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| 1 | Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis显示文摘The effective drug treatment of rheumatoid arthritis (RA) is hindered by poordelivery efficiency to the diseased site and the serious side effects caused bywide-spread drug distribution. Traditional drug-targeting strategies, such asligand modification, are complex, laborious, and inefficient. Inspired by theintrinsic relationship between platelets and RA, platelet-mimetic nanoparticles(PNPs) were developed for targeted drug delivery in RA. Through plateletreceptor-mediated adhesion, an intact platelet membrane was coated onto poly(lactic-co-glycolic add) nanopartides, endowing the resulting PNPs with variousfunctional receptors. By coating with platelet membranes, the nanoparticleswere stabilized and had a better circulation profile, providing a benefit forpassive targeting. In vitro binding of PNPs to inflamed endothelium, and in vivoaccumulation in joints of a collagen-induced arthritis (CIA) mouse model of RAwere significantly improved via P-selectin and GVPI recognition, indicating thatthe PNPs could effectively target to RA tissues through multiple mechanisms,similar to natural platelets. Moreover, FK506, a model drug, was loaded into thePNPs and used to treat RA. Pharmacodynamic studies demonstrated that theFK506-PNPs had a notable anti-arthritic effect in CIA mice. This study provides anew biomimetic targeting strategy with great potential for the treatment of RA. | Yuwei He Ruixiang Li Jianming Liang Ying Zhu Shuya Zhang Zicong Zheng Jing Qin Zhiqing Pang Jianxin Wang | 2018 | Nano Research2018，11，11： | 9 |
| 2 | Referred Somatic Hyperalgesia Mediates Cardiac Regulation by the Activation of Sympathetic Nerves in a Rat Model of Myocardial Ischemia显示文摘Myocardial ischemia(MI)causes somatic referred pain and sympathetic hyperactivity,and the role of sensory inputs from referred areas in cardiac function and sympathetic hyperactivity remain unclear.Here,in a rat model,we showed that MI not only led to referred mechanical hypersensitivity on the forelimbs and upper back,but also elicited sympathetic sprouting in the skin of the referred area and C8–T6 dorsal root ganglia,and increased cardiac sympathetic tone,indicating sympathetic-sensory coupling.Moreover,intensifying referred hyperalgesic inputs with noxious mechanical,thermal,and electro-stimulation(ES)of the forearm augmented sympathetic hyperactivity and regulated cardiac function,whereas deafferentation of the left brachial plexus diminished sympathoexcitation.Intradermal injection of the α_(2) adrenoceptor(α_(2)AR)antagonist yohimbine and agonist dexmedetomidine in the forearm attenuated the cardiac adjustment by ES.Overall,these findings suggest that sensory inputs from the referred pain area contribute to cardiac functional adjustment via peripheral α_(2)AR-mediated sympathetic-sensory coupling. | Xiang Cui Guang Sun Honglei Cao Qun Liu Kun Liu Shuya Wang Bing Zhu Xinyan Gao | 2022 | Neuroscience Bulletin2022，38，4： | 4 |
| 3 | KOH-assisted aqueous synthesis of bimetallic metal-organic frameworks and their derived selenide composites for efficient lithium storage显示文摘To solve low efficiency,environmental pollution,and toxicity for synthesizing zeolitic imidazolate frameworks(ZIFs)in organic solvents,a KOH-assisted aqueous strategy is proposed to synthesize bimetallic ZIFs polyhedrons,which are used as precursors to prepare bimetallic selenide and N-doped carbon(NC)composites.Among them,Fe–Co–Se/NC retains the three-dimensional(3D)polyhedrons with mesoporous structure,and Fe–Co–Se nanoparticles are uniform in size and evenly distributed.When assessed as anode material for lithium-ion batteries,Fe–Co–Se/NC achieves an excellent initial specific capacity of 1165.9 m Ah·g^(-1)at 1.0 A·g^(-1),and the reversible capacity of Fe–Co–Se/NC anode is 1247.4 m Ah·g^(-1)after 550 cycles.It is attributed to that the uniform composite of bimetallic selenides and N-doped carbon can effectively tune redox active sites,the stable 3D structure of Fe–Co–Se/NCs guarantees the structural stability and wettability of the electrolyte,and the uniform distribution of Fe–Co–S nanoparticles in size esuppresses the volume expansion and accelerates the electrochemical reaction kinetics. | Shuya Zhang Yanchun Xue Yutang Zhang Chengxing Zhu Xingmei Guo Fu Cao Xiangjun Zheng Qinghong Kong Junhao Zhang Tongxiang Fan | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，4： | 2 |
| 4 | Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2显示文摘Dear Editor To date,tens of millions of people have been infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),causing the outbreak of the respiratory disease named the coronavirus disease 2019(COVID-19).As a newly emerged member of the coronavirus family,SARS-CoV-2 is an enveloped positive-strand RNA virus,which has probably the largest genome(approximately 30 kb)among all RNA viruses.The nucleocapsid(N)protein of SARS-CoV-2 is mainly responsible for recognizing and wrapping viral RNA into helically symmetric structures(Malik,2020). | Dan Zhao Weifan Xu Xiaofan Zhang Xiaoting Wang Yiyue Ge Enming Yuan Yuanpeng Xiong Shenyang Wu Shuya Li Nian Wu Tingzhong Tian Xiaolong Feng Hantao Shu Peng Lang Jingxin Li Fengcai Zhu Xiaokun Shen Haitao Li Pilong Li Jianyang Zeng | 2021 | Protein & Cell2021，12，9： | 1 |
| 5 | Step distribution of Yb filling fraction during microstructural evolution in skutterudites显示文摘To achieve a better material for thermoelectric power generation device, filled skutterudite Yb0.3 Co_4 Sb_(12) samples were fabricated by melting-quenching-annealing-spark plasma sintering(SPS)method. Two sets of samples, before and after SPS, were investigated. In both the two sets of samples,the average grain size of the samples increases monotonously with the increase of annealing time,while Yb filling fraction firstly increases and then decreases. Yb not filling into the skutterudite remains at the grain boundaries in the form of Yb_2 O_3 after SPS, which could be quantified by the spatially difference method of energy dispersive spectra. Step distribution of Yb filling fraction was observed in the samples annealed for 1 h, which was caused by the microstructural evolution from the peritectic phases to the skutterudite phase. The sample annealed for 3 days and SPS sintered possesses the maximum value of Yb filling fraction 0.249 and the maximum ZT value of 1.24 at 850 K. These results are helpful to better understand the microstructural evolution and Yb filling behavior in skutterudite materials. | Jing MEI Zheng YAO Shuya ZHU Dongli HU Ying JIANG Juanjuan XING Hui GU Lidong CHEN | 2019 | Journal of Advanced Ceramics2019，8，1： | 0 |
| 6 | An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19显示文摘The global spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019(COVID-19).In this study,we developed an integrative drug repositioning framework,which fully takes advantage of machine learning and statistical analysis approaches to systematically integrate and mine large-scale knowledge graph,literature and transcriptome data to discover the potential drug candidates against SARS-CoV-2.Our in silico screening followed by wet-lab validation indicated that a poly-ADP-ribose polymerase 1(PARP1)inhibitor,CVL218,currently in Phase I clinical trial,may be repurposed to treat COVID-19.Our in vitro assays revealed that CVL218 can exhibit effective inhibitory activity against SARS-CoV-2 replication without obvious cytopathic effect.In addition,we showed that CVL218 can interact with the nucleocapsid(N)protein of SARS-CoV-2 and is able to suppress the LPS-induced production of several inflammatory cytokines that are highly relevant to the prevention of immunopathology induced by SARS-CoV-2 infection. | Yiyue Ge Tingzhong Tian Suling Huang Fangping Wan Jingxin Li Shuya Li Xiaoting Wang Hui Yang Lixiang Hong Nian Wu Enming Yuan Yunan Luo Lili Cheng Chengliang Hu Yipin Lei Hantao Shu Xiaolong Feng Ziyuan Jiang Yunfu Wu Ying Chi Xiling Guo Lunbiao Cui Liang Xiao Zeng Li Chunhao Yang Zehong Miao Ligong Chen Haitao Li Hainian Zeng Dan Zhao Fengcai Zhu Xiaokun Shen Jianyang Zeng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 7 | Transcriptome analysis revealing the mechanism of soybean protein isolates and soybean peptides on Lacticaseibacillus rhamnosus Lra05显示文摘To further investigate the promoting effect of soybean protein and peptides on Lacticaseibacillus rhamnosus Lra05(L.rhamnosus Lra05),the overall changes of gene expression of it was investigated through transcriptome analysis treated with dPEP and dSPI The results showed that there were 890,113,and 1073 differentially expressed genes(DEGs)in dPEP/MRS,dSPI/MRS and dPEP/dSPI comparison,respectively.Besides,we found dPEP could promote the expression of acc and fab family genes related to fatty acid biosynthesis,but dSPI played the opposite role.Moreover,dPEP stimulated genes clustered in pur family and ribosome protein,responsible for purine and protein synthesis.Interestingly,dPEP suppressed genes regulating peptides and amino acids transportation and dSPI specially inhibited the pyr family genes involved in pyrimidine metabolism.These data revealed the knowledge about the metabolic pathways affected by dPEP and dSPI and provide a preliminary understanding of the relationship between soybean proteins and peptides and L.rhamnosus Lra05. | Yinxiao Zhang Shuya Zhu Chi Zhang Mohamed Mohamed Soliman He Li Xinqi Liu | 2022 | Food Bioscience2022，47，3： | 0 |
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