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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Two-photon-excited fluorescence imaging of human RPE cells with a femtosecond Ti: Sapphire laser显示文摘 | Bindewald-Wittich A Han M Schmitz-Valckenberg S Snyder Sar- ah R Giese G Bille Josef F | 2006 | Invest Ophthalmol Vis Sci2006，47，10： | 1 |
| 3 | Mierofibrillated cellulose new cellulose product : properties, uses, and commercial potential 显示文摘 | Turbak A Snyder F W Sandberg K R | 1983 | Journal of Applied Polymer Science: Applied Polymer Symposium1983，37，2： | 1 |
| 4 | 查看详情显示文摘 | Fan W Snyder M A Kumar S Lee P S Yoo W C McCormick A V Penn R L Stein A Tsapatsis M | | 0，，： | 1 |
| 5 | The heat of formation of molybdenum dioxide and molybdenum trioxide显示文摘 | Staskievicz B A Tucker J R Snyder P E | 1955 | J Am Chem Soc1955，77，11： | 1 |
| 6 | Risk Analysis for Information Technology 显示文摘 | RAINER R K J R SNYDER C A CARR H H | 1991 | Journal of Management Information Systems1991，8，1： | 1 |
| 7 | The relationship between serum vascular endothelial growth factor,persistent disease,and survival at second-look laparotomy in ovarian cancer显示文摘 | Alvarez Secord A Sayer R Snyder SA | 2004 | Gynecol Oncol2004，94，1： | 1 |
| 8 | Cardiovascular effects of acute and chronic cocaine administration in pregnant and nonpregnant rabbits显示文摘 | Sutliff R L Gayheart-Walsten P A Snyder D L | 1999 | Toxicon1999，37，3： | 1 |
| 9 | virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks显示文摘 | Summers J Smolec J M Snyder R A | 1978 | Proc Natl Acad Sci USA1978，75，9： | 1 |
| 10 | Ballistic fibers : A Review of the thermal, ultraviolet and hydrolytic stability of the benzoxazole ring strueture 显示文摘 | Holmes G A Rice K Snyder C R | 2006 | JMaterSei2006，41，13： | 1 |
| 11 | Perceptions of the ethics of medical tourism by Canadian patients: Comparing patient and academic perspectives显示文摘 | Snyder J Crooks V A Johnston R | 2012 | Public Health Ethics2012，5，1： | 1 |
| 12 | Forecasting for inventory control with exponential smoothing显示文摘 | Snyder R D Koehlerb A B Keith Ordc J | 2002 | International Journal of Forecasting2002，18，： | 1 |
| 13 | Aldehydo boronic acids and boronic acid analog of tyrosine显示文摘 | SNYDER H R REEDY A J LENNARZ W J | 1958 | J Am Chem Sue1958，80，： | 1 |
| 14 | Microfibrillated cellulose, a new cellulose product: properties, uses, and commercial potential显示文摘 | Turbak A F Snyder F W Sandberg K R | 1983 | Appl Polym Sci1983，37，： | 1 |
| 15 | Synthesis of Aromatic boronic acids, aldehydo boronic acids and a boronic acid analog of tyrosine显示文摘 | SNYDER H R REEDY A J LENNARZ W J | 1958 | Am Chem Soc1958，80，： | 1 |
| 16 | Synthesis of phytoalexlns insorghum as a site-specific response to fungal ingress显示文摘 | Snyder B A Nicholson R L | 1990 | Science1990，248，： | 1 |
| 17 | Privileged scaffolds for library design and drug discovery显示文摘 | Matthew E Welsch Scott A Snyder Brent R Stockwell | 2010 | Current Opinion in Chemical Biology2010，，3： | 1 |
| 18 | Crystallization of glasses in the system BaO-TiO2- B2O3显示文摘 | BHARGAVA A SHELBY J E SNYDER R L | 1988 | Non Cryst Solids1988，102，： | 1 |
| 19 | Quantitative infrared methods for the measurement of crystallinity and its temperature dependence:polyethylene显示文摘 | Hagemam H Snyder R G Peacock A J | 1989 | Macromolecule1989，22，9： | 1 |
| 20 | Kinase regulation of hENaC mediated through a regionin the COOH - terminal portion of the α - subunit 显示文摘 | VOLK K A HUSTLED R F SNYDER P M | 2000 | Am J Physiol2000，27，5： | 1 |
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