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| 1 | Esophageal tissue engineering:A new approach for esophageal replacement显示文摘A number of congenital and acquired disorders require esophageal tissue replacement.Various surgical techniques,such as gastric and colonic interposition,are standards of treatment,but frequently complicated by stenosis and other problems.Regenerative medicine approaches facilitate the use of biological constructs to replace or regenerate normal tissue function.We review the literature of esophageal tissue engineering,discuss its implications,compare the methodologies that have been employed and suggest possible directions for the future.Medline,Embase,the Cochrane Library,National Research Register and ClinicalTrials.gov databases were searched with the following search terms:stem cell and esophagus,esophageal replacement,esophageal tissue engineering,esophageal substitution.Reference lists of papers identified were also examined and experts in this field contacted for further information.All full-text articles in English of all potentially relevant abstracts were reviewed.Tissue engineering has involved acellular scaffolds that were either transplanted with the aim of being repopulated by host cells or seeded prior to transplantation.When acellular scaffolds were used to replace patch and short tubular defects they allowed epithelial and partial muscular migration whereas when employed for long tubular defects the results were poor leading to an increased rate of stenosis and mortality.Stenting has been shown as an effective means to reduce stenotic changes and promote cell migration,whilst omental wrapping to induce vascularization of the construct has an uncertain benefit.Decellularized matrices have been recently suggested as the optimal choice for scaffolds,but smart polymers that will incorporate signalling to promote cell-scaffold interaction may provide a more reproducible and available solution.Results in animal models that have used seeded scaffolds strongly suggest that seeding of both muscle and epithelial cells on scaffolds prior to implantation is a prerequisite for complete esophageal replacement.Novel approaches need to be designed to allow for peristalsis and vascularization in the engineered esophagus.Although esophageal tissue engineering potentially offers a real alternative to conventional treatments for severe esophageal disease,important barriers remain that need to be addressed. | Giorgia Totonelli Panagiotis Maghsoudlou Jonathan M Fishman Giuseppe Orlando Tahera Ansari Paul Sibbons Martin A Birchall Agostino Pierro Simon Eaton Paolo De Coppi | 2012 | World Journal of Gastroenterology2012，18，47： | 5 |
| 2 | Determination of the optimal production run and the optimal initial means of a process with dependent multiple quality characteristics subject to a random deterioration显示文摘 | Tahera K | 2008 | Int J Adv Manuf Technol2008，39，： | 1 |
| 3 | A fuzzy logic approach for dealing with qualitative quality characteristics of a process显示文摘 | TAHERA K IBRAHIM R N LOCHERT P B | 2008 | Expert Systems with Applications2008，34，4： | 1 |
| 4 | Amyloid - 13 alters the DNA methylation status of cell -fate genes in an Alzheimer's dis- ease model显示文摘 | Tahera N McKenziea C Garretta R | 2014 | J Alzheimer''s Dis2014，38，： | 1 |
| 5 | Functional Responses of Estrogen Receptors in the Male and Female Auditory System显示文摘 | Charitidi K Mehser I Tahera Y | 2009 | Hear Res2009，252，12： | 1 |
| 6 | Estrogen receptor beta protect against acoustic trauma in mice显示文摘 | Meltser I Tahera Y Simpson E | 2008 | J Clin Invest2008，118，4： | 1 |
| 7 | Sound conditioning protects hearing by activating the hypothalamic-pituitary-adrenal axis 显示文摘 | Tahera Y Mehser I Johansson P | 2007 | Neurobiol Dis2007，25，1： | 1 |
| 8 | Protection against acoustic trauma by forward and backward sound conditioning 显示文摘 | Niu X Tahera Y Canlon B | 2004 | Audiol Neurootol2004，9，5： | 1 |
| 9 | Sound conditioning protects hearing by activating the hypothalamic-pituitary-adrenal axis显示文摘 | TAHERA Y MELTSER I JOHANSSON P | 2007 | Neurobiol Dis2007，25，1： | 1 |
| 10 | Estrogen receptor beta protects against acoustic trauma in mice显示文摘 | Meltser I Tahera Y Simpson E | 2008 | Clin Invest2008，118，4： | 1 |
| 11 | Estrogen re- ceptor beta protects against acoustic trauma in mice 显示文摘 | MELTSER I TAHERA Y SIMPSON E | 2008 | J Clin Invest2008，118，4： | 1 |
| 12 | Functional responses of estrogen receptors in the nmle and fenmle auditory system 显示文摘 | CHARITIDI K MELTSER I TAHERA Y | 2009 | HearRes2009，252，12： | 1 |
| 13 | Experimental Model of Fistula-In-Ano显示文摘 | Gordon N. Buchanan M.Sc. F.R.C.S. Paul Sibbons Ph.D. Mike Osborn B.Sc. M.R.C.S. Clive I. Bartram F.R.C.R. Tahera Ansari Ph.D. Steve Halligan M.D. F.R.C.R. C. Richard G. Cohen M.D. F.R.C.S | 2005 | Diseases of the Colon & Rectum2005，，2： | 1 |
| 14 | Estrogen receptor 显示文摘 | Meltser I Tahera Y Simpson E | 2008 | J Clin Invest2008，118，4： | 1 |
| 15 | Protection against acoustic trauma by forward and backward sound conditioning显示文摘 | Niu X Tahera Y Canlon B | 2004 | Audiol Neurootol2004，9，： | 1 |
| 16 | Glucocorticoid riceptor and mitogenactivated protein kinase activity after restraint stress and acoustic trauma显示文摘 | Meltser I Tahera Y Canlon B | 2009 | J Neurotrauma2009，26，10： | 1 |
| 17 | Sound conditioning protects hearing by activating the hypothalamic-pituitary-adrenal axis 显示文摘 | Tahera Y Mehser I Johansson P | 2007 | Neurobiol Dis2007，25，1： | 1 |
| 18 | Sound conditioning protects hearing by activating the hypothalamic--pituitary-- adrenal axis显示文摘 | Tahera Y Mehser I Johansson P | 2007 | Neurobiol Dis2007，25，： | 1 |
| 19 | Estrogen receptor beta protects against acoustic trauma in miee显示文摘 | Meltser I Tahera Y Simpson E | 2008 | J Clin Invest2008，118，4： | 1 |
| 20 | NF--kappa B mediated glucocorticoid response in the inner ear after acoustic trauma显示文摘 | Tahera Y Meltser I Johansson P | 2006 | J Neurosci Res2006，83，： | 1 |
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