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| 1 | Non-invasive means of measuring hepatic fat content显示文摘Hepatic steatosis affects 20% to 30% of the general adult population in the western world. Currently, the technique of choice for determining hepatic fat deposition and the stage of fibrosis is liver biopsy. However, it is an invasive procedure and its use is limited, particularly in children. It may also be subject to sampling error. Non-invasive techniques such as ultrasound, computerised tomography (CT), magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) can detect hepatic steatosis, but currently cannot distinguish between simple steatosis and steatohepatitis, or stage the degree of fibrosis accurately. Ultrasound is widely used to detect hepatic steatosis, but its sensitivity is reduced in the morbidly obese and also in those with small amounts of fatty infiltration. It has been used to grade hepatic fat content, but this is subjective. CT can detect hepatic steatosis, but exposes subjects to ionising radiation, thus limiting its use in longitudinal studies and in children. Recently, magnetic resonance (MR) techniques using chemical shift imaging have provided a quantitative assessment of the degree of hepatic fatty infiltration, which correlates well with liver biopsy results in the same patients. Similarly, in vivo 1H MRS is a fast, safe, non-invasive method forthe quantification of intrahepatocellular lipid (IHCL) levels. Both techniques will be useful tools in future longitudinal clinical studies, either in examining the natural history of conditions causing hepatic steatosis (e.g. non-alcoholic fatty liver disease), or in testing new treatments for these conditions. | Sanjeev R Mehta E Louise Thomas Jimmy D Bell Desmond G Johnston Simon D Taylor-Robinson | 2008 | World Journal of Gastroenterology2008，14，22： | 21 |
| 2 | Effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease显示文摘AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and 1H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs. | E Louise Thomas Audrey E Brynes Gavin Hamilton Nayna Patel Adam Spong Robert D Goldin Gary Frost Jimmy D Bell Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，36： | 13 |
| 3 | The employee-organization relationship, organizational citizenship behaviors, and superior service quality显示文摘 | Simon J Bell Bulent Menguc | 2002 | Journal of Retailing2002，，2： | 2 |
| 4 | The European Cancer Anaemia Survey (ECAS): A large, multinational, prospective survey defining the prevalence, incidence, and treatment of anaemia in cancer patients显示文摘 | Heinz Ludwig Simon Van Belle Peter Barrett-Lee Gunnar Birgeg?rd Carsten Bokemeyer Pere Gascón Paris Kosmidis Maciej Krzakowski Johan Nortier Patrizia Olmi Maurice Schneider Dirk Schrijvers | 2004 | European Journal of Cancer2004，，15： | 2 |
| 5 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 6 | Experiences with sustainability indicators and stakeholder participation: a case study relating to a blue plan' project in Malta显示文摘 | Simon Bell Stephen Morse | 2004 | Sustainable Development2004，，12： | 1 |
| 7 | (iii) Elbow instability, mechanism and management显示文摘 | Simon Bell | 2008 | Current Orthopaedics2008，，2： | 1 |
| 8 | The phase II urokinase-streptokinase pulmonary embolism trial: a national cooperative study显示文摘 | Sasahra A A Bell W R Simon T L Stengle J M Sherry S | 1975 | Thromb Diath Haemorrh1975，33，： | 1 |
| 9 | Just entrepreneurial enough: the moderating effect of entrepreneurship on the relationship between market orientation and performance显示文摘 | Shahid N. Bhuian Bulent Menguc Simon J. Bell | 2003 | Journal of Business Research2003，，1： | 1 |
| 10 | Maintaining customer relationships in high credence services显示文摘 | Andreas B. Eisingerich Simon J. Bell | 2007 | Journal of Services Marketing2007，，4： | 1 |
| 11 | In ternational Retirement Migration in the Alicante Region, Spain: Process,Spatial Pattern and Environmental Impacts显示文摘 | Fields Muller Annette Piorr Regine Berges and Simon Bell | 2010 | Journal of Environmental Planning and Management2010，53，1： | 1 |
| 12 | The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2 – therapy显示文摘 | Nadia A. Khan Brenda Hemmelgarn Robert J. Herman Simon W. Rabkin Finlay A. McAlister Chaim M. Bell Rhian M. Touyz Raj Padwal Lawrence A. Leiter Jeff L. Mahon Michael D. Hill Pierre Larochelle Ross D. Feldman Ernesto L. Schiffrin Norman R.C. Campbell Malco | 2008 | Canadian Journal of Cardiology2008，，6： | 1 |
| 13 | DPSIR显示文摘 | Simon Bell | 2012 | European Journal of Operational Research2012，，2： | 1 |
| 14 | Current Status of pulmonary thromboembolic diseas:pathophy siology, diagnosis,prevention,and treatment显示文摘 | Bell WR Simon TL | 1982 | Am Heart J1982，103，2： | 1 |
| 15 | Landscape pattern,pereeption and visualization in the visual management of forests显示文摘 | Simon Bell | 2001 | Landscape and Urban Planning2001，，54： | 1 |
| 16 | Current status of pulmonary thrombo- embolic disease pathophysiology diagnosis prevention and treatment显示文摘 | Bell WR Simon TL | 1982 | Am Heart J1982，103，2： | 1 |
| 17 | Current status of pulmonary thromboembolic disease:pathophysiology,diagnosis,prevention and treatment显示文摘 | Bell W R Simon T L | 1982 | Am Heart J1982，103，： | 1 |
| 18 | The European Cancer Anaemia Survey (ECAS): A large, multinational, prospective survey defining the prevalence, incidence, and treatment of anaemia in cancer patients显示文摘 | Heinz Ludwig Simon Van Belle Peter Barrett-Lee Gunnar Birgeg?rd Carsten Bokemeyer Pere Gascón Paris Kosmidis Maciej Krzakowski Johan Nortier Patrizia Olmi Maurice Schneider Dirk Schrijvers | 2004 | European Journal of Cancer2004，，15： | 1 |
| 19 | Co-production and customer loyalty in financial services显示文摘 | Seigyoung Auh Simon J. Bell Colin S. McLeod Eric Shih | 2007 | Journal of Retailing2007，，3： | 1 |
| 20 | The clinical features of massive and submassive pulmonary embolism显示文摘 | Bell WR Simon TL Demets DL | 1977 | Am J Med1977，62，： | 1 |
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