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| 1 | esveratrol inhibits necroptosis by mediating the TNF-α/RIP1/RIP3/MLKL pathway in myocardial hypoxia/reoxygenation injury显示文摘Resveratrol(RES)protects myocardial cells from hypoxia/reoxygenation(H/R)-caused injury.However,the mechanism of this effect has not been clarified.Thus,in this study,we aimed to determine whether RES attenuates H/R-induced cell necroptosis by inhibiting the tumor necrosis factor-alpha(TNF-α)/receptor-interacting protein kinase 1(RIP1)/RIP3/mixed-lineage kinase domain-like(MLKL)signaling pathway.Rat myocardial ischemia/reperfusion(I/R)models and H/R-injured cell models were constructed.Our study showed that myocardial H/R injury significantly increased the levels of TNF-α,RIP1,RIP3,and p-MLKL/MLKL by western blot analysis.Cell viability assay and 4,6-dianmidino-2-phenylindole(DAPI)-propidium iodide staining showed that the cell viability was decreased,and necroptosis was increased after myocardial H/R injury.The expressions of TNF-α,RIP1,RIP3,and p-MLKL/MLKL in H/R myocardial cells treated with different concentrations of RES were significantly downregulated.In addition,we also found that the cell viability was increased and necroptosis was decreased in dose-dependent manners when H/R-injured cells were treated with RES.In addition,the enhanced effect of TNF-αon necroptosis in myocardial H/R-injured cells was improved by RES,and the effect of RES was confirmed in vivo in I/R rats.This study also showed that RES suppresses necroptosis in H9c2 cells,which may occur through the inhibition of the TNF-α/RIP1/RIP3/MLKL signaling pathway.Our data suggest that necroptosis is a promising therapeutic target and may be a promising therapeutic target for the treatment of myocardial I/R injury. | Yongjun Hu Hongwei Pan Jianqiang Peng Jin He Mingxiang Tang Sulan Yan Jingjing Rong Junshan Li Zhaofen Zheng Haijun Wang Yanfu Liu Xin Zhong | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 6 |
| 2 | Precipitate-stabilized surface enabling high-performance Na_(0.67)Ni_(0.33-x)Mn_(0.67)Zn_(x)O_(2) for sodium-ion battery显示文摘Electrode interfacial degradations are the key challenges for high-performance rechargeable batteries,usually mitigated through surface modification/coating strategies.Herein,we report a novel mechanism to enhance the surface stability of P2 layered cathodes by introducing a high density of dopant-enriched precipitates.Based on microscopic analysis,we show that forming a high density of precipitates at the grain surface can effectively suppress surface cracking and corrosion,which not only improves the surface/interface stability but also effectively suppresses the intergranular cracking issue.Increasing the doping level can lead to a greater density of precipitates at the surface region,which results in higher surface stability and increased cycling stability of the P2 layered cathode for a sodium-ion battery.We further reveal that prolonged cycling can induce the formation of a precipitate-free surface region due to the loss of Zn dopant and Na.Our in-depth microanalysis reveals cycling-induced dynamic structural evolution of the P2 layered cathodes,highlighting that dopant segregation-induced precipitation is a new approach to achieving high interfacial stability. | Kuan Wang Zhengfeng Zhang Sulan Cheng Xiao Han Junjie Fu Manling Sui Pengfei Yan | 2022 | eScience2022，2，5： | 2 |
| 3 | Simulation of the Northern and Southern Hemisphere Annular Modes by CAMS-CSM显示文摘As leading modes of the planetary-scale atmospheric circulation in the extratropics, the Northern Hemisphere(NH)annular mode(NAM) and Southern Hemisphere(SH) annular mode(SAM) are important components of global circulation, and their variabilities substantially impact the climate in mid-high latitudes. A 35-yr(1979-2013) simulation by the climate system model developed at the Chinese Academy of Meteorological Sciences(CAMS-CSM) was carried out based on observed sea surface temperature and sea ice data. The ability of CAMS-CSM in simulating horizontal and vertical structures of the NAM and SAM, relation of the NAM to the East Asian climate, and temporal variability of the SAM is examined and validated against the observational data. The results show that CAMS-CSM captures the zonally symmetric and out-of-phase variations of sea level pressure anomaly between the midlatitudes and polar zones in the extratropics of the NH and SH. The model has also captured the equivalent barotropic structure in tropospheric geopotential height and the meridional shifts of the NH and SH jet systems associated with the NAM and SAM anomalies. Furthermore, the model is able to reflect the variability of northern and southern Ferrel cells corresponding to the NAM and SAM anomalies. The model reproduces the observed relationship of the boreal winter NAM with the East Asian trough and air temperature over East Asia. It also captures the upward trend of the austral summer SAM index during recent decades. However, compared with the observation, the model shows biases in both the intensity and center locations of the NAM's and SAM's horizontal and vertical structures. Specifically, it overestimates their intensities. | Sulan NAN Junli YANG Yan BAO Jian LI Xinyao RONG | 2019 | Journal of Meteorological Research2019，33，5： | 0 |
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