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| 1 | Inhibitory effects of regorafenib, a multiple tyrosine kinase inhibitor, on corneal neovascularization显示文摘AIM:To evaluate the inhibitory effects of regorafenib(BAY 73-4506),a multikinase inhibitor,on corneal neovascularization(NV).METHODS:Thirty adult male Sprague-Dawley rats weighing 250-300 g,were used.Corneal NV was induced by NaOH in the left eyes of each rat.Following the establishment of alkali burn,the animals were randomized into five groups according to topical treatment.Group 1(n=6)received 0.9%NaCl,Group 2(n=6)received dimethyl sulfoxide,Group 3(n=6)received regorafenib 1 mg/mL,Group 4(n=6)received bevacizumab 5 mg/mL and Group 5(n=6)received 0.1%dexamethasone phosphate.On the 7d,the corneal surface covered with neovascular vessels was measured on photographs as the percentage of the cornea's total area using computer-imaging analysis.The corneas obtained from rats were semiquantitatively evaluated for caspase-3 and vascular endothelial growth factor by immunostaining.RESULTS:A statistically significant difference in the percent area of corneal NV was found among the groups(P<0.001).Although the Group 5 had the smallest percent area of corneal NV,there was no difference among Groups 3,4 and 5(P>0.005).There was a statistically significant difference among the groups in apoptotic cell density(P=0.002).The staining intensity of vascular endothelial growth factor in the epithelial and endothelial layers of cornea was significantly different among the groups(P<0.05).The staining intensity of epithelial and endothelial vascular endothelial growth factor was significantly weaker in Groups 3,4 and 5 thanin Groups 1 and 2.CONCLUSION:Topical administration of regorafenib 1mg/mL is partly effective for preventing alkali-induced corneal NV in rats. | Halil Ibrahim Onder Mesut Erdurmus Yasin Yücel Bucak Hüseyin Simavli Murat Oktay Ahmet Sahap Kukner | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 2 | Short-term effects of intravitreal triamcinolone acetonide injection on ocular blood flow evaluated with color Doppler ultrasonography显示文摘AIM:To evaluate the changes in ocular blood flow with color Doppler ultrasonography(CDU) after intravitreal triamcinolone acetonide(IVTA) injection.METHODS:A total of 46 patients who underwent IVTA(4 mg/0.1 mL) injection for diabetic macular edema(DME)(n =22), central retinal vein occlusion(CRVO)(n =12) and choroidal neovascular membrane(CNVM)(n =12) were included in the study. Peak systolic velocity(PSV), end diastolic velocity(EDV) and resistivity index(RI) were measured from the ophthalmic artery(OA), the central retinal artery(CRA) and the posterior ciliary artery(PCA)of each patient with CDU before, at the end of the first week and at the end of the first month following IVTA injection.RESULTS:In the DME group, PSV of OA at the first of the first month(mean ±SD)(37.48 ±10.87 cm/s) increased compared to pre-injection value(31.39 ±10.84 cm/s)(P =0.048). There was a statistically significant decrease(P =0.049) in PSV of CRA at the end of the first month(7.97±2.67 cm/s) compared to the pre-injection(9.47±3.37 cm/s).There was not any statistically significant difference onthe other parameters in the DME group. Also, there was not any statistically significant difference on the ocular blood flow values in the CRVO and CNVM groups.CONCLUSION:We observed that 4 mg/0.1 mL IVTA increased PSV of OA and decreased PSV of CRA in DME patients and did not have any effect on ocular blood flow values of CRVO and CNVM patients. | Mustafa Alpaslan Anayol Yasin Toklu Elif Asik Kamberoglu Sabri Raza Hasan Basri Arifoglu Huseyin Simavli Ayse Gul Kocak Altintas Saban Simsek | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 4 |
| 3 | Serum heidin is associated with parameters of glucose metabolism in women with gestational diabetes mellitus显示文摘 | Derbent AU Simavli SA Kaygusuz I | 2013 | J Matern Fetal Neonatal IVied2013，26，11： | 1 |
| 4 | Effect of music therapy during vaginal delivery on postpartum pain relief and mental health显示文摘 | Simavli S Kaygusuz I Gumus I | 2014 | J Affect Disord2014，156，3： | 1 |
| 5 | Corneal white-to-white distance and mesopic pupil diameter显示文摘·AIM:To study the relationship between corneal white-to- white (WTW) distance and mesopic pupil diameter. ·METHODS:This study is composed of 30 cases that underwent photorefractive keratotomy (PRK). Pupil size measurements were performed with Schwind ORK wavefront analyzer in mesopic conditions. WTW distance was measured with a measuring caliper. Also, A-scan ultrasound examination was performed in all patients. The relationship among the mesopic pupil diameter and age, sex, axial length, lens thickness, anterior chamber depth(ACD), horizontal WTW distance, vertical WTW distance, spherical equivalent, and average keratometry were analyzed with univariate and multivariate regression analysis. ·RESULTS:Mean pupil diameter was (6.39±0.80)mm (range:3.70mm to 7.73mm. Horizontal WTW distance measurements were between 11.00mm and 12.50mm and mean horizontal WTW distance was (11.79±0.43)mm. On the other hand, vertical WTW distances ranged between 10.00mm and 13.00mm, and their mean was(11.42±0.72)mm. Bivariate correlation between pupil diameter and other variables showed that the axial length, ACD, spherical equivalent, and horizontal WTW distance had a moderate correlation with mesopic pupil diameter. Multiple regression analysis revealed that spherical equivalent and horizontal WTW distances were significantly associated with mesopic pupil diameter (R =0.598, R 2=0.358 P =0.02). ·CONCLUSION:This study shows that mesopic pupil diameter is closely related to horizontal WTW distance. These two factors must be taken in consideration together in preoperative ablation zone planning. | Hasan Basri Cakmak Nurullah Cagil Huseyin Simavli Sabri Raza | 2012 | International Journal of Ophthalmology(English edition)2012，5，4： | 1 |
| 6 | Effect of music thera- py during vaginal delivery on postpartum pain relief and mental health显示文摘 | Simavli S Kaygusuz I Gumus I | 2014 | J Affective Disorders2014，156，： | 1 |
| 7 | Detection of Cord Blood Hepcidin Levels as a Biomarker for Early-Onset Neonatal Sepsis显示文摘 | Mehmet Nevzat Cizmeci Semra Kara Mehmet Kenan Kanburoglu Serap Simavli Candan Iltemur Duvan Mustafa Mansur Tatli | 2013 | Medical Hypotheses2013，，： | 1 |
| 8 | Nifedipine for the treatment of preterm labor in twin and singleton pregnancies显示文摘 | Derbent A Simavli S Gumus II | 2011 | Arch Gynecol Obstet2011，284，4： | 1 |
| 9 | Effect of refractive error on temperament and character properties显示文摘AIM: To determine the effect of refractive error on temperament and character properties using Cloninger's psychobiological model of personality.METHODS: Using the Temperament and Character Inventory(TCI), the temperament and character profiles of 41 participants with refractive errors(17 with myopia,12 with hyperopia, and 12 with myopic astigmatism) were compared to those of 30 healthy control participants.Here, temperament comprised the traits of novelty seeking, harm-avoidance, and reward dependence, while character comprised traits of self-directedness,cooperativeness, and self-transcendence.RESULTS: Participants with refractive error showed significantly lower scores on purposefulness,cooperativeness, empathy, helpfulness, and compassion(P <0.05, P <0.01, P <0.05, P <0.05, and P <0.01,respectively).CONCLUSION: Refractive error might have a negative influence on some character traits, and different types of refractive error might have different temperament and character properties. These personality traits may be implicated in the onset and/or perpetuation of refractive errors and may be a productive focus for psychotherapy. | Emine Kalkan Akcay Fatih Canan Huseyin Simavli Derya Dal Hacer Yalniz Nagihan Ugurlu Omer Gecici Nurullah Cagil | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 1 |
| 10 | Effect of musictherapy during vaginal delivery on postpartum pain reliefand mental health显示文摘 | Simavli S Kaygusuz I Gumus I | 2014 | J Affect Dis2014，156，10： | 1 |
| 11 | First trimester maternal serum PAPP-A and free β-HCG levels in hyperemesis gravidarum显示文摘 | Derbent AU Yanik FF Simavli S | 2013 | Prenatal Diagnosis2013，33，10： | 1 |
| 12 | Impact of inherited thrombophilias on first and second trimester maternal serum markers for aneuploidy显示文摘 | Aysel Uysal Derbent Filiz Fatma Yanik &Idot lknur &Idot neg? l Gü mü &scedil Serap Simavli Nilgü n ? ztü rk Turhan | 2012 | Journal of Maternal-Fetal and Neonatal Medicine2012，，11： | 1 |
| 13 | 双眼Brown’s综合征合并小眼球及系统性关节僵硬(英文)显示文摘Brown’s综合征(上斜肌腱鞘综合征)是指患眼在内转位时不能上转或上转严重受限,内转时被动牵拉试验阳性,在外转和第一眼位是上转受限程度极小。小眼球是一种不常见的先天性眼畸形,表现为眼球极小。本论文报告1例双眼Brown’s综合征及小眼球合并系统性关节僵硬。 | Ayse Gul Kocak Altintas Huseyin Simavli Gulin Gorkem Mehmet Rustu Midillioglu Saban Simsekl | 2009 | 国际眼科杂志2009，9，1： | 0 |
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