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| 1 | Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction显示文摘It is a long-standing question as to which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial traits were analyzed based on high-dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inter-landmark distances to dense shape geometrics. Genome-wide association studies(GWAS) were conducted on a discovery panel of Uyghurs. Six significant loci were identified, four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in independent cohorts of Uyghurs or Southern Han Chinese. A prospective model was also developed to predict 3D faces based on top GWAS signals and tested in hypothetic forensic scenarios. | Lu Qiao Yajun Yang Pengcheng Fu Sile Hu Hang Zhou Shouneng Peng Jingze Tan Yan Lu Haiyi Lou Dongsheng Lu Sijie Wu Jing Guo Li Jin Yaqun Guan Sijia Wang Shuhua Xu Kun Tang | 2018 | Journal of Genetics and Genomics2018，45，8： | 7 |
| 2 | Alginate encapsulated mesoporous silica nanospheres as a sustained drug delivery system for the poorly water-soluble drug indomethacin显示文摘We applied a combination of inorganic mesoporous silica material,frequently used as drug carriers,and a natural organic polymer alginate(ALG),to establish a sustained drug delivery system for the poorly water-soluble drug Indomethacin(IND).Mesoporous silica nanospheres(MSNs)were synthesized using an organic template method and then functionalized with aminopropyl groups through postsynthesis.After drug loading into the pores of aninopropyl functionalized MSNs(AP-MSNs),IND loaded AP-MSNs(IND-AP-MSNs)were encapsulated by ALG through the ionic interaction.The effects of surface chemical groups and ALG layer on IND release were systematically studied using scanning electron microscopy(SEM),transmission electron microscopy(TEM),nitrogen adsorption,zetapotential analysis and TGA analysis.The surface structure and surface charge changes of the ALG encapsulated AP-MSNs(ALG-AP-MSNs)were also investigated.The results showed that sustained release of IND from the designed drug delivery system was mainly due to the blockage effect from the coated ALG.We believe that this combination will help designing oral sustained drug delivery systems for poorly water-soluble drugs. | Liang Hu Changshan Sun Aihua Song Di Chang Xin Zheng Yikun Gao Tongying Jiang Siling Wang | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，4： | 2 |
| 3 | 3D cubic mesoporous silica microsphere as a carrier for poorly soluble drug carvedilol显示文摘 | Yanchen Hu Zhuangzhi Zhi Qinfu Zhao Chao Wu Peng Zhao Haitao Jiang Tongying Jiang Siling Wang | 2011 | Microporous and Mesoporous Materials2011，，1： | 1 |
| 4 | Large transverse thermoelectric figure of merit in a topological Dirac semimetal显示文摘The Seebeck effect encounters a few fundamental constraints hindering its thermoelectric(TE)conversion efficiency.Most notably,there are the charge compensation of electrons and holes that diminishes this effect,and the Wiedemann-Franz(WF)law that makes independent optimization of the corresponding electrical and thermal conductivities impossible.Here,we demonstrate that in the topological Dirac semimetal Cd3As2 the Nernst effect,i.e.,the transverse counterpart of the Seebeck effect,can generate a large TE figure of merit zNT.At room temperature,zNT≈0.5 in a small field of 2 T and it significantly surmounts its longitudinal counterpart for any field.A large Nernst effect is generically expected in topological semimetals,benefiting from both the bipolar transport of compensated electrons and holes and their high mobilities.In this case,heat and charge transport are orthogonal,i.e.,not intertwined by the WF law anymore.More importantly,further optimization of zNT by tuning the Fermi level to the Dirac node can be anticipated due to not only the enhanced bipolar transport,but also the anomalous Nernst effect arising from a pronounced Berry curvature.A combination of the topologically trivial and nontrivial advantages promises to open a new avenue towards high-efficient transverse thermoelectricity. | JunSen Xiang SiLe Hu Meng Lyu WenLiang Zhu ChaoYang Ma ZiYu Chen Frank Steglich GenFu Chen PeiJie Sun | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，3： | 0 |
| 5 | Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids显示文摘Studies of cultured embryos have provided insights into human peri-implantation development.However,detailed knowledge of peri-implantation lineage development as well as underlying mechanisms remains obscure.Using 3D-cultured human embryos,herein we report a complete cell atlas of the early post-implantation lineages and decipher cellular composition and gene signatures of the epiblast and hypoblast derivatives.In addition,we develop an embryo-like assembloid(E-assembloid)by assembling naive hESCs and extraembryonic cells.Using human embryos and E-assembloids,we reveal that WNT,BMP and Nodal signaling pathways synergistically,but functionally differently,orchestrate human peri-implantation lineage development.Specially,we dissect mechanisms underlying extraembryonic mesoderm and extraembryonic endoderm specifications.Finally,an improved E-assembloid is developed to recapitulate the epiblast and hypoblast development and tissue architectures in the pregastrulation human embryo.Our findings provide insights into human peri-implantation development,and the E-assembloid offers a useful model to disentangle cellular behaviors and signaling interactions that drive human embryogenesis. | Zongyong Ai Baohua Niu Yu Yin Lifeng Xiang Gaohui Shi Kui Duan Sile Wang Yingjie Hu Chi Zhang Chengting Zhang Lujuan Rong Ruize Kong Tingwei Chen Yixin Guo Wanlu Liu Nan Li Shumei Zhao Xiaoqing Zhu Xuancheng Mai Yonggang Li Ze Wu Yi Zheng Jianping Fu Weizhi Ji Tianqing Li | 2023 | Cell Research2023，33，9： | 0 |
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