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| 1 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 2 | Holmium Laser Enucleation of Prostate (HoLEP): The Methodist Hospital Experience With Greater Than 75 Gram Enucleations显示文摘 | RAMSAY L. KUO SAMUEL C. KIM JAMES E. LINGEMAN RYAN F. PATERSON STEPHANIE L. WATKINS GARRICK R. SIMMONS RONALD E. STEELE | 2003 | The Journal of Urology2003，，1： | 1 |
| 3 | MR imaging of term infants with HIE as a predictor of neurodevelopmental outcome and late MRI appearances显示文摘 | Eilish Twomey Anne Twomey Stephanie Ryan et aI | 2010 | Pediatric Radiology2010，40，9： | 1 |
| 4 | Purification and characterization of a new low molecular weight endoxylanase from Penicillium capsulatum 显示文摘 | Ryan Stephanie E Nolan Kieran Thompson R6isfn | 2003 | Enzyme and Microbial Technology2003，33，6： | 1 |
| 5 | MR imaging of term infants with hypoxic-ischaemic encephalopathy as a predictor of neurodevelopmental outcome and late MRI appearances显示文摘 | Eilish Twomey Anne Twomey Stephanie Ryan John Murphy Veronica B. Donoghue | 2010 | Pediatric Radiology2010，，9： | 1 |
| 6 | Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements显示文摘 | Neil G. Terry Yizheng Zhu Matthew T. Rinehart William J. Brown Steven C. Gebhart Stephanie Bright Elizabeth Carretta Courtney G. Ziefle Masoud Panjehpour Joseph Galanko Ryan D. Madanick Evan S. Dellon Dimitri Trembath Ana Bennett John R. Goldblum Bergein | 2011 | Gastroenterology2011，，1： | 1 |
| 7 | Assessment of multi-modality evaluations of obscure gastrointestinal bleeding显示文摘AIM To determine the frequency of bleeding source detection in patients with obscure gastrointestinal bleeding(OGIB) who underwent double balloon enteroscopy(DBE) after pre-procedure imaging [multiphase computed tomography enterography(MPCTE), video capsule endoscopy(VCE), or both] and assess the impact of imaging on DBE diagnostic yield.METHODS Retrospective cohort study using a prospectively maintained database of all adult patients presenting with OGIB who underwent DBE from September 1^(st), 2002 to June 30^(th), 2013 at a single tertiary center.RESULTS Four hundred and ninety five patients(52% females; median age 68 years) underwent DBE for OGIB. AVCE and/or MPCTE performed within 1 year prior to DBE(in 441 patients) increased the diagnostic yield of DBE(67.1% with preceding imaging vs 59.5% without). Using DBE as the gold standard, VCE and MPCTE had a diagnostic yield of 72.7% and 32.5% respectively. There were no increased odds of finding a bleeding site at DBE compared to VCE(OR = 1.3, P = 0.150). There were increased odds of finding a bleeding site at DBE compared to MPCTE(OR = 5.9, P < 0.001). In inpatients with overt OGIB, diagnostic yield of DBE was not affected by preceding imaging.CONCLUSION DBE is a safe and well-tolerated procedure for the diagnosis and treatment of OGIB, with a diagnostic yield that may be increased after obtaining a preceding VCE or MPCTE. However, inpatients with active ongoing bleeding may benefit from proceeding directly to antegrade DBE. | Ryan Law Jithinraj E Varayil Louis M Wong Kee Song Jeff Fidler Joel G Fletcher John Barlow Jeffrey Alexander Elizabeth Rajan Stephanie Hansel Brenda Becker Joseph J Larson Felicity T Enders David H Bruining Nayantara Coelho-Prabhu | 2017 | World Journal of Gastroenterology2017，23，4： | 1 |
| 8 | Characterzation of a common ragweed (Ambrosia artemisiifolia)population resistant to ALS-and PPO-inhibiting herbicides显示文摘 | STEPHANIE L.ROUSONELOS RYAN M.LEE MURILO S.MOREIRA | | 0，，3： | 1 |
| 9 | The effects of 12 weeks of beta-hydroxy-beta-methylbutyrate free acid supplementation on muscle mass, strength, and power in resistance-trained individuals: a randomized, double-blind, placebo-controlled study显示文摘 | Jacob M. Wilson Ryan P. Lowery Jordan M. Joy J. C. Andersen Stephanie M. C. Wilson Jeffrey R. Stout Nevine Duncan John C. Fuller Shawn M. Baier Marshall A. Naimo John Rathmacher | 2014 | European Journal of Applied Physiology2014，，6： | 1 |
| 10 | Biliary Sterol Secretion Is Not Required for Macrophage Reverse Cholesterol Transport显示文摘 | Ryan E. Temel Janet K. Sawyer Liqing Yu Caleb Lord Chiara Degirolamo Allison McDaniel Stephanie Marshall Nanping Wang Ramesh Shah Lawrence L. Rudel J. Mark Brown | 2010 | Cell Metabolism2010，，1： | 1 |
| 11 | Purification and characterization of a new low mole-cular weight endoxylanase from Penicillium capsulatum显示文摘 | Stephanie E Ryan Kieran Nolan R(o)isín Thompson | 2003 | Enzyme and Microbial Technology2003，33，： | 1 |
| 12 | Sickness behavior induced by endotoxin can be mitigated by the dietary soluble fiber, pectin, through up-regulation of IL-4 and Th2 polarization显示文摘 | Christina L. Sherry Stephanie S. Kim Ryan N. Dilger Laura L. Bauer Morgan L. Moon Richard I. Tapping George C. Fahey Kelly A. Tappenden Gregory G. Freund | 2010 | Brain Behavior and Immunity2010，，4： | 1 |
| 13 | Diagnostic role of fractional exhaled nitric oxide in pediatric eosinophilic esophagitis, relationship with gastric and duodenal eosinophils显示文摘BACKGROUND Eosinophilic esophagitis(EoE)is an eosinophilic-predominant inflammation of the esophagus diagnosed by upper endoscopy and biopsies.A non-invasive and cost-effective alternative for management of EoE is being researched.Previous studies assessing utility of fractional exhaled nitric oxide(FeNO)in EoE were low powered.None investigated the contribution of eosinophilic inflammation of the stomach and duodenum to FeNO.AIM To assess the utility of FeNO as a non-invasive biomarker of esophageal eosinophilic inflammation for monitoring disease activity.METHODS Patients aged 6-21 years undergoing scheduled upper endoscopy with biopsy for suspected EoE were recruited in our observational study.Patients on steroids and with persistent asthma requiring daily controller medication were excluded.FeNO measurements were obtained in duplicate using a chemiluminescence nitric oxide analyzer(NIOX MINO,Aerocrine,Inc.;Stockholm,Sweden)prior to endoscopy.Based on the esophageal peak eosinophil count(PEC)/high power field on biopsy,patients were classified as EoE(PEC≥15)or control(PEC≤14).Mean FeNO levels were correlated with presence or absence of EoE,eosinophil counts on esophageal biopsy,and abnormal downstream eosinophilia in the stomach(PEC≥10)and duodenum(PEC≥20).Wilcoxon rank-sum test,Spearman correlation,and logistic regression were used for analysis.P value<0.05 was considered significant.RESULTS We recruited a total of 134 patients,of which 45 were diagnosed with EoE by histopathology.The median interquartile range FeNO level was 17 parts per billion(11-37,range:7-81)in the EoE group and 12 parts per billion(8-19,range:5-71)in the control group.After adjusting for atopic diseases,EoE patients had significantly higher FeNO levels as compared to patients without EoE(Z=3.33,P<0.001).A weak yet statistically significant positive association was found between the number of esophageal eosinophils and FeNO levels(r=0.30,P<0.005).On subgroup analysis within the EoE cohort,higher FeNO levels were noted in patients with abnormal gastric(n=23,18 vs 15)and duodenal eosinophilia(n=28,21 vs 14);however,the difference was not statistically significant.CONCLUSION After ruling out atopy as possible confounder,we found significantly higher FeNO levels in the EoE cohort than in the control group. | Panamdeep Kaur Rachel Chevalier Craig Friesen Jamie Ryan Ashley Sherman Stephanie Page | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，5： | 0 |
| 14 | 婴幼儿腮腺血管瘤:40年经验总结显示文摘背景与目的婴幼儿血管瘤是幼儿最常见的肿瘤之一。笔者先前已证实过其最有效的治疗方式是非手术治疗。近年来,一些学者提倡手术治疗为其首选治疗方式。同时,还有提倡类固醇疗法或干扰素疗法的。采取何种方式治疗婴幼儿腮腺血管瘤,目前仍存在争议。方法本文回顾性研究部分,对过去40年内蒙特利尔儿童医院收治的400例婴幼儿血管瘤的相关信息进行了回顾分析。其中,20例确定为腮腺血管瘤。本文文献回顾部分,检索Ovid医学数据库和PubMed数据库,对1950—2008年发表的所有腮腺血管瘤相关的文献进行了回顾分析。结果本组所有患儿均行非手术治疗,治疗均成功,腮腺血管瘤均在2年内100%消退,平均随访(8.6±5.7)年。治疗后均未出现并发症。共对12篇论著和4篇病例报告的413例患儿信息进行分析。处理方式包括保守观察、药物治疗(类固醇疗法或干扰素疗法)和/或手术治疗。并发症包括发育不良、瘢痕形成、面神经麻痹和死亡。结论非手术方式治疗婴幼儿腮腺血管瘤可获得血管瘤退行性变、消退的结果,无明显并发症。 | Hani Sinno Stephanie Thibaudeau Ryan Coughlin Sachin Chitte Bruce Williams 魏峰 高景恒 张晨 | 2012 | 中国美容整形外科杂志2012，23，3： | 0 |
| 15 | Farnesylcysteine Lyase Regulation of Abscisic Arabidopsis is Involved in Negative Acid Signaling in显示文摘 | David H. Huizinga Ryan Denton Kelly G. Koehler Ashley Tomasello Lyndsay Wood Stephanie E. Sen Dring N. Crowell | 2010 | Molecular Plant2010，3，1： | 0 |
| 16 | 英国退欧:接下来将如何?显示文摘英国与欧盟的分手不会是一件容易的事情。这方面没有先例,而在这一历史性公投之前也没做过任何规划。在公投过去一个月之际,决策者开始着手弄清英国退欧的真正含义。以下是我们所了解和仍需了解的投资者和企业高管面临的主要问题。 | Simon Kennedy Stephanie Bodoni Charlotte Ryan 融汐 | 2016 | 商业周刊(中文版)2016，0，16： | 0 |
| 17 | Enhancing pedestrian mobility in Smart Cities using Big Data显示文摘Smart City is an emerging concept in global urban development.A Smart City applies ICT technologies to provide greater efficiencies for its urban areas and civilian population.One of the key requirements for a Smart City is to exploit data from its ICT infrastructure(such as Internet of Things connected sensors)to improve city services and features such as accessibility and sustainability.To address this requirement,the City of Melbourne(COM)Smart City office maintains several hundred data sets relating to urban activity and development.These datasets address parking,mobility,land use,3D data,statistics,environment,and major city developments such as rail projects.One promising dataset relates to pedestrian traffic.Data are obtained from sensors and updated on the COM website(City of Melbourne Open Data Platform:http://gffzzd1269692889842a8scux6bqv9fb956cqp.ffgz.tsg.suse.edu.cn/.)at regular intervals.These data include the number of pedestrians passing 53 specific locations in the central business district and also their times and directions of travel.In a 24 h period,over 650,000 pedestrians were counted passing all locations.Peak rates of several thousand pedestrians per minute are regularly recorded during city rush hours at hotspots making the data amenable to Big Data analysis techniques.Results are obtained in graphical format as heatmaps and charts of city pedestrian traffic using both Microsoft Excel^(■)for static analysis and PowerBI^(■)for more advanced interactive visualisation and analysis.These findings can identify pedestrian hotspots and inform future locations of traffic lights and street configurations to make the city more pedestrian friendly.Further,the experience gained can be used to examine other data sets such as bicycle traffic that can be analysed to inform city infrastructure projects.Future work is suggested that could link these pedestrian flow data with social media data from smartphones and potentially wearable devices such as fitness monitors to correlate pedestrian satisfaction with traffic flow.The‘happiness’effect of pedestrians passing through green areas such as city parks can also be quantified.This research was undertaken with the assistance of Swinburne University under its Capstone Project scheme. | Ebony Carter Patrick Adam Deon Tsakis Stephanie Shaw Richard Watson Peter Ryan | 2020 | Journal of Management Analytics2020，7，2： | 0 |
| 18 | Superior Conjugative Plasmids Delivered by Bacteria to Diverse Fungi显示文摘Fungi are nature’s recyclers,allowing for ecological nutrient cycling and,in turn,the continuation of life on Earth.Some fungi inhabit the human microbiome where they can provide health benefits,while others are opportunistic pathogens that can cause disease.Yeasts,members of the fungal kingdom,have been domesticated by humans for the production of beer,bread,and,recently,medicine and chemicals.Still,the great untapped potential exists within the diverse fungal kingdom.However,many yeasts are intractable,preventing their use in biotechnology or in the development of novel treatments for pathogenic fungi.Therefore,as a first step for the domestication of new fungi,an efficient DNA delivery method needs to be developed.Here,we report the creation of superior conjugative plasmids and demonstrate their transfer via conjugation from bacteria to 7 diverse yeast species including the emerging pathogen Candida auris.To create our superior plasmids,derivatives of the 57 kb conjugative plasmid pTA-Mob 2.0 were built using designed gene deletions and insertions,as well as some unintentional mutations.Specifically,a cluster mutation in the promoter of the conjugative gene traJ had the most significant effect on improving conjugation to yeasts.In addition,we created Golden Gate assembly-compatible plasmid derivatives that allow for the generation of custom plasmids to enable the rapid insertion of designer genetic cassettes.Finally,we demonstrated that designer conjugative plasmids harboring engineered restriction endonucleases can be used as a novel antifungal agent,with important applications for the development of next-generation antifungal therapeutics. | Ryan R.Cochrane Arina Shrestha Mariana M.Severo de Almeida Michelle Agyare-Tabbi Stephanie L.Brumwell Samir Hamadache Jordyn S.Meaney Daniel P.Nucifora Henry Heng Say Jehoshua Sharma Maximillian P.M.Soltysiak Cheryl Tong Katherine Van Belois Emma J.L.Walker Marc-AndréLachance Gregory B.Gloor David R.Edgell Rebecca S.Shapiro Bogumil J.Karas | 2022 | BioDesign Research2022，，1： | 0 |
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