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| 1 | Expression and methylation status of the Syk gene in cervical carcinoma显示文摘 | Zhao S Sun G Tony PW | 2011 | Arch Gynecol Obstet2011，283，： | 1 |
| 2 | Methods for the characterization of deformable membrane mirrors 显示文摘 | Martin Booth Tony Wilson Hong-Bo Sun | 2005 | Applied Optics(S0003-6935)2005，44，24： | 1 |
| 3 | An Eva- lution Study of Mobility Support in Zigbee Networks 显示文摘 | Chen Ling-Jyh Sun Tony Liang Nia-chiang | 2010 | Springer US2010，59，1： | 1 |
| 4 | The effect of injection level on the quality of a rapid vacuum cooled cooked beef product 显示文摘 | KARL M D SUN Dawen TONY K | 2001 | Journal of Food Engineering2001，48，： | 1 |
| 5 | Large-scale multiple testing under dependence 显示文摘 | Sun W Tony Cai T | 2009 | Journal or the Royal Statistical Society: Series B (Statistical Methodology)2009，，2： | 1 |
| 6 | AdHoc Probe:end-to-end capacity probing in wireless ad hocnetworks显示文摘 | Chen Ling-Jyh Sun Tony Yang Guang | 2009 | Wireless Netw2009，，15： | 1 |
| 7 | Expression and methyla- tion status of the Syk gene in cervical carcinoma显示文摘 | Zhao S Sun G Tony PW | 2011 | Arch Gynecol Obstet2011，283，5： | 1 |
| 8 | Immediate Versus Delayed Treatment with EGFR Tyrosine Kinase Inhibitors after First-line Therapy in Advanced Non-small-cell Lung Cancer显示文摘Objective: To analyze the outcomes of patients who received TKI immediately after the first-line without progression as maintenance treatment (immediate group) vs. those received delayed treatment upon disease progression as second-line therapy (delayed group). Methods: The study included 159 no-small-cell lung cancer (NSCLC) patients who received gefitinib or erlotinib as maintenance treatment in the immediate group (85 patients) or as second-line therapy in the delayed group (74 patients). The primary end point was progression-free survival (PFS). EGFR mutation status was detected using denaturing high-performance liquid chromatography (DHPLC). Results: PFS was 17.3 and 16.4 months in the immediate and delayed groups, respectively (hazard ratio [HR], 0.99; 95% Confidence Interval [CI]: 0.69-1.42; P=0.947). In a subgroup analysis that included only patients with EGFR mutation, however, PFS was significantly longer in the immediate group than in the delayed group (HR, 0.48; 95% CI: 0.27-0.85; P=0.012). In patients with wild type EGFR, the risk for disease progression was comparable between the two groups (HR, 1.23; 95% CI: 0.61-2.51; P=0.564). No significant difference was demonstrated between the immediate and delayed group in terms of the overall survival (OS) (26.1 months vs. 21.6 months, respectively; HR=0.53; 95% CI: 0.27 to 1.06; P=0.072). There was also no difference in the incidence of adverse events between the two groups. Conclusions: EGFR TKI maintenance improves PFS in patients with EGFR mutation. Prospectively designed clinical studies that compare TKI immediate vs. delayed treatment after first-line chemotherapy upon disease progression are needed. | Zhi-jie Wang Tong-tong An Tony Mok Lu Yang Hua Bai Jun Zhao Jian-chun Duan Mei-na Wu Yu-yan Wang Ping-ping Li Hong Sun Ping Yang Jie Wang | 2011 | Chinese Journal of Cancer Research2011，23，2： | 1 |
| 9 | The effect of injection level on the quality of a rapid vacuum cooled cooked beef product显示文摘 | Da Wen Sun Tony Kenny | 2001 | Journal of Food Engineering2001，47，： | 1 |
| 10 | The effect of injection level on the quality of a rapid vacuum cooled cooked beef product 显示文摘 | Karl McDonald Da-Wen Sun Tony Kenny | 2001 | Journal of Food Engineering2001，47，： | 1 |
| 11 | AdI-Ioc Probe : end - to - end capacity probing in wireless adhoc networks显示文摘 | Chen Ling - Jyh Sun Tony Yang Guang M Y Sanadidi Mario Gerla | 2009 | Wireless Netw2009，15，11： | 1 |
| 12 | Causality assessment of herb-induced liver injury using multidisciplinary approach and Roussel Uclaf Causality Assessment Method (RUCAM)显示文摘 | Tai Nin Chau Wing I. Cheung Teresa Ngan Jieru Lin Ken Wing San Lee Wing Tat Poon Vincent King Sun Leung Tony Mak Man Li Tse | 2011 | Clinical Toxicology2011，，1： | 1 |
| 13 | Methods for the characterization of deformable membrane mirrors 显示文摘 | Martin Booth Tony Wilson Sun Hongbo | 2005 | Applied Optics(S0003-6935)2005，44，24： | 1 |
| 14 | RIP3, a novel apoptosis-induced kinases 显示文摘 | James L Tony N | 1999 | J Biol Chem1999，274，16： | 1 |
| 15 | Expression and methylation status of the Syk gene in cervical carcinoma显示文摘 | Zhao S Sun G Tony PW | 2011 | Arch Gynecol Obstet2011，283，5： | 1 |
| 16 | An evaluation study of mobility support in ZigBee networks 显示文摘 | Chen Lingjyh Sun Tony Liang Niachiang | 2010 | Journal Signal Process System2010，，59： | 1 |
| 17 | The evolving species concepts used for yeasts:from phenotypes and genomes to speciation networks显示文摘Here we review how evolving species concepts have been applied to understand yeast diversity.Initially,a phenotypic species concept was utilized taking into consideration morphological aspects of colonies and cells,and growth profiles.Later the biological species concept was added,which applied data from mating experiments.Biophysical measurements of DNA similarity between isolates were an early measure that became more broadly applied with the advent of sequencing technology,leading to a sequence-based species concept using comparisons of parts of the ribosomal DNA.At present phylogenetic species concepts that employ sequence data of rDNA and other genes are universally applied in fungal taxonomy,including yeasts,because various studies revealed a relatively good correlation between the biological species concept and sequence divergence.The application of genome information is becoming increasingly common,and we strongly recommend the use of complete,rather than draft genomes to improve our understanding of species and their genome and genetic dynamics.Complete genomes allow in-depth comparisons on the evolvability of genomes and,consequently,of the species to which they belong.Hybridization seems a relatively common phenomenon and has been observed in all major fungal lineages that contain yeasts.Note that hybrids may greatly differ in their post-hybridization development.Future in-depth studies,initially using some model species or complexes may shift the traditional species concept as isolated clusters of genetically compatible isolates to a cohesive speciation network in which such clusters are interconnected by genetic processes,such as hybridization. | Teun Boekhout M.Catherine Aime Dominik Begerow Toni Gabaldón Joseph Heitman Martin Kemler Kantarawee Khayhan Marc-AndréLachance Edward J.Louis Sheng Sun Duong Vu Andrey Yurkov | 2021 | Fungal Diversity2021，，4： | 0 |
| 18 | Correction to:The evolving species concepts used for yeasts:from phenotypes and genomes to speciation networks显示文摘The name of the second author was incorrectly captured in the initial online publication,and due to an error at the proofs stage,several proof corrections had been left undone.The original online article has been corrected. | Teun Boekhout M.Catherine Aime Dominik Begerow Toni Gabaldón Joseph Heitman Martin Kemler Kantarawee Khayhan Marc-AndréLachance Edward J.Louis Sheng Sun Duong Vu Andrey Yurkov | 2021 | Fungal Diversity2021，，4： | 0 |
| 19 | 吉非替尼与多西紫杉醇在化疗后非小细胞肺癌患者中的疗效对比(INTEREST):一项随机Ⅲ期临床试验显示文摘背景两项在既往接受过治疗的晚期非小细胞肺癌患者中进行的Ⅱ期临床试验结果表明,吉非替尼的疗效优于化疗,且毒副作用更小:局部晚期或转移性非小细胞肺癌患者在接受以铂类药物为基础的化疗后,继续使用吉非替尼和多西紫杉醇进行治疗,观察并比较两类药物的疗效:方法2004年3月1日至2006年2月17日,采用开放标记的Ⅲ期临床研究的方法,在全球24个国家的149家中心招募受试者。1466例晚期非小细胞肺癌患者在接受铂类药物化疗后(铂类药物化疗至少1个疗程),经随机分组,分别接受吉非替尼(250mg口服,每日1次;n=733)或多西紫杉醇(75mg/m^2静脉注射,1h注射完毕,每3周1次;n=733)治疗,并保持两组间样本数量的动态平衡。本研究的主要目的是采用协同主要分析法,比较两组间的存活情况,以此评估吉非替尼在总体符合方案人群中的非劣效性,在意向治疗人群高表皮生长因子受体(EGFR)基因拷贝数患者中的优效性。本临床研究在ClinicalTrials.gov上注册,编号为NCT00076388。结果本研究分析了两种治疗方案下的共计1433例患者(吉非替尼组723例,多西紫杉醇组710例)。总体存活情况确认了吉非替尼相对于多西紫杉醇的非劣效性(事件593例Fs576例,HR1.020,96%C10.905~1.150,达到预定非劣效性标准;中位存活时间7.6月 vs8.0月):具有高EGFR基因拷贝数的患者(85例 vs 89例)未显示出吉非替尼治疗的优效性证据(事件72例vs 71例,HR1.09,95%C10.78-1.51,P=0.62;中位存活时间8.4个月Fs7.5个月)?在吉非替尼治疗组中,最常见的不良事件包括皮疹或痤疮[360例(49%)vs 73例(10%)]以及腹泻[255例(35%)vs 177例(25%)];然而,在多西紫杉醇治疗组中,中性粒细胞减少症[35例(5%)vs 514例(74%)]、乏力不适[182例(25%)vs 334例(47%)]以及脱发[23例(3%)vs 254例(36%)1是最常见的不良事件。结论INTEREST研究确立了吉非替尼与多西紫杉醇相比在存活率方面的非劣效性,提示吉非替尼对于既往接受过治疗的晚期非小细胞肺癌患者是一项有效的治疗措施。 | Edward SKim Vera Hirsh Tony Mok Mark A Socinski Radj Gervais Yi-Long Wu Long-Yun Li Claire L Watkins Mark V Sellers Elizabeth S Lowe Yan Sun Mei-Lin Liao Kell Osterlind Martin Reck Alison A Armour Frances A Shepherd Scott M Lippman lean-Yves Douillard | 2009 | 世界临床医学2009，，7： | 0 |
| 20 | The development of microfabricated solenoids with magnetic cores for micromagnetic neural stimulation显示文摘Electrical stimulation via invasive microelectrodes is commonly used to treat a wide range of neurological and psychiatric conditions.Despite its remarkable success,the stimulation performance is not sustainable since the electrodes become encapsulated by gliosis due to foreign body reactions.Magnetic stimulation overcomes these limitations by eliminating the need for a metal-electrode contact.Here,we demonstrate a novel microfabricated solenoid inductor(80µm×40µm)with a magnetic core that can activate neuronal tissue.The characterization and proof-of-concept of the device raise the possibility that micromagnetic stimulation solenoids that are small enough to be implanted within the brain may prove to be an effective alternative to existing electrode-based stimulation devices for chronic neural interfacing applications. | Adam Khalifa Mohsen Zaeimbashi Tony X.Zhou Seyed Mahdi Abrishami Neville Sun Seunghyun Park TamaraŠumarac Jason Qu Inbar Zohar Amir Yacoby Sydney Cash Nian X.Sun | 2021 | Microsystems & Nanoengineering2021，7，6： | 0 |
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