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| 1 | Control of a Quadruped Robot with Bionic Springy Legs in Trotting Gait显示文摘 | Mantian Li Zhenyu Jiang Pengfei Wang Lining Sun Shuzhi Sam Ge | 2014 | Journal of Bionic Engineering2014，11，2： | 25 |
| 2 | Endoscopic Palliative Treatment for Malignant Obstructive Jaundice: A Report of 929 Cases显示文摘Objective:To review the experience with endoscopic palliative treatment for malignant obstructive jaundice (MOJ) in 929 patients. Methods:929 patients (598 males and 331 females) underwent 1215 endoscopic palliative drainages for MOJ in our hospital. Tumor obstruetion oeeurred in the distal common bile duet(CBD)(263 patients), the middle CBD (43),and the hilum(909).The mean bilirubin level was 284.3 μmol/L(range 26-810). Of the 1215 drainages, 599 were performed by stenting with plastic endoprosthesis, 385 by naso-biliary eatheterization, 167 by expandable metal stents,39 by combined drainage method,19 by tumor sphincterotomy and 6 by endoseopie fistulostomy. Results:The successful rate of endoscopic procedure was 94.3%. The jaundice symptom was improved in 81.8% of the patients with a significant reduetion of serum bilirubin in 64.7%. The complication after treatment occurred in 23 eases (2.6%), including eholangitis(23 eases), panereatitis (8 eases), and bleeding (one ease), and 3 eases were dead (0.2%).The median survival time of all patients was 14 months and life time analysis showed a life expectancy of 75.9%, 44.0% and 25.2% at 1, 2 and 3 years respectively. Conclusion:In the patients with MOJ seeondary to panereatobiliary malignancy, sueeessful endoscopic drainage provides adequate relief of biliary obstruetion and is associated with low morbidity and mortality. Enduseopie interventional treatment may be considered as an alternative of palliative biliary operation for the late stage of pancreatic and biliary malignaneies. | HU Bing, ZHOU Daiyun, GONG Biao, WANG Shuzhi, WU Mengchao Eastern Hepatohiliary Surgery Hospital, Second Military Medical University Shanghai 200438, China | 2002 | The Chinese-German Journal of Clinical Oncology2002，1，1： | 15 |
| 3 | Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer显示文摘To flourish,cancers greatly depend on their surrounding tumor microenvironment(TME),and cancer-associated fibroblasts(CAFs)in TME are critical for cancer occurrence and progression because of their versatile roles in extracellular matrix remodeling,maintenance of sternness,blood vessel formation,modulation of tumor metabolism,immune response,and promotion of cancer cell proliferation,migration,invasion,and therapeutic resistance.CAFs are highly heterogeneous stromal cells and their crosstalk with cancer cells is mediated by a complex and intricate signaling network consisting of transforming growth factor-beta,phosphoinositide 3-kinase/AKT/mammalian target of rapamycin,mitogen-activated protein kinase,Wnt,Janus kinase/signal transducers and activators of transcription,epidermal growth factor receptor,Hippo,and nuclear factor kappa-light-chain-enhancer of activated B cells,etc.,signaling pathways.These signals in CAFs exhibit their own special characteristics during the cancer progression and have the potential to be targeted for anticancer therapy.Therefore,a comprehensive understanding of these signaling cascades in interactions between cancer cells and CAFs is necessary to fully realize the pivotal roles of CAFs in cancers.Herein,in this review,we will summarize the enormous amounts of findings on the signals mediating crosstalk of CAFs with cancer cells and its related targets or trials.Further,we hypothesize three potential targeting strategies,including,namely,epithelial-mesenchymal common targets,sequential target perturbation,and crosstalk-directed signaling targets,paving the way for CAF-directed or host cell-directed antitumor therapy. | Fanglong Wu Jin Yang Junjiang Liu Ye Wang Jingtian Mu Qingxiang Zeng Shuzhi Deng Hongmei Zhou | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 9 |
| 4 | Apelin-13 inhibits lipoprotein lipase expression via the APJ/PKCα/miR-361-5p signaling pathway in THP-1 macrophage-derived foam cells显示文摘动脉粥样硬化患者损害被丰富的类脂化合物和长期的发炎的累积描绘。以前的研究显示了导出巨噬细胞的脂蛋白脂肪分解酵素(LPL ) 由加速类脂化合物累积和支持 inflammatory cytokine 分泌物支持动脉粥样硬化前进。尽管 apelin-13 被认为是一个 atheroprotective 因素,它是否能调整 LPL 的表示,仍然保持不清楚。这研究的目的是在 THP-1 导出巨噬细胞的泡沫房间在 LPL 和内在的机制的表示上探索 apelin-13 的效果。Apelin-13 显著地减少了在 10 和 100 nM 的集中的全部的胆固醇,免费胆固醇,和胆固醇酉旨的细胞的层次。ELISA 分析证实有 apelin-13 的处理减少了支持 inflammatory cytokine 分泌物,例如 interleukin-6 (IL-6 ) , interleukin-1 (IL-1 ) 和肿瘤坏死 factor-alpha (TNF-) 。apelin-13 禁止了由西方的污点和即时 PCR 分析揭示了的 LPL 的表示,这也被发现。生物信息学分析和双酶的记者试金直接显示了那 miR-361-5p downregulated 由指向 LPL 的 3UTR 的 LPL 的表示。另外, apelin-13 + miR-361-5p 显著地模仿 downregulated 在房间的 LPL 的表示。最后,我们表明了那 apelin-13 downregulated 通过激活 PKC 的活动的 LPL 的表示。一起拿,我们的结果显示出那 apelin-13 downregulated 经由激活在 THP-1 导出巨噬细胞的泡沫房间表明小径的 APJ/PKC/miR-361-5p 的 LPL 的表示,导致类脂化合物累积和支持 inflammatory cytokine 分泌物的抑制。因此,我们的研究由 apelin-13 提供重要新卓见进类脂化合物累积和支持 inflammatory cytokine 分泌物的抑制,并且在动脉粥样硬化作为一个有希望的治疗学的目标加亮 apelin-13。 | Xin Zhang Qiong Ye Duo Gong Yuan Lv Haipeng Cheng Chong Huang Lingyan Chen Zhenwang Zhao Liang Li Xie Wei Min Zhang Xiaodan Xia Xiaohua Yu Xilong Zheng Shuzhi Wang Zongbao Wang Chaoke Tang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，6： | 6 |
| 5 | Analysis of Rockfall and Its Impact on the Cut-and-Cover Tunnel in Dynamics显示文摘This paper presents the effect of thickness of Buffer layer on the safety of cut-and-cover tunnel under the given magnitude and height of rockfall, and the limit load of the structure. To establish calculating models of rockfall in different conditions, the dynamics of the fall down to the surface of the slope is taken into account and the exterior characteristics of the rockfall is analyzed. We have derived the formula for calculating velocity of rocks before and after collision, calculated the impact load upon the structures below and the limit load, and compared the impact force and limit load to judge the safety of the structure. Finally, the validity of models is approved by the safety evaluation of cut-and-cover tunnel in the mouth of Heshang Mountain in Nandan County. | SONG Shuzhi KONG Jiming WANG Chenghua CHENG Zefu YANG Zongji | 2006 | Wuhan University Journal of Natural Sciences2006，11，4： | 5 |
| 6 | δ^(13)C and water-use efficiency indicated by δ^(13)C of different plant functional groups on Changbai Mountains, Northeast China显示文摘Leaf δ13C of different plant functional groups (trees, shrubs and forbs; evergreen and deciduous; annual, biennial and perennial) were examined on the Changbai Mountains, China. Life form has a significant influence on plant δ13C, suggesting that leaf δ13C is also ideal for distinguishing functional groups species in temperate and frigid zones with high humidity. Additionally, the difference of water-use efficiency (WUE) is significant among different plant functional groups. δ13C and WUE are in the following order of forbs < shrubs < trees. Within shrubs, δ13C and WUE are higher for evergreen shrubs than deciduous shrubs. Differences in δ13C and WUE are significant among different lifespan herbs, and δ13C and WUE follow the order of annual herbs > biennial herbs > perennial herbs, not in accordance with the pattern obtained by previous studies in deserts, suggesting that the ranking of δ13C and WUE among annual, biennial and perennial herbs may be dependent on local water availability. | TAN WenBing WANG GuoAn HAN JiaMao LIU Min ZHOU LiPing LUO Ting CAO ZiYu CHENG ShuZhi | 2009 | Chinese Science Bulletin2009，54，10： | 4 |
| 7 | Transcriptomics and metabolomics analyses provide insights into postharvest ripening and senescence of tomato fruit under low temperature显示文摘Tomato is one of the most important vegetable crops in the world and is a model plant used to study the ripening of climacteric fleshy fruit.During the ripening process of tomato fruit,flavor and aroma metabolites,color,texture and plant hormones undergo significant changes.However,low temperatures delayed the ripening process of tomato fruit,inhibiting flavor compounds and ethylene production.Metabolomics and transcriptomics analyses of tomato fruit stored under low temperature(LT,5°C)and room temperature(RT,25°C)were carried out to investigate the effects of storage temperature on the physiological changes in tomato fruit after harvest.The results of transcriptomics changes revealed that the differentially expressed genes(DEGs)involved in tomato fruit ripening,including several kinds of transcription factors(TFs)(TCP,WRKY,MYB and bZIP),enzymes involved in cell wall metabolism[beta-galactosidase(β-GAL),pectinesterase(PE)and pectate lyase(PL),cellulose and cellulose synthase(CESA)],enzymes associated with fruit flavor and aroma[acetyltransferase(AT),malic enzyme(ME),lipoxygenase(LOX),aldehyde dehydrogenase(ALDH),alcohol dehydrogenase(ADH)and hexokinase(HK)],genes associated with heat stress protein 70 and genes involved in the production of plant hormones such as Ethylene responsive factor 1(ERF1),Auxin/indoleacetic acids protein(AUX/IAA),gibberellin regulated protein.Based on the above results,we constructed a regulatory network model of the effects of different temperatures during the fruit ripening process.According to the analysis of the metabolomics results,it was found that the contents of many metabolites in tomato fruit were greatly affected by storage temperature,including,organic acids(L-tartaric acid,a-hydroxyisobutyric acid and 4-acetamidobutyric acid),sugars(melezitose,beta-Dlactose,D-sedoheptulose 7-phosphate,2-deoxyribose 1-phosphate and raffinose)and phenols(coniferin,curcumin and feruloylputrescine).This study revealed the effects of storage temperature on postharvest tomato fruit and provided a basis for further understanding of the molecular biology and biochemistry of fruit ripening. | Chunmei Bai Caie Wu Lili Ma Anzhen Fu Yanyan Zheng Jiawei Han Changbao Li Shuzhi Yuan Shufang Zheng Lipu Gao Xinhua Zhang Qing Wang Demei Meng Jinhua Zuo | 2023 | Horticultural Plant Journal2023，9，1： | 3 |
| 8 | Robust adaptive tracking for time-varying uncertain nonlinear systems with unknown control coefficients显示文摘 | Shuzhi Sam Ge Wang J | 2003 | IEEE Transactions on Automatic Control2003，48，8： | 1 |
| 9 | Direct adaptive NN control of a class of nonlinear systems显示文摘 | GE SHUZHI S WANG C | 2002 | IEEE Transations on Neural Networks2002，13，1： | 1 |
| 10 | Robust adaptive tracking for timevarying uncertain nonlinear systems with unknown control coefficients显示文摘 | SHUZHI Sam Ge WANG J | 2003 | IEEE Transactions on Automatic Control2003，48，8： | 1 |
| 11 | A new approachto the prediction of passenger flow in a transit system显示文摘 | ZHAO Shuzhi NI Tonghe WANG Yang | 2011 | Computers and Mathematics with Applications2011，61，： | 1 |
| 12 | Synthesis, characterization and intramolecular diels-alder reaction tandem dehydroaromatization of a diene-diyne 显示文摘 | Liu Shuzhi Tang Guangshi Wang Jing | 2005 | Chemistry Letters2005，34，7： | 1 |
| 13 | Direct adaptive NN control of a class of nonlinear systems显示文摘 | SHUZHI S G WANG Cong | 2002 | IEEE Transactions On Neural Networks2002，13，1： | 1 |
| 14 | Stable Isotopic Geochemical and Geochronological Constraints on the Formation of the S hihu Gold Deposit: The Intracontinental Metallogeny of the T aihang T ectonic Belt, Eastern C hina显示文摘 | Shuzhi Wang Jianzhong Hu Yang Song Xiao Cai Tao Wang | 2015 | Resource Geology2015，，： | 1 |
| 15 | Viologen-Decorated TEMPO for Neutral Aqueous Organic Redox Flow Batteries显示文摘A novel electroactive organic molecule,viz.,1-(1-oxyl-2,2,6,6-tetramethylpiperidin-4-yl)-1′-(3-(trimethylammonio)propyl)-4,4′-bipyridinium trichloride((TPABPy)Cl3),is synthesized by decorating 2,2,6,6-tetramethylpiperidin-1-oxyl(TEMPO)with viologen,which is used as the positive electrolyte in neutral aqueous redox flow battery(ARFB).Extensive characterizations are performed to investigate the composition/structure and the electrochemical behavior,revealing the favorable effect of introducing the cationic viologen group on the electroactive TEMPO.Salient findings are as follows.First,the redox potential is elevated from+0.745V for TEMPO to+0.967V for decorated TEMPO,favoring its use as the positive electrolyte.Such an elevation originates from the electron-withdrawing effect of the viologen unit,as evidenced by the nuclear magnetic resonance and single crystal structure analysis.Second,linear sweep voltammetry reveals that the diffusion coefficient is 2:97×10^(−6) cm^(2) s^(−1),and the rate constant of the one-electron transfer process is 7:50×10^(−2) cm s^(−1).The two values are sufficiently high as to ensure low concentration and kinetics polarization losses during the battery operation.Third,the permeability through anion-exchange membrane is as low as 1:80×10^(−11) cm^(2) s^(−1).It is understandable as the positive-charged viologen unit prevents the molecule from permeating through the anion exchange membrane by the Donnan effect.Fourth,the ionic nature features a decent conductivity and thus eliminates the use of additional supporting electrolyte.Finally,a flow battery is operated with 1.50M(TPABPy)Cl3 as the positive electrolyte,which affords a high energy density of 19.0WhL-1 and a stable cycling performance with capacity retention of 99.98%per cycle. | Shuzhi Hu Liwen Wang Xianzhi Yuan Zhipeng Xiang Mingbao Huang Peng Luo Yufeng Liu Zhiyong Fu Zhenxing Liang | 2021 | Energy Material Advances2021，，1： | 1 |
| 16 | Deep desulfufization of diesel oil oxidized by Fe (VI) systems显示文摘 | Liu Shuzhi Wang Baohui Cui Baochen | 2008 | Fuel2008，87，： | 1 |
| 17 | Intraspecific and interspecific variation in Setaria revealed by RAPD analysis显示文摘 | Yu Li Jizeng Jia Yaru Wang Shuzhi Wu | 1998 | Genetic Resources and Crop Evolution1998，，3： | 1 |
| 18 | Robust adaptive neural control for a class of perturbed strict feedback nonlinear systems显示文摘 | GE Shuzhi Sam WANG J | 2002 | IEEE Trans on Neural Networks2002，13，11： | 1 |
| 19 | Robust adaptive tracking for time-varying uncertain nonlinear systems with unknown control coefficients显示文摘 | GE Shuzhi Sam WANG J | 2003 | IEEE Trans on Automatic Control2003，48，8： | 1 |
| 20 | A new ap- proach to the prediction of passenger flow in a transit system显示文摘 | Zhao Shuzhi Ni Tonghe Wang Yang | 2011 | Computers and Mathematics with Applica- tion2011，61，8： | 1 |
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