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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Embolization of splenorenal shunt associated to portal vein thrombosis and hepatic encephalopathy显示文摘Hepatic encephalopathy(HE)is a cognitive disturbance characterized by neuropsychiatric alterations.It occurs in acute and chronic hepatic disease and also in patients with portosystemic shunts.The presence of these portosystemic shunts allows the passage of nitrogenous substances from the intestines through systemic veins without liver depuration.Therefore,the embolization of these shunts has been performed tocontrol HE manifestations,but the presence of portal vein thrombosis is considered a contraindication.In this presentation we show a cirrhotic patient with severe HE and portal vein thrombosis who was submitted to embolization of a large portosystemic shunt.Case report:a 57 years-old cirrhotic patient who had been hospitalized many times for persistent HE and hepatic coma,even without precipitant factors.She had a wide portosystemic shunt and also portal vein thrombosis.The abdominal angiography confirmed the splenorenal shunt and showed other shunts.The larger shunt was embolized through placement of microcoils,and the patient had no recurrence of overt HE.There was a little increase of esophageal and gastric varices,but no endoscopic treatment was needed.Since portosystemic shunts are frequent causes of recurrent HE in cirrhotic patients,portal vein thrombosis should be considered a relative contraindication to perform a shunt embolization.However,in particular cases with many shunts and severe HE,we found that one of these shunts can be safely embolized and this procedure can be sufficient to obtain a good HE recovery.In conclusion,we reported a case of persistent HE due to a wide portosystemic shunt associated with portal vein thrombosis.As the patient had other shunts,she was successfully treated by embolization of the larger shunt. | Letícia de Campos Franzoni Fábio Cardoso de Carvalho Rafael Gomes de Almeida Garzon Fábio da Silva Yamashiro Laís Augusti Lívia Alves Amaral Santos Mariana de Souza Dorna Júlio Pinheiro Baima Talles Bazeia Lima Carlos Antonio Caramori Giovanni Faria Silva Fernando Gomes Romeiro | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 3 | Two-phase catalytic NBR hydrogenation by RuHCI( CO ) ( PCy3 ) 2 immobilized in 1-butyl-3-methylimidazolium tetrafluoroborate molten salt显示文摘 | Mtlller L A Dupont J de Souza R F | 1998 | Macromolecular Rapid Communications1998，19，8： | 1 |
| 4 | Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension 显示文摘 | Perros F Dorfmuller P Souza R l | 2007 | Eur Respir J2007，29，5： | 1 |
| 5 | Two-phase n-butenes dimerization by nickel complexes in molten salt media显示文摘 | Dupont J de Souza R F | 1998 | Appl Catal A:General1998，775，： | 1 |
| 6 | Meat flavor volatiles: a review of the composition, techniques of analysis, and sensory evaluation显示文摘 | SHAHIDI F RUBIN LJ D'SOUZA L A | 1986 | Critical Reviews in Food Science and Nutrition1986，24，2： | 1 |
| 7 | Emission profile of 18 carbonyl compounds, CO, Cf-h, and NOx emitted by a diesel engine fuelled with diesel and t:nary blends containing diesel, ethanol and biodiasel or vegetable oils显示文摘 | Guarieiro L L N Souza A F Tones E A | 2009 | A1mosphericEnvironment2009，43，： | 1 |
| 8 | Uncertain estimate in resources assessment: A geostatistical contribution 显示文摘 | Souza L E Costa J F C L Koppe J C | 2004 | Natural Resources Research2004，13，1： | 1 |
| 9 | Expression of the bovine papillomavirus type 1, 2 and 4 L1 genes in the yeast Pichia pastoris显示文摘 | Jesus A L Mariz F C Souza H M | 2012 | Genet Mol Res2012，11，3： | 1 |
| 10 | Effect of soil moisture and fertilization on Perola pineapple in Coastal Tableland areas of Brazil 显示文摘 | Souza L F D de Almeida O A Caldas R C | 2002 | Tropical Agriculture2002，79，2： | 1 |
| 11 | A new guaiane mannoside from a Eutypa-like fungus isolated from Murraya paniculata in Brazil 显示文摘 | AFONSO D L EDSON R F SOUZA A Q L | 2008 | J Braz Chem Soc2008，19，7： | 1 |
| 12 | Effect of a diet of nitrogen limited alga ( Tetraselmis suecica) on growth, survival and biochemical composition of tiger prawn (Penaeus semisulcatus) larvae 显示文摘 | D'Souza F M L Kelly G J | 2000 | Aquaculture2000，181，： | 1 |
| 13 | Marine macro-alga sargassum cymosum as electron donor for hexavalent chromium reduction to trivalent state in aqueous solutions显示文摘 | SOUZA F B D BRANDAO H D L HACKBARTH F V | 2015 | Chemical Engineering Journal2015，，： | 1 |
| 14 | Neurokinin- 1 receptor antagonists for chemotherapy - in- duced nausea and vomiting;a systematic review显示文摘 | DOS SANTOS L V SOUZA F H BRUNETTO A T | 2012 | J Natl Cancer Inst2012，104，17： | 1 |
| 15 | Effect of magnetic treatment of tomato ( Lycopersicon esculentum Mill) seeds on ger mination and seedling growth 显示文摘 | Souza T A Porras L E Casate F R | 1999 | Horticult Abs1999，70，8： | 1 |
| 16 | Depositional and diagenetic controls on the reservoir quality of Lower Creta- ceous Pendeneia sandstones, Potiguar rift basin, Brazil显示文摘 | dos Anjos S M C de Ros L F de Souza R S | 2000 | AAPG Bulletin2000，84，11： | 1 |
| 17 | The use of new ionic liquids in two-phase catalytic hydrogenation reaction by rhodium complexes显示文摘 | Suarez P A Z Dullius J E L Souza R F de | 1996 | Polyhedron1996，15，7： | 1 |
| 18 | Enlarged electrochemical window in dialkyl-imidazolium cation based room-temperature air and water-stable molten salts 显示文摘 | Suarez P A Z Selbach V M Dullius J E L Einloft S Piatnicki C M S Azambuja D S Souza R F D Dupont | 1997 | J Electrochim Acta1997，42，： | 1 |
| 19 | Effect of magnetic treatment of tomato (Lycopersicon esculervtum Mill) seeds on germination and seedling growth显示文摘 | SOUZA T E PORRAS L E CASATE F R | 1999 | Horticult Abs1999，，8： | 1 |
| 20 | Characterization and kinetic compensation effect of corn biodiesel显示文摘 | DANTAS M B ALMEIDA A A F CONCEICAO M M FERNANDES V J Jr SANTOS I M G SILVA F C SOLEDADE L F B SOUZA A G | 2007 | J Therm Anal Calorim2007，87，3： | 1 |
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