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| 1 | Radial artery access site complications during cardiac procedures,clinical implications and potential solutions: The role of nitric oxide显示文摘Percutaneous coronary intervention for the treatment of coronary artery disease is most commonly performed in the UK through the radial artery,as this is considered to be safer than the femoral approach.However,despite improvements in technology and techniques,complications can occur.The most common complication,arterial spasm,can cause intense pain and,in some cases,procedural failure.The incidence of spasm is dependent on several variables,including operator experience,artery size,and equipment used.An antispasmolytic cocktail can be applied to reduce spasm,which usually includes an exogenous nitric oxide(NO)donor(glyceryl trinitrate).NO is an endogenous local vasodilator and therefore is a potential target for anti-spasm intervention.However,systemic administration can result in unwanted side-effects,such as hypotension.A method that adopts local delivery of NO might be advantageous.This review article describes the mechanisms involved in radial artery spasm,discusses the advantages and disadvantages of current strategies to reduce spasm,and highlight the potential of NO-loaded nanoporous materials for use in this setting. | Emma M Coghill Timothy Johnson Russell E Morris Ian L Megson Stephen J Leslie | 2020 | World Journal of Cardiology2020，12，1： | 4 |
| 2 | Interprofessional, multiple step simulation course improves pediatric resident and nursing staff management of pediatric patients with diabetic ketoacidosis显示文摘AIM To investigate the use of a multidisciplinary, longitudinal simulation to educate pediatric residents and nurses on management of pediatric diabetic ketoacidosis.METHODS A multidisciplinary, multiple step simulation course was developed by faculty and staff using a modified Delphi method from the Pediatric Simulation Center and pediatric endocrinology department. Effectiveness of the simulation for the residents was measured with a pre- and post-test and a reference group not exposed to simulation. A follow up post-test was completed 3-6 mo after the simulation. Nurses completed a survey regarding the education activity. RESULTS Pediatric and medicine-pediatric residents(n = 20) and pediatric nurses(n = 25) completed the simulation course. Graduating residents(n = 16) were used as reference group. Pretest results were similar in the control and intervention group(74% ± 10% vs 76% ± 15%, P = 0.658). After completing the intervention, participants improved in the immediate post-test in comparison to themselves and the control group(84% ± 12% post study; P < 0.05). The 3-6 mo follow up post-test results demonstrated knowledge decay when compared to their immediate post-test results(78% ± 14%, P = 0.761). Residents and nurses felt the interdisciplinary and longitudinal nature of the simulation helped with learning.CONCLUSION Results suggest a multidisciplinary, longitudinal simulation improves immediate post-intervention knowledge but important knowledge decay occurs, future studies are needed to determine ways to decrease this decay. | Linnea M Larson-Williams Amber Q Youngblood Dawn Taylor Peterson J Lynn Zinkan Marjorie L White Hussein Abdul-Latif Leen Matalka Stephen N Epps Nancy M Tofil | 2016 | World Journal of Critical Care Medicine2016，5，4： | 4 |
| 3 | Human dNK cell function is differentially regulated by extrinsic cellular engagement and intrinsic activating receptors in first and second trimester pregnancy显示文摘蜕膜的生来的杀手(dNK ) 房间表示一连串的激活受体在早怀孕期间调整胎盘的免疫和开发。我们在在 dNK 和 trophoblast 房间之间的怀孕期和相互作用的第一和第二个三个月期间调查了人的 dNK 房间的功能的特性。尽管 CD56 + 在全部的 CD45 + 白血球之中的 CD16 − dNK 没在这个句号,激活的受体的表示, NKp80 和 NKG2D 上变化,极大地 upregulated。我们与第二三个月蜕膜比较在第一个三个月在最近观察了 extravillous trophoblast 房间的一个显著地更高的数字到 dNK 房间。当 co 有教养时,由第一个三个月 dNK 房间的 NKG2D 表示与 HTR-8 trophoblast 房间线被减少。在第二个三个月, dNK 激活的功能的标记,即, angiogenic 因素生产(例如,脉管的 endothelial 生长因素, interleukin-8, interferon-gamma ) ,尽管有 NKp80 或 NKG2D 表面表示的增加的仍然是的马厩。而且, dNK 房间的 degranulation 能力由 CD107a 估计了在第二个三个月被减少。我们建议在第一个三个月, trophoblast-dNK 相互作用与压制的激活的显型产生 dNK 房间的一张人口。在第二个三个月, trophoblast-dNK 相互作用的损失导致了 dNK 房间功能的抑制,尽管他们的激活的受体表示被增加。我们推测在怀孕期间,二机制操作调制激活受体的 dNK 房间 activation:suppression,这由在第二个三个月联合的 receptor-ligand 的 trophoblasts 和解开在第一个三个月铺平。 | Jianhong Zhang Caroline E Dunk Melissa Kwan Rebecca L Jones Lynda K Harris Sarah Keating Stephen J Lye | 2017 | Cellular & Molecular Immunology2017，14，2： | 4 |
| 4 | Slowing Production Deline and Extending the Economic Life of an Oil Field:New MEOR Technology 显示文摘 | Brown L R Vadie A A Stephens J O | | SPE0，，： | 2 |
| 5 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 6 | Influence of marbling and animal age on factors associated with beef quality显示文摘 | Tuma H J Henrickson R L Stephens D F | 1962 | Animal Science1962，21，11： | 1 |
| 7 | Predicting the service life of concrete marine structures; an environmental methodology显示文摘 | Stephen L A Dwayne A J Matthew A M | 1998 | ACI Structural Journal1998，95，1： | 1 |
| 8 | A maximum entropy approach to natural language processing显示文摘 | Adam L Berger Stephen A Della Pietra Vincent J Della Pietra | 1996 | Computational Linguistics1996，22，1： | 1 |
| 9 | Performance Appraisals: Usage, Criteria and Obserbations显示文摘 | Pettijohn L S Stephen Parker R Pettijohn C E Kent J L | 2001 | Journal of Management Development2001，20，9： | 1 |
| 10 | Estimation of uncertainties in ICP-MS analysis:a practical methodology显示文摘 | Barwick Vicki J Stephen L R Ellison Ben Fairman | 1999 | Analytica Chimica Acta1999，，394： | 1 |
| 11 | Direct dating of sulfides by Rb-Sr:Acritical test using the Polaris Mississippi Valley-type Zn-Pb deposit显示文摘 | Christensen J N Halliday A N Kenneth E L Roderick N R and Stephen E K | | 0，，： | 1 |
| 12 | Epigeneticevents underlie‘pathogenesis of sinonasal papillomas显示文摘 | STEPHEN J K VAUGHT L E CHEN K M | 2007 | Modern Pathology2007，20，： | 1 |
| 13 | Quantification of mRNA in human tissue using fluorescent nested reverse transcriptate polymerse chain reaction 显示文摘 | Karet F E Stephen C J Mira L H | 1994 | Anal Biochem1994，220，3： | 1 |
| 14 | A maximum entropy approach to natural language显示文摘 | Adam L Berger Stephen A Della Pietra Vincent J Della Pietra | 1999 | Processing Computational Linguistics1999，22，： | 1 |
| 15 | A Maximum Entropy Approach to Natural Language Processing显示文摘 | Adam L Berger Stephen A DellaPietra Vincent J Della Pietra | 1996 | Computational Linguistics1996，1，22： | 1 |
| 16 | Activity and safety of crizotinib in patients with ALK -positive non-small-cell lung cancer: updated results from a phase 1 study显示文摘 | D Ross Camidge Yung-Jue Bang Eunice L Kwak A John Iafrate Marileila Varella-Garcia Stephen B Fox Gregory J Riely Benjamin Solomon Sai-Hong I Ou Dong-Wan Kim Ravi Salgia Panagiotis Fidias Jeffrey A Engelman Leena Gandhi Pasi A J?nne Daniel B Costa Geoffrey | 2012 | Lancet Oncology2012，，10： | 1 |
| 17 | Imaging features of primary and recurrent esophageal cancer at FDG PET显示文摘 | Stephen J Skehan MB Andrea L | 2000 | Radiographics2000，20，： | 1 |
| 18 | Predicting the service life of concrete structures: an environmental methodology 显示文摘 | Stephen L A Dwayne A J Matthew A M | 1998 | ACI Structural Journal1998，95，2： | 1 |
| 19 | Tropical oceanic cloudiness and the in- cidence of precipitation:Early results from CloudSat显示文摘 | Haynes J M Stephens G L | 2007 | Geophysi- cal Research Letters2007，34，9： | 1 |
| 20 | Predieting the service life of concrete marine structures:An environmental methodology显示文摘 | STEPHEN L A DWAYNE A J MATTHEN A M | 1998 | ACI Structural Journal1998，95，2： | 1 |
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