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| 1 | Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products显示文摘最近的婴儿的公式奶粉污染事件证明了在牛奶质量控制的经典标记或标准在识别鈥渕a nipulated 鈥 ? 是不够的差质量的牛奶。在现在的学习,我们第一次证明奶牛牛奶包含大量 microRNAs ( miRNAs )并且牛奶特定的 miRNAs 的唯一的表示侧面能为未加工的牛奶和牛奶相关的商业产品的质量控制用作新奇指示物和可能的新标准,例如液体牛奶和粉状的公式牛奶。用定序的 Solexa,首先,我们系统地在未加工的牛奶屏蔽了 miRNA 表示并且在未加工的牛奶识别了 245 miRNAs 的一个总数。不同于层次在哺乳的不同时期是其表达式将近相同的另外的经典 biomarkers,单个 miRNAs 能显著地在哺乳过程期间被改变,含有那 miRNAs 可以是更精确的指示物反映牛奶的优秀改变。第二,使用 TaqMan 基于探查的 miRNA 量的 RT-PCR ,我们进一步识别了七 miRNAs 重要地在整个哺乳过程,和更多有相对一致的表情,这七牛奶特定的 miRNAs 的表示侧面能为区别用作理想的 biomarker 差质量或从纯未加工的牛奶的 鈥渕a nipulated 鈥?牛奶,象为商业乳制品的质量控制一样,例如液体,牛奶和粉状的公式挤。一起,我们的调查结果为为决定未加工的牛奶或牛奶相关的商业产品的质量理解牛奶 miRNAs 和一个新潜在的标准的生理的角色提供一个基础。 | Xi Chen Chao Gao Haijin Li Lei Huang Qi Sun Yanye Dong Chunliang Tian Shengpu Gao Hailin Dong Danping Guan Xiaoyun Hu Shujian Zhao Liang Li Lin Zhu Qiao Yan Junfeng Zhang Ke Zen Chen-Yu Zhang | 2010 | Cell Research2010，20，10： | 29 |
| 2 | PGC-1α induces apoptosis in human epithelial ovarian cancer cells through a PPARy-dependent pathway显示文摘Peroxisome 激活 proliferator 的受体鲸鱼群妈(PPAR γ) coactivator-1 高山哈(PGC-1 α) coactivates 多重抄写因素并且调整几个代谢过程。Thecurrent 学习在人的上皮的卵巢的癌症房间在 apoptosis 的正式就职调查了 PGC-1 α的角色。在人的卵巢和人的卵巢的上皮的肿瘤之间的 PGC-1 α信使 rna 水平被量的 RT-PCR 检验。更少的 PGC-1 α表示与正常卵巢相比在恶意的肿瘤的表面上皮被发现。在人的上皮的卵巢的癌症房间线 Ho-8910 的 PGC-1 α的 Overexpression 通过 Bcl-2 和 Bax 表示的协调规定导致了房间 apoptosis。Microarray 分析证实 PGC-1 α戏剧性地在 Ho-8910 房间影响了 apoptosis 相关的基因。 Mitochondrial 功能的试金证明 apoptosis 的正式就职通过由细胞色素 c.Furthermore 的版本的终端阶段,导致的 apoptosis 部分是,然而并非完全,由 PPAR γa ntagonist ( GW9662 )堵住了的 PGC-1 α-,并且由 siRNA 的 PPAR γ 表示的抑制也在 Ho-8910 房间禁止了 PGC-1 α- inducedapoptosis 。这些数据建议 PGC-1 α通过 aPPAR γ - 依赖者小径施加了它的效果。我们的调查结果显示 PGC-1 α涉及 apoptotic signaltransduction 小径, PGC-1 α的 down 规定可以是在支持上皮的卵巢的癌症生长和前进的一个关键点。 | Yan Zhang Yi Ba Chang Liu Guoxun Sun Li Ding Songyuan Gao Jihui Hao Zhentao Yu Junfeng Zhang Ke Zen Zhongsheng Tong Yang Xiang Chen-Yu Zhang | 2007 | Cell Research2007，17，4： | 14 |
| 3 | Chemical vapor deposition growth of large-scale hexagonal boron nitride with controllable orientation显示文摘有一致厚度的大域的六角形的硼氮化物(h-BN ) 的化学蒸汽免职(CVD ) 合成是很挑战性的,主要由于这材料的极其高的成核密度。此处,我们报导晶片规模的成功的生长,有大单人赛水晶的领域尺寸的高质量的 h-BN 单层电影,吗直到~ 72 ??????????????????????????慮潮档湡敮獬???????慮潮畴敢??洠獥灯牯???? ?? | Xiuju Song Junfeng Gao Yufeng Nie Teng Gao Jingyu Sun Donglin Ma Qiucheng Li Yubin Chen Chuanhong Jin Alicja Bachmatiuk Mark H. Rummeli Feng Ding Yanfeng Zhang Zhongfan Liu | 2015 | Nano Research2015，8，10： | 12 |
| 4 | Evidences of rapid erosion driven by climate in the Yarlung Zangbo (Tsangpo) Great Canyon,the eastern Himalayan syntaxis显示文摘Climate and tectonism are both particularly intense in the Yarlung Zangbo (Tsangpo) Great Canyon in the eastern Himalayan syntaxis,which is characterized by the most rapid landscape evolution of anywhere in the world.Thus,the eastern Himalayan syntaxis is one of the best locations to study the interactions between climate and tectonics.This paper investigates the cooling ages of the Doxong La-Baibung profile using apatite fission track (AFT) dating on 11 bedrock samples at elevations ranging from 4210 to 710 m.There are topographic,climatic,metamorphic,and thermochronological gradients in the profile,providing good conditions to study interactions between climate and tectonics.AFT ages ranged from 4.6±0.6 Ma to 1.7±0.3 Ma,and the mean fission track lengths ranged from 11.0 to 12.4 μm.It was found that the cooling rates revealed by AFT ages increased with decreasing elevation.However,the tendency of the cooling rates revealed by the 40 Ar-39 Ar ages was different from that indicated by the AFT ages.Moreover,for most districts of the eastern Himalayan syntaxis,the compiled AFT age distribution correlates well with the annual average precipitation,indicating the coupling of the cooling and erosion rates of the near-surface rock and precipitation.The geothermal history modeling results indicate an obvious increase in the cooling and erosion rate between 1.0 and 0.5 Ma.This age is consistent with other research findings for this time,when the vapor channel of the Yarlung Zangbo Great Canyon began to take effect.These evidences suggest that climate,especially precipitation,has acting as a key factor influencing the rapid cooling and erosion in the Yarlung Zangbo Great Canyon since 1-0.5 Ma. | YU XiangJiang JI JianQing GONG JunFeng SUN DongXia QING JianChun WANG LiNing ZHONG DaLai ZHANG ZhiCheng | 2011 | Chinese Science Bulletin2011，56，11： | 11 |
| 5 | Metal-organic framework-derived, Zn-doped porous carbon polyhedra with enhanced activity as bifunctional catalysts for rechargeable zinc-air batteries显示文摘锌空气电池最近与他们的锂离子对应物相比由于更大的存储能力和更低的费用吸引了可观的兴趣。为氧减小反应(ORR ) 和氧进化反应(OER ) 的电极催化剂在可充电的锌空气电池的操作起一个关键作用。此处,我们报导简单、可伸缩的策略作为先锋用做 Zn 的共同基于的 zeolitic imidazolate 框架(ZnCo-ZIFs ) 制作多孔的碳 polyhedra。惊人地,做的 Zn 导致更小的公司 nanoparticles 和更高的氮内容,它接着提高获得的多孔的碳 polyhedra 的 ORR 和 OER 活动。做 N 的碳和钴 nanoparticles 在的 synergistic 效果合成,源于碳的高 graphitization 的改进传导性,和多孔的多面的结构的大表面区域在碱的媒介与优秀 ORR 和 OER electrocatalytic 活动导致了多孔的碳 polyhedra。更重要地,空气阴极在新窗户中在主要、可充电的锌空气 batteries.Open 图象基于最佳的多孔的碳 polyhedra 推进展出优异性能到 Pt/C | Xuan Wu Ge Meng Wenxian Liu Tian Li Qiu Yang Xiaoming Sun Junfeng Liu | 2018 | Nano Research2018，11，1： | 10 |
| 6 | Metal oxide and hydroxide nanoarrays: Hydrothermal synthesis and applications as supercapacitors and nanocatalysts显示文摘The development of nanotechnology in recent decades has brought new opportunities in the exploration of new materials for solving the issues of fossil fuel consumption and environment pollution.Materials with nano-array architecture are emerging as the key due to their structure advantages,which offer the possibility to fabricate high-performance electrochemical electrodes and catalysts for both energy storage and effcient use of energy.The main challenges in this feld remain as rational structure design and corresponding controllable synthesis.This article reviews recent progress in our laboratory related to the hydrothermal synthesis of metal oxide and hydroxide nanoarrays,whose structures are designed aiming to the application on supercapacitors and catalysts.The strategies for developing advanced materials of metal oxide and hydroxide nanoarrays,including NiO,Ni(OH)2,Co3O4,Co3O4@Ni–Co–O,cobalt carbonate hydroxide array,and mixed metal oxide arrays like Co3 xFex O4and Znx Co3 xO4,are discussed.The different kinds of structure designs such as 1D nanorod,2D nanowall and hierarchical arrays were involved to meet the needs of the high performance materials.Finally,the future trends and perspectives in the development of advanced nanoarrays materials are highlighted. | Qiu Yang Zhiyi Lu Junfeng Liu Xiaodong Lei Zheng Chang Liang Luo Xiaoming Sun | 2013 | Progress in Natural Science:Materials International2013，23，4： | 9 |
| 7 | Stable Ultrahigh Specific Capacitance of NiO Nanorod Arrays显示文摘电气化学的 pseudocapacitors 的以前报导的例子基于便宜金属氧化物受不了需要在特定的电容,率电容,和可逆性之间妥协。这里,我们证明 Ni 泡沫上的 NiO nanorod 数组有联合超离频特定的电容(在 2.27 A/g 的 2018 F/g ),高力量密度(在 22.7 A/g 的 1536 F/g ),并且好骑车稳定性(仅仅,8%电容没有进一步的变化沉醉于开始的 100 个周期在随后 400 个周期)。这在 50% 或更为 NiO 在可逆电容记录导致了改进,到达 80% 理论价值,并且证明三维的常规多孔的数组结构能在 supercapacitor 这些优点负担得起所有。优秀性能能被归因于细长(< 20 nm )杆形态学,高 crystallinity ,定期排列的数组结构并且,的到金属性的 Ni 底层的 nanorods 的强壮的结合由扫描电子显微镜学( SEM )揭示了,传播电子显微镜学( TEM )和X光检查衍射( XRD )。 | Zhiyi Lu Zheng Chang Junfeng Liu Xiaoming Sun | 2011 | Nano Research2011，4，7： | 8 |
| 8 | Self-supported high-entropy alloy electrocatalyst for highly efficient H_(2) evolution in acid condition显示文摘Developing non-precious catalysts as Pt substitutes for electrochemical hydrogen evolution reaction(HER)with superior stability in acidic electrolyte is of critical importance for large-scale,low-cost hydrogen production from water.Herein,we report a CoCrFeNiAl high-entropy alloy(HEA)electrocatalyst with self-supported structure synthesized by mechanical alloying and spark plasma sintering(SPS)consolidation.The HEA after HF treatment and in situ electrochemical activation for 4000 cycles of cyclic voltammetry(HF-HEAa2)presents favourable activity with overpotential of 73 mV to reach a current density of 10 mA cm^(2) and a Tafel slope of 39.7 mV dec1.The alloy effect of Al/Cr with Co/Fe/Ni at atomic level,high-temperature crystallization,as well as consolidation by SPS endow CoCrFeNiAl HEA with high stability in 0.5 M H2SO4 solution.The superior performance of HF-HEAa2 is related with the presence of metal hydroxides/oxides groups on HEA. | Peiyan Ma Mingming Zhao Long Zhang Heng Wang Junfeng Gu Yuchen Sun Wei Ji Zhengyi Fu | 2020 | Journal of Materiomics2020，6，4： | 8 |
| 9 | Bottom water temperature measurements in the South China Sea,eastern Indian Ocean and western Pacific Ocean显示文摘文章报道了一批新的海底底水温度(BWT)数据,其中南海(SCS)158个站位、东印度洋(EIO)30个站位及西太平洋(WPO)37个站位。基于这批新的BWT数据,获得南海和西太平洋海域底水温度与水深经验关系,可为地球物理和物理海洋提供准确、可靠的海底温度边界。这将有助于海底油气资源调查与评估。同时,这批实测数据表明:1)水深超过3500m的海域,其底水温度在南海约为2.47℃,比东印度洋(~1.34℃)和西太平洋(~1.60℃)稍微偏高。这与大洋传送带模式所预测的情况比较吻合。该模式认为:低温高盐的海水,从北大西洋格陵兰岛和冰岛附近海域下沉到深层,然后向南流动,再与南极洲周围海域的低温高盐海水一同向北进入印度洋和太平洋。而南海是一个相对比较封闭的热带边缘海,其内部海水与印度洋和菲律宾海交换有限,导致海水温度整体高于印度洋和太平洋。2)台西南盆地水深在2700~3000m的部分站位,其底水温高达约3.00℃,明显高于其周边同水深海域底水温度(平均值约为2.33℃)。这可能是台西南盆地海底水热活动导致的结果。3)在东印度洋和西太平洋水深超过4800m海域,底水温度随着水压增大稍有升高,其升高率分别为10.6mK·MPa^(-1)和12.0mK·MPa^(-1)。这与理论估算的深层底水绝热压力温度梯度范围较为吻合。这也意味着东印度洋和西太平洋深层底水,主要由绝热自压作用导致其温度随着深度的增大而升高。 | YANG Xiaoqiu SHI Xiaobin ZHAO Junfeng YU Chuanhai GAO Hongfang CHEN Aihua LU Yuanzheng CEN Xianrong LIN Weiren ZENG Xin XU Hehua REN Ziqiang ZHOU Shengqi XU Ziying SUN Jinlong KAMIYA Nana LIN Jian | 2018 | 热带海洋学报2018，37，5： | 8 |
| 10 | The electron structure and photocatalytic activity of Ti(IV) doped Bi_2O_3显示文摘Density functional theory (DFT) plays a significant role in the development of visible light responsive photocatalysts.Based on the first-principles plane-wave ultrasoft pseudopotential (USPP) method,the crystal structures of α,β,γ,and δ-Bi2O3 were optimally calculated for the total density of states (TDOS) and the partial density of states (PDOS) of Bi,O atoms.The calculation for Ti(IV) doped Bi2O3 supercell was carried out.The effects of Ti(IV)-doping on the electron structures and light absorption properties of various Bi2O3 were analyzed.The results showed that Ti 3d orbital appeared in the forbidden band of Bi2O3 and hybridized with O 2p,Bi 6p orbitals.The narrowed band gap (Eg) and red-shift of light absorption edge are responsible for the enhanced photocatalytic activity of Bi2O3.The β-Bi2O3 and Ti-doped β-Bi2O3 were prepared by a hydrothermal synthesis method.The improvement of the photocatalytic activity of Bi2O3 has also been verified by the characteristics of the UV-vis diffuse reflection spectrum and the experimental evaluation of the photocatalytic degradation of crystal violet in aqueous solution. | YIN LiFeng NIU JunFeng SHEN ZhenYao SUN Ying | 2011 | Science China Chemistry2011，54，1： | 7 |
| 11 | Research on the Surface Subsidence Monitoring Technology Based on Fiber Bragg Grating Sensing显示文摘 | Jinyu WANG Long JIANG Zengrong SUN Binxin HU Faxiang ZHANG Guangdong SONG Tongyu LIU Junfeng QI Longping ZHANG | 2017 | Photonic Sensors2017，7，1： | 5 |
| 12 | Determining the microstructure and properties of magnesium aluminum composite panels by hot rolling and annealing显示文摘The researchers made magnesium aluminum composite panels by asymmetric metal packaging and studied rolling temperature,holding time,and high temperature heat treatment,such as short time and low temperatures over long periods of time parameters under the new preparation method.We tested the new magnesium aluminum composite panels’tensing properties and bending performance by using scanning electric mirror and EDS.It is concluded that the new magnesium aluminum composite panels’elongation is 24%under the tensile strength of 260 MPa.Regarding performance when compared with other methods,traditional magnesium aluminum composite panels’elongation is 10%,which shows its advanced nature.At the same time,bending performance test showed that the combination of the composite board has higher performance,offering the reference value for the preparation of magnesium–aluminum composite plate. | Zilong Zhao Qiang Gao Junfeng Hou Ziwei Sun Fei Chen | 2016 | Journal of Magnesium and Alloys2016，4，3： | 4 |
| 13 | Janus electrode with simultaneous management on gas and liquid transport for boosting oxygen reduction reaction显示文摘Oxygen reduction efficiency holds the key for renewable energy technologies including fuel cells and metal-air batteries,which involves coupling diffusion-reaction-conduction processes at the interface of catalyst/electrolyte,and thus rational electrode design facilitating mass transportation stands as a key issue for fast oxygen reduction reaction(ORR).Herein,we report a Janus electrode with asymmetric wettability prepared by partly modifying aerophobic nitrogen doped carbon nanotube arrays with polytetrafluoroethylene(PTFE)as a high performance catalytic electrode for ORR.The Janus electrode with opposite wettability on adjacent sides maintains stable gas reservoir in the aerophilic side while shortening O2 pathway to catalysts in the aerophobic side,resulting in superior ORR performance(22.5 mA/cm^2@0.5 V)than merely aerophilic or aerophilic electrodes.The Janus electrode endows catalytic performance even comparable to commercial,Pt/C in the alkali ne electrolyte,exploiting a previously unrecognized opport unity that guides electrode design for the gas-consumption electrocatalysis. | Yingjie Li Haichuan Zhang Nana Han Yun Kuang Junfeng Liu Wen Liu Haohong Duan Xiaoming Sun | 2019 | Nano Research2019，12，1： | 4 |
| 14 | Synthesis, DNA-binding and photocleavage studies of ruthenium(Ⅱ) complexes [Ru(btz)_3]^(2+) and [Ru(btz)(dppz)_2]^(2+)显示文摘Two new ruthenium(Ⅱ) complexes, [Ru(btz)3](ClO4)2 (1) and [Ru(btz)(dppz)2](ClO4)2 (2) (btz = 4,4′-bithi-azole, dppz = dipyrido[3,2-a:2′,3′-c]phenazine), have been synthesized and characterized by elemental analysis, 1H NMR, ES-MS and X-ray crystallography. The DNA binding behaviors of two complexes have been studied by spectroscopic and viscosity measurements. The results suggest that complex 1 binds to CT-DNA via an electrostatic mode, while complex 2 via an intercalative mode. Under irradiation at 365 nm, both complexes were found to promote the cleavage of plasmid pBR 322 DNA from supercoiled form Ⅰ to nicked form Ⅱ. The mechanism studies reveal that singlet oxygen 1O2 and hydroxyl radical (OH-) play a significant role in the photocleavage process. | YU HuiJuan, HUANG ShuMei, KOU JunFeng, LI LvYing, JIA HaiNa, CHAO Hui & JI LiangNian MOE Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China | 2009 | Science China Chemistry2009，52，9： | 4 |
| 15 | Ternary NiCoFe-layered double hydroxide hollow polyhedrons as highly efficient electrocatalysts for oxygen evolution reaction显示文摘With exhaustion of fossil fuels and the deterioration of global environment,widespread and intensive researches have been concentrated on clean and sustainable alternative energy sources,such as metal-air batteries[1],fuel cells[2]and water splitting devices[3].Electrocatalytic oxidation of water to O2(oxygen evolution reaction,OER)is a vital chemical process involved in energy storage and conversion from renewable sources in form of molecular fuels such as H2 via water electrolysis,which has attracted a great amount of research efforts in the past few years[4,5].Nowadays,RuO2 and IrO2 are widely used as typical excellent OER electrocatalysts.However,their high-cost and scarce nature restricts the broadly commercial application of those materials[6,7].Hence,there is an urgent demand to develop low cost,highly efficient,and superb stable OER catalysts. | Yongji Qin Fanping Wang Jing Shang Muzaffar Iqbal Aijuan Han Xiaoming Sun Haijun Xu Junfeng Liu | 2020 | Journal of Energy Chemistry2020，29，4： | 4 |
| 16 | Braided river and distribution patterns of sand bodies of Jurassic Badaowan formation in Block T13 of Junggar basin显示文摘In order to determine the planar and volume distribution of sand bodies of the Jurassic Badaowan formation in Block T13 of Junggar basin,we used analysis of field outcrop and 3D seismic data,which play an essential role in areas of sparse well coverage.We describe sedimentary facies characteristics,sand body planforms,width and connectivity patterns of sand bodies,and vertical associations and successions by acoustic impedance inversion technology and sedimentological theory.Results of our study show braided fluvial strata deposits in the Jurassic Badaowan formation.Each sand body is approximately lenticular in shape.The width of each sand body falls in the range 100~800 m,with most between 200 and 400 m.The sand bodies vary in thickness from 4 to 13 m,with most below 9 m.The width/thickness ratios lie in the range 20~55.The connectivity of braided fluvial channel sand bodies is controlled by changes of accommodation space.One fining-upward sedimentary cycle of base-level rise is recognized in Badaowan formation,representing an upward rise of base level.The connectivity of sand bodies was found to be greatest in the early stage of base-level rise,becoming progressively worse with increasing base-level rise. | SUN Xiaofang JIN Zhenkui WANG Zhaofeng HUANG Xiaoping GU Junfeng | 2010 | Mining Science and Technology2010，20，3： | 4 |
| 17 | Direct interaction between CD155 and CD96 promotes immunosuppression in lung adenocarcinoma显示文摘Despite the advance in targeted therapy,lung adenocarcinoma(LUAD)remains one of the leading causes of death in patients with cancer.CD155,a member of poliovirus receptor–related(PRR)family,has been identified as the ligand of the Ig-like receptors tactile(CD96)and DNAM-1(CD226)on T cells.The interaction of CD155 with CD96 transmits an inhibitory signal and suppresses immune response.The interaction of CD155 with CD226 enhances the immune response.1,2,3 CD155 expression has been shown to be elevated in many types of cancers4,5 and is involved with immune suppression in melanoma.6 However,how CD155/CD96 is involved in immune response in the tumor microenvironment of LUAD remains unknown. | Hui Zhang Qianwen Liu Yiyan Lei Jianwen Zhou Wenting Jiang Yongmei Cui Qiong He Junfeng Zhu Zheng Zhu Yu Sun Zunfu Ke | 2021 | Cellular & Molecular Immunology2021，18，6： | 3 |
| 18 | Distribution Features of the Nanhua-Sinian Rifts and their Significance to Hydrocarbon Accumulation in the Tarim Basin显示文摘On the basis of reprocessing 34 new two-dimensional spliced long sections(20,191 km) in the Tarim Basin, the deep structure features of the Tarim Basin were analyzed through interpreting 30,451 km of two-dimensional seismic data and compiling basic maps. Seismic interpretation and geological analysis conclude that the Nanhua-Sinian strata are a set of rift-depression depositional systems according to their tectonic and depositional features. The rift valley formed in the Nanhua Period, and the transformation became weaker during the late Sinian Period, which eventually turned into depression. From bottom to top, the deposited strata include mafic igneous, tillite, mudstone, and dolomite. Three major depocenters developed inside this basin during the rift stage and are distributed in the eastern Tarim Basin, the Awati area, and the southwestern Tarim Basin. Among them, the rift in the eastern Tarim Basin strikes in the near east-west direction on the plane and coincides with the aeromagnetic anomaly belt. This represents a strong magnetic zone formed by upwelling basic volcanic rock along high, steep normal faults of the Nanhua Period. Controlled by the tectonic background, two types of sedimentary systems were developed in the rift stage and depression stage, showing two types of sequence features in the Sinian depositional stage. The Nanhua System appears as a wedge-shaped formation, with its bottom in unconformable contact with the base. The rifting event has a strong influence on the current tectonic units in the Tarim Basin, and affects the distribution of source rock in the Yuertus Formation and reservoir beds in the Xiaoerbulake Formation in Lower Cambrian, as well as the gypseous cap rock in Middle Cambrian. The distribution features of the rifts have important and realistic significance for determining the direction of oil and gas exploration in the deep strata of the Tarim Basin. Comprehensive analysis suggests that the Tazhong region is the most favorable zone, and the Kalpin-Bachu region is the optimal potential zone for exploring sub-salt oil and gas in deep Cambrian strata. | BAI Zhongkai CHENG Minghua CHEN Cheng HUO Junzhou ZHANG Junfeng ZHOU Xingui GAO Yongjin ZHAO Bo QIU Haijun HAN Miao YANG Youxing SUN Zhichao MIAO Miaoqing ZHANG Jinhu LI Qingyao | 2020 | Acta Geologica Sinica(English Edition)2020，94，2： | 3 |
| 19 | Optimal four-impulse rendezvous between coplanar elliptical orbits显示文摘Rendezvous in circular or near circular orbits has been investigated in great detail,while rendezvous in arbitrary eccentricity elliptical orbits is not sufficiently explored.Among the various optimization methods proposed for fuel optimal orbital rendezvous,Lawden's primer vector theory is favored by many researchers with its clear physical concept and simplicity in solution.Prussing has applied the primer vector optimization theory to minimum-fuel,multiple-impulse,time-fixed orbital rendezvous in a near circular orbit and achieved great success.Extending Prussing's work,this paper will employ the primer vector theory to study trajectory optimization problems of arbitrary eccentricity elliptical orbit rendezvous.Based on linearized equations of relative motion on elliptical reference orbit (referred to as T-H equations),the primer vector theory is used to deal with time-fixed multiple-impulse optimal rendezvous between two coplanar,coaxial elliptical orbits with arbitrary large eccentricity.A parameter adjustment method is developed for the prime vector to satisfy the Lawden's necessary condition for the optimal solution.Finally,the optimal multiple-impulse rendezvous solution including the time,direction and magnitudes of the impulse is obtained by solving the two-point boundary value problem.The rendezvous error of the linearized equation is also analyzed.The simulation results confirmed the analyzed results that the rendezvous error is small for the small eccentricity case and is large for the higher eccentricity.For better rendezvous accuracy of high eccentricity orbits,a combined method of multiplier penalty function with the simplex search method is used for local optimization.The simplex search method is sensitive to the initial values of optimization variables,but the simulation results show that initial values with the primer vector theory,and the local optimization algorithm can improve the rendezvous accuracy effectively with fast convergence,because the optimal results obtained by the primer vector theory are already very close to the actual optimal solution.If the initial values are taken randomly,it is difficult to converge to the optimal solution. | WANG JianXia BAOYIN HeXi LI JunFeng SUN FuChun | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，4： | 3 |
| 20 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
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