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| 1 | Esophageal tissue engineering:A new approach for esophageal replacement显示文摘A number of congenital and acquired disorders require esophageal tissue replacement.Various surgical techniques,such as gastric and colonic interposition,are standards of treatment,but frequently complicated by stenosis and other problems.Regenerative medicine approaches facilitate the use of biological constructs to replace or regenerate normal tissue function.We review the literature of esophageal tissue engineering,discuss its implications,compare the methodologies that have been employed and suggest possible directions for the future.Medline,Embase,the Cochrane Library,National Research Register and ClinicalTrials.gov databases were searched with the following search terms:stem cell and esophagus,esophageal replacement,esophageal tissue engineering,esophageal substitution.Reference lists of papers identified were also examined and experts in this field contacted for further information.All full-text articles in English of all potentially relevant abstracts were reviewed.Tissue engineering has involved acellular scaffolds that were either transplanted with the aim of being repopulated by host cells or seeded prior to transplantation.When acellular scaffolds were used to replace patch and short tubular defects they allowed epithelial and partial muscular migration whereas when employed for long tubular defects the results were poor leading to an increased rate of stenosis and mortality.Stenting has been shown as an effective means to reduce stenotic changes and promote cell migration,whilst omental wrapping to induce vascularization of the construct has an uncertain benefit.Decellularized matrices have been recently suggested as the optimal choice for scaffolds,but smart polymers that will incorporate signalling to promote cell-scaffold interaction may provide a more reproducible and available solution.Results in animal models that have used seeded scaffolds strongly suggest that seeding of both muscle and epithelial cells on scaffolds prior to implantation is a prerequisite for complete esophageal replacement.Novel approaches need to be designed to allow for peristalsis and vascularization in the engineered esophagus.Although esophageal tissue engineering potentially offers a real alternative to conventional treatments for severe esophageal disease,important barriers remain that need to be addressed. | Giorgia Totonelli Panagiotis Maghsoudlou Jonathan M Fishman Giuseppe Orlando Tahera Ansari Paul Sibbons Martin A Birchall Agostino Pierro Simon Eaton Paolo De Coppi | 2012 | World Journal of Gastroenterology2012，18，47： | 5 |
| 2 | Lung development:number of terminal bronchiolar duct endings and gas exchange surface area in victims of sudden infant death syndrome显示文摘 | Beech DJ Sibbons PD Howar CV | 2001 | Pediatr Pulmonol2001，31，： | 1 |
| 3 | Experimental study of faecal continence and colostomy irrigation显示文摘 | O'Bichere A Sibbons P Dore C | 2000 | Br J Surg2000，87，7： | 1 |
| 4 | Experimental Model of Fistula-In-Ano显示文摘 | Gordon N. Buchanan M.Sc. F.R.C.S. Paul Sibbons Ph.D. Mike Osborn B.Sc. M.R.C.S. Clive I. Bartram F.R.C.R. Tahera Ansari Ph.D. Steve Halligan M.D. F.R.C.R. C. Richard G. Cohen M.D. F.R.C.S | 2005 | Diseases of the Colon & Rectum2005，，2： | 1 |
| 5 | Experimental study of faecal continence and colostomy irrigation显示文摘 | Bichere A Sibbons P Dore C | 2000 | Br J Surg2000，87，7： | 1 |
| 6 | Histooglical evidence for enhanced anal fistula repair using autologous fibroblasts in a dermal collagen matrix显示文摘 | COHEN C R G SIBBONS P | 2007 | Comparative Clinical Pathology2007，16，1： | 1 |
| 7 | Efficacy of Fibrin Sealant in the Management of Complex Anal Fistula: A Prospective Trial显示文摘 | Gordon N. Buchanan Clive I. Bartram Robin K. S. Phillips Stuart W. T. Gould Steve Halligan Tim A. Rockall Paul Sibbons Richard G. Cohen | 2003 | Diseases of the Colon & Rectum2003，，9： | 1 |
| 8 | Pathological chan- ges in the rabbit ileal loop model caused by Campylobacter jejuni from human colitis显示文摘 | Everest P H Goossens H Sibbons P | 1993 | J Med Microbiol1993，38，： | 1 |
| 9 | Quantitative analysis ofthe development of experimentally induced post surgical adhesions:a microstereological study 显示文摘 | Ricketts SA Sibbons PD Green CJ | 1999 | Int J Exp Pathol1999，80，： | 1 |
| 10 | Experimental study of faecal continence and coloctomy irrigation显示文摘 | O' Bicfere A Sibbons P Dore C | 2000 | Br J surg2000，87，7： | 1 |
| 11 | Experimental study of faecal continence and colostomy irrigation显示文摘 | O' Bichere A Sibbons P Dote C | 2000 | Br J Surg2000，87，7： | 1 |
| 12 | Experimental model of fistula-in-ano显示文摘 | Buchanan GN Sibbons P Osborn M Bartram CI Ansari T Halligan S Cohen CR | 2005 | Dis Colon Rectum2005，48，2： | 1 |
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