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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 3 | Online topology determination and bad data suppression in power system operation using artificial neural networks显示文摘 | Souza J C S Silva A M L d Silva A P A d | 1998 | IEEE Transactions on Power Systems1998，13，3： | 1 |
| 4 | Targeting key alteration minerals in epithermal deposits in Patagonia,Argentina,using ASTER imagery and principal component analysis显示文摘 | Crosta A P Souza C R Azevedo F | 2003 | International Journal of Remote Sensing2003，24，21： | 1 |
| 5 | Synthesis of tungsten carbide through gas-solid reaction at low temperatures 显示文摘 | Medeiros F F P De Oliveira S A De Souza C P | 2001 | Materials Science and Engineering2001，315，： | 1 |
| 6 | B-type nartruretic peptide limits infract size in rat isolated hearts via KATP channel opening显示文摘 | D'souza S P Yellon D M Martin C | 2003 | Am J Physiol Heart Cric Physiol2003，284，3： | 1 |
| 7 | Targeting key alteration minerals in epithermal deposits in Patagonia, Argentina, using ASTER imagery and principal component analysis显示文摘 | Crosta A P Souza Filho C R D E | 2003 | INT J Remote Sensing2003，24，21： | 1 |
| 8 | Selenium assimil-ation and volatilization from dimethylselenoniopmpionate by Indianmustard显示文摘 | DE SOUZA M P LYTLE C M MULHOLLANI)M M | 2000 | Plant Physiol2000，122，4： | 1 |
| 9 | Targeting key alteration minerals in epithermal deposits in Patagonia,Argentina,using ASTER imagery and principal component analysis显示文摘 | Crosta A P Souza Filho C R Azevedo F Brodie C | | 0，，21： | 1 |
| 10 | ICP OES simultaneous determination of Ca, Cu, Fe, Mg, Mn, Na, and P inbiodiesel by axial and radial inductively coupled plasma-optical emission spectrometry显示文摘 | de SOUZA R M LEOCADIO L G da SILVEIRA C L P | 2008 | Analytical Letter2008，41，9： | 1 |
| 11 | QTL mapping for yield components in a tropical maize population using microsatellite markers显示文摘 | SABADIN P K JUNIOR C L D S SOUZA A P D | 2008 | Hereditas2008，145，4： | 1 |
| 12 | A component of the Xanthomonadaceae type IV secretion system combines a VirB7 motif with a NO domain found in outer membrane transport proteins 显示文摘 | Souza D P Andrade M O Alvarez-Martinez C E | 2011 | PLoS Pathogens2011，7，10： | 1 |
| 13 | Robust H∞ filtering design for uncertain linear systems with multiple time-varying state delays显示文摘 | De Souza C E Palhares R M Peres P L D | 2001 | IEEE Trans on Signal Processing2001，49，3： | 1 |
| 14 | Interleukin -21 expanded NKDC in vitro reduces the B16F10 tumor growth invivo显示文摘 | SOUZA A P BONORINO C MURARO SP | 2013 | Cytokine2013，61，1： | 1 |
| 15 | Powder properties and system behavior during spray drying of Bauhinia fomicata link extract显示文摘 | Souza C R F Oliveira W P | 2006 | Drying Technology2006，24，46： | 1 |
| 16 | Photosynthetic gas exchange,chlorophyll fluorescence and some associated metabolic changes in cowpea (Vigna unguiculata) during water stress and recovery显示文摘 | Souza R P Machado E C Silva J A B | 2004 | Environ Exp Bot2004，51，： | 1 |
| 17 | Photosynthetic gas exchange, chlorophyll fluorescence and some associated rectabolic changes in cowpea (Vigna unguiculata) during water stress and recoyery显示文摘 | Souza R P Machado E C Silva J A B | 2004 | Environmental and Experimental Botany2004，51，1： | 1 |
| 18 | Enlarged electrochemical window in dialkyl-imidazolium cation based room-temperature air and water-stable molten salts 显示文摘 | Suarez P A Z Selbach V M Dullius J E L Einloft S Piatnicki C M S Azambuja D S Souza R F D Dupont | 1997 | J Electrochim Acta1997，42，： | 1 |
| 19 | Photosynthetic gas exchange, chlorophyll fluorescence and some associatedm etabolic changes in cowpea (Vigna unguiculata) during water stress and reeovery显示文摘 | Souza R P Machado E C Silva J A | 2004 | Environmental and Experimental Botany2004，51，1： | 1 |
| 20 | Adaptive fuzzy controller for efficiency optimization of induction motors 显示文摘 | Souza D A Filho W C P Sousa G C D | 2007 | IEEE Transactions on Industrial Electronics2007，54，4： | 1 |
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