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| 1 | Tillage and straw mulching impacts on grain yield and water use efficiency of spring maize in Northern Huang–Huai–Hai Valley显示文摘A two-year field experiment(2012–2013) was conducted to investigate the effects of two tillage methods and five maize straw mulching patterns on the yield, water consumption,and water use efficiency(WUE) of spring maize(Zea mays L.) in the northern Huang–Huai–Hai valley of China. Compared to rotary tillage, subsoil tillage resulted in decreases in water consumption by 6.3–7.8% and increases in maize yield by 644.5–673.9 kg ha-1, soil water content by 2.9–3.0%, and WUE by 12.7–15.2%. Chopped straw mulching led to higher yield,soil water content, and WUE as well as lower water consumption than prostrate whole straw mulching. Mulching with 50% chopped straw had the largest positive effects on maize yield, soil water content, and WUE among the five mulching treatments. Tillage had greater influence on maize yield than straw mulching, whereas straw mulching had greater influence on soil water content, water consumption, and WUE than tillage. These results suggest that 50% chopped straw mulching with subsoil tillage is beneficial in spring maize production aiming at high yield and high WUE in the Huang–Huai–Hai valley. | Zhiqiang Tao Congfeng Li Jingjing Li Zaisong Ding Jie Xu Xuefang Sun Peilu Zhou Ming Zhao | 2015 | The Crop Journal2015，3，5： | 26 |
| 2 | Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration显示文摘Heart regeneration occurs by dedifferentiation and proliferation of pre-existing cardiomyocytes(CMs).However,the signaling mechanisms by which injury induces CM renewal remain incompletely understood.Here,we find that cardiac injury in zebrafish induces expression of the secreted Wnt inhibitors,including Dickkopf 1(Dkkl),Dkk3,secreted Frizzled-related protein 1(sFrpl),and sFrp2,in cardiac tissue adjacent to injury sites.Experimental blocking of Wnt activity via Dkkl overexpression enhances CM proliferation and heart regeneration,whereas ectopic activation of Wnt8 signaling blunts injury-induced CM dedifferentiation and proliferation.Although Wnt signaling is dampened upon injury,the cytoplasmic β-catenin is unexpectedly increased at disarrayed CM sarcomeres in myocardial wound edges.Our analyses indicated that p21-activated kinase 2(Pak2)is induced at regenerating CMs,where it phosphorylates cytoplasmic β-catenin at Ser 675 and increases its stability at disassembled sarcomeres.Myocardial-specific induction of the phospho-mimeticβ-catenin(S675E)enhances CM dedifferentiation and sarcomere disassembly in response to injury.Conversely,inactivation of Pak2 kinase activity reduces the Ser 675-phosphorylatedβ-catenin(pS675-β-catenin)and attenuates CM sarcomere disorganization and dedifferentiation・Taken together,these findings demonstrate that coordination of Wnt signaling inhibition and Pak2/pS675-βYatenin signaling enhances zebrafish heart regeneration by supporting CM dedifferentiation and proliferation. | Xiangwen Peng Kaa Seng Lai Peilu She Junsu Kang Tingting Wang Guobao Li Yating Zhou jianjian Sun Daqing Jin Xiaolei Xu Lujian Liao Jiandong Liu Ethan Lee Kenneth D.Poss Tao P.Zhong | 2021 | Journal of Molecular Cell Biology2021，13，1： | 3 |
| 3 | A framework for implemen- ting RFII)-based cutting tools management system in a machining workshop 显示文摘 | Sun Peilu Jiang Pingyu | 2012 | Applied Mechanics and Mate- rials2012，22，0223： | 1 |
| 4 | PROTACs:great opportunities for academia and industry (an update from 2020 to 2021)显示文摘PROteolysis TArgeting Chimeras(PROTACs)technology is a new protein-degradation strategy that has emerged in recent years.It uses bifunctional small molecules to induce the ubiquitination and degradation of target proteins through the ubiquitin–proteasome system.PROTACs can not only be used as potential clinical treatments for diseases such as cancer,immune disorders,viral infections,and neurodegenerative diseases,but also provide unique chemical knockdown tools for biological research in a catalytic,reversible,and rapid manner.In 2019,our group published a review article“PROTACs:great opportunities for academia and industry”in the journal,summarizing the representative compounds of PROTACs reported before the end of 2019.In the past 2 years,the entire field of protein degradation has experienced rapid development,including not only a large increase in the number of research papers on protein-degradation technology but also a rapid increase in the number of small-molecule degraders that have entered the clinical and will enter the clinical stage.In addition to PROTAC and molecular glue technology,other new degradation technologies are also developing rapidly.In this article,we mainly summarize and review the representative PROTACs of related targets published in 2020–2021 to present to researchers the exciting developments in the field of protein degradation.The problems that need to be solved in this field will also be briefly introduced. | Ming He Chaoguo Cao Zhihao Ni Yongbo Liu Peilu Song Shuang Hao Yuna He Xiuyun Sun Yu Rao | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 1 |
| 5 | Preparation and gas sensing properties of hierarchical flower-like In 2 O 3 microspheres显示文摘 | Xiumei Xu Peilu Zhao Dawei Wang Peng Sun Lu You Yanfeng Sun Xishuang Liang Fengmin Liu Hong Chen Geyu Lu | 2013 | Sensors & Actuators: B. Chemical2013，，： | 1 |
| 6 | Research progress on neutralizing epitopes and antibodies for the Rabies virus显示文摘Rabies is a zoonotic infectious disease with a high fatality rate.It is caused by a virus in the genus Lyssavirus and is a global public health threat.The rabies virus invades and infects cells mainly via a glycoprotein,which may involve multiple receptors.Neutralizing antibodies against the rabies virus function by blocking the binding of the glycoprotein to a receptor or preventing the membrane fusion process.Vaccination combined with anti-rabies virus neutralizing antibodies is essential for postexposure prophylaxis for category III exposure to the rabies virus.In this review,we discussed the neutralizing epitopes of the rabies virus and the neutralization mechanism of monoclonal antibodies.The neutralizing antibodies that have been commercialized or are under development are also summarized.Our review would provide a basis for the further development of safe and effective broadspectrum neutralizing antibodies to replace the rabies virus immunoglobulin in rabies post-exposure prophylaxis. | Chenjuan Shi Peilu Sun Pan Yang Lele Liu Li Tian Wenkai Liu Min Wang Xuexing Zheng Wenwen Zheng | 2022 | Infectious Medicine2022，1，4： | 0 |
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