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| 1 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 2 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis: Special situations显示文摘 | Gert Van Assche Axel Dignass Bernd Bokemeyer Silvio Danese Paolo Gionchetti Gabriele Moser Laurent Beaugerie Fernando Gomollón Winfried H?user Klaus Herrlinger Bas Oldenburg Julian Panes Francisco Portela Gerhard Rogler Jürgen Stein Herbert Tilg Simon Tra | 2012 | Journal of Crohn’s and Colitis2012，，： | 4 |
| 3 | California Simulation of Evapotranspiration of Applied Water and Agricultural Energy Use in California显示文摘The California Simulation of Evapotranspiration of Applied Water (Cal-SIMETAW) model is a new tool developed by the California Department of Water Resources and the University of California, Davis to perform daily soil water balance and determine crop evapotranspiration (ET c ), evapotranspiration of applied water (ET aw ), and applied water (AW) for use in California water resources planning. ET aw is a seasonal estimate of the water needed to irrigate a crop assuming 100% irrigation efficiency. The model accounts for soils, crop coefficients, rooting depths, seepage, etc. that influence crop water balance. It provides spatial soil and climate information and it uses historical crop and land-use category information to provide seasonal water balance estimates by combinations of detailed analysis unit and county (DAU/County) over California. The result is a large data base of ET c and ET aw that will be used to update information in the new California Water Plan (CWP). The application uses the daily climate data, i.e., maximum (T x ) and minimum (T n ) temperature and precipitation (P cp ), which were derived from monthly USDA-NRCS PRISM data (PRISM Group 2011) and daily US National Climate Data Center (NCDC) climate station data to cover California on a 4 km×4 km change grid spacing. The application uses daily weather data to determine reference evapotranspiration (ET o ), using the Hargreaves-Samani (HS) equation (Hargreaves and Samani 1982, 1985). Because the HS equation is based on temperature only, ET o from the HS equation were compared with CIMIS ET o at the same locations using available CIMIS data to determine correction factors to estimate CIMIS ET o from the HS ET o to account for spatial climate differences. Cal-SIMETAW also employs near real-time reference evapotranspiration (ET o ) information from Spatial CIMIS, which is a model that combines weather station data and remote sensing to provide a grid of ET o information. A second database containing the available soil water holding capacity and soil depth information for all of California was also developed from the USDA-NRCS SSURGO database. The Cal-SIMETAW program also has the ability to generate daily weather data from monthly mean values for use in studying climate change scenarios and their possible impacts on water demand in the state. The key objective of this project is to improve the accuracy of water use estimates for the California Water Plan (CWP), which provides a comprehensive report on water supply, demand, and management in California. In this paper, we will discuss the model and how it determines ET aw for use in water resources planning. | Morteza N Orang Richard L Snyder Shu Geng Quinn J Hart Sara Sarreshteh Matthias Falk Dylan Beaudette Scott Hayes Simon Eching | 2013 | Journal of Integrative Agriculture2013，12，8： | 3 |
| 4 | Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma显示文摘 | Bonertz Andreas Weitz Jürgen Pietsch Dong-Ho Kim Rahbari Nuh N Schlude Christoph Ge Yingzi Juenger Simone Vlodavsky Israel Khazaie Khashayarsha Jaeger Dirk Reissfelder Christoph Antolovic Dalibor Aigner Maximilian Koch Moritz Beckhove Phili | 2009 | Journal of Clinical Investigation2009，，11： | 2 |
| 5 | Estimating the Global Public Health Implications of Electricity and Coal Consumption显示文摘 | Gohlke Julia M Thomas Reuben Woodward Alistair Campbell-Lendrum Diarmid Prüss-üstün Annette Hales Simon Portier Christopher J | 2011 | Environmental Health Perspectives2011，，6： | 2 |
| 6 | 查看详情显示文摘 | Mijatovic T De Nève N Bruyère C Simon G Dewelle J Van Quaquebeke E Van Der A.E Van Vynckt F Lefranc F Kiss R | | 0，，： | 1 |
| 7 | Supercritical fluid extraction of essential oil components from lemon-scented botanicals显示文摘 | Rozzi N L Phippen W Simon J E | 2002 | Lebensm Wiss U Technol2002，35，： | 1 |
| 8 | Activation of matrix me talloproteinase-9( MMP-9 )via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion显示文摘 | Simone N Hahn-Danfona E Sipley J | 1999 | J Biol Chem1999，274，13： | 1 |
| 9 | Routine morphine infusion in preterm newborns who received ventilatory support:a randomized controlled trial 显示文摘 | Simons SH van Dijk M van Lingen RA Roofthooft D Duivenvoorden H J Jongeneel N | 2003 | JAMA2003，290，18： | 1 |
| 10 | A novel and easy method for the production of recombinant peptides for use in the generation of monospecific antisera against Lama glama IgG2b and IgG2c subclasses显示文摘 | Saccodossi N De Simone E Leoni J | 2006 | J Immunol Methods2006，313，12： | 1 |
| 11 | Second-harmonic light generation in generation in crystals with natural optical activity显示文摘 | Simon H J Bloembergen N | 1968 | Physical Review1968，171，3： | 1 |
| 12 | Effect of salt and water balance on recovery of gastrointestinal function after elective colonic resection: a randomised controlled trial显示文摘 | Dileep N Lobo Kate A Bostock Keith R Neal Alan C Perkins Brain J Rowlands Simon P Allison | 2002 | The Lancet . 2002 (9320)2002，，9320： | 1 |
| 13 | A QTL affecting milk yield and composition maps to bovine chromosome 20: A confirmation 显示文摘 | Arranz J J Coppieters W Berzi P Cambisano N Grisart B Karim L Marcq F Moreau L Mezer C Riquet J Simon P Vanmanshoven P Wagenaar D and Georges M | 1998 | Animal Genetics1998，29，： | 1 |
| 14 | Decision framing:Moderating effects of individual differences and cognitive processing显示文摘 | Simon A F Fagley N S Halleran J G | 2004 | Journal of Behavioral Decision Making2004，，17： | 1 |
| 15 | Transformations in the Ti-5Al-2Sn-2Zr-4Mo-4Cr(Ti-17) alloy and mechanical and microstructural characteristics显示文摘 | TARIN P FERNANDEZ A L SIMON A G BADIA J M PIRIS N M | 2006 | Materials Science and Engineering A2006，，： | 1 |
| 16 | A six-axis MEMS force-torque sensor with micro-Newton and nano-New-tonmeter resolution显示文摘 | Beyeler Felix Muntwyler Simon Nelso Bradly J n | 2009 | Journal of Microelectromechanical Systems2009，18，2： | 1 |
| 17 | Measuring and Explaining the Cost Efficiencyof Municipal Solid Waste Collection and Processing Services显示文摘 | Rogge N Simon D J | 2013 | OMEGA-Intemational Journal of Management Science2013，41，4： | 1 |
| 18 | Encapsulation response of 6th instar of Pseudaletia unipuncta (Lepidoptera: Noctuidae) to Steinernema carpocapsae (Nematoda: Steinernematidae)显示文摘 | Cruz N Rosa J S Simons N | 2001 | Journal of Invertebrate Pathology2001，78，： | 1 |
| 19 | Plasma insulin levels are rather similar in chicken and rat显示文摘 | Simon J Rideau N Taouis M | 2011 | Gen Comp Endocrinol2011，171，： | 1 |
| 20 | Interaction of Nonlinear Dynamics and Unsteady Flow in Fuel Injectors显示文摘 | Spurk J H Betzel T Simon N | 1992 | SAE1992，101，6： | 1 |
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