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| 1 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 2 | Natural history of focal nodular hyperplasia of the liver显示文摘 | Caturelli E Sio D | 1996 | J Clin Ultrasound1996，24，： | 1 |
| 3 | Bipolar plasmakinetic technology for the treatment of symptomatic benign prostatic hyperplasia:evidence beyond marketing hype显示文摘 | Autorino R De Sio M D'Armiento M | | 0，，05： | 1 |
| 4 | Transcatheter closure of perimembranous ventricular septal defects with the Amplatzer asymmetric ventricular septal defect occluder preliminary experience in children 显示文摘 | THANOPOULOS B D TSAOUSIS G S KARANA- SIOS E | 2003 | Heart2003，89，： | 1 |
| 5 | The preparation of coumaric acids via styrylisoxazoles 显示文摘 | Chimichi S De Sio F Donati D | 1983 | Heterocycle1983，20，19： | 1 |
| 6 | Bipolar plasma kinetic technology for the treatment of symptomatic benign prostatic hyperplasia: evidence beyond marketing hype? 显示文摘 | Autorino R De Sio M D'Armiento M | 2007 | BJU Int2007，100，5： | 1 |
| 7 | ITO-free inverted polymer solar cells with Zn O:Al cathodes and stable top anodes显示文摘 | Sio A D Chakanga K Sergeev O | 2012 | Sol Energy Mater Sol Cells2012，98，1： | 1 |
| 8 | Liver Retransplantation: A Model for Determining Long-Term Survival显示文摘 | Marcelo M. Linhares Daniel Azoulay Délcio Matos Adauto Castelo-Filho Tarcísio Trivi?o Alberto Goldenberg Denis Castaing René Adam Valerie Délvart Phillipe Ichai Fauze Saliba Antoine Lemoine Didier Samuel Henry Bismuth | 2006 | Transplantation2006，，7： | 1 |
| 9 | Bipolar plasmaki-netic technology for the treatment of symptomatic benignprostatic hyperplasia ; evidence beyond marketing hype?显示文摘 | Autorino R De Sio M D * Armiento M | 2007 | BJU Int2007，100，5： | 1 |
| 10 | Tetra-acetyl-ethylene: a new intermediate for synthesising hetero-cyclic rings显示文摘 | ADEMBRI G SIO F D NESI R | 1970 | J Chem Soc C1970，11，： | 1 |
| 11 | Abrasive wear of HDPE/UHMWPE blends显示文摘 | LUCASA A A AMBR(O)SIO J D OTAGURO H | 2011 | Wear2011，270，： | 1 |
| 12 | 3 Choosing The Nephrostomy Size After Percutaneous Nephrolithotmy显示文摘 | Sio M D Giugliano F Sorrentino D | 2010 | European Urology Supplements2010，9，2： | 1 |
| 13 | Photochemical synthesis of citric acid cycle intermediates based on titanium dioxide显示文摘 | Saladino R Brucato J R Sio A D | 2011 | Astrobiology2011，11，： | 1 |
| 14 | Intraparenchymal solitary fibrous tumor of the lung:an uncommon cause of a pulmonary nodule显示文摘 | Pat sios D Hwang D M Chung T B | | 0，，1： | 1 |
| 15 | The use of tamsulosin in the medical treatment of ureteral calculi: where do we stand显示文摘 | AUTORINO R SIO M D DAMIANO R | 2005 | Urol Res2005，33，3： | 1 |
| 16 | Stent Positioning after Ureteroscopy for Urinary Calculi: The Question Is Still Open显示文摘 | Rocco Damiano Riccardo Autorino Ciro Esposito Francesco Cantiello Rosario Sacco Marco de Sio Massimo D’Armiento | 2004 | European Urology2004，，： | 1 |
| 17 | Four-Year Outcome of a Prospective Randomised Trial Comparing Bipolar Plasmakinetic and Monopolar Transurethral Resection of the Prostate显示文摘 | Riccardo Autorino Rocco Damiano Giuseppe Di Lorenzo Giuseppe Quarto Sisto Perdonà Massimo D’Armiento Marco De Sio | 2009 | European Urology2009，，： | 1 |
| 18 | The use of tamsulosin in the medical treatment of ureteral calculi: where do we stand?显示文摘 | Riccardo Autorino Marco Sio Rocco Damiano Giuseppe Lorenzo Sisto Perdonà Aniello Russo Giuseppe Quarto Luca Cosentino Massimo D’Armiento | 2005 | Urological Research2005，，6： | 1 |
| 19 | Four-Year Outcome of a Prospective Randomised Trial Comparing Bipolar Plasmakinetic and Monopolar Transurethral Resection of the Prostate显示文摘 | Riccardo Autorino Rocco Damiano Giuseppe Di Lorenzo Giuseppe Quarto Sisto Perdonà Massimo D'Armiento Marco De Sio | 2009 | European Urology2009，，4： | 1 |
| 20 | The Effect of a Silybin-Vitamin E-Phospholipid Complex on Nonalcoholic Fatty Liver Disease: A Pilot Study显示文摘 | Carmela Loguercio Alessandro Federico Marco Trappoliere Concetta Tuccillo Ilario de Sio Agnese Di Leva Marco Niosi Mauro Valeriano D'Auria Rita Capasso Camillo Del Vecchio Blanco | 2007 | Digestive Diseases and Sciences2007，，9： | 1 |
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