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| 1 | MicroRNA regulation of innate immune responses in epithelial cells显示文摘Mucosal surface epithelial cells are equipped with several defense mechanisms that guard against pathogens.Recent studies indicate that microRNAs(miRNAs)mediate post-transcriptional gene suppression and may be a critical component of the complex regulatory networks in epithelial immune responses.Transcription of miRNA genes in epithelial cells can be elaborately controlled through pathogen recognition receptors,such as Toll-like receptors(TLRs),and associated nuclear factor kappaB(NF-kB)and mitogen-activated protein kinase(MAPK)pathways,and ultimately nuclear transcription factor associated-transactivation and transrepression.Activation of these intracellular signaling pathways may also modulate the process of miRNA maturation.Functionally,miRNAs may modulate epithelial immune responses at every step of the innate immune network,including production and release of cytokines/chemokines,expression of adhesion and costimulatory molecules,shuttling of miRNAs through release of exosomes and feedback regulation of immune homeostasis.Therefore,miRNAs act as critical regulators to the fine-tuning of epithelial immune responses. | Rui Zhou Steven P O’Hara Xian-Ming Chen | 2011 | Cellular & Molecular Immunology2011，8，5： | 13 |
| 2 | Advanced Irrigation Engineering: Precision and Precise显示文摘 | Terry A. Howell Steven R. EveR Susan A. O' Shaughnessy Paul D. Colaizzi Prasanna H. Gowda | 2012 | Journal of Agricultural Science and Technology(A)2012，2，1： | 3 |
| 3 | Heart Disease and Stroke Statistics—2006 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Thomas Thom Nancy Haase Wayne Rosamond Virginia J. Howard John Rumsfeld Teri Manolio Zhi-Jie Zheng Katherine Flegal Christopher O’Donnell Steven Kittner Donald Lloyd-Jones David C. Goff Yuling Hong Robert Adams Gary Friday Karen Furie Philip Gorelick Bret | 2006 | Circulation2006，，6： | 3 |
| 4 | Shoot and root traits in drought tolerant maize(Zea mays L.) hybrids显示文摘This study aimed to investigate the differences in shoot and root traits, and water use and water use efficiency(WUE) in drought tolerant(DT) maize(Zea mays L.) hybrids under full and deficit irrigated conditions. A two-year greenhouse study was conducted with four hybrids(one conventional hybrid, 33D53AM, two commercial DT hybrids, P1151 AM, N75H, and an experimental hybrid, Exp HB) grown under two water regimes(I_(100) and I_(50), referring to 100 and 50% of evapotranspiration requirements). Under water stress, the hybids P1151 AM, N75, and Exp HB showed more drought tolerance and had either greater shoot dry weight or less dry weight reduction than the conventional hybrid(33 D53 AM). However, these three hybrids responded to water stress using different mechanisms. Compared with the conventional hybrid, the two commercial DT hybrids(P1151 AM and N75H) had a smaller leaf area, shoot dry weight, and root system per plant. As a result, these hybrids used less water but had a higher WUE compared with the conventional hybrid. In contrast, the experimental hybrid(ExpHB) produced more shoot biomass by silking stage at both irrigation levels than all other hybrids, but it had relatively lower WUE. The hybrids demonstrated different drought response mechanisms that may require different irrigation management strategies. More investigation and validation are needed under field conditions and in different soil types. | ZHAO Jin XUE Qing-wu Kirk E Jessup HOU Xiao-bo HAO Bao-zhen Thomas H Marek XU Wen-wei Steven R Evett Susan A O'Shaughnessy David K Brauer | 2018 | Journal of Integrative Agriculture2018，17，5： | 3 |
| 5 | Pedicle Morphology In Thoracic Adolescent Idiopathic Scoliosis: Is Pedicle Fixation an Anatomically Viable Technique?显示文摘 | Michael F O’Brien Lawrence G Lenke Steven Mardjetko Thomas G Lowe Yinong Kong Kevin Eck David Smith | 2000 | Spine2000，，18： | 2 |
| 6 | The Genetic Architecture of Multiple Myeloma显示文摘 | Steven M. Prideaux Emma Conway O’Brien Timothy J. Chevassut G?sta Gahrton | 2014 | Advances in Hematology2014，，： | 2 |
| 7 | A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study显示文摘 | Michael J. Proctor David S. Morrison Dinesh Talwar Steven M. Balmer Colin D. Fletcher Denis St.J. O’Reilly Alan K. Foulis Paul G. Horgan Donald C. McMillan | 2011 | European Journal of Cancer2011，，17： | 2 |
| 8 | 亚太区2005生态足迹与自然财富(上)显示文摘亚太区各国已共同做出坚决承诺。矢志迈向可持续发展的目标。我们希望区内所有人民均可拥有更美好的生活,与此同时维护地球拥有的支援万物生长的能力,尊重地球自然资源的极限。面对今日亚太区以至全世界人口持续增长。消费模式不断改变,我们怎样才能实现这个目标? | Emil Salim Mathis Wackernagel Justin Kitzes Deborah Cheng Steven Goldfinger James Espinas Dan Moran Chad Monfreda Jonathan Loh Dermont O'Gorman Idy Wong | 2006 | 世界环境2006，，4： | 2 |
| 9 | Hepatitis C and Alcohol Exacerbate Liver Injury by Suppression of FOXO3显示文摘 | Batbayar Tumurbaatar Irina Tikhanovich Zhuan Li Jinyu Ren Robert Ralston Sudhakiranmayi Kuravi Roosevelt Campbell Gaurav Chaturvedi Ting-Ting Huang Jie Zhao Junfang Hao Maura O’Neil Steven A. Weinman | 2013 | The American Journal of Pathology2013，，6： | 2 |
| 10 | Perioperative Use of Dexmedetomidine Is Associated With Decreased Incidence of Ventricular and Supraventricular Tachyarrhythmias After Congenital Cardiac Operations显示文摘 | Constantinos Chrysostomou Joan Sanchez-de-Toledo Peter Wearden Edmund H. Jooste Steven E. Lichtenstein Patrick M. Callahan Tunga Suresh Elizabeth O’Malley Dana Shiderly Jamie Haney Masahiro Yoshida Richard Orr Ricardo Munoz Victor O. Morell | 2011 | The Annals of Thoracic Surgery2011，，3： | 2 |
| 11 | Downregulation of the epidermal growth factor receptor by human cytomegalovirus infection in human fetal lung fibroblasts显示文摘 | Beutler T H(o)lich C Stevens PA | 2003 | Am J Respir Cell Mol Biol2003，28，1： | 1 |
| 12 | Evaluating Failure in the Innovation Process:The Micro-Politics of New Product Development显示文摘 | JONES O STEVEN S | 1999 | R&D Management1999，29，2： | 1 |
| 13 | Lithoautotrophic microbial ecosystems in deep basalt aquifers显示文摘 | Todd O Stevens James P McKinley | 1995 | Science1995，270，： | 1 |
| 14 | Nitrogen loss from unpolluted South American forestsmainly via dis- solved organic compounds 显示文摘 | Steven S Perakis Lars O | 2002 | Nature2002，415，24： | 1 |
| 15 | Heart Disease and Stroke Statistics—2008 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Wayne Rosamond Katherine Flegal Karen Furie Alan Go Kurt Greenlund Nancy Haase Susan M. Hailpern Michael Ho Virginia Howard Brett Kissela Steven Kittner Donald Lloyd-Jones Mary McDermott James Meigs Claudia Moy Graham Nichol Christopher O’Donnell Veroniqu | 2008 | Circulation2008，，4： | 1 |
| 16 | Polyethylene wear debris and long-term clinical failure of the Charite disc prosthesis: A study of 4 patients 显示文摘 | Andre V O Steven M Filip S | 2007 | Spine2007，32，2： | 1 |
| 17 | Evolutionary structural optimization(ESO)using a bi-directional algorithm显示文摘 | Steven G P Xie Y M | 1998 | Engi-neering Computation1998，15，8： | 1 |
| 18 | Automatic Generation of 2-axis Lasercutter NC Machine Program and Path Planning from CAD 显示文摘 | STEVEN D Jackon RAVI O Mittal | 1993 | Computers in Industry1993，，21： | 1 |
| 19 | Fast accurate fuzzy clustering through data reduction 显示文摘 | Steven E Jing W K Lawrence O | 2003 | IEEE Trans on Fuzzy Systems2003，11，2： | 1 |
| 20 | A simple checkerboard suppression algorithm for evolutionary structural optimization 显示文摘 | Li O Steven G P Xie Y M | 2001 | Structural and Multidisciplinary Optimization2001，22，3： | 1 |
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