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| 1 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet . 2012 (9859)2012，，9859： | 7 |
| 2 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet2012，，9859： | 5 |
| 3 | Labeling of influenza viruses with synthetic fluorescent and biotin-labeled lipids显示文摘Direct labeling of virus particles is a powerful tool for the visualization of virus–cell interaction events. However, this technique involves the chemical modification of viral proteins that affects viral biological properties. Here we describe an alternative approach of influenza virus labeling that utilizes Function-Spacer-Lipid(FSL) constructs that can be gently inserted into the virus membrane. We assessed whether labeling with fluorescent(fluo-Ad-DOPE) or biotin-labeled(biot-CMG2-DOPE) probes has any deleterious effect on influenza virus hemagglutinin(HA) receptor specificity, neuraminidase(NA) activity, or replicative ability in vitro. Our data clearly show that neither construct significantly affected influenza virus infectivity or viral affinity to sialyl receptors. Neither construct influenced the NA activities of the influenza viruses tested, except the A/Puerto Rico/8/34(H1N1) strain. Our data indicate that lipid labeling provides a powerful tool to analyze influenza virus infection in vitro. | Natalia A Ilyushina Evgeny S Chernyy Elena Y Korchagina Aleksra S Gambaryan Stephen M Henry Nicolai V Bovin | 2014 | Virologica Sinica2014，29，4： | 2 |
| 4 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | 2012 (9859)2012，，9859： | 2 |
| 5 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 6 | Strategic outsourcing for competing OEMs that face cost reduction opportunities 显示文摘 | Stephen G M Xia Y S Yu G | 2006 | IIE Transactions2006，38，11： | 1 |
| 7 | Hematopoietic stem cells convert into liver cells within days without fusion 显示文摘 | JANG Y Y STEPHEN B B ANNA M D | 2004 | Nature Cell Biolo2004，6，6： | 1 |
| 8 | A numerical study of flow and heat transfer in a smooth and ribbed U-duct with and without rotation显示文摘 | LIN Y L SHIH T I P STEPHENS M A | 2001 | Journal of Heat Transfer2001，123，： | 1 |
| 9 | Intermediate temperature joining of dissimilar metals显示文摘 | Hosking Y F M Stephens J J Rejent J A | 1996 | Welding Research1996，4，： | 1 |
| 10 | Apoptosis in tumors and normal tissues induced by whole body hyperthermia in rats显示文摘 | Sakaguchi Y Stephens LC Makino M | 1995 | Cancer Res1995，55，22： | 1 |
| 11 | Two-state option pricing:binomial models revisited显示文摘 | Gerge M J Marat V K Stephen D Y | 2002 | The Journal of Futures Markets2002，22，60： | 1 |
| 12 | System response function: a new approach to minimize IR testing errors显示文摘 | Stephen W M Dave A G Eden Y M | 1990 | SPIE1990，1309，： | 1 |
| 13 | Neoadjuvant Therapy for Breast Cancer显示文摘 | Stephen L Laleh M Kathy Y | | 0，，04： | 1 |
| 14 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 15 | A new strategy for harnessing knowledge management in e-commerce显示文摘 | STEPHEN A O DAVID C Y JEFFREY W M | 2005 | Technology in Society2005，27，： | 1 |
| 16 | A comparison of bayesian methods for haplotype reconstruction from population genotype data显示文摘 | Stephens M Donnel]y P | 2003 | Am J Hum Genet2003，73，5： | 1 |
| 17 | CRH-R1 is significantly up-regulated at the time of labor in the human myometrium显示文摘 | Stevens M Y Jones R G C Stephen J L | 1998 | J Clin Endocrinol Metab1998，83，： | 1 |
| 18 | Neoadjuvant Therapy Breast Canc- er显示文摘 | Stephen L laleh M Kathy Y | 2010 | J Surg Oncol2010，101，4： | 1 |
| 19 | RNA-Seq:An assessment of technical reproducibility andcomparison with gene expression arrays显示文摘 | Marioni J C Mason C E Mane S M Stephens M Gilad Y | 2008 | Genome Research2008，18，9： | 1 |
| 20 | Apoptosis in tumor and normal tissues induced by whole body hyperthermia in rats显示文摘 | Sakaguchi Y Stephens L C Makino M | 1995 | Cancer Res1995，55，1： | 1 |
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