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| 1 | Flavonoids, anti-inflammatory activity and cytotoxicity of Macfadyena unguiscati 显示文摘 | Aboutabl E A Hashem F A Sleem A A | 2008 | African Journal of Traditional Complementary and Alternative Medicines2008，5，1： | 1 |
| 2 | Effects of biphenyldimethyl - dicarboxylate administration alone or com- bined with silymarin in the CC14 model of liver fibrosis in rats显示文摘 | ABDEL SALAM O M SLEEM A A MORSY F A | 2007 | Scientific World Journal2007，7，： | 1 |
| 3 | Neuroprotection by misoprostol against rotenone-induced neurotoxicity in rat brain显示文摘Objective: To investigate the effect of the prostaglandin E1 analogue misoprostol on oxidative stress and neurodegeration caused by subcutaneous rotenone administration in rats. Methods:Rotenone was administered in a dose of 1.5 mg/kg every other day for 2 weeks. Starting from the 1 st day of rotenone injection, rats were subcutaneously treated with misoprostol at doses of10, 100 or 1 000 μg/kg. Rats were evaluated for brain lipid peroxidation(malondialdehyde:MDA), reduced glutathione(GSH), nitric oxide(NO) levels, and paraoxonase-1(PON-1) activity.The concentrations of the anti-apoptotic protein B cell/lymphoma-2(Bcl-2) were determined in the striatum. Histopathologic examination and the expression of inducible nitric oxide synthase(iNOS) in the cerebral cortex and striatum were also performed. Results: Compared with the vehicle-treated group, rotenone caused a significant increase in brain lipid proxidation(MDA)by 61%(P<0.05) accompanied by an increase in NO by 73.1%(P<0.05) and a decrease in GSH concentration by 29.4%(P<0.05). In addition, brain PON-1 activity significantly decreased by63.0%(P<0.05) and striatal Bcl-2 significantly decreased by 27.9%(P<0.05) with respect to the corresponding control value. Brain sections from rotenone treated rats showed extensive dark pyknotic and apoptotic nuclei in neurons, shrunken cytoplasm and perineuronal vacuolation.Rotenone also caused pronounced expression of iNOS in the cerebral cortex and striatum.Treatment with misoprostol at doses of 100 and 1 000 μg/kg resulted in decreased brain MDA(by 16.5%-23.0%)(P<0.05) and NO levels(by 37.1%-40.7%)(P<0.05) and increased GSH concentrations(by 18.8%-30.1%)(P<0.05). PON-1 activity was significantly increased by80.0%-114.8%(P<0.05) by misoprostol at 100 and 1 000 μg/kg, respectively. In addition,misoprostol treatment restored striatal Bcl-2 concentrations to its normal value. Misoprostol treatment resulted in markedly reduced brain injury and decreased iNOS expression in the cerebral cortex and striatum of rotenone intoxicated rats. Conclusions: These data suggest that misoprostol prevents the rotenone-induced neurodegeneration in rat brain by reducing brain oxidative stress. | Omar M.E.Abdel-Salam Amany A Sleem Eman R Youness Nadia A Mohammed Enayat A Omara | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，1： | 1 |
| 4 | Antiplatelet antibodies contribute to thrombocytopenia associated with chronic hepatitis C virus infection显示文摘 | Salah Aref Tarek Sleem Nadia El Menshawy | 2009 | Hematology2009，14，5： | 1 |
| 5 | Water soluble polysaceharides extracted from Pterocladia capillacea and I)ictyopterismembranacea and their biological activities显示文摘 | A H AbouZeid E A Aboutabl A A Sleem | 2014 | Carbohydrate Polymers2014，113，： | 1 |
| 6 | A new method for pI-I triggered cur- cumin release by applying poly (L-lysine) mediated nanoparticle-congregation显示文摘 | PATRA D SLEEM F | 2013 | Anal Chim Acta2013，795，： | 1 |
| 7 | Perforated appendicitis: Is early laparoscopic appendectomy appropriate?显示文摘 | Rami Sleem Sabrina Fisher Mark Gestring Julius Cheng Ayodele Sangosanya Nicole Stassen Paul Bankey | 2009 | Surgery2009，，4： | 1 |
| 8 | Acridine orange and silica nanoparticles facilitated novel robust fluorescent hollow microcapsules toward DNA bio-sensor 显示文摘 | Patra D Sleem F | 2014 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2014，443，： | 1 |
| 9 | Water soluble polysaccharides extracted from Pterocladiacapillacea and Dictyopterismembranacea and their biological activities显示文摘 | A H AbouZeid E A Aboutabl A A Sleem | 2014 | Carbohydrate Polymers2014，113，： | 1 |
| 10 | Isozyme polymorphism of esterases in the genus Lanistes (Mollusca : Prosobranchiata) and genetic analysis of populations显示文摘 | Abdelmordy MB Sleem SH Tantawi TA | 1997 | Biochem Genet1997，35，34： | 1 |
| 11 | Perforated aPPendicitis:is early Laparoscopic appendectomy显示文摘 | Sleem R Fisher S Gestring M | 2009 | Pro Priate Surg2009，146，4： | 1 |
| 12 | Water soluble polysaccharides extracted from Pterocladia capiUacea and Dictyopteris membranacea and their biological activities 显示文摘 | Zeid A H A Aboutabl E A Sleem A A | 2014 | Carbohydr Polym2014，113，： | 1 |
| 13 | Nurse-physician collaboration: a comparative study of the attitudes of nurses and physicians at Mansoura University Hospital 显示文摘 | Sayed KAE Sleem WF | 2011 | Life Science Journal2011，8，： | 1 |
| 14 | Water soluble polysaccharides extracted from Pterocladia capill acea and Dictyopteris membranacea and their biological activities显示文摘 | Abou Zeid AH Aboutabl EA Sleem AA | 2014 | Carbohydrate Polymers2014，，113： | 1 |
| 15 | Modu- lation of lipopolysaccharide -induced oxidative stress by cap-saicin显示文摘 | AbdeI-Salam O M AbdeI-Rahman R F Sleem A A et aI | 2012 | Inflammopharmacology2012，20，4： | 1 |
| 16 | Application of RAPD-PCR in taxonomy of certain freshwater bivalves of genus Caelatura显示文摘 | Sleem S H Ali T G | 2008 | Global J Mol Sci2008，3，1： | 1 |
| 17 | Perforated aPPendicitis:is earlylaparoscopic appendectomy显示文摘 | Sleem R Fisher S Gestring M | 2009 | Pro Priate Surg2009，146，4： | 1 |
| 18 | Water soluble polysaccharides extracted from Pterocladia capillacea and Dictyopteris membranacea and their biological activities显示文摘 | Abou Zeid A H Aboutabl E A Sleem A A | 2014 | Carbohydrate Polymers2014，113，： | 1 |
| 19 | Perforated appendicitis : is early laparoscopic appendectomy appropriate ? 显示文摘 | Sleem R Fisher S Gestring M | 2009 | Surgery2009，146，4： | 1 |
| 20 | Serum mannan-binding lectin in egyptian patients with chronic hepatitis C:its relation to disease progression and response to treatment显示文摘 | Esmat S Omran D Sleem GA | | 0，，04： | 1 |
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