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| 1 | Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study显示文摘Background and purpose COVID-19 is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2).Apart from respiratory complications,acute cerebrovascular disease(CVD)has been observed in some patients with COVID-19.Therefore,we described the clinical characteristics,laboratory features,treatment and outcomes of CVD complicating SARS-CoV-2 infection.Materials and methods Demographic and clinical characteristics,laboratory findings,treatments and clinical outcomes were collected and analysed.Clinical characteristics and laboratory findings of patients with COVID-19 with or without new-onset CVD were compared.Results Of 219 patients with COVID-19,10(4.6%)developed acute ischaemic stroke and 1(0.5%)had intracerebral haemorrhage.COVID-19 with new onset of CVD were significantly older(75.7±10.8 years vs 52.1±15.3 years,p<0.001),more likely to present with severe COVID-19(81.8%vs 39.9%,p<0.01)and were more likely to have cardiovascular risk factors,including hypertension,diabetes and medical history of CVD(all p<0.05).In addition,they were more likely to have increased inflammatory response and hypercoagulable state as reflected in C reactive protein(51.1(1.3-127.9)vs 12.1(0.1-212.0)mg/L,p<0.05)and D-dimer(6.9(0.3-20.0)vs 0.5(0.1-20.0)mg/L,p<0.001).Of 10 patients with ischemic stroke;6 received antiplatelet treatment with aspirin or clopidogrel;and 3 of them died.The other four patients received anticoagulant treatment with enoxaparin and 2 of them died.As of 24 March 2020,six patients with CVD died(54.5%).Conclusion Acute CVD is not uncommon in COVID-19.Our findings suggest that older patients with risk factors are more likely to develop CVD.The development of CVD is an important negative prognostic factor which requires further study to identify optimal management strategy to combat the COVID-19 outbreak. | Yanan Li Man Li Mengdie Wang Yifan Zhou Jiang Chang Ying Xian David Wang Ling Mao Huijuan Jin Bo Hu | 2020 | Stroke & Vascular Neurology2020，5，3： | 22 |
| 2 | Generation of B Cell-Deficient Pigs by Highly Efficient CRISPR/Cas9-Mediated Gene Targeting显示文摘Generating B cell-deficient mutant is the first step to produce human antibody repertoires in large animal models. In this study, we applied the clustered regularly interspaced short palindromic repeat(CRISPR)/CRISPR-associated(Cas) system to target the JHregion of the pig Ig M heavy chain gene which is crucial for B cell development and differentiation. Transfection of Ig M-targeting Cas9 plasmid in primary porcine fetal fibroblasts(PFFs) enabled inducing gene knock out(KO) in up to 53.3% of colonies analyzed, a quarter of which harbored biallelic modification, which was much higher than that of the traditional homologous recombination(HR). With the aid of somatic cell nuclear transfer(SCNT) technology, three piglets with the biallelic Ig M heavy chain gene mutation were produced. The piglets showed no antibody-producing B cells which indicated that the biallelic mutation of the Ig M heavy chain gene effectively knocked out the function of the Ig M and resulted in a B cell-deficient phenotype. Our study suggests that the CRISPR/Cas9 system combined with SCNT technology is an efficient genome-editing approach in pigs. | Fengjiao Chen Ying Wang Yilin Yuan Wei Zhang Zijian Ren Yong Jin Xiaorui Liu Qiang Xiong Qin Chen Manling Zhang Xiaokang Li Lihua Zhao Ze Li Zhaoqiang Wu Yanfei Zhang Feifei Hu Juan Huang Rongfeng Li Yifan Dai | 2015 | Journal of Genetics and Genomics2015，42，8： | 15 |
| 3 | Towards reliable Arctic sea ice prediction using multivariate data assimilation显示文摘Rapid declines in Arctic sea ice have captured attention and pose significant challenges to a variety of stakeholders. There is a rising demand for Arctic sea ice prediction at daily to seasonal time scales, which is partly a sea ice initial condition problem. Thus, a multivariate data assimilation that integrates sea ice observations to generate realistic and skillful model initialization is needed to improve predictive skill of Arctic sea ice. Sea ice data assimilation is a relatively new research area. In this review paper, we focus on two challenges for implementing multivariate data assimilation systems for sea ice forecast. First, to address the challenge of limited spatiotemporal coverage and large uncertainties of observations, we discuss sea ice parameters derived from satellite remote sensing that(1) have been utilized for improved model initialization, including concentration, thickness and drift, and(2) are currently under development with the potential for enhancing the predictability of Arctic sea ice, including melt ponds and sea ice leads. Second, to strive to generate the ‘‘best' estimate of sea ice initial conditions by combining model simulations/forecasts and observations, we review capabilities and limitations of different data assimilation techniques that have been developed and used to assimilate observed sea ice parameters in dynamical models. | Jiping Liu Zhiqiang Chen Yongyun Hu Yuanyuan Zhang Yifan Ding Xiao Cheng Qinghua Yang Lars Nerger Gunnar Spreen Radley Horton Jun Inoue Chaoyuan Yang Ming Li Mirong Song | 2019 | Science Bulletin2019，64，1： | 10 |
| 4 | Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer显示文摘MicroRNAs (miRNAs ) 玩在在各种各样的癌症的发展和前进的关键角色。不正常的 miR-9 表示仍然保持模糊,并且卵巢的癌症的变形前进上的一致都没被到达。在这研究,从生物信息学分析的结果证明 E-cadherin mRNA 的 3-UTR 被 miR-9 直接调整。酶记者试金结果证实 miR-9 能直接指向这 3-UTR。在卵巢的癌症织物的 miR-9 和 E-cadherin 表示被 qRT-PCR 确定。移植和侵略被在 SKOV3 和 A2780 愈合弯屈和 Transwell 系统试金检测。qRT-PCR 和西方的污点被执行检测上皮 ? 间充质的联系转变的 mRNA 和蛋白质。Immunofluorescence 技术被用来分析表示和 E-cadherin, N-cadherin,和 vimentin 的 subcellular 本地化。结果证明 miR-9 经常与配对的主要的相比是在变形浆液的卵巢的癌症织物的 upregulated。miR-9 的 Upregulation 能 downregulate E-cadherin 的表示但是 upregulate 间充质的标记(N-cadherin 和 vimentin ) 的表示。miR-9 的 Overexpression 能在卵巢的癌症支持房间移植和侵略,并且这些进程能有效地经由 miR-9 禁止者被禁止。因此,我们的学习证明 miR-9 可以经由指向 E-cadherin 和一条新奇潜在的治疗学的途径控制卵巢的癌症的转移支持卵巢的癌症转移。 | Bo Zhou Hongbin Xu Meng Xia Chaoyang Sun Na Li Ensong Guo Lili Guo Wanying Shan Hao Lu Yifan Wu Yuan Li Degui Yang Danhui Weng Li Meng Junbo Hu Ding Ma Gang Chen Kezhen Li | 2017 | Frontiers of Medicine2017，11，2： | 10 |
| 5 | Transcriptional landscape of rice roots at the single-cell resolution显示文摘There are two main types of root systems in flowering plants,namely taproot systems of dicots and fibrous root systems found in monocots.Despite this fundamental split,our current knowledge of cellular and molecular mechanism driving root development is mainly based on studies of the dicot model Arabidopsis.However,the world major crops are monocots and little is known about the transcriptional programs underlying cell-type specification in this clade.Here,we report the transcriptomes of more than 20000 single cells derived from root tips of two agronomically important rice cultivars.Using combined computational and experimental analyses we were able to robustly identify most of the major cell types and define novel cell-type-specific marker genes for both cultivars.Importantly,we found divergent cell types associated with specific regulatory programs,including phytohormone biosynthesis,signaling,and response,which were well conserved between the two rice cultivars.In addition,we detected substantial differences between the cell-type transcript profiles of Arabidopsis and rice.These species-specific features emphasize the importance of analyzing tissues across diverse model species,including rice.Taken together,our study provides insight into the transcriptomic landscape of major cell types of rice root tip at single-cell resolution and opens new avenues to study cell-type specification,function,and evolution in plants. | Qing Liu Zhe Liang Dan Feng Sanjie Jiang Yifan Wang Zhuoying Du Ruoxi Li Guihua Hu Pingxian Zhang Yanfei Ma Jan ULohmann Xiaofeng Gu | 2021 | Molecular Plant2021，14，3： | 9 |
| 6 | Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a global crisis,urgently necessitating the development of safe,efficacious,convenient-to-store,and low-cost vaccine options.A major challenge is that the receptor-binding domain(RBD)-only vaccine fails to trigger long-lasting protective immunity if used alone for vaccination. | Shiyu Sun Yueqi Cai Tian-Zhang Song Yang Pu Lin Cheng Hairong Xu Jing Sun Chaoyang Meng Yifan Lin Haibin Huang Fang Zhao Silin Zhang Yu Gao Jian-Bao Han Xiao-Li Feng Dan-Dan Yu Yalan Zhu Pu Gao Haidong Tang Jincun Zhao Zheng Zhang Jiaming Yang Zhenxiang Hu Yang-Xin Fu Yong-Tang Zheng Hua Peng | 2021 | Cell Research2021，31，9： | 7 |
| 7 | Combination Patterns and Depositional Characteristics of Ordovician Carbonate Banks in the Western Tarim Basin,China显示文摘碳酸盐银行的联合模式和 depositional 特征在西方的 Tarim 盆基于奥陶纪的露头节,薄节,和碳同位素被调查,中国。四个碳酸盐银行联合模式在奥陶纪被扔,西方的 Tarim 盆,包括:礁石银行建筑群(RBC ) , Algae-Reef-Bank Interbed (ARBI ) ,厚层的蛋糕沉积银行(TLCAB ) ,和薄层的蛋糕逆行银行(TLCRB ) 。所有联合模式垂直地显示出清楚的时期。RBC 主要由礁石和 bioclastic 银行组成,并且 RBC 的尺寸取决于礁石的规模。Bioclastic 银行存款包围礁石。ARBI 的范围被水藻礁石,水藻 peloid 白云石 microfacies 和垂直地轮流出现的海藻的白云石 microfacies 沉积物的规模决定。当在周期叠并且与生气床上用品广泛地延长的层蛋糕发展了, TLCAB 和 TLCRB 被扔。TLCAB 和 TLCRB 的谷物是多样的并且多来源。与影响相对的海水平变化,生物发展和地形学, ARBI, TLCAB 或 TLCRB, RBC 连续地从更低的奥陶纪 Penglaiba 形成被开发到中间的奥陶纪 Yijianfang 形成。奥陶纪的 depositional 环境分析显示 RBC 和 ARBI 能形成有效的油和煤气的水库,并且 TLCAB 和 TLCRB 有潜力形成巨大的规模油和煤气的水库并且以后是为奥陶纪碳酸盐银行的探索的关键目标。 | HU Xiaolan FAN Tailiang GAO Zhiqian YU Bingsong CHEN Xiaozhi WANG Hongyu WANG Jianping LI Rangbin DING Meng LI Yifan | 2012 | Acta Geologica Sinica(English Edition)2012，86，4： | 7 |
| 8 | DUXAP8, a pseudogene derived lncRNA, promotes growth of pancreatic carcinoma cells by epigenetically silencing CDKN1A and KLF2显示文摘Background:Recent studies highlight pseudogene derived long non-coding RNAs(lncRNAs)as key regulators of cancer biology.However,few of them have been well characterized in pancreatic cancer.Here,we aimed to identify the association between pseudogene derived lncRNA DUXAP8 and growth of pancreatic cancer cells.Methods:We screened for pseudogene derived lncRNAs associated with human pancreatic cancer by compara-tive analysis of three independent datasets from GEO.Quantitative real-time reverse transcription polymerase chain reaction was used to assess the relative expression of DUXAP8 in pancreatic cancer tissues and cells.Loss-of-function approaches were used to investigate the potential functional roles of DUXAP8 in pancreatic cancer cell proliferation and apoptosis in vitro and in vivo.RNA immunoprecipitation,chromosome immunoprecipitation assay and rescue experiments were performed to analyze the association of DUXAP8 with target proteins and genes in pancreatic cancer cells.Results:Pancreatic cancer tissues had significantly higher DUXAP8 levels than paired adjacent normal tissues.High DUXAP8 expression was associated with a larger tumor size,advanced pathological stage and shorter overall survival of pancreatic cancer patients.Moreover,silencing DUXAP8 expression by siRNA or shRNA inhibited pancreatic cancer cell proliferation and promoted apoptosis in vitro and in vivo.Mechanistic analyses indicated that DUXAP8 regulates PC cell proliferation partly through downregulation of tumor suppressor CDKN1A and KLF2 expression.Conclusion:Our results suggest that tumor expression of pseudogene derived lncRNA DUXAP8 plays an important role in pancreatic cancer progression.DUXAP8 may serve as a candidate biomarker and represent a novel therapeutic target of pancreatic cancer. | Yifan Lian Jiebin Yang Yikai Lian Chuangxing Xiao Xuezhen Hu Hongzhi Xu | 2018 | Cancer Communications2018，38，1： | 7 |
| 9 | Atomic Fe-Zn dual-metal sites for high-efficiency pH-universal oxygen reduction catalysis显示文摘An effective electrocatalyst being highly active in all pH range for oxygen reduction reaction(ORR)is crucial for energy conversion and storage devices.However,most of the high-efficiency ORR catalysis was reported in alkaline conditions.Herein,we demonstrated the preparation of atomically dispersed Fe-Zn pairs anchored on porous N-doped carbon frameworks(Fe-Zn-SA/NC),which works efficiently as ORR catalyst in the whole pH range.It achieves high half-wave potentials of 0.78,0.85 and 0.72 V in 0.1 M HClO4,0.1 M KOH and 0.1 M phosphate buffer saline(PBS)solutions,respectively,as well as respectable stability.The performances are even comparable to Pt/C.Furthermore,when assembled into a Zn-air battery,the high power density of 167.2 mWcm−2 and 120 h durability reveal the feasibility of Fe-Zn-SA/NC in real energy-related devices.Theoretical calculations demonstrate that the superior catalytic activity of Fe-Zn-SA/NC can be contributed to the lower energy barriers of ORR at the Fe-Zn-N6 centers.This work demonstrates the potential of Fe-Zn pairs as alternatives to the Pt catalysts for efficient catalytic ORR and provides new insights of dual-atom catalysts for other energy conversion related catalytic reactions. | Jie Xu Shuhua Lai Defeng Qi Min Hu Xianyun Peng Yifan Liu Wei Liu Guangzhi Hu Heng Xu Fan Li Chao Li Jia He Longchao Zhuo Jiaqiang Sun Yuan Qiu Shusheng Zhang Jun Luo Xijun Liu | 2021 | Nano Research2021，14，5： | 6 |
| 10 | Accurate Analysis of Connectivity and Resilience for a Class of Wireless Sensor Networks显示文摘Increasing attention is being devoted to network security with the extensive application of wireless sensor networks in various fields. Connectivity and resilience are the crucial metrics of network security.We establish precise formulas for obtaining the resilience of a Key predistribution scheme(KPS) obtained from an Orthogonal array(OA). We study the connectivity and resilience of the Broadcast-enhanced key predistribution scheme(BEKPS) based on OAs and improve the existing methods. We also present precise formulas for evaluating the resilience of these schemes based on any number of partitions, completely solving the problem regarding the resilience of this type of BEKPS. We obtain precise formulas for ensuring the connectivity of two partitions under the condition that each pair of trees from different partitions intersects at exactly one node. We present a general approximate formula for evaluating the connectivity of more than two partitions, providing a positive solution to the open problem in Kendall et al.'s paper in ACM Transactions on Sensor Networks(Vol.11,No.1, 2014). Thus, we can conclude that for this type of BEKPS, connectivity increases, whereas resilience remains unchanged as the number of partitions increases. A comparison of the obtained results and the previously reported results reveals the superior performance of the proposed BEKPSs. | PANG Shanqi HU Xianchao GAO Qiang LI Yongmei XIA Yifan | 2020 | Chinese Journal of Electronics2020，29，2： | 5 |
| 11 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 12 | Construction of NH2-MIL-125(Ti)/Bi2WO6 composites with accelerated charge separation for degradation of organic contaminants under visible light irradiation显示文摘Photocatalysis is considered as an ideal strategy for water pollution treatment.However,it remains challenging to design a highly efficient photo-catalytic system through regulating the charge flow via a precise approach.In this work,a novel NH2-MIL-125(Ti)/Bi2WO6 composite was constructed via self-assembly growing Bi2WO6 nanosheets on NH2-MIL-125(Ti)material.The characterization results demonstrated that NH2-MIL-125(Ti)was successfully incorporated into Bi2WO6 and the photoexcited carriers could be efficiently separated and transferred between the two components.NH2-MIL-125(Ti)/Bi2WO6 composites displayed enhanced photocatalytic activity for the removal of rhodamine B(RhB)and tetracycline(TC)under visible light irradiation,and the optimal weight ratio of NH2-MIL-125(Ti)was determined to be 7 wt%.The introduction of NH2-MIL-125(Ti)into Bi2WO6 could raise the absorption of visible light,accelerate the separation and transfer of charge carriers,and boost photocatalytic activity.This research presents a wide range of possibilities for the further development of novel composites in the field of environment purification. | Sheng Yin Yong Chen Ming Li Qingsong Hu Yi Ding Yifan Shao Jun Di Jiexiang Xia Huaming Li | 2020 | Green Energy & Environment2020，5，2： | 5 |
| 13 | PhaseⅠdose-escalation and expansion study of PARP inhibitor,fluzoparib(SHR3162),in patients with advanced solid tumors显示文摘Objective:Fluzoparib(SHR3162)is a novel,potent poly(ADP-ribose)polymerases(PARP)1,2 inhibitor that showed anti-tumor activity in xenograft models.We conducted a phaseⅠ,first-in-human,dose-escalation and expansion(D-Esc and D-Ex)trial in patients with advanced solid cancer.Methods:This was a 3+3 phaseⅠD-Esc trial with a 3-level D-Ex at 5 hospitals in China.Eligible patients for DEsc had advanced solid tumors refractory to standard therapies,and D-Ex enrolled patients with ovarian cancer(OC).Fluzoparib was administered orally once or twice daily(bid)at 11 dose levels from 10 to 400 mg/d.Endpoints included dose-finding,safety,pharmacokinetics,and antitumor activity.Results:Seventy-nine patients were enrolled from March,2015 to January,2018[OC(47,59.5%);breast cancer(BC)(16,20.3%);colorectal cancer(8,10.1%),other tumors(8,10.1%)];48 patients were treated in the D-Esc arm and 31 in the D-Ex arm.The maximum tolerated dose(MTD)was 150 mg bid,with a half-life of 9.14 h.Grade 3/4 adverse events included anemia(7.6%)and neutropenia(5.1%).The objective response rate(ORR)was 30%(3/10)in patients with platinum-sensitive OC and 7.7%(1/13)in patients with BC.Among patients treated with fluzoparib≥120 mg/d,median progression-free survival(m PFS)was 7.2[95%confidence interval(95%CI),1.8-9.3]months in OC,9.3(95%CI,7.2-9.3)months in platinum-sensitive OC,and 3.5(range,2.0-28.0)months in BC.In patients with germline BC susceptibility gene mutation(g BRCAMut)(11/43 OC;2/16 BC),m PFS was 8.9 months for OC(range,1.0-23.2;95%CI,1.0-16.8)and 14 and 28 months for BC(those two patients both also had somatic BRCAMut).Conclusions:The MTD of fluzoparib was 150 mg bid in advanced solid malignancies.Fluzoparib demonstrated single-agent antitumor activity in BC and OC,particularly in BRCAMut and platinum-sensitive OC. | Huiping Li Rongrui Liu Bin Shao Ran Ran Guohong Song Ke Wang Yehui Shi Jihong Liu Wenjing Hu Fu Chen Xiaoran Liu Gairong Zhang Chuanhua Zhao Ru Jia Quanren Wang Hope S.Rugo Yifan Zhang Guangze Li Jianming Xu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 4 |
| 14 | To image,or not to image:class-specific diffractive cameras with all-optical erasure of undesired objects显示文摘Privacy protection is a growing concern in the digital era,with machine vision techniques widely used throughout public and private settings.Existing methods address this growing problem by,e.g.,encrypting camera images or obscuring/blurring the imaged information through digital algorithms.Here,we demonstrate a camera design that performs class-specific imaging of target objects with instantaneous all-optical erasure of other classes of objects.This diffractive camera consists of transmissive surfaces structured using deep learning to perform selective imaging of target classes of objects positioned at its input field-of-view.After their fabrication,the thin diffractive layers collectively perform optical mode filtering to accurately form images of the objects that belong to a target data class or group of classes,while instantaneously erasing objects of the other data classes at the output field-of-view.Using the same framework,we also demonstrate the design of class-specific permutation and class-specific linear transformation cameras,where the objects of a target data class are pixel-wise permuted or linearly transformed following an arbitrarily selected transformation matrix for all-optical class-specific encryption,while the other classes of objects are irreversibly erased from the output image.The success of class-specific diffractive cameras was experimentally demonstrated using terahertz(THz)waves and 3D-printed diffractive layers that selectively imaged only one class of the MNIST handwritten digit dataset,all-optically erasing the other handwritten digits.This diffractive camera design can be scaled to different parts of the electromagnetic spectrum,including,e.g.,the visible and infrared wavelengths,to provide transformative opportunities for privacy-preserving digital cameras and task-specific data-efficient imaging. | Bijie Bai Yi Luo Tianyi Gan Jingtian Hu Yuhang Li Yifan Zhao Deniz Mengu Mona Jarrahi Aydogan Ozcan | 2022 | eLight2022，2，1： | 4 |
| 15 | Consensus for prevention and management of coronavirus disease 2019 (COVID-19) for neurologists显示文摘Coronavirus disease 2019(COVID‐19)has become a pandemic disease globally.Although COVID-19 directly invades lungs,it also involves the nervous system.Therefore,patients with nervous system involvement as the presenting symptoms in the early stage of infection may easily be misdiagnosed and their treatment delayed.They become silent contagious sources or‘virus spreaders’.In order to help neurologists to better understand the occurrence,development and prognosis,we have developed this consensus of prevention and management of COVID‐19.It can also assist other healthcare providers to be familiar with and recognise COVID-19 in their evaluation of patients in the clinic and hospital environment. | Huijuan Jin Candong Hong Shengcai Chen Yifan Zhou Yong Wang Ling Mao Yanan Li Quanwei He Man Li Ying Su David Wang Longde Wang Bo Hu | 2020 | Stroke & Vascular Neurology2020，5，2： | 3 |
| 16 | Variation in hydraulic conductivity of fractured rocks at a dam foundation during operation显示文摘Characterizing the permeability variation in fractured rocks is important in various subsurface applications,but how the permeability evolves in the foundation rocks of high dams during operation remains poorly understood.This permeability change is commonly evidenced by a continuous decrease in the amount of discharge(especially for dams on sediment-laden rivers),and can be attributed to fracture clogging and/or hydromechanical coupling.In this study,the permeability evolution of fractured rocks at a high arch dam foundation during operationwas evaluated by inverse modeling based on the field timeseries data of both pore pressure and discharge.A procedure combining orthogonal design,transient flow modeling,artificial neural network,and genetic algorithm was adopted to efficiently estimate the hydraulic conductivity values in each annual cycle after initial reservoir filling.The inverse results show that the permeability of the dam foundation rocks follows an exponential decay annually during operation(i.e.K/K0=0.97e^(-0.59t)+0.03),with good agreement between field observations and numerical simulations.The significance of the obtained permeability decay function was manifested by an assessment of the long-term seepage control performance and groundwater flow behaviors at the dam site.The proposed formula is also of merit for characterizing the permeability change in riverbed rocks induced by sediment transport and deposition. | Yi-Feng Chen Jun Zeng Hongtao Shi Yifan Wang Ran Hu Zhibing Yang Chuang-Bing Zhou | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，2： | 3 |
| 17 | Plant synthetic epigenomic engineering for crop improvement显示文摘Efforts have been directed to redesign crops with increased yield,stress adaptability,and nutritional value through synthetic biology—the application of engineering principles to biology.A recent expansion in our understanding of how epigenetic mechanisms regulate plant development and stress responses has unveiled a new set of resources that can be harnessed to develop improved crops,thus heralding the promise of“synthetic epigenetics.”In this review,we summarize the latest advances in epigenetic regulation and highlight how innovative sequencing techniques,epigenetic editing,and deep learning-driven predictive tools can rapidly extend these insights.We also proposed the future directions of synthetic epigenetics for the development of engineered smart crops that can actively monitor and respond to internal and external cues throughout their life cycles. | Liwen Yang Pingxian Zhang Yifan Wang Guihua Hu Weijun Guo Xiaofeng Gu Li Pu | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 18 | Novel chitosan-ethylene glycol hydrogel for the removal of aqueous perfluorooctanoic acid显示文摘It is urgent to explore an effective removal method for perfluorooctanoic acid(PFOA)due to its recalcitrant nature.In this study,a novel chitosan-based hydrogel(CEGH)was prepared with a simple method using chitosan and ethylene glycol through a repeated freezingthawing procedure.The adsorption of PFOA anions to CEGH agreed well to the FreundlichLangmuir model with a maximum adsorption capacity as high as 1275.9 mg/g,which is higher than reported values of most adsorbents for PFOA.The adsorption was influenced by experimental conditions.Experimental results showed that the main removal mechanism was the ionic hydrogen bond interaction between carbonyl groups(COO-)of PFOA and protonated amine(NH^+)of the CEGH adsorbent.Therefore,CEGH is a very attractive adsorbent that can be used to remove PFOA from water in the future. | Li Long Xiaolan Hu Jinpeng Yan Yifan Zeng Jiaqi Zhang Yingwen Xue | 2019 | Journal of Environmental Sciences2019，31，10： | 2 |
| 19 | Intestinal dysbiosis exacerbates the pathogenesis of psoriasis-like phenotype through changes in fatty acid metabolism显示文摘The intestinal microbiota has been associated with host immunity as well as psoriasis;however,the mechanism of intestinal microbiota regulating psoriasis needs to be demonstrated systematically.Here,we sought to examine its role and mechanism of action in the pathogenesis of psoriasis.We found that the severity of psoriasis-like skin phenotype was accompanied by changes in the composition of the intestinal microbiota.We performed co-housing and fecal microbial transplantation(FMT)experiments using the K14-VEGF transgenic mouse model of psoriasis and demonstrated that the transfer of intestinal microbiota from mice with severe psoriasis-like skin phenotype exacerbated psoriasiform skin inflammation in mice with mild symptoms,including increasing the infiltration and differentiation of Th17,and increased the abundance of Prevotella,while decreasing that of Parabacteroides distasonis,in the colon.These alterations affected fatty acid metabolism,increasing the abundance of oleic and stearic acids.Meanwhile,gentamicin treatment significantly reduced the abundance of Prevotella and alleviated the psoriasis-like symptoms in both K14-VEGF mice and imiquimod(IMQ)-induced psoriasis-like mice.Indeed,administration of oleic and stearic acids exacerbated psoriasis-like symptoms and increased Th17 and monocyte-derived dendritic cell infiltration in the skin lesion areas in vivo,as well as increased the secretion of IL-23 by stimulating DCs in vitro.At last,we found that,treatment of PDE-4 inhibitor alleviated psoriasis-like phenotype of K14-VEGF mice accompanied by the recovery of intestinal microbiota,including the decrease of Prevotella and increase of Parabacteroides distasonis.Overall,our findings reveal that the intestinal microbiota modulates host metabolism and psoriasis-like skin inflammation in mice,suggesting a new target for the clinical diagnosis and treatment of psoriasis. | Qixiang Zhao Jiadong Yu Hong Zhou Xiaoyan Wang Chen Zhang Jing Hu Yawen Hu Huaping Zheng Fanlian Zeng Chengcheng Yue Linna Gu Zhen Wang Fulei Zhao Pei Zhou Haozhou Zhang Nongyu Huang Wenling Wu Yifan Zhou Jiong Li | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 2 |
| 20 | A Bama miniature pig model of monoallelic TSC1 mutation for human tuberous sclerosis complex显示文摘Tuberous sclerosis complex(TSC)is a dominant genetic neurocutaneous syndrome characterized by multiple organ hamartomas.Although rodent models bearing a germline mutation in either TSC1 or TSC2 gene have been generated,they do not develop pathogenic lesions matching those seen in patients with TSC because of the significant differences between mice and humans,highlighting the need for an improved large animal model of TSC.Here,we successfully generate monoallelic TSC1-modified Bama miniature pigs using the CRISPR/Cas9 system along with somatic cell nuclear transfer(SCNT)technology.The expression of phosphorylated target ribosomal protein S6 is significantly enhanced in the piglets,indicating that disruption of a TSC1 allele activate the mechanistic target of rapamycin(mTOR)signaling pathway.Notably,differing from the mouse TSC models reported previously,the TSC1^(+/−)Bama miniature pig developed cardiac rhabdomyoma and subependymal nodules,resembling the major clinical features that occur in patients with TSC.These TSC1^(+/−)Bama miniature pigs could serve as valuable large animal models for further elucidation of the pathogenesis of TSC and the development of therapeutic strategies for TSC disease. | Xiaoxue Li Tingdong Hu Jiying Liu Bin Fang Xue Geng Qiang Xiong Lining Zhang Yong Jin Xiaorui Liu Lin Li Ying Wang Rongfeng Li Xiaochun Bai Haiyuan Yang Yifan Dai | 2020 | Journal of Genetics and Genomics2020，47，12： | 2 |
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