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| 1 | Heteromeric and Homomeric Geranyl Diphosphate Synthases from Catharanthus roseus and Their Role in Monoterpene Indole Alkaloid Biosynthesis显示文摘Catharanthus roseus 是二很重要的 monoterpene 吲哚碱(MIA ) 的唯一的来源反癌症代理人:vinblastine 和长春新碱。MIA 拥有萜烯和分别地从 terpenoid 和 shikimate 小径导出的吲哚一半。Geranyl diphosphate (GPP ) ,入口点到萜烯一半的形成,由 GPP synthase (GPPS ) 是 isopentenyl diphosphate (IPP ) 和 dimethylallyl diphosphate (DMAPP ) 的冷凝作用的一个产品。这里,我们报导与顺序类似编码蛋白质到大子单元(CrGPPS.LSU ) 和 heteromeric GPPS,和 homomeric 的小子单元(CrGPPS.SSU ) 的三基因 GPPS。CrGPPS.LSU 是生产 GPP 和 geranyl geranyl diphosphate (GGPP ) 的 bifunctional 酶, CrGPPS.SSU 是不活跃的,而 CrGPPS 是形成 GPP 的 homomeric 酶。在 Escherichia coli 的两个子单元的合作表示与生产仅仅 GPP 的提高的活动导致了 heteromeric 酶。当 CrGPPS.LSU 和 CrGPPS 在更旧、更年轻的叶子显示出更高的表示时,分别地, CrGPPS.SSU 显示出一个增加的趋势并且逐渐地减少了。叶子的甲基 jasmonate (MeJA ) 处理显著地导致了仅仅 CrGPPS.SSU 的表示。而 CrGPPS 是 mitochondrial, GFP 本地化显示 CrGPPS.SSU 是 plastidial。在 C 的 AmGPPS.SSU 的短暂 overexpression。roseus 叶子导致了增加的 vindoline, vinblastine 和长春新碱的立即的 monomeric 先锋。尽管 C。roseus 有 heteromeric 和 homomeric GPPS 酶,我们的结果含有有为 MIA 生合成调整 GPP 流动的 CrGPPS.SSU 的仅仅 heteromeric GPPS 的参与。 | Avanish Rai Shachi S. Smita Anup Kumar Singh Karuna Shanker Dinesh A. Nagegowda | 2013 | Molecular Plant2013，6，5： | 20 |
| 2 | Differential Sensitivity of Macrocarpa and Microcarpa Types of Chickpea (Cicer arietinum L.) to Water Stress: Association of Contrasting Stress Response with Oxidative Injury显示文摘Chickpea (Cicer arietinum L.) 是特别地敏感的在它的繁殖阶段浇应力并且在水应力的条件下面,将放弃花和豆荚,因此减少收益潜力。有 chickpea 的二种类型:(i) Macrocarpa (Kabuli ) 它有大,击打塑造头的、轻棕色的种子;并且(ii ) Microcarpa (Desi ) 它有小、尖、黑暗褐的种子。相对说, Kabuli 被报导了更敏感比 Desi 浇应力。与对比敏感流水联系的内在的机制在新陈代谢的水平强调井没被理解。我们假设了一个原因因为在 chickpea 的二种类型的形成对照的水压力敏感可以是在氧化损害的一个变化。在现在的学习,两种类型的植物是为 14 d 在繁殖舞台强调的水。由于压力, Kabuli 类型与为 Desi 类型观察的 64% 减小相比在控制上在种子产量展出了 80% 减小。在叶水潜力(w) 的减少与 Desi 类型相比在 Kabuli 是更快的。在水压力时期的结束, w 被归结为 ? 2.9 并且 ? 分别地,没有他们之间的任何重要差别,在 Desi 和 Kabuli 的 3.1 MPa 打字。在应力的最后一天, Kabuli 比 Desi 经历了 20% 更多的膜损害。叶绿素内容和光合的率与 Kabuli 相比在 Desi 是显著地更大的。malondialdehyde 和 H2O2 内容与 Desi 相比在在 Kabuli 的水压力的结束是显著地更高的,显示在前者的更大的氧化应力。抗氧化剂的层次例如维生素酸和谷胱甘肽,比 Kabuli 在 Desi 是显著地更高的。, Superoxide dismutase 和过氧化氢酶活动没在第 10 天, ascorbate peroxidase 的活动, dehydroascorbate reductase,和谷胱甘肽 reductase 在 chickpea 的二种类型之间显著地不同在 Desi 是更高的。这些调查结果显示在 Desi 类型的更大的应力公差可以被归功于到它维持更好的水地位的优异能力,它导致更少的氧化损坏。另外,实验室研究由使 chickpea 的两种类型遭到到聚乙烯的类似的层次进行了导致乙二醇的水应力并且到 10 .mol/L abscisic,酸显示了 Desi 类型的一个更大的能力比 Kabuli 类型处理氧化应力。 | Harsh Nayyar Smita Singh Satwinder Kaur Sanjeev Kumar Hari D. Upadhyaya | 2006 | Journal of Integrative Plant Biology2006，48，11： | 6 |
| 3 | Correlation of pattern reversal visual evoked potential parameters with the pattern standard deviation in primary open angle glaucoma显示文摘AIM:To evaluate whether glaucomatous visual field defect particularly the pattern standard deviation(PSD)of Humphrey visual field could be associated with visual evoked potential(VEP)parameters of patients having primary open angle glaucoma(POAG).METHODS:Visual field by Humphrey perimetry and simultaneous recordings of pattern reversal visual evoked potential(PRVEP)were assessed in 100 patients with POAG.The stimulus configuration for VEP recordings consisted of the transient pattern reversal method in which a black and white checker board pattern was generated(full field)and displayed on VEP monitor(colour 14')by an electronic pattern regenerator inbuilt in an evoked potential recorder(RMS EMG EP MARK II).RESULTS:The results of our study indicate that there is a highly significant(P<0.001)negative correlation of P100 amplitude and a statistically significant(P<0.05)positive correlation of N70 latency,P100 latency and N155 latency with the PSD of Humphrey visual field in the subjects of POAG in various age groups as evaluated by Student's t-test.CONCLUSION:Prolongation of VEP latencies were mirrored by a corresponding increase of PSD values.Conversely,as PSD increases the magnitude of VEP excursions were found to be diminished. | Ruchi Kothari Pradeep Bokariya Ramji Singh Smita Singh Purvasha Narang | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 3 |
| 4 | Evaluation of antihyperglycemic and antioxidant activities of Saraca asoca (Roxb.) De Wild leaves in streptozotocin induced diabetic mice显示文摘 | Sunil Kumar Smita Narwal Dinesh Kumar Gurvirender Singh Sumit Narwal Renu Arya | 2012 | Asian Pacific Journal of Tropical Disease2012，，3： | 3 |
| 5 | Deciphering the traits associated with PAH degradation by a novel Serratia marcesencs L-11 strain显示文摘 | AlokK. Pandey Priyanka Chaudhary ShashiB. Singh Anju Arora Kanika Kumar Smita Chaudhry Lata Nain | 2012 | Journal of Environmental Science and Health, Part A2012，，5： | 1 |
| 6 | Methane flux from rice/wheat agroecosystem as affected by crop phenology, fertilization and water level显示文摘 | J. S. Singh Smita Singh A. S. Raghubanshi Saranath Singh A. K. Kashyap | 1996 | Plant and Soil1996，，2： | 1 |
| 7 | QSAR analyses and pharmacophore studies of tetrazole and sulfonamide analogs of imidazo pyridine using simulated annealing based feature selection 显示文摘 | Mukesh C Sharma Smita Sharma Kamlendra Singh Bhadoriya | 2012 | Journal of Saudi Chemical Society2012，，： | 1 |
| 8 | Methane flux from irrigated rice fields in relation to crop growth and N-fertilization显示文摘 | Smita Singh J.S Singh A.K Kashyap | 1999 | Soil Biology and Biochemistry1999，，9： | 1 |
| 9 | Appli- cation of PRF in surgical management of periapical lesions 显示文摘 | Smita Singh Arunendra Singh Sourav Singh | 2013 | NatlJ Maxillofac Surg2013，4，1： | 1 |
| 10 | Bacteriocins as antimicrobial and preservative agents in food:Biosynthesis,separation and application显示文摘Emerging evidence shows the trend of using safe and natural preservatives like bacteriocins in food processing.The increasing demand by the food industry to extend keeping quality and prevent spoilage of various food products has appealed for new preservatives and new methods of conservation.Further,to discover the novel spectrum of antimicrobial compounds that could effectively battle food-borne pathogens,bacteriocins have been intensively studied in the last few years.Recently,great attention has been paid to the application of lactic acid-bacterial bacteriocins targeting food spoilage-causing or pathogenic microorganisms with no significant side effects.Different mechanisms of action like pore-formation,retarding cell-wall/nucleic acid/protein synthesis have been proposed and described for diverse bacteriocins.Therefore,the syntheses,purification of bacteriocins in addition to their applications as antimicrobial and preservative agents in food processing are reviewed in detail.The review will also discuss the preservative effect of bacteriocins and their combinations having multiple modes of action(hurdle approach)to reduce the microbial load as well as antimicrobial resistance. | Deepak Kumar Verma Mamta Thakur Smita Singh Soubhagya Tripathy Alok Kumar Gupta Deepika Baranwal Ami R.Patel Nihir Shah Gemilang Lara Utama Alaa Kareem Niamah M´onica L.Ch´avez-Gonz´alez Carolina Flores Gallegos Cristobal Noe Aguilar Prem Prakash Srivastav | 2022 | Food Bioscience2022，46，2： | 1 |
| 11 | Schizophrenia with and without obsessive-compulsive symptoms:a comparative analysis of performance on trail making test and disability on WHOD AS显示文摘Background Presence of obsessive-compulsive symptoms(0CS)affects performance on tests of some cognitive functions,such as the trail making test(TMT),and may affect the level of disability in schizophrenia(SZ).Aim s The aim of the present study was to compare performance on TMT and disability on WHO Disability Assessment Schedule(WHODAS)in persons with SZ with and without 0CS in a cross-sectional study.Methods Persons with SZ(n=200)fulfilling DSM-V(Diagnostic and Statistical Manual)diagnostic criteria were assessed on Yale Brown Obsessive Compulsive Scale(YB0CS)and divided into two groups based on presence or absence of OCS.TMT and WHODAS V.2.0 were applied.The two groups as a whole,as well as a subsample matched on age,gender and age of onset were compared.Results Out of 200 persons with SZ,37(18.5%)reported OCS.The OCS group took a significantly longer mean time to complete TMT-A(Z=-3.02,p=0.003)as well as TMT-B(Z=-3.551,p<0.001).Significant correlations were found between TMT-A and total YB0CS Scores(r=0.351,p=0.033),as well as TMT-A and YB0CS compulsion scores(r=0.404,p=0.013)but not with TMT-B Scores.The OCS group reported greater disability in all domains separately as well as on average WHODAS Scores(Z=-5.969,p<0.001).Significant correlations were found between YB0CS obsession scores and YBOCS total scores with average WHODAS Scores(r=0.614,p<0.001 and r=0.406,p=0.013,respectively).We obtained essentially similar results with the matched subsample as well as with the entire group.Conclusion Persons with SZ and comorbid OCS had significantly poorer performance on TMTs and greater disability in comparison to persons with SZ alone.Magnitude of disability correlated with severity of OCS. | Apala Singh Ram Pratap Beniwal Triptish Bhatia Smita Neelkanth Deshpande | 2020 | General Psychiatry2020，33，6： | 0 |
| 12 | Diagnostic dilemma in a patient with chronic non-healing ulcer on leg:A case report显示文摘Rationale:Though cutaneous tuberculosis accounts for a small proportion of all tuberculosis cases,it becomes an important health issue considering its high prevalence in tropical countries.Due to its myriad clinical manifestations,it becomes difficult to diagnose and may pose a great diagnostic dilemma.Patient concerns:A 17-year-old male complaint of ulcerproliferative lesion on the left lower leg for 5 years.There was no history suggestive of tuberculosis.On cutaneous examination,single well-defined erosiocrustive plaque of size 14 cm×13 cm with yellowish adherent crust presented over the left lower leg.The underlying surface shows ulceration after removing the crust.Diagnosis:Ulcerative Lupus vulgaris.Interventions:Anti-tubercular drug therapy(isoniazid,rifampicin,pyrazinamide and ethambutol).Outcomes:Lesion showed dramatic improvement after one month of anti-tubercular therapy.Lessons:Dermatologists should be aware of variable clinical presentations of cutaneous tuberculosis so as to diagnose it timely and correctly. | Mendiratta Vibhu Meena Amit Singh Smita | 2022 | Asian Pacific Journal of Tropical Medicine2022，15，12： | 0 |
| 13 | 竹子作为结构荷载构件:实验性能评估显示文摘竹子自古就是建筑材料,但其使用因屋顶的荷载分布受到限制。竹建筑技术的标准化受制于不同地理和环境条件下竹子性能各有不同。另外,由于缺乏成本效益来确定竹结构的安全性,竹子不能大量用在建筑结构中。为解决这些缺点和对竹子作为建筑荷载构件的研究中不足,本试验研究评估了结构竹横梁的荷载能力,该实验是通过特别设计的测验设备来进行的。通过对横梁结构的荷载分析,取得了可喜的成果,从而证明竹子有极高可能用于建筑结构的荷载构件。将竹子大量用在建筑上不仅能提供更多的经济适用房,还可以解决环境问题。 | Smita Chugh | 2012 | 世界竹藤通讯2012，，4： | 0 |
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