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| 1 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 2 | Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease显示文摘AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management. | Muhammed Hadithi Chris JJ Mulder Frank Stam Joshan Azizi J Bart A Crusius Amado Salvador Pea Coen DA Stehouwer Yvo M Smulders | 2009 | World Journal of Gastroenterology2009，15，8： | 3 |
| 3 | Randomized Clinical Trial of Laparoscopic Versus Open Repair of the Perforated Peptic Ulcer: The LAMA Trial显示文摘 | Mari?tta J. O. E. Bertleff Jens A. Halm Willem A. Bemelman Arie C. Ham Erwin Harst Hok I. Oei J. F. Smulders E. W. Steyerberg Johan F. Lange | 2009 | World Journal of Surgery2009，，： | 2 |
| 4 | Analysis of SSRs Uncovers Hierarchical Structure and Genetic Diversity in Chinese Soybean Landraces显示文摘For clarifying the hierarchical patterns of population structure of soybean landraces in China, the seven clusters previously identified using Bayesian clustering of 1 504 soybean landraces based on SSR markers genotyping data were further analyzed. Using the largest value of ΔK, these landraces could be split into 20 sub-clusters, which was supported by highly significant pairwise Fst-values and generally in accordance with the geographic origin and sowing types. The autumn-sowing types ended up in one distinct sub-cluster from the otherwise summer-sowing type, where the autumn-sowing types are most likely derived from. The division into 20 sub-clusters explained 7.3% of the genetic variation, next to 9.7% present among the seven clusters, 81.1% residing among landraces within sub-clusters, and 1.9% within the landraces. The distribution pattern of genetic diversity among the sub-clusters of each cluster was uneven, with two HSuM sub-clusters (Central China) and some South China sub-clusters showing significantly higher level of genetic diversity. | LI Ying-hui Marinus J M Smulders CHANG Ru-zhen QIU Li-juan | 2010 | Agricultural Sciences in China2010，9，12： | 2 |
| 5 | Development of SNP markers and haplotype analysis of the candidate gene for rhg1, which confers resistance to soybean cyst nematode in soybean显示文摘 | Ying-Hui Li Chen Zhang Zhong-Shan Gao Marinus Johannes Maria Smulders Zulu Ma Zhang-Xiong Liu Hai-Yang Nan Ru-Zhen Chang Li-Juan Qiu | 2009 | Molecular Breeding2009，，1： | 2 |
| 6 | Microalbuminuria and risk for car- diovascular disease: Analysis o{ potential mechanisms显示文摘 | Stehouwer CD Smulders YM | 2006 | J Am Soc Nephrol2006，17，8： | 1 |
| 7 | Post-mortern variation in pH, temperature, and colour profiles of veal carcasses in relation to breed, blood hemoglobin content, and carcass characteristics显示文摘 | Klont R E Barnier V M H Smulders F J M | 1999 | Meat Sci1999，53，： | 1 |
| 8 | Comparison of data on occupational health service, systems in Australia, Finland, Germany, TheNetherlands, Norway and Sweden显示文摘 | Draaisma D van Putten DJ Smulders PG | 1993 | Occup Med1993，43，： | 1 |
| 9 | A randomized clinical trial of intermittent subglottic secretion drainage in patients receiving mechanical venti- lation 显示文摘 | Smulders K vander Hoeven H | 2002 | Chest2002，121，3： | 1 |
| 10 | Antimicrohial re- sistance profile of five major food-borne pathogens isolated from beef,pork and poultry显示文摘 | Mayrhofer S Paulsen P Smulders FJ | 2004 | Int J Food Microbiol2004，97，1： | 1 |
| 11 | Use of short microsatel- lites from database sequences to generate polymorphisms among Lycopersicon esc Lentum cuhivars and accessions of other Lycopersicon species 显示文摘 | Smulders M J M Bredemeijer G | 1997 | Theoretical and Ap- plied Genetics1997，97，： | 1 |
| 12 | The impact of energy conservation on technology and economic growth显示文摘 | Smulders S de Nooij M | 2003 | Resource and Energy Economics2003，25，1： | 1 |
| 13 | Job resources and emotional exhaustion: the mediating role of learning opportunities显示文摘 | RUYSSEVELDT J V VERBOON P SMULDERS P | 2011 | Work & Stress2011，25，3： | 1 |
| 14 | A deletion in the bone morphogenetic protein 15 gene causes sterility and increased prolificacy in Rasa Aragonesa sheep 显示文摘 | Martinez-Royo A Jurado J J Smulders J P | 2008 | Animal Ge- netics2008，39，3： | 1 |
| 15 | A comparative study on irritation and reside aspects of five oxytetraeycline formulations administered intramuscularly to calves, pigs and sheep显示文摘 | Nouws J F Smulders A Rappalini M | 1990 | Vet Q1990，12，3： | 1 |
| 16 | Tissue culturereduced DNA methylation polymor phisms in repetitive DNA of tomato calli and regenerated plants 显示文摘 | Smulders M J M Rus KortekaasW Vosman B | 1995 | Theor Appl Genet1995，91，： | 1 |
| 17 | Can adverse drug reactions be detected earlier? A comparison by patients and professionals 显示文摘 | Egberts T C Smulders M Koning F H | 1996 | BMJ1996，313，7056： | 1 |
| 18 | The origin and early development of wheat glutenin particles显示文摘 | T.W.J.M. van Herpen J.H.G. Cordewener H.J. Klok J. Freeman A.H.P. America D. Bosch M.J.M. Smulders L.J.W.J. Gilissen P.R. Shewry R.J. Hamer | 2008 | Journal of Cereal Science2008，，3： | 1 |
| 19 | Nutrient deficiencies before and after sleeve gastrectomy显示文摘 | van Rutte PW Aarts EO Smulders JF | 2014 | Obes Surg2014，24，10： | 1 |
| 20 | Environmental Quality and Pollution Augmenting Technological Change in a Two- sector Endogenous Growth Model 显示文摘 | Bovenberg A L Smulders S | 1995 | Journal of Public Economics1995，57，3： | 1 |
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