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49篇 您的检索式:作者名="Shuo Pan"
    题名 作者 年代 出处 被引量
1MiR-27a Promotes Hepatocellular Carcinoma Cell Proliferation Through Suppression of its Target Gene Peroxisome Proliferator-activated Receptor γ显示文摘Shuo Li Jing Li Bing-Yuan Fei Dan Shao Yue Pan Zhan-Hao MO Bao-Zhen Sun Dan Zhang Xiao Zheng Ming Zhang Xue-Wen Zhang Li Chen 2015Chinese Medical Journal2015,,7:15
2Potential biomarkers predicting risk of pulmonary hypertension in congenital heart disease: the role of homocysteine and hydrogen sulfide显示文摘Sun Ling Sun Shuo Li Yufen Pan Wei Xie Yumei Wang Shushui Zhang Zhiwei 2014Chinese Medical Journal2014,,5:13
3Facilitating Lithium-Ion Diffusion in Layered Cathode Materials by Introducing Li^(+)/Ni^(2+) Antisite Defects for High-Rate Li-Ion Batteries显示文摘Li^(+)/Ni^(2+) antisite defects mainly resulting from their similar ionic radii in the layered nickel-rich cathode materials belong to one of cation disordering scenarios.They are commonly considered harmful to the electrochemical properties,so a minimum degree of cation disordering is usually desired.However,this study indicates that LiNi_(0.8)Co_(0.15)Al_(0.05)O_(2)as the key material for Tesla batteries possesses the highest rate capability when there is a minor degree(2.3%)of Li^(+)/Ni^(2+) antisite defects existing in its layered structure.By combining a theoretical calculation,the improvement mechanism is attributed to two effects to decrease the activation barrier for lithium migration:(1)the anchoring of a low fraction of high-valence Ni^(2+) ions in the Li slab pushes uphill the nearest Li^(+)ions and(2)the same fraction of low-valence Li^(+) ions in the Ni slab weakens the repulsive interaction to the Li^(+) ions at the saddle point.Zhongfeng Tang Sen Wang Jiaying Liao Shuo Wang Xiaodong He Bicai Pan Haiyan He Chunhua Chen 2019Research2019,,1:8
4Tissue P systems with cell separation: attacking the partition problem显示文摘Tissue P systems are distributed parallel and non-deterministic computing models in the framework of membrane computing, which are inspired by intercellular communication and cooperation between neurons. Recently, cell separation is introduced into tissue P systems, which enables systems to generate an exponential workspace in a polynomial time. In this work, the computational power of tissue P systems with cell separation is investigated. Specifically, a uniform family of tissue P systems with cell separation is constructed for effciently solving a well-known NP-complete problem, the partition problem.ZHANG XingYi WANG Shuo NIU YunYun PAN LinQiang 2011Science China(Information Sciences)2011,54,2:6
5Curcumin inhibits the replication of enterovirus 71 in vitro显示文摘Human enterovirus 71(EV71)is the main causative pathogen of hand,foot,and mouth disease(HFMD)in children.The epidemic of HFMD has been a public health problem in Asia-Pacific region for decades,and no vaccine and effective antiviral medicine are available.Curcumin has been used as a traditional medicine for centuries to treat a diversity of disorders including viral infections.In this study,we demonstrated that curcumin showed potent antiviral effect again EV71.In Vero cells infected with EV71,the addition of curcumin significantly suppressed the synthesis of viral RNA,the expression of viral protein,and the overall production of viral progeny.Similar with the previous reports,curcumin reduced the production of ROS induced by viral infection.However,the antioxidant property of curcumin did not contribute to its antiviral activity,since N-acetyl-L-cysteine,the potent antioxidant failed to suppress viral replication.This study also showed that extracellular signal-regulated kinase(ERK)was activated by either viral infection or curcumin treatment,but the activated ERK did not interfere with the antiviral effect of curcumin,indicating ERK is not involved in the antiviral mechanism of curcumin.Unlike the previous reports that curcumin inhibited protein degradation through ubiquitin–proteasome system(UPS),we found that curcumin had no impact on UPS in control cells.However,curcumin did reduce the activity of proteasomes which was increased by viral infection.In addition,the accumulation of the short-lived proteins,p53 and p21,was increased by the treatment of curcumin in EV71-infected cells.We further probed the antiviral mechanism of curcumin by examining the expression of GBF1 and PI4KB,both of which are required for the formation of viral replication complex.We found that curcumin significantly reduced the level of both proteins.Moreover,the decreased expression of either GBF1 or PI4KB by the application of siRNAs was sufficient to suppress viral replication.We also demonstrated that curcumin showed anti-apoptotic activity at the early stage of viral infection.The results of this study provide solid evidence that curcumin has potent anti-EV71 activity.Whether or not the down-regulated GBF1 and PI4KB by curcumin contribute to its antiviral effect needs further studies.Ying Qin Lexun Lin Yang Chen Shuo Wu Xiaoning Si Heng Wu Xia Zhai Yan Wang Lei Tong Bo Pan Xiaoyan Zhong Tianying Wang Wenran Zhao Zhaohua Zhong 2014Acta Pharmaceutica Sinica B2014,4,4:5
6Application of Principal Component Analysis(PCA)to the Evaluation and Screening of Multiactivity Fungi显示文摘Continued innovation in screening methodologies remains important for the discovery of high-quality multiactive fungi,which have been of great significance to the development of new drugs.Mangrove-derived fungi,which are well recognized as prolific sources of natural products,are worth sustained attention and further study.In this study,118 fungi,which mainly included Aspergillus spp.(34.62%)and Penicillium spp.(15.38%),were isolated from the mangrove ecosystem of the Maowei Sea,and 83.1%of the cultured fungi showed at least one bioactivity in four antibacterial and three antioxidant assays.To accurately evaluate the fungal bioactivities,the fungi with multiple bioactivities were successfully evaluated and screened by principal component analysis(PCA),and this analysis provided a dataset for comparing and selecting multibioactive fungi.Among the 118 mangrove-derived fungi tested in this study,Aspergillus spp.showed the best comprehensive activity.Fungi such as A.clavatonanicus,A.flavipes and A.citrinoterreus,which exhibited high comprehensive bioactivity as determined by the PCA,have great potential in the exploitation of natural products and the development of new drugs.This study demonstrated the first use of PCA as a time-saving,scientific method with a strong ability to evaluate and screen multiactive fungi,which indicated that this method can affect the discovery and development of new drugs.YANG Zonglin SHI Yaqi LI Pinglin PAN Kanghong LI Guoqiang LI Xianguo YAO Shuo ZHANG Dahai 2022Journal of Ocean University of China2022,21,3:4
7Distinct functions of polycomb group proteins in regulating Ci transcription in developing Drosophila显示文摘Xiangdong Lv Hao Chen Shuo Zhang Zhao Zhang Chenyu Pan Yuanxin Xia Jialin Fan Wenqing Wu Yi Lu Lei Zhang Hailong Wu Yun Zhao 2018Journal of Molecular Cell Biology2018,10,5:3
8Novel rat model of multiple mitochondrial dysfunction syndromes(MMDS)complicated with cardiomyopathy显示文摘Background:Multiple mitochondrial dysfunction syndromes(MMDS)presents as complex mitochondrial damage,thus impairing a variety of metabolic pathways.Heart dysplasia has been reported in MMDS patients;however,the specific clinical symptoms and pathogenesis remain unclear.More urgently,there is a lack of an animal model to aid research.Therefore,we selected a reported MMDS causal gene,Isca1,and established an animal model of MMDS complicated with cardiac dysplasia.Methods:The myocardium-specific Isca1 knockout heterozygote(Isca1 HET)rat was obtained by crossing the Isca1 conditional knockout(Isca1 cKO)rat with theαmyosin heavy chain Cre(α-MHC-Cre)rat.Cardiac development characteristics were determined by ECG,blood pressure measurement,echocardiography and histopatho-logical analysis.The responsiveness to pathological stimuli were observed through adriamycin treatment.Mitochondria and metabolism disorder were determined by activity analysis of mitochondrial respiratory chain complex and ATP production in myocardium.Results:ISCA1 expression in myocardium exhibited a semizygous effect.Isca1 HET rats exhibited dilated cardiomyopathy characteristics,including thin-walled ventri-cles,larger chambers,cardiac dysfunction and myocardium fibrosis.Downregulated ISCA1 led to deteriorating cardiac pathological processes at the global and organiza-tional levels.Meanwhile,HET rats exhibited typical MMDS characteristics,including damaged mitochondrial morphology and enzyme activity for mitochondrial respira-tory chain complexesⅠ,ⅡandⅣ,and impaired ATP production.Conclusion:We have established a rat model of MMDS complicated with cardiomyopathy,it can also be used as model of myocardial energy metabolism dysfunction and mitochondrial cardiomyopathy.This model can be applied to the study of the mechanism of energy metabolism in cardiovascular diseases,as well as research and development of drugs.Yahao Ling Jiaxin Ma Xiaolong Qi Xu Zhang Qi Kong Feifei Guan Wei Dong Wei Chen Shan Gao Xiang Gao Shuo Pan Yuanwu Ma Dan Lu Lianfeng Zhang 2021Animal Models and Experimental Medicine2021,4,4:2
9Synthesis and Characterization of Electroless Ni-P/Ni-Mo-P Duplex Coating with Different Thickness Combinations显示文摘In this work, a novel duplex Ni-P/Ni-Mo-P coating upon the aluminum(Al) substrate was synthesized via an electroless plating, i.e., the binary Ni-P coating as a transition layer and the ternary Ni-Mo-P coating on the top. It was found that the duplex coating was of a high hardness,large elastic modulus,low porosity and excellent corrosion resistance. In addition, experimental results revealed that for a total 20 μm coating thickness, the duplex coating with a 7 μm of the Ni-Mo-P coating exhibited the best corrosion resistance in 0.5 mol/L sulfuric acid solution, which was attributed to its compact structure and low porosity. This duplex Ni-P/Ni-Mo-P coating with a thin ternary Ni-Mo-P layer is expected to solve the problem of low deposition rate of ternary alloy coating and thereby may expand applications of Al and its alloys in the fields of machine manufacture and corrosion environment.Gong-Sheng Song Shuo Sun Zhong-Chi Wang Cheng-Zhi Luo Chun-Xu Pan 2017Acta Metallurgica Sinica(English Letters)2017,30,10:2
10Fsh-Pc-Sce complex mediates active transcription of Cubitus interruptus (Ci)显示文摘表明小径的刺猬(Hh ) 在胚胎的开发和成年织物动态平衡起重要作用。如此的生物功能被抄写因素肘脉 interruptus (Ci ) 调停。然而,受动器 Ci 本身的 transcriptional 规定糟糕被调查。通过一幅基于 RNAi 的基因屏幕,我们识别了那女性无菌(1 ) homeotic (Fsh ) ,抄写激活剂,直接激活 Ci 抄写。生物化学试金在 Fsh 之中表明了物理相互作用,性梳子额外(Sce ) ,并且 Polycomb (Pc ) 。功能的试金进一步证明 Pc 和 Sce 为 Ci 被要求表示,没被 Engrailed 的 derepression 多半调停,) , Ci 的一个抑压者,在 Pc 或 Sce 异种房间。最后,我们提供证明 Pc/Sce 在 Ci 地点便于 Fsh 的绑定并且在 Fsh 和 Pc 之间的物理相互作用为调停 Fsh 的 Ci 抄写是必要的证据。一起拿,我们不仅揭开那 Ci 被复杂的 Fsh-Pc-Sce transcriptionally 调整而且在 transcriptional 为在 Fsh 和 PcG 蛋白质之间的协作提供证据规定。Xiangdong Lv Hao Chen Shuo Zhang Zhao Zhang Chenyu Pan Yuanxin Xia Jialin Fan Wenqing Wu Yi Lu Lei Zhang Hailong Wu Yun Zhao 2018Journal of Molecular Cell Biology2018,10,5:2
11Control over π-π stacking of heteroheptacene-based nonfullerene acceptors for 16% efficiency polymer solar cells显示文摘Nonfullerene acceptors are being investigated for use in polymer solar cells(PSCs),with their advantages of extending the absorption range,reducing the energy loss and therefore enhancing the power conversion efficiency(PCE).However,to further boost the PCE,mobilities of these nonfullerene acceptors should be improved.For nonfullerene acceptors,the π-π stacking distance between cofacially stacked molecules significantly affects their mobility.Here;we demonstrate a strategy to increase the mobility of heteroheptacene-based nonfullerene acceptors by reducing their n'-7r stacking distances via control over the bulkiness of lateral side chains.Incorporation of 2-butyloctyl substituents into the nonfullerene acceptor(M36)leads to an increased mobility with a reduced π-π stacking distance of 3.45 A.Consequently,M36 affords an enhanced PCE of 16%,which is the highest among all acceptor-donor-acceptor-type nonfullerene acceptors to date.This strategy of control over the bulkiness of side chains on nonfullerene acceptors should aid the development of more efficient PSCs.Yunlong Ma Dongdong Cai Shuo Wan Pan Yin Pengsong Wang Wenyuan Lin Qingdong Zheng 2020National Science Review2020,7,12:2
12Efficacy and safety of antifibrinolytic agents in spinal surgery: a network meta-analysis显示文摘Background: Significant blood loss is still one of the most frequent complications in spinal surgery, which often necessitates blood transfusion. Massive perioperative blood loss and blood transfusion can create additional risks. Aprotinin, tranexamic acid (TXA), and epsilon-aminocaproic acid (EACA) are antifibrinolytics currently offered as prophylactic agents to reduce surgery-ass oci a ted blood loss. The aim of this study was to evaluate the efficacy and safety of aprotinin, EACA, and low/high doses of TXA in spinal surgery, and assess the use of which agent is the most optimal intervention using the network meta-analysis (NMA) method. Methods: Five electronic databases were searched, including PubMed, Cochrane Library, ScienceDirect, Embase, and Web of Science, from the inception to March 1,2018. Trials that were randomized and compared results between TXA, EACA, and placebo were identified. The NMA was conducted with software R 3.3.2 and STATA 14.0. Results: Thirty randomized controlled trial (RCT) studies were analyzed. Aprotinin (standardized mean difference [SMD]=-0.65, 95% credibility intervals [CrI;-1.25,-0.06]), low-dose TXA (SMD=-0.58, 95% CrI [-0.92,-0.25]), and high-dose TXA (SMD =-0.70, 95% CrI [-1.04,-0.36]) were more effective than the respective placebos in reducing intraoperative blood loss. Low-dose TXA (SMD=-1.90, 95% CrI [-3.32,-0.48]) and high-dose TXA (SMD =-2.31, 95% CrI [-3.75,-0.87]) had less postoperative blood loss. Low-dose TXA (SMD=-1.07, 95% CrI [-1.82,-0.31]) and high-dose TXA (SMD =-1.07, 95% CrI[-1.82,-0.31]) significantly reduced total blood loss. However, only high-dose TXA (SMD =-2.07, 95% CrI [-3.26,-0.87]) was more effective in reducing the amount of transfusion, and was significantly superior to low-dose TXA in this regard (SMD =-1.67, 95% CrI [-3.20,-0.13]). Furthermore, aprotinin (odds ratio [OR]= 0.16, 95% CrI [0.05, 0.54]), EACA (OR = 0.46, 95% CrI [0.22, 0.97]) and high dose of TXA (OR = 0.34, 95% CrI [0.19, 0.58]) had a significant reduction in transfusion rates. Antifibrinolytics did not show a significantly increased risk of postoperative thrombosis. Results of ranking probabilities indicated that high-dose TXA had the greatest efficacy and a relatively high safety level. Conclusions: The antifibrinolytic agents are able to reduce perioperative blood loss and transfusion requirement during spine surgery. And the high-dose TXA administration might be used as the optimal treatment to reduce blood loss and transfusion.Lei Yuan Yan Zeng Zhong-Qiang Chen Xin-Ling Zhang Shuo Mai Pan Song Li-Yuan Tao 2019Chinese Medical Journal2019,,5:2
13Evodiamine derivatives improve cognitive abilities in APP^(swe)/PS1^(ΔE9) transgenic mouse models of Alzheimer's disease显示文摘Background: Alzheimer's disease(AD) is a complex neurodegenerative disease. Due to the complexity of its molecular pathogenesis and the interaction of the numerous factors involved, the etiology and pathogenesis of AD have not been fully elucidated. Therefore, effective treatment for AD remains to be developed. Evodiamine, a quinolone alkaloid, has been found to improve learning and memory ability to in the APP^(swe)/PS1^(ΔE9) mouse model of dementia. However, the cytotoxicity and physicochemical properties of evodiamine have limited its use in the treatment of AD.Methods: Evodiamine and its derivatives were effectively synthesized by EDCImediated condensation at room temperature. These target compounds contained 1 thio-and 21 oxo-evodiamine derivatives with different substituted groups. The cytotoxicity of evodiamine and its derivatives and the neuroprotective effects of the evodiamine derivatives against H_2O_2-induced cell loss in SH-SY5 Y cells were investigated using the WST-8 assay. The Morris water-maze test was used to detect the effect of evodiamine and its derivatives on improving learning and memory in APP^(swe)/PS1^(ΔE9) mice.Results: In this study, a series of oxo-and thio-evodiamine derivatives was synthesized. Several derivatives showed lower cytotoxicity and stronger neuroprotective effects than evodiamine and elicited enhanced cognitive improvement, especially in the test of spatial memory in APP^(swe)/PS1^(ΔE9) mice.Conclusion: Our study provides insights for developing novel evodiamine derivatives for chemical intervention and treatment of AD.Shuo Pang Caixian Sun Shan Gao Yajun Yang Xiandao Pan Lianfeng Zhang 2020Animal Models and Experimental Medicine2020,3,2:2
14Sugar transfer of nanomaterials and flexible electrodes显示文摘Nanomaterials with various dimensionalities(e.g.,nanowires,nanofilms,two-dimensional materials,and three-dimensional nanostructures)have shown great potential in the recent development of flexible electronics.Conventionally,organic solvents are inevitable while integrating nanomaterials onto flexible substrates,where polymer mediator-assisted transfer techniques are involved.This often damages the flexible substrate and thus hamper the large-scale application of nanomaterials.Here we report a method using watersoluble sugar as a mediator to facilely transfer nanomaterials onto rigid or flexible substrates.This method requires no organic solvent during transfer.More importantly,the morphology and properties of transferred nanomaterials,such as shape,microstructure,resistivity,and transmittance are well preserved on the target substrate.We believe that this universal and rapid transfer method can greatly advance the applications of nanomaterials in the field of flexible devices and beyond.Tianzeng Hong Tianze Shen Junlong Yang Yichen Sun Jianming Zhang Haiyang Pan Ying Hong Yan Wang Shuo Chen Yue Zhao Chuan Fei Guo 2020International Journal of Smart and Nano Materials2020,11,1:1
15Three-Dimensional Measurement Using Structured Light Based on Deep Learning显示文摘Three-dimensional(3D)reconstruction using structured light projection has the characteristics of non-contact,high precision,easy operation,and strong real-time performance.However,for actual measurement,projection modulated images are disturbed by electronic noise or other interference,which reduces the precision of the measurement system.To solve this problem,a 3D measurement algorithm of structured light based on deep learning is proposed.The end-to-end multi-convolution neural network model is designed to separately extract the coarse-and fine-layer features of a 3D image.The point-cloud model is obtained by nonlinear regression.The weighting coefficient loss function is introduced to the multi-convolution neural network,and the point-cloud data are continuously optimized to obtain the 3D reconstruction model.To verify the effectiveness of the method,image datasets of different 3D gypsum models were collected,trained,and tested using the above method.Experimental results show that the algorithm effectively eliminates external light environmental interference,avoids the influence of object shape,and achieves higher stability and precision.The proposed method is proved to be effective for regular objects.Tao Zhang Jinxing Niu Shuo Liu Taotao Pan Brij B.Gupta 2021Computer Systems Science & Engineering2021,36,1:1
16Down-Regulation of Platelet-Activating Factor Receptor Gene Expression During Focal Reversible Cerebral Ischemia inRats显示文摘Xiong Zhang Xi-Long Pan Xin-Tong Liu Shuo Wang Li-Juan Wang 2007Neurochemical Research2007,32,3:1
17A complete assembly of the rice Nipponbare reference genome显示文摘Dear Editor,In 2005,the current commonly used rice reference genome(Oryza sativa ssp.japonica cv.Nipponbare)was initially released by the International Rice Genome Sequencing Project(International Rice Genome Sequencing Project,2005).Thereafter,the reference genome was further updated in 2013 with improved genome assembly(IRGSP-1.0)and gene annotations(MSU7,RAP-DB)(Kawahara et al.,2013;Sakai et al.,2013).In the past 10 years,this reference has been serving as one of the most important genetic resources for subsequent rice functional genomics efforts.As several rice genomes had been assembled into gapless chromosomes with only 2–5 telomeres absent(Li et al.,2021;Song et al.,2021;Zhang et al.,2022),the IRGSP1.0 and its annotations still performed as the most widely used reference.However,limitations of sequencing technology and intricate genomic organization led to an under-representation of complex regions in this reference,leaving a total of 72 major gaps(including 19 telomeres),167 minor gaps,and 779 unknown bases(Kawahara et al.,2013),with an estimated length of3%of the genome unsolved.Lianguang Shang Wenchuang He Tianyi Wang Yingxue Yang Qiang Xu Xianjia Zhao Longbo Yang Hong Zhang Xiaoxia Li Yang Lv Wu Chen Shuo Cao Xianmeng Wang Bin Zhang Xiangpei Liu Xiaoman Yu Huiying He Hua Wei Yue Leng Chuanlin Shi Mingliang Guo Zhipeng Zhang Bintao Zhang Qiaoling Yuan Hongge Qian Xinglan Cao Yan Cui Qianqian Zhang Xiaofan Dai Congcong Liu Longbiao Guo Yongfeng Zhou Xiaoming Zheng Jue Ruan Zhukuan Cheng Weihua Pan Qian Qian 2023Molecular Plant2023,16,8:1
18Coherent noise reduction in digital holographic phase contrast microscopy by slitly shifting object显示文摘PAN Feng XIAO Wen LIU Shuo 2011Optics Express(S1094-4087)2011,19,5:1
19Diferences and similarities of high-resolution computed tomography features between pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients显示文摘Background:Accurately diferentiating pneumocystis from cytomegalovirus pneumonia is crucial for correct therapy selection in AIDS patients.Hence,the goal of this study was to compare the computerized tomography(CT)features of pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients and identify clinical hallmarks to accurately distinguish these two pathologies.Methods:A total of 112 AIDS patients(78 with pneumocystis pneumonia and 34 cytomegalovirus pneumonia)at Beijing Ditan Hospital from January 2017 to May 2019 were included in this study.Two experienced chest radiologists retrospectively reviewed CT images for 17 features including ground-glass opacity,consolidation,nodules,and halo sign.Binary logistic regression analyses were conducted to identify the signifcant parameters that distinguished pneumocystis pneumonia from cytomegalovirus pneumonia.Correlations were analyzed by Pearson or Spearman correlation analyses.Result were considered signifcant if P<0.05.Results:The presence of consolidation,halo signs,and nodules(all P<0.05)were signifcantly more frequent in patients with cytomegalovirus pneumonia than in those with pneumocystis pneumonia.Small nodules(32.5%in cytomegalovirus pneumonia,6.41%in pneumocystis pneumonia,P<0.001)without perilymphatic distribution were particularly common in patients with cytomegalovirus pneumonia.Large nodules were not found in any of patients with cytomegalovirus pneumonia.The presence of ground-glass opacity,reticulation,and bronchial wall thickening(all P>0.05)were common in both groups.Conclusions:Analysis of consolidation,nodules,and halo signs may contribute to the diferential diagnosis of pneumocystis pneumonia or cytomegalovirus pneumonia.However,some CT features considered typical in one or other diseases appear with similar frequency in both cohorts of AIDS patients.CT features are potentially useful for the diferential diagnosis of pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients.Chun‑Jing Du Jing‑Yuan Liu Hui Chen Shuo Yan Lin Pu Hao‑Feng Xiong Pan Xiang Chuan‑Sheng Li Ming Zhang Ru‑Ming Xie Bu‑Dong Chen Ang Li 2020Infectious Diseases of Poverty2020,9,5:1
20An electrochemical sensor for rapid determination of ractopamine based on a molecularly imprinted electrosynthesized o -aminothiophenol film显示文摘Ling-Jie Kong Ming-Fei Pan Guo-Zhen Fang Kun Qian Shuo Wang 2012Analytical and Bioanalytical Chemistry2012,,6:1
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