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| 1 | Replacement of Dietary Fish Oil with Vegetable Oils Improves the Growth and Flesh Quality of Large Yellow Croaker(Larmichthys crocea)显示文摘We investigated the effect of the replacement of dietary fish oil with vegetable oils on the growth and flesh quality of large yellow croaker(Larmichthys crocea). The basal diet(FO) was formulated to contain 66.5% fish meal and 6.4% menhaden fish oil; whereas the other 3 experimental diets were formulated by replacing the fish oil with 50% soybean oil(SO50), 100% soybean oil(SO100) and 100% palm oil(PO100), respectively. The 4 diets were randomly assigned to 4 floating sea cages(3.0 m × 3.0 m × 3.0 m), and each was stocked with 250 fish individuals with an initial average weight of 245.29 g ± 7.45 g. The fish were fed to apparent satiation twice a day at 5:00 and 17:00, respectively, for 12 weeks. Experimental analysis showed that the specific growth rate of fish fed SO50 or PO100 were significantly higher than that of fish fed FO or SO100(P<0.05), and crude lipid contents of ventral muscle and viscera were significantly lower in fish fed FO than in those fed the other 3 diets(P<0.05). No significant differences in condition factor, viscerosomatic index, hepatosomatic index, gutted yield and colorimetric values of fish among the dietary treatments were observed(P>0.05). Compared to FO diet, SO50, SO100 and PO100 diets led to substantial decreases in the liquid loss and water loss from fresh fillets(1 d, 4℃)(P<0.05). Similarly, thiobarbituric acid reactive substance(TBARS) values of fillets under different storage conditions(1 d, 4℃; 7 d, 4℃; 4 weeks,-20℃; 8 weeks,-20℃) decreased significantly after partial or complete replacement of fish oil with vegetable oils. These findings indicated that the growth performance and selected flesh quality properties(liquid holding capacity and TBARS value) of large yellow croaker were substantially improved by replacing dietary fish oil with vegetable oils. | DUAN Qingyuan MAI Kangsen SHENTU Jikang AI Qinghui ZHONG Huiying JIANG Yujian ZHANG Lu ZHANG Chunxiao GUO Sitong | 2014 | Journal of Ocean University of China2014，13，3： | 11 |
| 2 | Mild Renal Dysfunction and Risk of Thromboembolism and Bleeding in Patients with Atrial Fibrillation:The Chinese Atrial Fibrillation Registry Study显示文摘Objective:Previous studies indicated that patients with atrial fibrillation(AF)and moderate-to-severe chronic kidney disease(CKD)are at a higher risk of thromboembolism and bleeding during anticoagulation.Whether mild CKD is associated with an increased risk of thromboembolism and bleeding in AF patients remains unknown.This study aimed to evaluate the impact of mild CKD on thromboembolism and major bleeding among patients with AF.Methods:Baseline serum creatinine was available in 17,559 of 25,512 patients enrolled in the China-AF study between August 2011 and December 2018.After excluding those who underwent AF ablation or with moderate-to-severe CKD,7191 non-valvular AF patients(2059 with mild CKD and 5132 with normal renal function)with regular follow-up for at least 6 months were included.Primary outcomes were the time to the first occurrence of thromboembolic and major bleeding events.Results:Over a mean follow-up of(44.4±23.4)months,639 thromboembolism and 231 major bleeding events occurred.The crude incidence rates of thromboembolism were higher in the mild CKD group than that of the normal renal function group(3.0/100 person-years vs.2.2/100 person-years,P<0.0001),while the crude incidence rates of major bleeding were comparable between the two groups(1.0/100 person-years vs.0.8/100 person-years,P=0.076).After multivariate analyses,mild CKD was not associated with an increased risk of thromboembolism(HR=1.05,95%CI:0.89-1.25,P=0.547)or major bleeding(HR=1.11,95%CI:0.84–1.47,P=0.476).Conclusions:Mild CKD was not an independent risk factor of thromboembolism or major bleeding in patients with AF. | Jingye Li Sitong Li Chao Jiang Jing Du Xueyuan Guo Songnan Li Chenxi Jiang Ribo Tang Caihua Sang Deyong Long Xin Du Jianzeng Dong Changsheng Ma | 2021 | Cardiology Discovery2021，1，1： | 0 |
| 3 | Mapping QTL affecting the vertical distribution and seed set of soybean [Glycine max(L.) Merr.] pods显示文摘Number of pods per plant and number of seeds per pod are quantitative,multigenic traits and important components of yield in soybean[Glycine max(L.)Merr.].Pods are distributed unevenly in the upper,middle,and lower segments of the plant and this distribution is affected by sowing date(SD).A population of four-way recombinant inbred lines(FW-RIL),containing 160 F2:8 individuals,was generated from the cross(Kenfeng 14×Kenfeng 15)×(Heinong 48×Kenfeng 19).A linkage map consisting of 275 simple sequence repeat(SSR)markers was used to map quantitative trait loci(QTL)associated with the production of one,two,three,and four seeds per pod in the upper,middle,and lower segments of plants at two SDs,totaling 12 measurements per SD.A wide range of variation in the twelve characteristics was observed among the four parental lines and the FW-RIL population at the two SDs.The effect of SD2(May 17,2016)on pod number was stronger than that of SD1(May 7,2016)because the heritability of each trait in the SD1 experiment was generally greater than that of SD2.The study identified 76 QTL controlling pod number,with the phenotypic variation explained by each QTL ranging from 1.86%to 13.71%.The numbers of QTL controlling one,two,three,and four seeds per pod were 28,23,23,and 23,respectively.There were 30,28,and 28 QTL controlling the pod number in the upper,middle,and lower segments of the plant,respectively.Forty-five QTL were identified at SD1 and 38 QTL were identified at SD2.Seventeen QTL were associated with pod-number traits.The QTL qPNA1–3 was associated with the number of pods containing one seed in the middle segment of the plant at both SDs.Sixty-three QTL were published QTL(common areas existed when integrating on a map GmComposite2003 of Wm82 based on left and right markers).and 13 QTL related to pod number were newly discovered.These results provide a reference for breeders to improve soybean yield by combining advantageous alleles for these QTL.Future studies may reveal candidate genes for these QTL and identify causal alleles for markerassisted selection. | Shiping Liu Hong Xue Kaixin Zhang Ping Wang Daiqun Su Wenbin Li Shichao Xu Jianan Zhang Zhongying Qi Yanlong Fang Xiyu Li Yue Wang Xiaocui Tian Jie Song Jiajing Wang Chang Yang Sitong Jiang Wen-Xia Li Hailong Ning | 2019 | The Crop Journal2019，7，5： | 0 |
| 4 | Metformin:A promising clinical therapeutical approach for BPH treatment via inhibiting dysregulated steroid hormones-induced prostatic epithelial cells proliferation显示文摘The occurrence of benign prostate hyperplasia(BPH)was related to disrupted sex steroid hormones,and metformin(Met)had a clinical response to sex steroid hormone-related gynaecological disease.However,whether Met exerts an antiproliferative effect on BPH via sex steroid hormones remains unclear.Here,our clinical study showed that along with prostatic epithelial cell(PEC)proliferation,sex steroid hormones were dysregulated in the serum and prostate of BPH patients.As the major contributor to dysregulated sex steroid hormones,elevated dihydrotestosterone(DHT)had a significant positive relationship with the clinical characteristics of BPH patients.Activation of adenosine 5'-monophosphate(AMP)-activated protein kinase(AMPK)by Met restored dysregulated sex steroid hormone homeostasis and exerted antiproliferative effects against DHT-induced proliferation by inhibiting the formation of androgen receptor(AR)-mediated Yes-associated protein(YAP1)-TEA domain transcription factor(TEAD4)heterodimers.Met’s anti-proliferative effects were blocked by AMPK inhibitor or YAP1 overexpression in DHT-cultured BPH-1 cells.Our findings indicated that Met would be a promising clinical therapeutic approach for BPH by inhibiting dysregulated steroid hormone-induced PEC proliferation. | Tingting Yanga Jiayu Yuana Yuting Penga Jiale Pang Zhen Qiu Shangxiu Chen Yuhan Huang Zhenzhou Jiang Yilin Fan Junjie Liu Tao Wang Xueyan Zhou Sitong Qian Jinfang Song Yi Xu Qian Lu Xiaoxing Yin | 2024 | Journal of Pharmaceutical Analysis2024，14，1： | 0 |
| 5 | Expression of Phytoestrogens in pGL2/AQPI Promoter Reporter System显示文摘 | WEI Wei ZHAO Chaoyue LIU Sitong JIAO Xiaofei LIU Ximong LAN Chuanjian LI Jiang | 2018 | Chemical Research in Chinese Universities2018，34，6： | 0 |
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