besides,it is important that the chromosome of the cells in the group of 111 MBq showed no irradiation-related damages in our test.These results implied that ^(99m)Tc-MDP pinhole SPECT may provide another way other than conventional X-ray skeletal surveys in detecting bone metastasis of pulmonary adenocarcinoma in BNX mice. | GAO Xiuli YANG Shunfang YU Yongli SHI Meiping ZHAO Lanxiang YE Jianding LU Jianying | 2008 | Nuclear Science and Techniques2008，19，5： | 1 |
| 6 | Establishment of an experimental human lung adenocarcinoma cell line SPC-A-1BM with high bone metastases potency by 99m Tc-MDP bone scintigraphy显示文摘 | Shunfang Yang Qianggang Dong Ming Yao Meiping Shi Jianding Ye Langxiang Zhao Jianzhong Su Weiyong Gu Wenhui Xie Kankan Wang Yanzhi Du Yao Li Yan Huang | 2009 | Nuclear Medicine and Biology2009，，3： | 1 |
| 7 | Nutritional status changes in patients with advanced non-small cell lung cancer receiving first-line chemotherapy显示文摘Objective This study aimed to assess the real-life nutritional status changes and gastrointestinal symptoms in patients with advanced non-small cell lung cancer(NSCLC) receiving chemotherapy.Methods A total of 104 patients with metastatic NSCLC receiving first-line chemotherapy were included in this study. Unintentional weight loss, body mass index(BMI) changes, and gastrointestinal symptoms were recorded and evaluated. Biochemical parameters [hemoglobin(Hb) and albumin levels] were compared before and after two chemotherapy cycles using SPSS software.Results Of these patients, 65.38%(68/104) experienced unintentional weight loss, whereas 30.77% and 12.5% presented with ≥ 5% and ≥ 10% degrees of weight loss, respectively, within 6 months before first-line chemotherapy was administered. Then, 48.08%(50/104) of the patients experienced unintentional weight loss after two chemotherapy cycles. The mean body weight after chemotherapy was 61.47 ± 10.37 kg, which was significantly decreased relative to that before chemotherapy(P < 0.05). The mean BMI after chemotherapy was 22.66 ± 3.34 kg/m^2, which was also significantly diminished with respect to that during the previous chemotherapy cycle(P < 0.05). The most common gastrointestinal symptoms reported among all the study patients were anorexia(80/104, 76.92%), nausea(53/104, 50.96%), constipation(49/104, 47.12%), vomiting(48/104, 46.15%), taste disorders(40/104, 38.46%), and early satiety(32/104, 30.77%). The mean Hb levels after chemotherapy were 117.06 ± 16.67 g/L, which were significantly lower than those before chemotherapy(132.73 ± 16.42 g/L)(P < 0.05). No significant difference was noted between the mean albumin levels before and after chemotherapy(38.29 ± 4.22 g/L vs 38.17 ± 4.54 g/L; P = 0.798). Conclusion Weight loss history, gastrointestinal symptoms, and Hb level decreases are determinant factors of nutritional status in patients with advanced NSCLC and must be included in the screening, evaluation, and treatment of lung carcinoma. | Wei Sun Shunfang Liu Ping Peng Dongbo Liu | 2018 | Oncology and Translational Medicine2018，4，2： | 1 |
| 8 | Charge-induced structural changes in Al12C clusters显示文摘 | Li Shunfang Gong Xingao | 2004 | Phys Rev B2004，70，07： | 1 |
| 9 | Negative differential friction coefficients of two-dimensional commensurate contacts dominated by electronic phase transition显示文摘Friction force(f)usually increases with the normal load(N)macroscopically,according to the classic law of Da Vinci–Amontons(f=μN),with a positive and finite friction coefficient(μ).Herein near-zero and negative differential friction(ZNDF)coefficients are discovered in two-dimensional(2D)van der Waals(vdW)magnetic CrI_(3)commensurate contacts.It is identified that the ferromagnetic–antiferromagnetic phase transition of the interlayer couplings of the bilayer CrI_(3)can significantly reduce the interfacial sliding energy barriers and thus contribute to ZNDF.Moreover,phase transition between the in-plane(p_(x)and p_(y))and out-of-plane(p_(z))wave-functions dominates the sliding barrier evolutions,which is attributed to the delicate interplays among the interlayer vdW,electrostatic interactions,and the intralayer deformation of the CrI_(3)layers under external load.The present findings may motivate a new concept of slide-spintronics and are expected to play an instrumental role in design of novel magnetic solid lubricants applied in various spintronic nano-devices. | Kun Liu Jiangtao Cheng Xingju Zhao Yandi Zhu Xiaoyan Ren Jinlei Shi Zhengxiao Guo Chongxin Shan Hongjie Liu Shunfang Li | 2022 | Nano Research2022，15，6： | 0 |
| 10 | Revealing the atomic mechanism of diamond–iron interfacial reaction显示文摘Diamond,with ultrahigh hardness,high wear resistance,high thermal conductivity,and so forth,has attracted worldwide attention.However,researchers found emergent reactions at the interfaces between diamond and ferrous materials,which significantly affects the performance of diamond-based devices.Herein,combing experiments and theoretical calculations,taking diamond–iron(Fe)interface as a prototype,the counter-diffusion mechanism of Fe/carbon atoms has been established.Surprisingly,it is identified that Fe and diamond first form a coherent interface,and then Fe atoms diffuse into diamond and prefer the carbon vacancies sites.Meanwhile,the relaxed carbon atoms diffuse into the Fe lattice,forming Fe_(3)C.Moreover,graphite is observed at the Fe_(3)C surface when Fe_(3)C is over-saturated by carbon atoms.The present findings are expected to offer new insights into the atomic mechanism for diamondferrous material's interfacial reactions,benefiting diamond-based device applications. | Yalun Ku Kun Xu Longbin Yan Kuikui Zhang Dongsheng Song Xing Li Shunfang Li Shaobo Cheng Chongxin Shan | 2024 | Carbon Energy2024，6，3： | 0 |
| 11 | Modulating reaction pathways of formic acid oxidation for optimized electrocatalytic performance of PtAu/CoNC显示文摘Formic acid oxidation(FAO)is a typical anode reaction in fuel cells that can be facilitated by modulating its direct and indirect reaction pathways.Herein,PtAu bimetallic nanoparticles loaded onto Co and N co-doping carbon nanoframes(CoNC NFs)were designed to improve the selectivity of the direct reaction pathway for efficient FAO.Based on these subtle nanomaterials,the influences of elemental composition and carbon-support materials on the two pathways of FAO were investigated in detail.The results of fuel cell tests verified that the appropriate amount of Au in PtAu/CoNC can promote a direct reaction pathway for FAO,which is crucial for enhancing the oxidation efficiency of formic acid.In particular,the obtained PtAu/CoNC with an optimal Pt/Au atomic ratio of 1:1(PtAu/CoNC-3)manifests the best catalytic performance among the analogous obtained Pt-based electrocatalysts.The FAO mass activity of the PtAu/CoNC-3 sample reached 0.88 A·mg_(Pt)^(-1),which is 26.0 times higher than that of Pt/C.The results of first-principles calculation and CO stripping jointly demonstrate that the CO adsorption of PtAu/CoNC is considerably lower than that of Pt/CoNC and PtAu/C,which indicates that the synergistic effect of Pt,Au,and CoNC NFs is critical for the resistance of Pt to CO poisoning.This work is of great significance for a deeper understanding of the oxidation mechanism of formic acid and provides a feasible and promising strategy for enhancing the catalytic performance of the catalyst by improving the direct reaction pathway for FAO. | Mengchao Liang Tianyu Xia Han Gao Kai Zhao Tianqi Cao Meng Deng Xiaoyan Ren Shunfang Li Haizhong Guo Rongming Wang | 2022 | Nano Research2022，15，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员