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| 1 | Real-time intelligent big data processing:technology, platform, and applications显示文摘Human beings keep exploring the physical space using information means. Only recently, with the rapid development of information technologies and the increasing accumulation of data, human beings can learn more about the unknown world with data-driven methods. Given data timeliness, there is a growing awareness of the importance of real-time data. There are two categories of technologies accounting for data processing: batching big data and streaming processing, which have not been integrated well. Thus,we propose an innovative incremental processing technology named after Stream Cube to process both big data and stream data. Also, we implement a real-time intelligent data processing system, which is based on real-time acquisition, real-time processing, real-time analysis, and real-time decision-making. The real-time intelligent data processing technology system is equipped with a batching big data platform, data analysis tools, and machine learning models. Based on our applications and analysis, the real-time intelligent data processing system is a crucial solution to the problems of the national society and economy. | Tongya ZHENG Gang CHEN Xinyu WANG Chun CHEN Xingen WANG Sihui LUO | 2019 | Science China(Information Sciences)2019，62，8： | 8 |
| 2 | An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma显示文摘No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis.During the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs( | Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang Shugeng Gao Qi Xue Yi Zhang Jie He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 3 | Association between population migration and epidemic control of coronavirus disease 2019显示文摘Dear Editor,In January 2020,a widespread outbreak of coronavirus disease 2019(COVID-19)occurred after the beginning of the largest annual migration in China,which is known as the Spring Festival migration.Starting in January 20,2020,the Chinese government took a series of unprecedented measures to contain the spread of COVID-19.Because of the role of Wuhan as a central transportation hub. | Yu Ding Sihui Luo Xueying Zheng Ping Ling Tong Yue Zhirong Liu Jianping Weng | 2020 | Science China(Life Sciences)2020，63，6： | 2 |
| 4 | Asymptomatic patients and asymptomatic phases of Coronavirus Disease 2019(COVID-19):a population-based surveillance study显示文摘In this population-based study,we identified 307 confirmed COVID-19 cases from massive surveillance,including 129551 individuals screened at fever clinics or returning from Hubei and 3710 close contacts of confirmed COVID-19 patients.Among them,17 patients were asymptomatic at initial clinical assessment.These asymptomatic patients on admission accounted for a small proportion of all patients(5.54%)with relatively weak transmissibility,and the detection rate was 0.35 per 100 close contacts.Moreover,the dynamics of symptoms of the 307 patients showed that the interval from symptom remission to the final negativity of viral nucleic acid was 5.0 days(interquartile range 2.0 to 11.0 days),with 14 patients(4.56%)having re-detectable viral RNA after discharge.Overall;our findings suggested asymptomatic carriers and presymptomatic patients only accounted for a small proportion of COVID-19 patients.Also,the asymptomatic phase during recovery from COVID-19 implied that negativity in viral RNA is necessary as a de-isolation criterion and follow-up is recommended. | Xueying Zheng Sihui Luo Yong Sun Mingfeng Han Jian Liu Liangye Sun Liangming Zhang Ping Ling Yu Ding Tengchuan Jin Zhirong Liu Jianping Weng | 2020 | National Science Review2020，7，10： | 2 |
| 5 | The zinc finger transcription factor,KLF2,protects against COVID-19 associated endothelial dysfunction显示文摘Coronavirus disease 2019(COVID-19)is regarded as an endothelial disease(endothelialitis)with its patho-mechanism being incompletely understood.Emerging evidence has demonstrated that endothelial dysfunction precipitates COVID-19 and its accompanying multi-organ injuries.Thus,pharmacotherapies targeting endothelial dysfunction have potential to ameliorate COVID-19 and its cardiovascular complications.The objective of the present study is to evaluate whether kruppel-like factor 2(KLF2),a master regulator of vascular homeostasis,represents a therapeutic target for C0VID-19-induced endothelial dysfunction.Here,we demonstrate that the expression of KLF2 was reduced and monocyte adhesion was increased in endothelial cells treated with COVID-19 patient serum due to elevated levels of pro-adhesive molecules,ICAM1 and VCAM1.IL-1β and TNF-α;two cytokines elevated in cytokine release syndrome in COVID-19 patients,decreased KLF2 gene expression.Pharmacologic(atorvastatin and tannic acid)and genetic(adenoviral overexpression)approaches to augment KLF2 levels attenuated COVID-19-serum-induced increase in endothelial inflammation and monocyte adhesion.Next-generation RNA-sequencing data showed that atorvastatin treatment leads to a cardiovascular protective transcriptome associated with improved endothelial function(vasodilation,antiinflammation,antioxidant status,anti-thrombosis/-coagulation,anti-fibrosis,and reduced angiogenesis).Finally,knockdown of KLF2 partially reversed the ameliorative effect of atorvastatin on COVID-19-serum-induced endothelial inflammation and monocyte adhesion.Collectively,the present study implicates loss of KLF2 as an important molecular event in the development of COVID-19-induced vascular disease and suggests that efforts to augment KLF2 levels may be therapeutically beneficial. | Suowen Xu Yujie Liu Yu Ding Sihui Luo Xueying Zheng Xiumei Wu Zhenghong Liu Iqra Ilyas Suyu Chen Shuxin Han Peter J.Little Mukesh K.Jain Jianping Weng | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 1 |
| 6 | A study on the temperature sensitivity of NMR porosity in porous media based on the intensity of magnetization Dedicated to the special issue “Magnetic Resonance in Porous Media”显示文摘The measurement of nuclear magnetic resonance(NMR)porosity is affected by temperature.Without considering the impact of NMR logging tools,this phenomenon is mainly caused by variations in magnetization intensity of the measured system due to temperature fluctuations and difference between the temperature of the porous medium and calibration sample.In this study,the effect of temperature was explained based on the thermodynamic theory,and the rules of NMR porosity responses to temperature changes were identified through core physics experiments.In addition,a method for correcting the influence of temperature on NMR porosity measurement was proposed,and the possible factors that may affect its application were also discussed. | Lu Zhang Lizhi Xiao Wensheng Wu Guangzhi Liao Yan Zhang Sihui Luo Xinglong Lei | 2024 | Magnetic Resonance Letters2024，4，1： | 0 |
| 7 | Prospects of borehole NMR instruments and applications Dedicated to Professor Chaohui Ye on the occasion of his 80th birthday显示文摘Borehole nuclear magnetic resonance(NMR)is a powerful technology to characterize the petrophysical properties of underground reservoirs in the petroleum industry.The rising complexity of oil and gas exploration and development objectives,as well as the novel application contexts of underground reservoirs,have led to increasingly demanding requirements on borehole NMR technology including instrument design and related processing methods.This mini review summarizes the advances and applications of borehole NMR instruments along with some future possibilities.It may be helpful for researchers and engineers in the petroleum industry to understand the development status and future trends of borehole NMR technology. | Sihui Luo Jiangfeng Guo Lizhi Xiao | 2022 | Magnetic Resonance Letters2022，2，4： | 0 |
| 8 | Numerical simulation study on the effect of temperature on the restricted diffusion in porous media显示文摘It is of great significance to study how temperature affects the restricted diffusion in pores for an accurate evaluation of reservoir physical properties by using nuclear magnetic resonance(NMR)diffusion-transverse relaxation(D-T2)spectrum under reservoir temperature conditions.In this paper,we simulate the restricted diffusion and twodimensional(2D)NMR D-T2 spectra of water molecules at different temperatures using random-walk method.The one-dimensional(1D)restricted diffusion simulation results show that the diffusion coefficient in the pore at room temperature decays with the diffusion time and eventually reaches a plateau.Under the condition of long-time diffusion,the ratio of restricted diffusion coefficient to bulk diffusion coefficient at different temperatures tends to be the same constant.With the increase in temperature,the simulated D-T2 spectra also gradually move upward.The simulated D-T2 spectra at all temperatures are consistent with the Pade interpolation equation.In addition,the results calculated by Pade interpolation equation demonstrate that the degree of temperature influence on the D-T2 spectrum of rock is quantitatively related to the pore radius,porosity and cementation index. | Zhen Xie Lizhi Xiao Sihui Luo Guangzhi Liao | 2023 | Magnetic Resonance Letters2023，3，2： | 0 |
| 9 | Next-generation sequencing revealed influenza and Chlamydia infection in recurrent pneumonia in a patient who had recovered from COVID-19显示文摘Dear Editor,The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was identified as the cause of an outbreak of a global pandemic of coronavirus disease 2019(COVID-19)in December 2019.1 COVID-19 often starts with nonspecific upper respiratory tract symptoms,making it difficult to distinguish from other diseases that present similar symptoms,such as fever,lung infection,and asthenia. | Wen Wen Guorong Zhang Sihui Luo Zhaoqing Bai Wanyin Tao Meng Guo Kaixin He Shuafang Jia Wei Liu Kaiguang Zhang Jianping Weng Shu Zhu | 2020 | Precision Clinical Medicine2020，3，4： | 0 |
| 10 | Intrapartum and early postpartum glycemic profiles in women with gestational diabetes mellitus:an observational study显示文摘Background: Data on the glycemic profile of pregnant women with gestational diabetes mellitus (GDM) during the perinatal period are sparse. This study described the intrapartum and early postpartum glucose profiles among pregnant women with GDM, and analyzed factors potentially affecting glycemic parameters during the period.Methods: This was a prospective observational study conducted from March 2020 to November 2021. Pregnant women with GDM receiving lifestyle interventions alone during pregnancy and matched women with non-diabetic pregnancies (NDPs) were enrolled from among patients admitted to the obstetrics department for childbirth. Glucose monitoring was performed via a flash glucose monitoring (FGM) system on admission, and glucose readings during labor and early postpartum were analyzed. The clinical characteristics and FGM-based parameters of participants in the two groups were compared.Results: A total of 124 participants (mean age: 29.5 ± 3.5 years, 92 [74.2%] primipara) were included in the final analysis. A total of 17,571 glucose readings were retrieved. There were no significant differences in clinical characteristics between the GDM (n = 60) and NDP (n = 64) groups. The average glucose level was 92.2 mg/dL, and the level was higher in the GDM group (95.5 ± 12.1 mg/dLvs. 89.1 ± 13.4 mg/dL,P = 0.008) during the intrapartum and early postpartum periods. The data were split into the intrapartum period (from the start of labor to delivery of the placenta) and the early postpartum period (within 24 h after placental delivery) for analysis. During intrapartum, women with GDM exhibited glycemic profiles and fluctuations similar to those in the NDP group. However, women with GDM had higher postpartum glucose levels (97.7 ± 13.4 mg/dLvs. 90.8 ± 15.3 mg/dL,P = 0.009), a longer time spent >140 mg/dL (8.7 ± 9.3%vs. 5.9 ± 10.3%,P = 0.011), and greater glycemic fluctuations than those with NDP. Postpartum hyperglycemia in GDM might be associated with high parity and postprandial glucose abnormalities in GDM screening tests.Conclusion: Compared to those with normoglycemia, pregnant women with GDM receiving lifestyle interventions alone had similar intrapartum glucose profiles but higher early postpartum glucose levels and greater glucose variability, providing evidence for modification of the current perinatal glucose monitoring strategy for GDM.Trial Registration: ChiCTR.org.cn, ChiCTR2000030972. | Yu Ding Xueying Zheng Yujie Liu Tian Wei Tong Yue Siqi Wang Suyu Chen Jianping Weng Sihui Luo | 2022 | Chinese Medical Journal2022，135，21： | 0 |
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