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| 1 | The Development of Protein Microarrays and Their Applications in DNA-Protein and Protein-Protein Interaction Analyses of Arabidopsis Transcription Factors显示文摘 | Wei Gong Kun He Mike Covington S. R Dinesh-Kumar Michael Snyder Stacey L. Harmer Yu-Xian Zhu Xing Wang Denga | 2008 | Molecular Plant2008，1，1： | 7 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Role of simple biomarkers in predicting fibrosis progression in HCV infection显示文摘AIM: To examine the accuracy of the aspartate aminotransferase (AST)/Platelet Ratio Index (APRI) and FIB-4, in predicting longitudinal changes in liver histology in hepatitis C virus (HCV) patients.METHODS: Patients that underwent repeat liver biopsies at least 1 year apart from 1999 to 2007 were identified. Liver fibrosis was staged on needle core biopsies evaluated by a single expert liver pathologist. Only laboratory values within 3 mo of the liver biopsies were used.RESULTS: Thirty-six patients met the inclusion criteria with 50% stage 1 on initial biopsy, 25% stage 2, and 22% stage 3. Nineteen of 36 (53%) had progression of fibrosis on repeat biopsies, while 16 (44%) showed no change in stage, and one (3%) showed improvement. Patients that showed progression of fibrosis had significantly higher alanine aminotransferase and aspartate aminotransferase levels than the group that did not show progression. A significant correlation was seen between change in stage of fibrosis and change in APRI (r2 = 0.39, P = 0.00001) and a change in FIB-4 (r2 = 0.31, P = 0.00004). A change in APRI (ΔAPRI) of 0.18 had 80% positive predictive value (PPV) and 67% nega- tive predictive value (NPV) for progression of fibrosis. A change in FIB-4 (ΔFIB-4) of 0.39 had 75% PPV and 75% NPV for predicting progression of fibrosis. CONCLUSION: ΔAPRI and ΔFIB-4 parallel changes in fibrosis progression, and could be useful tools for clinicians in following patients with active chronic HCV infection. | Rajasekhara R Mummadi John R Petersen Ned Snyder | 2010 | World Journal of Gastroenterology2010，16，45： | 4 |
| 4 | 苯的生化毒理学显示文摘 | Snyder R 陈自强. | 1983 | 国外医学:卫生学分册1983，10，1： | 3 |
| 5 | Increasing diabetes self-management education in community settings显示文摘 | Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch | 2002 | American Journal of Preventive Medicine2002，，4： | 2 |
| 6 | Effect of air and oxygen content on the dielectric barrier discharge decomposition of chlorobenzene 显示文摘 | ANDERSON G K | 1998 | IEEE Trans Plasma Sci1998，26，6： | 1 |
| 7 | A fuel dryness index for grassland fire danger assessment 显示文摘 | SNYDER R L SPANO D DUCE P | 2006 | Agricultural and Forest Meteorology2006，139，： | 1 |
| 8 | Recent development in the understanding of benzene toxicity and leukemogenesis显示文摘 | SNYDER R | 2000 | Drug Chem Toxicol2000，23，1： | 1 |
| 9 | Control ofcolumn temperature in reversed-phase liquid chromatography显示文摘 | Wolcott R G Dolan J W Snyder L R | 2000 | J ChromatogrA2000，869，12： | 1 |
| 10 | Indole-3-aldehyde显示文摘 | James P N Snyder H R | 1963 | Org Synth Coll1963，，4： | 1 |
| 11 | Monoclonal autibody to the glycoprotein of VSV显示文摘 | Bricker B J Snyder R W Fox J W | 1997 | Virology1997，161，2： | 1 |
| 12 | Two-photon-excited fluorescence imaging of human RPE cells with a femtosecond Ti: Sapphire laser显示文摘 | Bindewald-Wittich A Han M Schmitz-Valckenberg S Snyder Sar- ah R Giese G Bille Josef F | 2006 | Invest Ophthalmol Vis Sci2006，47，10： | 1 |
| 13 | Thermoelectric microdevice fabricated by a MEMS-like electrochemical process 显示文摘 | Snyder G J Lira J R Huang C K | 2003 | Nature Materials & Design2003，2，5： | 1 |
| 14 | Laparoscopic anatomy of the equine abdomen 显示文摘 | Galuppo L D Snyder J R Pascoe J R | 1995 | Am J Vet Res1995，56，4： | 1 |
| 15 | Solubilization of histamine H-1, GABA and benzodiazepine receptors 显示文摘 | GAVISH M CHANG R S L SNYDER S H | 1979 | Life Sci1979，25，9： | 1 |
| 16 | 显示文摘 | Mo Y G Dillon R O Snyder P G | 1999 | Thin Solid Films1999，355，： | 1 |
| 17 | A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks显示文摘 | Summers J Smolec J M Snyder R | 1978 | Proc Natl Acad Sci U S A1978，75，： | 1 |
| 18 | Developmental exposure to endocrine disruptors and the obesity epidemic 显示文摘 | NEWBOLD R R PADILLA-BANKS E SNYDER R J | 2007 | Reprod Toxicol2007，23，3： | 1 |
| 19 | International symposium:Recent advances in benzene toxicity显示文摘 | Bird M G Greim H Snyder R | 2005 | Chemico-Biological Interactions2005，153，： | 1 |
| 20 | Broadband receiver response from dual-streamer data and applications in deep reflection seismology显示文摘 | Singh S C Hobbs R W Snyder D B | | 0，，01： | 1 |
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