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| 1 | Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial显示文摘 | Stephen B Hanauer Brian G Feagan Gary R Lichtenstein Lloyd F Mayer S Schreiber Jean Frederic Colombel Daniel Rachmilewitz Douglas C Wolf Allan Olson Weihang Bao Paul Rutgeerts | 2002 | The Lancet2002，，9317： | 6 |
| 2 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 3 | 光动力疗法治疗非小细胞肺癌显示文摘光动力疗法被越来越多地应用于治疗胸部恶性肿瘤。对于早期非小细胞肺癌(如支气管腔内肺癌)、X线检查阴性或同时性原发癌,光动疗法可作为主要治疗手段进行腔内根治性治疗。作为单一根治疗法,光动力疗法是治疗支气管镜可见≤1 cm且无软骨外浸润的肺部肿瘤的最有效方法。对于晚期非小细胞癌患者,光动力治疗可以作为综合根治疗法的一部分,用于减轻阻塞性支气管内病变,增加可手术性或缩小所需手术范围。本文对现有发表的应用光动力疗法治疗至少10例以上非小细胞肺癌病例的研究文献进行综述,提出了光动力疗法应用的治疗建议并进行了总结。 | Charles B Simone II Joseph S Friedberg Eli Glatstein James P Stevenson Daniel H Sterman Stephen M Hahn Keith A Cengel 袁光金 李金銮 朱宇熹 凌扬 | 2013 | 国际病理科学与临床杂志2013，33，3： | 3 |
| 4 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 5 | Inhibition of first polar body formation in Crassostrea gigas produces tetraploids,not meiotic 1 triploids显示文摘 | Stephens L B Downing S L | 1988 | J Shellfish Res1988，7，3： | 1 |
| 6 | Characterizing dissolved oxygen conditions in estuarine environ-ments显示文摘 | Kevin J Stephen S Weisberg B etc | 1997 | Environmental Monitoring and Assessment1997，45，： | 1 |
| 7 | Chemokine receptors CCR6 and CXCR3 are necessary for CD4 + T cell mediated ocular surface disease in experimen- tal dry eye disease显示文摘 | TERRY G NIRAL B EUGENE A STEPHEN C CINTIA S | 2013 | PLoS One2013，8，78： | 1 |
| 8 | Stability of networked control systems显示文摘 | Zhang W Michael S B Stephen M P | 2001 | IEEE Control Systems Magazine2001，21，1： | 1 |
| 9 | Controlled-root formulation for digital phase-locked loops显示文摘 | Stephens S A Thomas J B | 1995 | IEEE Transactions on Aerospace and Electronic Systems1995，3，1： | 1 |
| 10 | The effect of temperature varia- tion on spontaneous potential production from explants of brain tissue in culture 显示文摘 | Cunningham A W B Stephens S G | 1962 | Experientia1962，18，1： | 1 |
| 11 | SPH for High Velocity Impact Computations显示文摘 | Gordon R J Robert A S Stephen R B | 1996 | Computer Methods in Applied Mechanics and Engineering1996，139，14： | 1 |
| 12 | Controlled-root formulation for digital phase-locked loops显示文摘 | STEPHENS S A THOMAS J B | 1995 | IEEE Transactions on Aerospace and Electronic Systems1995，31，1： | 1 |
| 13 | Haema topoietic necrosis in a goldfish (Carassius auratus) associated with an agent morpho-logically similar to herpesvirus 显示文摘 | Stephens F J Raidal S R Jones B | 2004 | Aust Vet J2004，82，3： | 1 |
| 14 | Mycoplasma hominis and ure- aplasma urealyticum in midtrimester amniotic fluid : Association with amniotic fluid cytokine levels and pregnancy outcome显示文摘 | Stephen T Robin B Steven S | 2004 | Am J Obstet Gyne- col2004，191，4： | 1 |
| 15 | An open-label pilot study of high-concentration capsaicin patch in painful HIV neuropathy显示文摘 | David M S Lydla E Stephen J B | 2008 | Journal of Pain and Symptom Management2008，35，3： | 1 |
| 16 | Simple Accurate Expressions for Planar Spiral Inductances显示文摘 | Sunderarajan S M Maria M H Stephen P B | 1999 | IEEE Journal of Soild-state Circuits1999，34，10： | 1 |
| 17 | Haematopoietic necro- sis in a goldfish (Carassius auratus) associated with an agent morphologically similar to herpesvirus显示文摘 | STEPHENS F RAIDAL S JONES B | 2004 | Australian Veteri- nary Journal2004，82，3： | 1 |
| 18 | Micro and nanostructured surface morphology on eIectrospun polymer fibers 显示文摘 | MEGELSKI S STEPHENS J S CHASE D B | 2002 | Macromolecules2002，35，22： | 1 |
| 19 | A unified view of some vertex operator constructions显示文摘 | B Stephen Gao Y Tan S | 2003 | Israel Journal of Math2003，134，： | 1 |
| 20 | Design of Trip Current Monitoring System for Circuit Breaker Condition Assessment 显示文摘 | STEPHEN B STRACHAN S M MCARTHUR S D J | 2007 | IET Generation Transmission Distribution2007，1，1： | 1 |
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