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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Increasing diabetes self-management education in community settings显示文摘 | Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch | 2002 | American Journal of Preventive Medicine2002，，4： | 2 |
| 3 | Effect of air and oxygen content on the dielectric barrier discharge decomposition of chlorobenzene 显示文摘 | ANDERSON G K | 1998 | IEEE Trans Plasma Sci1998，26，6： | 1 |
| 4 | Control ofcolumn temperature in reversed-phase liquid chromatography显示文摘 | Wolcott R G Dolan J W Snyder L R | 2000 | J ChromatogrA2000，869，12： | 1 |
| 5 | Two-photon-excited fluorescence imaging of human RPE cells with a femtosecond Ti: Sapphire laser显示文摘 | Bindewald-Wittich A Han M Schmitz-Valckenberg S Snyder Sar- ah R Giese G Bille Josef F | 2006 | Invest Ophthalmol Vis Sci2006，47，10： | 1 |
| 6 | Thermoelectric microdevice fabricated by a MEMS-like electrochemical process 显示文摘 | Snyder G J Lira J R Huang C K | 2003 | Nature Materials & Design2003，2，5： | 1 |
| 7 | 显示文摘 | Mo Y G Dillon R O Snyder P G | 1999 | Thin Solid Films1999，355，： | 1 |
| 8 | International symposium:Recent advances in benzene toxicity显示文摘 | Bird M G Greim H Snyder R | 2005 | Chemico-Biological Interactions2005，153，： | 1 |
| 9 | Synthesis and opioid activity of Dynorphin A- (1-13) NH2 analogues containing cis- and trans-4- aminocyclohexanecarboxylic acid 显示文摘 | Snyder K R Murray T F DeLander G E | 1993 | J Med Chem1993，36，8： | 1 |
| 10 | Design of microwave filters显示文摘 | Levy R Snyder V R Matthaei R G | 2002 | IEEE MTT2002，50，3： | 1 |
| 11 | Design of microwave filters显示文摘 | Levy R Snyder R V Matthaei G | 2002 | IEEE Trans on Microwave Theory and Techniques2002，50，3： | 1 |
| 12 | Ballistic fibers : A Review of the thermal, ultraviolet and hydrolytic stability of the benzoxazole ring strueture 显示文摘 | Holmes G A Rice K Snyder C R | 2006 | JMaterSei2006，41，13： | 1 |
| 13 | Effect of air and oxygen content on the dielectric barrier discharge decomposition of chlorobenzene 显示文摘 | Anderson G K | 1998 | IEEE Transactions on Plasma Science1998，26，6： | 1 |
| 14 | Perform- ance Testing of Color-difference Metrics Using a Color Tol- erance Dataset显示文摘 | ALMAN D H BERNS R S SNYDER G D | 1989 | Color Research and Application1989，14，3： | 1 |
| 15 | Multistage thermoelectric microcoolers显示文摘 | YANG R CHEN G SNYDER G J | 2004 | Journal of Applied Physics2004，95，12： | 1 |
| 16 | Optical properties of photochromic organic-inorganic composites显示文摘 | MO Y G DILLON R O SNYDER P G | 1999 | Thin Solid Films1999，3553，： | 1 |
| 17 | Understanding and assessing the motivations of volunteers: A functional approach 显示文摘 | Clary E G Snyder M Ridge R D | 1998 | Journal of Personality and Social Psychology1998，74，6： | 1 |
| 18 | 查看详情显示文摘 | Snyder G J Lim J R Huang C K | | 0，，： | 1 |
| 19 | Quantitative infrared methods for the measurement of crystallinity and its temperature dependence:polyethylene显示文摘 | Hagemam H Snyder R G Peacock A J | 1989 | Macromolecule1989，22，9： | 1 |
| 20 | 显示文摘 | G J Snyder R Hiskes S DiCarolis | 1996 | Phys Rev B1996，53，14： | 1 |
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