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| 1 | Dual-priming oligonucleotide-based multiplex PCR using tissue samples in rapid urease test in the detection of Helicobacter pylori infection显示文摘AIM:To investigate whether tissue samples processed by the rapid urease test(RUT)kit are suitable for dualpriming oligonucleotide-based multiplex polymerase chain reaction(DPO-PCR)to detect Helicobacter pylori(H.pylori).METHODS:A total of 54 patients with specific gastrointestinal symptom were enrolled in this study.During endoscopy,gastric biopsy specimens were taken for histology,RUT,and DPO-PCR.DPO-PCR was performed on gastric biopsy samples and tissue samples that were analyzed by RUT at 2 separate institutes.In detecting H.pylori,the concordance rate of the DPO-PCR tests between the tissue samples that had been submitted to RUT and the gastric biopsy samples was investigated.RESULTS:H.pylori co-occurred with 76.0%(19/25)of gastric ulcers,64.3%(9/14)of duodenal ulcers,and 33.3%(4/12)of gastritis cases.H.pylori infection was found in 100%(3/3)of the patients with both gastric and duodenal ulcers.Overall,H.pylori was detected in 35 of 54(64.8%)patients.The diagnostic sensitivities of histology,RUT,and DPO-PCR were85.7%(30/35),74.3%(26/35),and 97.1%(34/35),respectively(P=0.02).The positive predictive value(PPV)of DPO-PCR was 94.4%,whereas the negative predictive value(NPV)was 94.7%.In the rapid urease test(CLOtest)-negative cases,the frequency of positive DPO-PCR and histologic results was 20.0%(7/35).The concordance rate of the DPO-PCR tests between the tissue samples from the RUT kit and the gastric biopsy samples was 94.4%(51/54).The rate of DPOPCR and silver stain positivity in the RUT-negative cases was 20.0%(7/35).CONCLUSION:In diagnosing H.pylori infection,DPO-PCR can be performed on tissue samples that have been processed by the RUT kit.Particularly,in patients with RUT-negative results,DPO-PCR on these tissue samples could be helpful in detecting of H.pylori infection. | Woo Chul Chung Sung Hoon Jung Jung Hwan Oh Tae Ho Kim Dae Young Cheung Byung Wook Kim Sung Soo Kim Jin Il Kim Eun Young Sin | 2014 | World Journal of Gastroenterology2014，20，21： | 10 |
| 2 | Clinical implication of FDG uptake of bone marrow on PET/CT in gastric cancer patients with surgical resection显示文摘AIM To determine the relationship between F-18 fluorodeoxyglucose(FDG) uptake of bone marrow(BM) on positron emission tomography/computed tomography(PET/CT) and clinical factors and to assess the prognostic value of FDG uptake of BM in gastric carcinoma.METHODS We retrospectively enrolled 309 gastric cancer patients who underwent staging FDG PET/CT and curative surgical resection. FDG uptake of primary tumor was visually classified as positive or negative FDG uptake. Mean FDG uptake of BM(BM SUV) and BM-to-liver uptake ratio(BLR) were measured. The relationships of BM SUV or BLR with clinical factors were evaluated. The prognostic values of BM SUV, BLR, and other clinical factors for predicting recurrence-free survival(RFS) and overall survival(OS) were assessed.RESULTS Of 309 patients, 38 patients(12.3%) experienced cancer recurrence and 18 patients(5.8%) died. Patients with advanced gastric cancer, positive FDG uptake, and recurrence had higher values of BM SUV and BLR than those with early gastric cancer, negative FDG uptake, and no recurrence(P < 0.05). BM SUV and BLR were significantly correlated with hemoglobin level, neutrophil-to-lymphocyte ratio, and platelet-tolymphocyte ratio(P < 0.05). On multivariate analysis, multiple tumors, T stage, lymph node metastasis, tumor involvement of resection margin, and BLR were significantly associated with RFS(P < 0.05). T stage, lymph node metastasis, hemoglobin level, and BLR were significantly associated with OS(P < 0.05). CONCLUSION BLR on PET/CT was an independent prognostic factor for RFS and OS in gastric cancer patients with curative surgical resection. | Jeong Won Lee Moon-Soo Lee Il Kwon Chung Myoung Won Son Young Sin Cho Sang Mi Lee | 2017 | World Journal of Gastroenterology2017，23，13： | 2 |
| 3 | Skeletal muscle mass to visceral fat area ratio is associated with metabolic syndrome and arterial stiffness: The Korean Sarcopenic Obesity Study (KSOS)显示文摘 | Tae Nyun Kim Man Sik Park Kang Il Lim Sae Jeong Yang Hye Jin Yoo Hyun Joo Kang Wook Song Ji A. Seo Sin Gon Kim Nan Hee Kim Sei Hyun Baik Dong Seop Choi Kyung Mook Choi | 2011 | Diabetes Research and Clinical Practice2011，，2： | 2 |
| 4 | Vascular endothelial growth factor and leptin:regulate in human cumulus cells and in follicles显示文摘 | Abbas MM Evans JJ Sin IL | 2003 | Acta Obstet Gynecol Scand2003，82，11： | 1 |
| 5 | Association of a novel human mtDNA ATPase6 mutation with immature sperm cells 显示文摘 | Holyoake AJ Sin IL Benny PS | 1999 | Andrologia1999，31，6： | 1 |
| 6 | Estrogen-induced transcortin increase and progesterone and cortisol interactions: Implications from pregnancy studies显示文摘 | Evans JJ Sin IL Duff GB | 1987 | Ann Clin Lab Sci1987，17，2： | 1 |
| 7 | A quantitative analysis of N-myc downstream regulated gene 2 (NDRG 2) in human tissues and cell lysates by reverse-phase protein microarray显示文摘 | Mi-Young Park Seung- Chul Choi Hayang Sin Lee Daekwang Kim Kyoung Eun Baek Jong Tae Kim Jong-Seok Lim Young Il Yeom Jin Woong Chung Jong Wan Kim Pyung-Keun Myung Hee Gu Lee Jae Wha Kim Eun Young Song | 2007 | Clinica Chimica Acta2007，，1： | 1 |
| 8 | Association of a novel human mtDNA ATPase6 mutation with immature sperm cells 显示文摘 | Holyoake AJ Sin IL Benny PS | 1999 | Andrologia1999，31，6： | 1 |
| 9 | Vascular endothelial growth factor and leptin: regulation in human cumulus cells and in follicles显示文摘 | Abbas MM Evans JJ Sin IL | 2003 | Acta Obstet Gynecol Scand2003，82，11： | 1 |
| 10 | Comparison of double pants with single pants on satisfaction with colonoscopy显示文摘AIM: To increase satisfaction and diminish anxiety and shame during colonoscopy, we developed novel double pants (NDP) which consist of doubled fabrics with an inner hole. The aim of study was to compare satisfaction, anxiety and shame between NDP and conventional single pants (CSP). METHODS: Total 160 consecutive examinees were randomly divided into NDP and CSP group. Before colonoscopy, questionnaires identifying state and trait anxiety were completed. After colonoscopy, questionnaires for overall satisfaction (Group Health Association of America 9) and pants-specific satisfaction (5-20), state anxiety (20-80), and shame (6-24) were interviewed. RESULTS: Pants-specific satisfaction scores regarding willingness to repeat colonoscopy using same pants (3.3 ± 0.8 vs 2.1 ± 0.9, P < 0.001) and recommendation of same pants to other people (3.3 ± 0.7 vs 2.0 ± 1.0, P < 0.001) were significantly higher in NDP than CSP groups. State anxiety (33.0 ± 7.0 vs 35.4 ± 6.9, P = 0.028) and shame (6.6 ± 1.5 vs 8.1 ± 3.2, P = 0.001) after colonoscopy was lower in NDP group compared with CSP group. CONCLUSION: The NDP contribute to increase satisfaction and decrease anxiety and shame after colonoscopy. | Sook Hee Chung Soo Jung Park Jong Suk Hong Jee Young Hwang Sin Ae Lee Kyung Ran Kim Hye Sun Lee Sung Pil Hong Jae Hee Cheon Tae Il Kim Won Ho Kim | 2013 | World Journal of Gastroenterology2013，19，26： | 0 |
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