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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Combining ability for grain chemistry quality traits in a white oat dial- lelic cross显示文摘 | Crestani M Silveira Silveira SF Tessmann EW Mezzalira I Souza Luche H Silva JAG Gutkoski LC Carvalho FIF Oliveira AC | 2012 | Euphytica2012，185，1： | 1 |
| 3 | Neural correlates of cognitive impairment in posterior cortical atrophy显示文摘 | Kas A de Souza LC Samri D | 2011 | Brain2011，134，： | 1 |
| 4 | Palate cleft显示文摘 | Loffredo LC Souza JM Freitas Jet | 2002 | Craniofac J2002，43，1： | 1 |
| 5 | Obstructive sleep apnea affects hospital outcomes of patients with non - ST - elevation acute coronary syndromes 显示文摘 | Correia LC Souza AC Garcia G | 2012 | Sleep2012，35，9： | 1 |
| 6 | Susceptibility weighted imaging for the evaluation of patients with familial cerebtal cavernous malformations: A comparison with T2-weighted fast spin-echo and gradient-echo sequences显示文摘 | Souza JM Domingues Re Cruz LC | 2008 | American Journal of Neuroradiology2008，29，1： | 1 |
| 7 | Flavonoids and antiulcerogenic activity from Byrsonima crassa leaves extracts显示文摘 | Sannomiya M Fonseca VB da Silva MA Rocha LR Dos Santos LC Hiruma-Lima CA Souza Brito AR Vilegas W | | 0，，1： | 1 |
| 8 | Screening of reduc-ing agents for anaerobic growth of Candida albicans SC5314显示文摘 | Rymovicz AU Souza RD Gursky LC | 2011 | J Microbiol Methods2011，84，3： | 1 |
| 9 | Photodynamic thera- py with two different photosensitizers as a supplement to instru- mentation / irrigation procedures in promoting intracanal reduc- tion of Enterococcus faecalis 显示文摘 | Souza LC Brito PR de Oliveira JC | 2010 | J Endod2010，36，2： | 1 |
| 10 | Comparison of the effectiveness of three !tigation tech- niques in reducing intraeanal Enteroeoecu faeealis pop- ulations: An in vitro study显示文摘 | Brito PR Souza LC Machado de Oliv!ia JC | 2009 | J Endod2009，35，10： | 1 |
| 11 | Endophytic popula- tion of Pantoea agglomerans in citrus plants and development of a cloning vector for endophytes 显示文摘 | FD Andreote PB Rossetto LC Souza | 2008 | Basic Microbiol2008，48，5： | 1 |
| 12 | Plantar hyperhidrosis and pitted keratolysis treated with botulinum toxin injection 显示文摘 | Tamura BM Cuc6 LC Souza RL | 2004 | Dermatol Surg2004，30，122： | 1 |
| 13 | Nutritional as- sessment in hepatic cirrhosis ; clinical, anthropomctric, bi- ochemical and hematological parameters 显示文摘 | Vieira PM De -Souza DA Oliveira LC | 2013 | Nutr Hosp2013，28，5： | 1 |
| 14 | Oxidative stress as a signaling mechanism of the vascular response to injury: the redox hypothesis of restenosis显示文摘 | Azevedo LC Pedro MA Souza LC | 2000 | Cardiovasc Res2000，47，3： | 1 |
| 15 | Serum beta 2-microglobulin values among healthy Brazilians using a DPC IMMULITE(R) assay显示文摘 | Filippin FB Souza LC | 2005 | Clinics2005，60，1： | 1 |
| 16 | Nuclear factor kappa B-dependent activation of the antiapoptotic bfl-1 gene by the Epstein-Barr virus latent membrane protein 1 and activated CD40 receptor显示文摘 | D'Souza BN Edelstein LC Pegman P | 2004 | J Virol2004，78，4： | 1 |
| 17 | Susceptibility- weighted imaging for the evaluation of patients with familial cerebral cavernous malformations: a comparison with t2-weighted fast spin-echo and gradient-echo sequences显示文摘 | de Souza JM Domingues RC Cruz LC Jr | 2008 | AJNR Am J Neuroradiol2008，29，： | 1 |
| 18 | Clinical investigations in primary care显示文摘 | de Souza LC Sarazin M Goetz C | | 0，，： | 1 |
| 19 | Plantar hyperhidrosis and pitted keratolysis treated with botulinum toxin injection显示文摘 | Tamura BM Cucé LC Souza RL | | 0，，12： | 1 |
| 20 | Obstructive sleep apnea affects hospi- tal outcomes of patients with non-ST-elevation acute coronary syndromes 显示文摘 | Correia LC Souza AC Garcia G | 2012 | Sleep2012，35，9： | 1 |
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