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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Plant Prime Editors Enable Precise Gene Editing in Rice Cells显示文摘Genome editing is revolutionizing plant research and crop breeding.Sequence-specific nucleases(SSNs)such as zinc finger nuclease(ZFN)and TAL effector nuclease(TALEN)have been used to create site-specific DNA double-strand breaks and to achieve precise DNA modifications by promoting homology-directed repair(HDR)(Steinert et al.,2016;Voytas,2013).Later,RNA-guided SSNs such as CRISPR-Cas9,Cas12a,Cas12b,and their variants were applied for genome editing in plants(Li et al.,2013;Nekrasov et alM 2013;Tang et al.,2017;Zhong et al.,2019;Ming et al.,2020;Tang et al.,2019).However,HDR relies on simultaneous delivery of SSNs and DNA donors,which has been challenging in plants(Steinert et al.,2016;Zhang et aL,2019).Another challenge for realizing efficient HDR in plants is that DNA repair favors nonhomologous end joining(NHEJ)pathways over HDR in most cell types(Puchta,2005;Qi et al.,2013). | Xu Tang Simon Sretenovic Qiurong Ren Xinyu Jia Mengke Li Tingting Fan Desuo Yin Shuyue Xiang Yachong Guo Li Liu Xuelian Zheng Yiping Qi Yong Zhang | 2020 | Molecular Plant2020，13，5： | 20 |
| 3 | Multimorbidity patterns and association with mortality in 0.5 million Chinese adults显示文摘Background:Few studies have assessed the relationship between multimorbidity patterns and mortality risk in the Chinese population.We aimed to identify multimorbidity patterns and examined the associations of multimorbidity patterns and the number of chronic diseases with the risk of mortality among Chinese middle-aged and older adults.Methods:We used data from the China Kadoorie Biobank and included 512,723 participants aged 30 to 79 years.Multimorbidity was defined as the presence of two or more of the 15 chronic diseases collected by self-report or physical examination at baseline.Multimorbidity patterns were identified using hierarchical cluster analysis.Cox regression was used to estimate the associations of multimorbidity patterns and the number of chronic diseases with all-cause and cause-specific mortality.Results:Overall,15.8%of participants had multimorbidity.The prevalence of multimorbidity increased with age and was higher in urban than rural participants.Four multimorbidity patterns were identified,including cardiometabolic multimorbidity(diabetes,coronary heart disease,stroke,and hypertension),respiratory multimorbidity(tuberculosis,asthma,and chronic obstructive pulmonary disease),gastrointestinal and hepatorenal multimorbidity(gallstone disease,chronic kidney disease,cirrhosis,peptic ulcer,and cancer),and mental and arthritis multimorbidity(neurasthenia,psychiatric disorder,and rheumatoid arthritis).During a median of 10.8 years of follow-up,49,371 deaths occurred.Compared with participants without multimorbidity,cardiometabolic multimorbidity(hazard ratios[HR]=2.20,95%confidence intervals[CI]:2.14-2.26)and respiratory multimorbidity(HR=2.13,95%CI:1.97-2.31)demonstrated relatively higher risks of mortality,followed by gastrointestinal and hepatorenal multimorbidity(HR=1.33,95%CI:1.22-1.46).The mortality risk increased by 36%(HR=1.36,95%CI:1.35-1.37)with every additional disease.Conclusion:Cardiometabolic multimorbidity and respiratory multimorbidity posed the highest threat on mortality risk and deserved particular attention in Chinese adults. | Junning Fan Zhijia Sun Canqing Yu Yu Guo Pei Pei Ling Yang Yiping Chen Huaidong Du Dianjianyi Sun Yuanjie Pang Jun Zhang Simon Gilbert Daniel Avery Junshi Chen Zhengming Chen Jun Lyu Liming Li On Behalf of the China Kadoorie Biobank Collaborative Group | 2022 | Chinese Medical Journal2022，，6： | 17 |
| 4 | Pancreaticoduodenectomy with vascular reconstruction for adenocarcinoma of the pancreas with borderline resectability显示文摘AIM:To analyze whether pancreaticoduodenectomy with simultaneous resection of tumor-involved vessels is a safe approach with acceptable patient survival.METHODS:Between January 2001 and March 2012,136 patients received pancreaticoduodenectomy for adenocarcinoma at our hospital.Seventy-eight patients diagnosed with pancreatic head carcinoma were included in this study.Among them,46 patients received standard pancreaticoduodenectomy(group 1)and32 patients received pancreaticoduodenectomy with simultaneous resection of the portal vein or the superior mesenteric vein or artery(group 2)followed by reconstruction.The immediate surgical outcomes and survivals were compared between the groups.Fifty-five patients with unresectable adenocarcinoma of the pancreas without liver metastasis who received only bypassoperations(group 3)were selected for additional survival comparison.RESULTS:The median ages of patients were 67 years(range:37-82 years)in group 1,and 63 years(range:35-86 years)in group 2.All group 2 patients had resection of the portal vein or the superior mesenteric vein and three patients had resection of the superior mesenteric artery.The pancreatic fistula formation rate was21.7%(10/46)in group 1 and 15.6%(5/32)in group2(P=0.662).Two hospital deaths(4.3%)occurred in group 1 and one hospital death(3.1%)occurred in group 2(P=0.641).The one-year,three-year and five-year overall survival rates in group 1 were 71.1%,23.6%and 13.5%,respectively.The corresponding rates in group 2 were 70.6%,33.3%and 22.2%(P=0.815).The one-year survival rate in group 3 was13.8%.Pancreaticoduodenectomy with simultaneous vascular resection was safe for pancreatic head adenocarcinoma.CONCLUSION:The short-term and survival outcomes with simultaneous resection were not compromised when compared with that of standard pancreaticoduodenectomy. | Tan To Cheung Ronnie TP Poon Kenneth SH Chok Albert CY Chan Simon HY Tsang Wing Chiu Dai See Ching Chan Sheung Tat Fan Chung Mau Lo | 2014 | World Journal of Gastroenterology2014，20，46： | 8 |
| 5 | Modulation of graft vascular inflow guided by flowmetry and manometry in liver transplantation显示文摘BACKGROUND:Survival of the partial graft after living donor liver transplantation owes much to its tremendous regenerative ability.With excellent venous outflow capacity,a graft within a wide range of graft-to-standard-liver-volume ratios can cope with portal hypertension that is common in liver transplant recipients.However,when the ratio range is exceeded,modulation of graft vascular inflow becomes necessary for graft survival.The interplay between graft-to-standard-liver-volume ratio and portal pressure,in the presence of portosystemic shunt or otherwise,requires individualized modulation of graft portal and arterial inflows.Boosting of portal inflow by shunt ligation can be guided by transonic flowmetry,whereas muting of portal inflow by splenic artery ligation can be monitored by portal electronic manometry.METHOD:We describe four cases to illustrate the above.RESULTS:One patient had hepatic artery thrombosis resulting from splenic artery steal syndrome which was the sequela of small-for-size syndrome.Emergency splenic artery ligation and re-anastomosis of the hepatic artery successfully muted the portal inflow and boosted the hepatic arterial inflow.Another patient with portal vein thrombosis underwent thrombendvenectomy.Portal inflow was boosted with ligation of portosystemic shunt,which is often present in these patients with portal hypertension.The coexistence of splenic aneurysm and splenorenal shunt required ligation of both in the third patient.The fourth patient,with portal pressure and flow monitoring,avoided ligation of a coronary vein which became a main portal inflow after portal thrombendvenectomy.CONCLUSION:Management of graft inflow modulation guided selectively by transonic flowmetry or portal manometry was described. | See Ching Chan Chung Mau Lo Kenneth SH Chok William W Sharr Tan To Cheung Simon HY Tsang Albert CY Chan Sheung Tat Fan | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，6： | 5 |
| 6 | Bile leakage after hepatobiliary and pancreatic surgery: A definition and grading of severity by the International Study Group of Liver Surgery显示文摘 | Moritz Koch O. James Garden Robert Padbury Nuh N. Rahbari Rene Adam Lorenzo Capussotti Sheung Tat Fan Yukihiro Yokoyama Michael Crawford Masatoshi Makuuchi Christopher Christophi Simon Banting Mark Brooke-Smith Val Usatoff Masato Nagino Guy Maddern Thomas | 2011 | Surgery2011，，5： | 2 |
| 7 | The impact of family history of hepatocellular carcinoma on its patients' survival显示文摘BACKGROUND:Family history of hepatocellular carcinoma(HCC) has been identified as a risk factor for the development of the disease.The aim of this study is to evaluate the impact of such a history on HCC patients' survival.METHODS:Data of all HCC patients(n=4532) managed at our center from 1989 to 2008 were prospectively collected.The patients were quizzed on their various characteristics including family HCC history.RESULTS:Totally 475(10.48%) patients had a family history of HCC.They presented the disease at a significantly earlier age(median 53 vs 59 years,P<0.0001) and at an earlier stage(the United Network for Organ Sharing staging system).They had significantly better liver function in terms of ChildPugh classification and serum albumin and bilirubin levels.Significantly more of them presented the disease without symptoms(44.0% vs 29.4%,P<0.0001).They also had significantly better overall survival under these specifications:patients in the whole study cohort,patients who had minor hepatectomy,patients with stage I disease,patients with stage II disease,and patients with stage III disease.CONCLUSIONS:Contrary to what is generally believed,we found in this study cohort that patients with a family history of HCC had better overall survival than those without such a history.We believe this was in part due to earlier diagnosis of the disease and better liver function in this group of patients.However,the effects of genetic factors on the risk of HCC cannot be overlooked and are yet to be identified. | Wing Chiu Dai Sheung Tat Fan Tan To Cheung Kenneth SH Chok Albert CY Chan Simon HY Tsang Ronnie TP Poon Chung Mau Lo | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 2 |
| 8 | Corrosion Behavior of AZ31 Magnesium Alloy in Highly Alkaline Environment显示文摘Industrial components made with a magnesium-aluminum alloy AZ31 are often used in diverse engineering applications where component weight,strength,and durability are critical.Similarly as other Mg alloys,however,the AZ31 is susceptible to corrosion in alkaline environments.In this work,corrosion of commercial grade AZ31 alloy plate was examined in potassium hydroxide(KOH) using immersion and potentiodynamic studies.The results suggest that the concentration of Al and Mn in the alloy may govern the kinetics of micro-galvanic corrosion and the initiation of corrosion pits.Further,trace amounts of Ni in the AZ31 alloy were seen to enable formation of Ni(OH)2 surface layer,which may have further accelerated alloy corrosion due to its cracking and void coalescence.The effect of pH on the corrosion behavior of AZ31 was studied with reference to Pourbaix diagrams. | Somi Doja Lukas Bichler Simon Fan | 2017 | Acta Metallurgica Sinica(English Letters)2017，30，4： | 2 |
| 9 | Bile leakage after hepatobiliary and pancreatic surgery: A definition and grading of severity by the International Study Group of Liver Surgery显示文摘 | Moritz Koch O. James Garden Robert Padbury Nuh N. Rahbari Rene Adam Lorenzo Capussotti Sheung Tat Fan Yukihiro Yokoyama Michael Crawford Masatoshi Makuuchi Christopher Christophi Simon Banting Mark Brooke-Smith Val Usatoff Masato Nagino Guy Maddern Thomas | 2011 | Surgery2011，，5： | 2 |
| 10 | DmpIRFs and DmpST:DAMPE instrument response functions and science tools for gamma-ray data analysis显示文摘Observing GeV gamma-rays is an important goal of the DArk Matter Particle Explorer(DAMPE)for indirect dark matter searching and high energy astrophysics. In this work, we present a set of accurate instrument response functions for DAMPE(DmpIRFs) including the effective area, point-spread function and energy dispersion, which are crucial for gamma-ray data analysis based on statistics from simulation data. A dedicated software named DmpST is developed to facilitate the scientific analyses of DAMPE gamma-ray data. Considering the limited number of photons and angular resolution of DAMPE, the maximum likelihood method is adopted in DmpST to better disentangle different source components. The basic mathematics and framework regarding this software are also introduced in this paper. | Kai-Kai Duan Wei Jiang Yun-Feng Liang Zhao-Qiang Shen Zun-Lei Xu Yi-Zhong Fan Fabio Gargano Simone Garrappa Dong-Ya Guo Shi-Jun Lei Xiang Li Mario Nicola Mazziotta Maria Ferna Munoz Salinas Meng Su Valerio Vagelli Qiang Yuan Chuan Yue Stephan Zimmer | 2019 | Research in Astronomy and Astrophysics2019，19，9： | 2 |
| 11 | Imerfacial shear rheol- ogy of asphaltenes at oil-water interface and its relation to emulsion stability: influence of concentration, solvent ar- omaticity and nonionic surfactant 显示文摘 | FAN Y SIMON S SJOBLOM J | 2010 | Colloids and Sur- faces A: Physicochemical and Engineering Aspects2010，366，13： | 1 |
| 12 | Interfacial shear rheologyof asphaltenes at oil-water interface and its relationto emulsion stability: influence of concentration,solvent aromaticity and nonionic surfactant 显示文摘 | FAN Y SIMON S SJOBLOM J | 2010 | Colloidsand Surfaces A : Physicochemical and Engineering Aspects2010，366，123： | 1 |
| 13 | Effects of Clay Content on the Properties of Nanocomposite Hydrogels Composed of Poly( N-isopropylacrylamide) and Clay 显示文摘 | Kazutoshi Haraguchi Toru Takehisa Simon Fan | 2002 | Macromolecules2002，35，10： | 1 |
| 14 | The law of one price:Evidence from the transitional economy of China显示文摘 | Fan C Simon Wei Xiangdong | 2006 | Review of Economics and Statistics2006，88，4： | 1 |
| 15 | Mid-Triassic felsic igneous rocks from the southern Lancangjiang Zone, SW China: Petrogenesis and implications for the evolution of Paleo-Tethys显示文摘 | Touping Peng Simon A. Wilde Yuejun Wang Weiming Fan Bingxia Peng | 2013 | LITHOS2013，，： | 1 |
| 16 | High-quality binary protein interaction map of the yeast interactome network显示文摘 | Yu HY Braun P Yildirim MA Lemmens I Venkatesan K Sahalie J Hirozane-Kishikawa T Gebreab F Li N Simonis N Hao T Rual JF Dricot A Vazquez A Murray RR Simon C Tardivo L Tam S Svrzikapa N Fan CY de Smet AS Motyl A Hudson ME Park J Xin XF Cusick ME Moore T Boo | | 0，，5898： | 1 |
| 17 | Foreign Direct Investment and Indigenous Technological Efforts : Evidence from Provincial Data 显示文摘 | Fan Simon Yifan Hu | 2007 | China Economic Review2007，15，1： | 1 |
| 18 | Effects of clay content on the properties of nanocomposite hydrogels composed of poly (N-isopropylacrylamide) and clay显示文摘 | Kazutoshi Haraguchi Toru Takehisa Simon Fan | 2002 | Macromolecules2002，35，10： | 1 |
| 19 | Simulating the sheltering effects of windbreaks in urban outdoor open space 显示文摘 | Wei L Fan W Simon B | 2007 | Journal of Wind Engineering and Industrial Aerodynamics2007，，95： | 1 |
| 20 | Flow distribution in solar collector panel with horizontally inclined absorber strips显示文摘 | Jianhua Fan Louise Jivan Shah Simon Furbo | | 0，，12： | 1 |
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