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| 1 | Prevalence and evolution of drug resistance HIV-1 variants in Henan, China显示文摘To understand the prevalence and evolution of drug resistant HIV strains in Henan China after the implementation of free antiretroviral therapy for AIDS patients. 45 drug nave AIDS patients, 118 AIDS patients who received three months antiretroviral therapy and 124 AIDS patients who received six months antiretroviral treatment were recruited in the southern part of Henan province. Information on general condition, antiretroviral medicines, adherence and clinical syndromes were collected by face to face interview. Meanwhile, 14ml EDTA anticoagulant blood was drawn. CD4/CD8 T cell count, viral load and genotypic drug resistance were tested. The rates of clinical improvement were 55.1% and 50.8% respectively three months and six months after antiretroviral therapy. The mean CD4 cell count after antiretroviral therapy was significantly higher than in drug nave patients. The prevalence rate of drug resistant HIV strains were 13. 9%, 45.4% and 62.7% in drug nave patients, three month treatment patients and six month treatment patients, respectively. The number of resistance mutation codons and the frequency of mutations increased significantly with continued antiretroviral therapy. The mutation sites were primarily at the 103, 106 and 215 codons in the three-month treatment group and they increased to 15 codon mutations in the six-month treatment group. From this result, the evolution of drug resistant strains was inferred to begin with the high level NNRTI resistant strain, and then develop low level resistant strains to NRTIs. The HIV strains with high level resistance to NVP and low level resistance to AZT and DDI were highly prevalent because of the AZT+DDI+NVP combination therapy. These HIV strains were also cross resistant to DLV, EFV, DDC and D4T. Poor adherence to therapy was believed to be the main reason for the emergence and prevalence of drug resistant HIV strains. The prevalence of drug resistant HIV strains was increased with the continu- ation of antiretroviral therapy in the southern part of Henan province. Measures, that could promote high level adherence, provide new drugs and change ART regimens in failing patients, should be implemented as soon as possible. | Jing Yun LI Han Ping LI Lin LI Hong LI Zhe WANG Kun YANG Zuo Yi BAO Dao Min ZHUANG Si Yang LIU Yong Jian LIU Hui XING Yi Ming SHAO | 2005 | Cell Research2005，15，11： | 34 |
| 2 | Infection with novel coronavirus(SARS-CoV-2)causes pneumonia in Rhesus macaques显示文摘The 2019 novel coronavirus(SARS-CoV-2)outbreak is a major challenge for public health.SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases,with a mortality rate of^6.4%worldwide(based on World Health Organization daily situation report).However,the dynamics of viral infection,replication and shedding are poorly understood.Here,we show that Rhesus macaques are susceptible to the infection by SARS-CoV-2.After intratracheal inoculation,the first peak of viral RNA was observed in oropharyngeal swabs one day post infection(1 d.p.i.),mainly from the input of the inoculation,while the second peak occurred at 5 d.p.i.,which reflected on-site replication in the respiratory tract.Histopathological observation shows that SARS-CoV-2 infection can cause interstitial pneumonia in animals,characterized by hyperemia and edema,and infiltration of monocytes and lymphocytes in alveoli.We also identified SARS-CoV-2 RNA in respiratory tract tissues,including trachea,bronchus and lung;and viruses were also re-isolated from oropharyngeal swabs,bronchus and lung,respectively.Furthermore,we demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a second-round challenge by SARS-CoV-2.The non-human primate model that we established here provides a valuable platform to study SARS-CoV-2 pathogenesis and to evaluate candidate vaccines and therapeutics. | Chao Shan Yan-Feng Yao Xing-Lou Yang Yi-Wu Zhou Ge Gao Yun Peng Lian Yang Xue Hu Jin Xiong Ren-Di Jiang Hua-Jun Zhang Xiao-Xiao Gao Cheng Peng Juan Min Ying Chen Hao-Rui Si Jia Wu Peng Zhou Yan-Yi Wang Hong-Ping Wei Wei Pang Zheng-Fei Hu Long-Bao Lv Yong-Tang Zheng Zheng-Li Shi Zhi-Ming Yuan | 2020 | Cell Research2020，30，8： | 19 |
| 3 | CHEMICAL CONSTITUENTS OF LONICERA MACRANTHOIDES HAND.-MAZZ Ⅰ.STRUCTURE OF MACRANTHOISIDE I显示文摘A new bisdesmosidic triterpene saponin,macranthoiside I,wasisolated from L.macranthoides.Its structure was determinedby chemical degradation and spectroscopic analysis. | Min CHEN Si Qi LUO Hui Ting LI Shanghai Institute of Pharmaceutical Industry Shanghai,200040 | 1990 | Chinese Chemical Letters1990，1，3： | 11 |
| 4 | On-chip plasmonic spin-Hall nanograting for simultaneously detecting phase and polarization singularities显示文摘Phase and polarization singularities are important degrees of freedom for electromagnetic field manipulation.Detecting these singularities is essential for modern optics,but it is still a challenge,especially in integrated optical systems.In this paper,we propose an on-chip plasmonic spin-Hall nanograting structure that simultaneously detects both the polarization and phase singularities of the incident cylindrical vortex vector beam(CVVB).The nanograting is symmetry-breaking with different periods for the upper and lower parts,which enables the unidirectional excitation of the surface plasmon polariton depending on the topological charge of the incident optical vortex beam.Additionally,spin-Hall meta-slits are integrated onto the grating so that the structure has a chiral response for polarization detection.We demonstrate theoretically and experimentally that the designed structure fully discriminates both the topological charges and polarization states of the incident beam simultaneously.The proposed structure has great potential in compact integrated photonic circuits. | Fu Feng Guangyuan Si Changjun Min Xiaocong Yuan Michael Somekh | 2020 | Light(Science & Applications)2020，9，1： | 11 |
| 5 | Identification and Fine Mapping of a Gene Related to Pale Green Leaf Phenotype near the Centromere Region in Rice(Oryza sativa)显示文摘A thermo-insensitive pale green leaf mutant (pgl2) was isolated from T-DNA inserted transgenic lines of rice (Oryza sativa L. subsp. japonica cv. Nipponbare). Genetic analysis indicated that the phenotype was caused by a recessive mutation in a single nuclear-encoded gene. To map the PGL2 gene, an F2 population was constructed by crossing the mutant with Longtefu (Oryza sativa L. subsp. indica). The PGL2 locus was roughly linked to SSR marker RM331 on chromosome 8. To finely map the gene, 14 new InDel markers were developed around the marker, and PGL2 was further mapped to a 2.37 Mb centromeric region. Analysis on chlorophyll contents of leaves showed that there was no obvious difference between the mutant and the wild type in total chlorophyll (Chl) content, while the ratio of Chl a / Chl b in the mutant was only about 1, which was distinctly lower than that in the wild type, suggesting that the PGL2 gene was related to the conversion between Chl a and Chl b. Moreover, the method of primer design around the centromeric region was discussed, which would provide insight into fine mapping of the functional genes in plant centromeres. | ZHU Li LiuWenzhen WU Chao LUAN Wei jiang Fu Ya ping Hu Guo cheng SI Hua min SUN Zong xiu | 2007 | Rice science2007，14，3： | 11 |
| 6 | The ultratrace detection of crystal violet using surface enhanced Raman scattering on colloidal Ag nanoparticles prepared by electrolysis显示文摘高度活跃、稳定、买得起的表面提高了散布的拉曼(重量的单位)底层被 electrolyzing 获得 AgNO 3的混合物( 4 × ; 10 −4 mol/L )并且 Na 3 C 6 H 5 O 7·H2 O ( 6 × ; 10 −5 mol/L )为 1 ,在 7 V 的 2 , 3 和 4 h 。与水晶紫(CV ) 作为一个测试分子,有 785 nm 激光刺激的一个便携式的拉曼分光计被采用执行 SERS 察觉。胶体的 Ag nanoparticles 与粒子尺寸为 3 h 由 electrolyzing 准备了(65 ± 17 ) nm 是为 CV 的极端踪迹察觉的完美的重量的单位底层,它显示了 ca 的一个改进因素。1.3 × 10 8 和 CV 的察觉限制对 ca 感到不满。10 −15 mol/L (ca。10 −4 ppb ) 与是的 10 −1 mol/L KBr 聚集代理人。因此,这重量的单位底层将在极端踪迹察觉提供有希望的前景。同时,从实验室带给拉曼分析在 situ,即时察觉和鉴定处理将提供可能性。 | Ren Ming Liu Yi Pu Kang Xing Fa Zi Ming Jun Feng Man Cheng Min Zhen Si | 2009 | Chinese Chemical Letters2009，20，6： | 10 |
| 7 | Continuous Low-dose-rate Irradiation of Iodine-125 Seeds Inhibiting Perineural Invasion in Pancreatic Cancer显示文摘 | Zheng Lu Teng-Hui Dong Pei-Ren Si Wei Shen Yi-Liang Bi Min Min Xin Chen Yan Liu | 2016 | Chinese Medical Journal2016，，20： | 9 |
| 8 | Genetic susceptibility to ulcerative colitis in the Chinese Han ethnic population:association with TNF polymorphisms显示文摘背景肿瘤坏死因素α(TNF α) 是在煽动性的肠疾病(IBD ) 的致病被含有的重要 proinflammatorycytokine。Recentstudies 在 IBD 评估了 TNF 倡导者多型性的角色,而数据是不一致的。在不同却同质的人口可以帮助澄清这些协会的人种上的 Trans 种族的印射。我们在中国汉种族人口调查在 TNF 倡导者多型性和危险性之间的协会到 ulcerative 大肠炎(UC ) 。方法我们 studied110 从浙江省的无关的 UC 病人和 292 健康控制,中国。为 6common TNF 倡导者多型性的 Genotyping (TNF -1031T/C,-863C/A,-857C/T,-380G/A,-308G/A,-238G/A) 被聚合酶链反应执行顺序特定的教材(PCR-SSP ) 。结果 TNF-308A 与疾病被联系(等位基因频率病人 14.6% 对控制 8.9% , P=0.02 ) 。TNF -857T 在病人,但是没有统计意义被增加(等位基因频率 17.3% 对 12.2% , P=0.06 ) 。Haplotype 分析揭示了包括二的 6 haplotypes (H5 和 H3 ) ,它包含了 TNF-308A。H5 与疾病被联系(haplotype 频率病人 -12.3% 对控制 7.5% , P=0.03 ) 。笔记,稀罕 haplotype H3 以前没在白种人 populations.Homozygosity 被识别因为在每 TNF promotersingle 核苷酸多型性(SNP ) 包括普通等位基因的 haplotype H4 否定地与疾病被联系(病人对 controls24.5% 对 34.9% , P <
0.05 ) 。我们与 ulcerative 大肠炎在中国病人与 TNF -308A 多型性报导协会的结论。在中国汉种族人口的功能的学习现在被要求。 | CAO Qian ZHU Qin WU Min-liang HU Wei-ling GAO Min SI Jian-min | 2006 | Chinese Medical Journal2006，，14： | 8 |
| 9 | CRISPR/Cas9-mediated multiple gene editing in Brassica oleracea var.capitata using the endogenous tRNA-processing system显示文摘Cabbage(Brassica oleracea var.capitata)is a biennial plant with strong self-incompatibility and an obligate requirement for prolonged vernalization by exposure to low temperatures to induce flowering.These characteristics significantly increase the difficulty of exploiting novel germplasm induced by physical or chemical mutagens.In this study,we report a CRISPR/Cas9 gene-editing system based on endogenous tRNA processing to induce high efficiency and inheritable mutagenesis in cabbage.Using the phytoene desaturase gene BoPDS,the S-receptor kinase gene BoSRK,and the male-sterility-associated gene BoMS1 as the target genes,multisite and multiple gene mutations were achieved using a construct with tandemly arrayed tRNA-sgRNA architecture to express multiple sgRNAs.The BoSRK3 gene mutation suppressed self-incompatibility completely,converting the self-incompatible line into a self-compatible line.In addition,the BoMS1 gene mutation produced a completely male-sterile mutant,which was highly cross compatible with its nonmutant isoline at the flowering stage as a result of a simultaneous BoSRK3 gene mutation,enabling the economic propagation of the male-sterile line through bee-mediated cross-pollination.Interestingly,higher site mutation efficiency was detected when a guide sequence was inserted into a location in the tandemly arrayed tRNA-sgRNA architecture that was distal from the upstream Pol III promoter.In addition,mutation sites were also detected in the paralogous genes of the BoPDS and BoSRK genes that had fully consistent sequences or base mismatches but beyond the“seed”region in the spacer sequence compared with the target sgRNAs.Collectively,our results demonstrate that the CRISPR/Cas9 system,coupled with an endogenous tRNA-processing system,is an efficient tool to improve cabbage traits. | Cunfa Ma Chenzeng Zhu Min Zheng Mengci Liu Dejun Zhang Baoli Liu Qinfei Li Jun Si Xuesong Ren Hongyuan Song | 2019 | Horticulture Research2019，6，1： | 8 |
| 10 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 11 | Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction显示文摘Cockayne syndrome(CS)is a rare autosomal recessive inherited disorder characterized by a variety of clinical features,including increased sensitivity to sunlight,progressive neurological abnormalities,and the appearance of premature aging.However,the pathogenesis of CS remains unclear due to the limitations of current disease models.Here,we generate integration-free induced pluripotent stem cells(iPSCs)from fibroblasts from a CS patient bearing mutations in CSB/ERCC6 gene and further derive isogenic genecorrected CS-iPSCs(GC-iPSCs)using the CRISPR/Cas9 system.CS-associated phenotypic defects are recapitulated in CS-iPSC-derived mesenchymal stem cells(MSCs)and neural stem cells(NSCs),both of which display increased susceptibility to DNA damage stress.Premature aging defects in CS-MSCs are rescued by the targeted correction of mutant ERCC6.We next map the transcriptomic landscapes in CS-iPSCs and GC-iPSCs and their somatic stem cell derivatives(MSCs and NSCs)in the absence or presence of ultraviolet(UV)and replicative stresses,revealing that defects in DNA repair account for CS pathologies.Moreover,we generate autologous GC-MSCs free of pathogenic mutation under a cGMP(Current Good Manufacturing Practice)-compliant condition,which hold potential for use as improved biomaterials for future stem cell replacement therapy for CS.Collectively,our models demonstrate novel disease features and molecular mechanisms and lay a foundation for the development of novel therapeutic strategies to treat CS. | Si Wang Zheying Min Qianzhao Ji Lingling Geng Yao Su Zunpeng Liu Huifang Hu Lixia Wang Weiqi Zhang Keiichiro Suzuiki Yu Huang Puyao Zhang Tie-Shan Tang Jing Qu Yang Yu Guang-Hui Liu Jie Qiao | 2020 | Protein & Cell2020，11，1： | 7 |
| 12 | Agglutinin isolated from Arisema heterophyllum Blume induces apoptosis and autophagy in A549 cells through inhibiting PI3K/Akt pathway and inducing ER stress显示文摘Arisaema heterophyllum Blume is one of the three medicinal plants known as traditional Chinese medicine Rhizoma Arisaematis(RA). RA has been popularly used to treat patients with convulsions, inflammation, and cancer for a long time. However, the underlying mechanisms for RA effects are still unclear. The present study was designed to determine the cytotoxicity of agglutinin isolated from Arisema heterophyllum Blume(AHA) and explore the possible mechanisms in human non-small-cell lung cancer A549 cells. AHA with purity up to 95% was isolated and purified from Arisaema heterophyllum Blume using hydrophobic interaction chromatography. AHA dose-dependently inhibited the proliferation of A549 cells and induced G_1 phase cell cycle arrest. AHA induced apoptosis by up-regulating pro-apoptotic Bax, decreasing anti-apoptotic Bcl-2, and activating caspase-9 and caspase-3. In A549 cells treated with AHA, the PI3K/Akt pathway was inhibited. Furthermore, AHA induced increase in the levels of ER stress markers such as phosphorylated eukaryotic initiation factor 2α(p-eIF2α), C/EBP-homologous protein(CHOP), inositol-requiring enzyme 1α(IRE1α), and phosphorylated c-Jun NH_2-terminal kinase(p-JNK). AHA also induced autophagy in A549 cells. Staining of acidic vesicular organelles(AVOs) and increase in the levels of LC3II and ATG7 were observed in AHA-treated cells. These findings suggested that AHA might be one of the active components with anti-cancer effects in Arisaema heterophyllum Blume. In conclusion, cytotoxicity of AHA on cancer cells might be related to its effects on apoptosis and autophagy through inhibition of PI3K/Akt pathway and induction of ER stress. | FENG Li-Xing SUN Peng MI Tian LIU Miao LIU Wang YAO Si CAO Yi-Min YU Xiao-Lu WU Wan-Ying JIANG Bao-Hong YANG Min GUO De-An LIU Xuan | 2016 | Chinese Journal of Natural Medicines2016，14，11： | 6 |
| 13 | Online condition diagnosis for a two-stage gearbox machinery of an aerospace utilization system using an ensemble multi-fault features indexing approach显示文摘China manned space station is designed to operate for over ten years. Long-term and sustainable research on space science and technology will be conducted during its operation. The application payloads must meet the ‘‘long life and high reliability' mission requirement. Gearbox machinery is one of the essential devices in an aerospace utilization system, failure of which may lead to downtime loss even during some disastrous catastrophes. A fault diagnosis of gearbox has attracted attentions for its significance in preventing catastrophic accidents and guaranteeing sufficient maintenance. A novel fault diagnosis method based on the Ensemble Multi-Fault Features Indexing(EMFFI) approach is proposed for the condition monitoring of gearboxes. Different from traditional methods of signal analysis in the one-dimensional space, this study employs a supervised learning method to determine the faults of a gearbox in a two-dimensional space using the classification model established by training the features extracted automatically from diagnostic vibration signals captured. The proposed method mainly includes the following steps. First, the vibration signals are transformed into a bi-spectrum contour map utilizing bi-spectrum technology,which provides a basis for the following image-based feature extraction. Then, Speeded-Up Robustness Feature(SURF) is applied to automatically extract the image feature points of the bi-spectrum contour map using a multi-fault features indexing theory, and the feature dimension is reduced by Linear Discriminant Analysis(LDA). Finally, Random Forest(RF) is introduced to identify the fault types of the gearbox. The test results verify that the proposed method based on the multi-fault features indexing approach achieves the target of high diagnostic accuracy and can serve as a highly effective technique to discover faults in a gearbox machinery such as a two-stage one. | Min ZHOU Ke WANG Yang WANG Kaiji LUO Hongyong FU Liang SI | 2019 | Chinese Journal of Aeronautics2019，32，5： | 6 |
| 14 | Modulation of expression of P16 and Her2 in rat breast tissues of mammary hyperplasia model by external use of Rupifang Extract显示文摘OBJECTIVE:To observe the effect of Rupifang Extract in external use on expression of proto-oncogenes her2 and tumor suppression genes p16 in rat breast tissues of mammary hyperplasia model.To explore the mechanisms of Rupifang Extract in external use for preventing and treating mammary hyperplasia.METHODS:Thirty virginal female Wistar rats were randomized into 5 groups,6 in each,A:blank control group;B:model group;C:the low dose group of Rupifang;D:the middle dose group of Rupifang;and E:The high dose group of Rupifang.The mammary hyperplasia rat models were produced by injecting estradiol benzoate and progesterone and irritating by tail nipping.Drug intervention was also launched during the model formation.After 30 days,the expression of her2 and p16 in breast tissues of rats in each group were detected by the SP immunohistochemical method.RESULTS:Compared with Blank control group,the expression of her2 in breast tissues in Model group was higher,and the expression of p16 was lower(P<0.05 or P<0.01).After intervention with Rupifang Extract,compared with Model group,the expression of her2 in breast tissues in Rupifang groups was lower,and the expression of p16 higher(P<0.05 or P<0.01).CONCLUSION:The mechanisms of Rupifang Extract in external application for preventing and treating mammary hyperplasia may be reducing the expression of proto-oncogenes her2 and increasing the expression of tumor suppression genes p16. | Guijuan Zhang Dehui Li Hui Guo Rui Liao Bizhu Tan Suyi Zhang Yubin Liu Min Ma Xiaoting Zeng Zhuolong Peng Si Huang Yinghui Zheng Yi Ma | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 6 |
| 15 | A novel phycocyanin-Chla/c_2-protein complex isolated from chloroplasts of Chroomonas placoidea显示文摘Nine pigment-protein complexes were separated and characterized from intact Chroomonas placoidea chloroplasts by IEF.The bandsⅠ-Ⅵwith their isoelectric points (pI) values from 4 to 6 were phycocyanin components;bandsⅧandⅨ(pI=2.8-3.6) were chlorophyll-protein complexes.According to absorption and fluorescence spectra,bandⅦwas designated as a novel phycocyanin-Chla/c_2-protein complex (pI≈3.4-3.7).These results indicated that phycocyanin is structurally and functionally coupled with chlorophyll-protein complex in C.placoidea,and probably interacted with electrostatic force in combination. | Min Chen Si Hui Li Li Sun | 2007 | Chinese Chemical Letters2007，18，11： | 6 |
| 16 | Evolutionary ciphers against differential power analysis and differential fault analysis显示文摘Side channel analysis(SCA) focuses on attacking cryptographic algorithm implementations by collecting leaked information and analyzing the correlation between the leaked and key information in the cryptographic system.Currently,SCA is the main threat to cryptographic implementations,with DPA(differential power analysis) and DFA(differential fault analysis) being two of the most threatening types of SCA.However,the existing countermeasures against DPA and DFA have shortcomings and can hardly protect cipher designs perfectly.Based on a comprehensive analysis of DPA and DFA,this paper proposes a new idea of using an evolutionary cipher(EVOC) against DPAs based on the model proposed by Kocher,and several different new types of DFAs.In fact,an EVOC is a kind of dynamic cipher designing method.Moreover,combined with intelligent searching algorithms and cryptography design policies,EVOCs utilize the dynamic and unpredictable properties of TRNG(a truly random number generator) to ensure cipher design at a high level of security.Therefore,with an EVOC we could design cryptography algorithms with high security to resist mathematical analysis as well as DPAs and DFAs.This paper analyzes and proves the security,efficiency,cost,and original features of EVOCs against DPA and DFA both theoretically and experimentally.Compared with existing countermeasures against SCAs,EVOCs use dynamic non-linear operations to destroy the bases of DPA and DFA.At the algorithm level,EVOCs are more efficient than other resistance methods.Based on the theory and experiments,this paper proposes certain modifications to the EVOC in the AES(advanced encryption standard) algorithm,which can be referenced by other dynamic designs of cryptographic algorithms. | TANG Ming QIU ZhenLong YANG Min CHENG PingPan GAO Si LIU ShuBo MENG QinShu | 2012 | Science China(Information Sciences)2012，55，11： | 5 |
| 17 | Synthesis of novel chalcone derivatives and their stabilization effect of spiropyran in PMMA films显示文摘有不同 alkyldioxy 分隔符的三新奇 bis-chalcone 衍生物被综合并且与 6-nitro-1-ethyl-3,3-dimethylspiro-2H-1-benzopyran-2,2-indoline (ESP ) 驱散氯仿答案进 polymethyl methacrylate (PMMA ) 以一个灵巧的方法准备对光反应变色 PMMA 电影。在有 365 nm 的照耀以后紫外光,在 chalcone 单位之间的 photocrosslinking 反应被证明延迟 merocyanine 的 decolorization 有效地对光反应变色 spiropyran 形成,,位的阻碍者的结果由 chalcone 组的 photocycloaddition 生产了。有最短的分隔符的 bis-chalcone 分子在 spiropyran 的去色的延迟上有最有效的稳定效果,这被发现了。 | Zheng Kai Si Qing Zhang Min Zhao Xue Yuan Yuan Zhu Liang Ming Qiao Rong Sheng Yan Gang Liu | 2011 | Chinese Chemical Letters2011，22，9： | 4 |
| 18 | Induction of experimental acute ulcerative colitis in rats by administration of dextran sulfate sodium at low concentration followed by intracolonic administration of 30% ethanol显示文摘Several models of experimental ulcerative colitis have been reported previously. However, none of these models showed the optimum characteristics. Although dextran sulfate sodium-induced colitis results in inflammation resembling ulcera-tive colitis, an obvious obstacle is that dextran sulfate sodium is very expensive. The aim of this study was to develop an inex-pensive model of colitis in rats. Sprague-Dawley rats were treated with 2% dextran sulfate sodium in drinking water for 3 d fol-lowed by an intracolonic administration of 30% ethanol. The administration of 2% dextran sulfate sodium followed by 30% ethanol induced significant weight loss, diarrhea and hematochezia in rats. Severe ulceration and inflammation of the distal part of rat colon were developed rapidly. Histological examination showed increased infiltration of polymorphonuclear leukocytes, lymphocytes and existence of cryptic abscesses and dysplasia. The model induced by dextran sulfate sodium at lower concentra-tion followed by 30% ethanol is characterized by a clinical course, localization of the lesions and histopathological features similar to human ulcerative colitis and fulfills the criteria set out at the beginning of this study. | CHEN Yan SI Jian-min LIU Wei-li CAI Jian-ting DU Qin WANG Liang-jing GAO Min | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，9： | 4 |
| 19 | Sex-specific and Dose-response Relationship between the Incidence of Gallstones and Components of the Metabolic Syndrome in Jinchang Cohort:A Prospective Study显示文摘Gallstones is a very common gastrointestinal disease,involving the formation of masses in the gall bladder or biliary tract,due to abnormally high concentrations of cholesterol or bilirubin in the bile[1].There is a 10%–20%prevalence of gallstones worldwide,and>20%of patients with gallstones show clinical symptoms,implying a substantial disease burden[1]. | YANG Jing Li HUANG Jun Jun CHENG Ning ZHANG De Sheng LIU Si Min HUANG Wen Ya LI Na HUANG Pei Yao DING Jiao LIU Nian BAO Kai Fang DING Jie CHEN Xiao Liang ZHENG Tong Zhang BAI Ya Na | 2020 | Biomedical and Environmental Sciences2020，33，8： | 4 |
| 20 | Molecularly imprinted open porous membranes made from Pickering W/O HIPEs for selective adsorption and separation of methyl 4-hydroxybenzoate显示文摘In this study, novel molecularly imprinted open porous membranes(MIOPMs) were prepared using the Pickering HIPEs template method and molecular imprinting technology for selective adsorption and separation of methyl 4-hydroxybenzoate(M4HB). The template M4 HB, functional monomers,crosslinker and plastifier 2-ethylhexyl acrylate(2-EHA) were contained in the oil phase. Hydrophobic silica nanoparticles(HNP-Si O2) were employed as a stabilizer to establish stable W/O Pickering HIPEs with nonionic surfactant sorbitantrioleate(Span 85). The results of SEM and FTIR indicated that the optimal MIOPMs were prepared successfully and possessed open and interconnecting pores. Then, the MIOPMs were used as sorbents for M4 HB. The correlation coefficient(R2) values for the Langmuir–Freundlich isotherm model and pseudo-second-order kinetic model fitting to the adsorption equilibrium and kinetic data respectively were all higher than 0.95. The maximum adsorption capacity and the time of rapid adsorption for MIOPM4 were 4.146 mg g 1and 100 min, respectively. In addition, the permeability separation factor of MIOPMs for M4 HB compared to a structurally related analog methyl2-hydroxybenzoate(M2HB) could reach 3.122. | Hong-Yu Luo Min Zhang Nai-Chao Si Min-Jia Meng Li Yan Wen-Jing Zhu Chun-Xiang Li | 2015 | Chinese Chemical Letters2015，26，8： | 3 |
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