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| 1 | Modulation of expression of P16 and Her2 in rat breast tissues of mammary hyperplasia model by external use of Rupifang Extract显示文摘OBJECTIVE:To observe the effect of Rupifang Extract in external use on expression of proto-oncogenes her2 and tumor suppression genes p16 in rat breast tissues of mammary hyperplasia model.To explore the mechanisms of Rupifang Extract in external use for preventing and treating mammary hyperplasia.METHODS:Thirty virginal female Wistar rats were randomized into 5 groups,6 in each,A:blank control group;B:model group;C:the low dose group of Rupifang;D:the middle dose group of Rupifang;and E:The high dose group of Rupifang.The mammary hyperplasia rat models were produced by injecting estradiol benzoate and progesterone and irritating by tail nipping.Drug intervention was also launched during the model formation.After 30 days,the expression of her2 and p16 in breast tissues of rats in each group were detected by the SP immunohistochemical method.RESULTS:Compared with Blank control group,the expression of her2 in breast tissues in Model group was higher,and the expression of p16 was lower(P<0.05 or P<0.01).After intervention with Rupifang Extract,compared with Model group,the expression of her2 in breast tissues in Rupifang groups was lower,and the expression of p16 higher(P<0.05 or P<0.01).CONCLUSION:The mechanisms of Rupifang Extract in external application for preventing and treating mammary hyperplasia may be reducing the expression of proto-oncogenes her2 and increasing the expression of tumor suppression genes p16. | Guijuan Zhang Dehui Li Hui Guo Rui Liao Bizhu Tan Suyi Zhang Yubin Liu Min Ma Xiaoting Zeng Zhuolong Peng Si Huang Yinghui Zheng Yi Ma | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 6 |
| 2 | Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2显示文摘Dear Editor To date,tens of millions of people have been infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),causing the outbreak of the respiratory disease named the coronavirus disease 2019(COVID-19).As a newly emerged member of the coronavirus family,SARS-CoV-2 is an enveloped positive-strand RNA virus,which has probably the largest genome(approximately 30 kb)among all RNA viruses.The nucleocapsid(N)protein of SARS-CoV-2 is mainly responsible for recognizing and wrapping viral RNA into helically symmetric structures(Malik,2020). | Dan Zhao Weifan Xu Xiaofan Zhang Xiaoting Wang Yiyue Ge Enming Yuan Yuanpeng Xiong Shenyang Wu Shuya Li Nian Wu Tingzhong Tian Xiaolong Feng Hantao Shu Peng Lang Jingxin Li Fengcai Zhu Xiaokun Shen Haitao Li Pilong Li Jianyang Zeng | 2021 | Protein & Cell2021，12，9： | 1 |
| 3 | A putative transglycosylase encoded by SC04132 influences morphological differentiation and actinorhodin production in Streptomyces coelicolor显示文摘这里,我们报导那 tgdA,编码通常认为的 transglycosylase 的新奇基因,在 Streptomyces coelicolor 影响词法区别和蓝颜料的复合 actinorhodin 的收益。tgdA 0 异种显示稀少的天线 hyphae 和经常缺乏 chromosomal DNA 的不规则的孢子链。提高的 actinorhodin 生产在异种与 actII-orf4 的 overexpression 与一致。tgdA 表示时间地并且发展地被调整。在 Streptomyces avermilitis 和 Streptomyces lividans 的 tgdA orthologs 也影响区别。 | Pengfei Xie Ana Zeng Xiaoting Lv Qiuxiang Cheng Zhongjun Qin | 2013 | Acta Biochimica et Biophysica Sinica2013，45，4： | 1 |
| 4 | An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19显示文摘The global spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019(COVID-19).In this study,we developed an integrative drug repositioning framework,which fully takes advantage of machine learning and statistical analysis approaches to systematically integrate and mine large-scale knowledge graph,literature and transcriptome data to discover the potential drug candidates against SARS-CoV-2.Our in silico screening followed by wet-lab validation indicated that a poly-ADP-ribose polymerase 1(PARP1)inhibitor,CVL218,currently in Phase I clinical trial,may be repurposed to treat COVID-19.Our in vitro assays revealed that CVL218 can exhibit effective inhibitory activity against SARS-CoV-2 replication without obvious cytopathic effect.In addition,we showed that CVL218 can interact with the nucleocapsid(N)protein of SARS-CoV-2 and is able to suppress the LPS-induced production of several inflammatory cytokines that are highly relevant to the prevention of immunopathology induced by SARS-CoV-2 infection. | Yiyue Ge Tingzhong Tian Suling Huang Fangping Wan Jingxin Li Shuya Li Xiaoting Wang Hui Yang Lixiang Hong Nian Wu Enming Yuan Yunan Luo Lili Cheng Chengliang Hu Yipin Lei Hantao Shu Xiaolong Feng Ziyuan Jiang Yunfu Wu Ying Chi Xiling Guo Lunbiao Cui Liang Xiao Zeng Li Chunhao Yang Zehong Miao Ligong Chen Haitao Li Hainian Zeng Dan Zhao Fengcai Zhu Xiaokun Shen Jianyang Zeng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 5 | Selective hydroconversion of 5-hydroxymethylfurfural to 2,5-bis(hydroxymethyl)furan using carbon nanotubes-supported nickel catalysts显示文摘2,5-Bis(hydroxymethyl)furan(BHMF)is a high-value,bio-based,rigid diol that resembles aromatic monomers for the production of different polyesters.In this work,a carbon nanotubes(CNTs)-supported nickel catalyst(Ni/CNTs)was prepared and used for the selective hydrogenation of 5-hydroxymethylfurfural(HMF)to BHMF at low hydrogen pressure.The prepared catalyst was analyzed by nitrogen adsorption-desorption isotherms,X-ray diffraction(XRD),and X-ray photoelectron spectroscopy(XPS).According to kinetic studies,the rate constant for BHMF formation is significantly larger than that for the formation of the byproduct,5-methyl furfural(MF).At optimal reaction conditions,conversion and selectivity rates of HMF and BHMF were 99.8%and 95.0%,respectively.The mechanistic study indicated the coexistence of Ni0 and Ni2+species on the catalyst surface affects the catalytic performance.A possible mechanism was proposed to describe the synergetic effects of Ni0 and Ni2+.Furthermore,the catalyst can be easily separated from the reaction mixture for recycling. | Zexing Huang Xiaoao Sun Wenguang Zhao Xiaoting Zhu Zhijuan Zeng Qiong Xu Xianxiang Liu | 2022 | Carbon Resources Conversion2022，5，4： | 0 |
| 6 | Boehmite-supported CuO as a catalyst for catalytic transfer hydrogenation of 5-hydroxymethylfurfural to 2,5-bis(hydroxymethyl)furan显示文摘2,5-bis(hydroxymethyl)furan(BHMF)is an important monomer of polyester.Its oxygen-containing rigid ring structure and symmetrical diol functional group establish it as an alternative to petroleum-based monomer with unique advantages for the prodution of the degradable bio-based polyester materials.Herein,we prepared a boehmite-supported copper-oxide catalyst for the selective hydrogenation of 5-hydroxymethylfurfural into BHMF via catalytic transfer hydrogenation(CTH).Further,ethanol successfully replaced conventional high-pressure hydrogen as the hydrogen donor,with up to 96.9% BHMF selectivity achieved under suitable conditions.Through characterization and factor investigations,it was noted that CuO is crucial for high BHMF selectivity.Furthermore,kinetic studies revealed a higher by-product activation energy compared to that of BHMF,which explained the influence of reaction temperature on product distribution.To establish the catalyst structure-activity correlation,a possible mechanism was proposed.The copper-oxide catalyst deactivated following CTH because ethanol reduced the CuO,which consequently decreased the active sites.Finally,calcination of the catalyst in air recovered its activity.These results will have a positive impact on hydrogenation processes in the biomass industry. | Zexing Huang Zhijuan Zeng Xiaoting Zhu Wenguang Zhao Jing Lei Qiong Xu Yongjun Yang Xianxiang Liu | 2023 | Frontiers of Chemical Science and Engineering2023，17，4： | 0 |
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