|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mesenchymal stem cells: Molecular characteristics and clinical applications显示文摘Mesenchymal stem cells (MSCs) are non-hematopoietic stem cells with the capacity to differentiate into tissues of both mesenchymal and non-mesenchymal origin. MSCs can differentiate into osteoblastic, chondrogenic, and adipogenic lineages, although recent studies have demonstrated that MSCs are also able to differentiate into other lineages, including neuronal and cardiomyogenic lineages. Since their original isolation from the bone marrow, MSCs have been successfully harvested from many other tissues. Their ease of isolation and ex vivo expansion combined with their immunoprivileged nature has made these cells popular candidates for stem cell therapies. These cells have the potential to alter disease pathophysiology through many modalities including cytokine secretion, capacity to differentiate along various lineages, immune modulation and direct cell-cell interaction with diseased tissue. Here we first review basic features of MSC biology including MSC characteristics in culture, homing mechanisms, differentiation capabilities and immune modulation. We then highlight some in vivo and clinical evidence supporting the therapeutic roles of MSCs and their uses in orthopedic, autoimmune, and ischemic disorders. | Farbod Rastegar Deana Shenaq Eric R Wagner Stephanie H Kim Russell R Reid Hue H Luu Rex C Haydon | 2010 | World Journal of Stem Cells2010，2，4： | 35 |
| 2 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 3 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 4 | Measurement,analysis,and display of haptic signals during surgical cutting 显示文摘 | Stephanie G V H Vanessa C A O Thomas S | 2002 | Presence2002，11，6： | 1 |
| 5 | Evaluation the reinforcing effects of choice in comparison to reinforcement rate 显示文摘 | Rachel H T Wayne W F Stephanie A C | 1998 | Research in Developmental Disabilities1998，19，2： | 1 |
| 6 | Evaluation the reinforcing effects of choice in comparison to reinforcement rate显示文摘 | Rachel H T Wayne W F Stephanie A C | 1998 | Research in Developmental Disabilities1998，19，2： | 1 |
| 7 | TNP-470 inhibits intra-abdominal adhision formation显示文摘 | Stephanie C Chistopher H Karen S | 2000 | Pediatr Surg2000，135，2： | 1 |
| 8 | Inflammation enhances myeloid-derived suppressor cell crosstalk by signaling through Toll-like receptor 4显示文摘 | STEPHANIE K B VIRGINIA K C ERICA M H | 2009 | J Leukoc Biol2009，85，： | 1 |
| 9 | Direct and Indirect Economic Losses from Earthquake Damage显示文摘 | David S Brookshire Stephanie E C Cochrane H | 1997 | Earthquake Spectra1997，13，4： | 1 |
| 10 | TNP-470 inhibits intraabdominal adhesion formation 显示文摘 | Stephanie C Christopher H Karen S | 2000 | J Pediat Surg2000，135，2： | 1 |
| 11 | Real-time forensic DNA analysis at a crime scene using a portable microchip analyzer显示文摘 | Liu P Stephanie H I Y Karin A C | 2008 | Forensic Sci Int Genet2008，2，4： | 1 |
| 12 | Measurement,analysis,and display of haptic signals during surgical cutting显示文摘 | Stephanie G V H Vanessa C A O Thomas S | 2002 | Presence2002，11，6： | 1 |
| 13 | Understanding the dynamic interactions driving Zambian health centre performance:a case-based health systems analysis显示文摘 | Stephanie M T Julien M C Johanna H | 2014 | Health Policy and Planning2014，，： | 1 |
| 14 | Resistin is expressed in pancreatic islets显示文摘 | Alexandra H Minn Noelle B Patterson Stephanie Pack Steven C Hoffmann Oksana Gavrilova Charles Vinson David M Harlan Anath Shalev | 2003 | Biochemical and Biophysical Research Communications2003，，2： | 1 |
| 15 | Patients with mutations in Csαhave reduced activation of adownstream target in epithelial tissues due to haploinsufficiency显示文摘 | Stephanie C H Joshua D G Christian A M | 2007 | The Journal of Clinical Endocrinology and Metabolism2007，92，10： | 1 |
| 16 | A review of hereditary diseases of the German shepherd dog显示文摘 | Jacquelyn M W Stephanie M H Leigh A C | 2008 | Journal of Veterinary Behavior2008，，3： | 1 |
| 17 | Rotes of theLHX3 andLHX4 LIM homeodomain factors in pituitary develop- ment 显示文摘 | Rachel D M Stephanie C C Chad S H | 2007 | Molecular and Cellular Endocrinology2007，26，5266： | 1 |
| 18 | Wetland degradation and loss in the rapidly urbanizing area of Portland,Or- egon 显示文摘 | CINDY C H JOELLEN H STEPHANIE E G | 1995 | Wetlands1995，15，4： | 1 |
| 19 | Deficiency of the transcription factor PLAG1 results in aberrant coiling and morphology of the epididymis显示文摘Mice deficient in the transcription factor pleomorphic adenoma gene 1(PLAG1)exhibit reproductive issues that are characterized,in part,by decreased progressive sperm motility in the male.However,the underlying cause of this impairment is unknown.As epididymal transit is critical for sperm maturation and motility,the morphology of the epididymis of Plag1-deficient mice was investigated and the spatial expression patterns of PLAG1 protein and mRNA were identified.Using X-gal staining and in situ hybridization,PLAG1 was shown to be widely expressed in both the epithelium and stroma in all regions of the mouse epididymis.Interestingly,the X-gal staining pattern was markedly different in the cauda,where it could be suggestive of PLAG1 secretion into the epididymal lumen.At all ages investigated,the morphology of epididymides from Plag1 knockout(KO)mice was aberrant;the tubule failed to elongate and coil,particularly in the corpus and cauda,and the cauda was malformed,lacking its usual bulbous shape.Moreover,the epididymides from Plag1 KO mice were significantly reduced in size relative to body weight.In 20%of Plag1-deficient mice,the left testicle and epididymis were lacking.The impaired morphogenesis of the epididymal tubule is likely to be a major contributing factor to the fertility problems observed in male Plag1-deficient mice.These results also establish PLAG1 as an important regulator of male reproduction,not only through its involvement in testicular sperm production,but also via its role in the development and function of the epididymis. | Joanne Wong Almas R Juma Stephanie C Tran Jemma G Gasperoni Sylvia V H Grommen Bert De Groef | 2020 | Asian Journal of Andrology2020，22，4： | 1 |
| 20 | Iron transporters are differentially regulated by dietary iron, and modifications are associated with changes in man- ganese metabolism in young pigs 显示文摘 | STEPHANIE L H NARES T LIU H C | 2009 | The Journal of Nutrition2009，139，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员