|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite-stable colorectal cancer显示文摘Colorectal cancer is one of the leading causes of cancer death worldwide.According to global genomic status,colorectal cancer can be classified into two main types:microsatellite-stable and microsatellite-instable tumors.Moreover,the two subtypes also exhibit different responses to chemotherapeutic agents through distinctive molecular mechanisms.Recently,mitochondrial DNA depletion has been shown to induce apoptotic resistance in microsatellite-instable colorectal cancer.However,the effects of altered mitochondrial DNA copy number on the progression of microsatellite-stable colorectal cancer,which accounts for the majority of colorectal cancer,remain unclear.In this study,we systematically investigated the functional role of altered mitochondrial DNA copy number in the survival and metastasis of microsatellite-stable colorectal cancer cells.Moreover,the underlying molecular mechanisms were also explored.Our results demonstrated that increased mitochondrial DNA copy number by forced mitochondrial transcription factor A expression significantly facilitated cell proliferation and inhibited apoptosis of microsatellitestable colorectal cancer cells both in vitro and in vivo.Moreover,we demonstrated that increased mitochondrial DNA copy number enhanced the metastasis of microsatellite-stable colorectal cancer cells.Mechanistically,the survival advantage conferred by increased mitochondrial DNA copy number was caused in large part by elevated mitochondrial oxidative phosphorylation.Furthermore,treatment with oligomycin significantly suppressed the survival and metastasis of microsatellite-stable colorectal cancer cells with increased mitochondrial DNA copy number.Our study provides evidence supporting a possible tumor-promoting role for mitochondrial DNA and uncovers the underlying mechanism,which suggests a potential novel therapeutic target for microsatellite-stable colorectal cancer. | Xiacheng Sun Lei Zhan Yibing Chen Gang Wang Linjie He Qian Wang Feng Zhou Fang Yang Jin Wu Yousheng Wu Jinliang Xing Xianli He Qichao Huang | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 3 |
| 2 | Application of biologic silicon in modern sedimentary section to reconstruction of phytoplankton changes in the East China Sea and the Huanghai Sea during last 200 years显示文摘Biomarkers had been widely used to reconstruct phytoplankton productivity,and this method was applied in the East China Sea and the Huanghai Sea (Yellow Sea).In this study,Biologic Silicon (BSi) was used as productivity proxy to reconstruct productivity change of phytoplankton during last 200 years.The results show that the BSi contents of surficial sediments were in the range of 0.018%-2.516%,averaging 0.726%,and had a similar variation trend with phytoplankton biomass.The vertical distribution profiles revealed that BSi contents were relatively stable,in accordance with the variations of the contemporary phytoplankton standing crop index.According to the stability analysis of BSi in sediments,BSi was not degradaded for the past two hundred years and remained in sediments steadily.Thus,BSi in sediments had the potential to invert paleoproductivity.To conduct further survey,the linear regression equation between BSi contents and phytoplankton biomass index could be used to calculate the phytoplankton productivity by BSi,so that paleoproductivity may be reconstructed during last 200 years. | YANG Qian SONG Xianli SUN Yao HUANG Jiansheng | 2012 | Acta Oceanologica Sinica2012，31，2： | 2 |
| 3 | Two-phase anaerobic co-digestion of dairy manure with swine manure显示文摘In order to solve the problems associated with high fiber content,and the ensuing lower biogas volume yield in anaerobic digestion of dairy manure,a study of the co-digestion of separated liquids from dairy manure combined with swine manure using a two-phase anaerobic digestion process was conducted.The influence of level of total solids(TS)and hydraulic retention time(HRT)of the mixed liquor on the specific methane production were studied.Three TS levels 8%,10%and 12%were investigated.Analysis of the results show that a maximum specific methane yield of 132.99 L/kg volatile solids(VS),can be obtained with a TS of 9%,an inoculation rate of 30%,the duration of hydrolytic acidification phase of 5 d,and an HRT of the methanogenic phase of 10 d.These findings could provide directions for improving the biogas production by performing the co-digestion of dairy manure with swine manure. | Guan Zhengjun Sun Xianli Bi Lanping Li Wenzhe Zhang Ying Wang Zhigang | 2016 | International Journal of Agricultural and Biological Engineering2016，9，2： | 1 |
| 4 | Is southwestern China experiencing more frequent precipitation extremes?显示文摘 | Meixian Liu Xianli Xu Alexander Y Sun Kelin Wang Wen Liu Xiaoyan Zhang | 2014 | Environmental Research Letters2014，，6： | 1 |
| 5 | Adipose-derived stem cells in stroke treatment: translational possibility and mechanism显示文摘Stroke has become one of the secondary worldwide mortal diseases that burdens the family and the society both emotionally and economically.The announcement of China's Ministry of Health in 2008 showed that stroke had been the first cause of death in urban and rural residents.1,2 Traditional therapies such as thrombolysis,anti-platelets,and rehabilitation showed limited effects.Replacement therapy with stem cells promises to be a good solution due to its possible thorough therapy for the damaged brain area,reconstruction of neuronal circuitry,and probable long-term efficacy. | Zhou Fei Gao Shan'e Sun Chenxi Cao Limei Ren Haiyan Li Qiang Wang Guangming Dong Chuanming Zhu Liang Yang Danjing Wang Xianli Xu Jun Chen Xu | 2014 | Chinese Medical Journal2014，，20： | 1 |
| 6 | Innovative hydrophobic/hydrophilic perfluoropolyether(PFPE)/polyvinylidene fluoride(PVDF)composite membrane for vacuum membrane distillation显示文摘Though membrane distillation(MD)has gained more and more attention in the field of desalination,the wetting phenomenon was still a non-negligible problem.In this work,a method combined dip-coating and UV in situ polymerization for preparing hydrophobic/hydrophilic perfluoropolyether(PFPE)/polyvinylidene fluoride composite membranes.This composite membrane consisted of a top thin hydrophobic coating layer and hydrophilic substrate membrane.In terms of anti-wetting properties,contact angle and liquid entry pressure of all composite membranes(except for those based on 0.45μm)exceeded 160°and 0.3 MPa,respectively.In particular,the desalination performance was tested in vacuum membrane distillation tests by feeding 3.5%(mass)saline solution(NaCl)at 60℃.The composite membranes with larger support pore size and lower PFPE content had higher membrane distillation flux.And for stability tests(testing the 0.22μm membrane coated by 5%(mass)PFPE),the highest MD flux29.08 kg·m^(-2)·h^(-1) and stable salt rejection(over 99.99%)during the period.Except that,the effects of coating material concentration and pore sizes of substrate membrane were also investigated for surface morphology and topography,porosity,mechanical strength and pore size characteristics.This work provided a simple and effective alternative to prepare excellent hydrophobic composite membranes for MD applications. | Jun Pan Xianli Xu Zhaohui Wang Shi-Peng Sun Zhaoliang Cui Lassaad Gzara Iqbal Ahmed Omar Bamaga Mohammed Albeirutty Enrico Drioli | 2022 | Chinese Journal of Chemical Engineering2022，35，5： | 1 |
| 7 | Key factors governing alkaline pretreatment of waste activated sludge显示文摘Alkaline pretreatment is an effective technology to disintegrate sewage sludge, where alkali dosage and sludge concentration are two important factors. p H value or alkali concentration is usually adjusted in order to determine a proper dosage of alkali. Our work has found that this is not a good strategy. A new parameter, the ratio of alkali to sludge(Ra/s), is more sensitive in controlling the alkali dosage. The sludge concentration Csand retention time t are two other important factors to consider. The validity of these arguments is confirmed with modeling and experiments. The individual effect of Ra/s, Csand t was studied separately. Then the combined effect of these three factors was evaluated. The sludge disintegration degree of 44.7% was achieved with the optimized factors. Furthermore, an alkaline-microwave combined pretreatment process was carried out under these optimized conditions. A high disintegration degree of 62.3% was achieved while the energy consumption of microwave was much lower than previously reported. | Xianli Shi Li Deng Fangfang Sun Jieyu Liang Xu Deng | 2015 | Chinese Journal of Chemical Engineering2015，23，5： | 0 |
| 8 | For more and purer hydrogen-the progress and challenges in water gas shift reaction显示文摘The water gas shift(WGS) reaction is a standard reaction that is widely used in industrial hydrogen production and removal of carbon monoxide. The improved catalytic performance of WGS reaction also contributes to ammonia synthesis and other reactions. Advanced catalysts have been developed for both high and low-temperature reactions and are widely used in industry. In recent years, supported metal nanoparticle catalysts have been researched due to their high metal utilization. Low-temperature catalysts have shown promising results, including high selectivity, high shift rates, and higher activity potential. Additionally, significant progress has been made in removing trace CO through the redox reaction in electrolytic cell. This paper reviews the development of WGS reaction catalysts, including the reaction mechanism, catalyst design, and innovative research methods. The catalyst plays a crucial role in the WGS reaction, and this paper provides an instant of catalyst design under different conditions. The progress of catalysts is closely related to the development of advanced characterization techniques.Furthermore, modifying the catalyst surface to enhance activity and significantly increase reaction kinetics is a current research direction. This review goals to stimulate a better understanding of catalyst design, performance optimization, and driving mechanisms, leading to further progress in this field. | Limin Zhou Yanyan Liu Shuling Liu Huanhuan Zhang Xianli Wu Ruofan Shen Tao Liu Jie Gao Kang Sun Baojun Li Jianchun Jiang | 2023 | Journal of Energy Chemistry2023，，8： | 0 |
| 9 | Exotic Behavior of Elastic Scattering Differential Cross Sections of Weakly Bound Nucleus ^(17)F at Small Angels显示文摘The experiment of measuring the differential cross sections dσ/dθat forward angles for the elastically scattered 17F (141 MeV) and 17O (128 MeV) on the 208Pb target has been carried out at the Radioactive Ion Beam Line in Lanzhou (RIBLL). Fig. 1 shows the plots of In(dσ/dθ) versusθ2 for 17F (right panel) and 17O (left panel). The dependence of the ln(dσ/dθ) onθ2 shows quite different behaviors for the two nuclei. For the weakly bound nu- | Han Jianlong, Wang Qi, Xiao Zhigang, Xu Hushan, Sun Zhiyu,Hu Zhengguo, Zhang Xueyin Wang Hongwei, Mao Ruishi, Yuan Xiaohua, Xu Zhiguo, Zhao Tiecheng, Zhang Hongbin Xu Huagen, Qi Huirong, Wang Yue, Jia Fei, Wu Lijie, Ding Xianli, Gao Qi Gao Hui, Li Songlin, Xiao Guoqing and Jin Genming | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 10 | Visual Functions and TraceElement Metabolism in Tobacco-toxic Optic Neuropathy显示文摘Visual functions and nutrition metabolic characteristics werestudied in 8 subjects(16 eyes)with tobacco-toxic optic neuropathy(TTON).Their visual functions tested by psychophysical and electrophysiologicmethods showed that:1.central vision diminished in 16 eyes,2.dyschromatopsias were found in 14 tested eyes,3.bilateral symmetricalcentral or cecocentral scotomas were the visual field characteristics in allcases,4.PVEP were severe abnormal in 3 spatial frequencies in all cases and56.3% of 15' checkboard ... | Yu Wang Lezheng Wu De-Zheng Wu Futian Jiang Taiqing Luo National Ophthalmological Laboratories,Ministry of Public Heallth,China Zhongshan Ophthalmic Center,Sun Yat-sen University of Medical Sciences,Guangzhou 510060,China Shaoyu Sheng Zengxi Li Yechen Liang Guangdong lnstitute of Analysis,100 Xianlie Road,Guangzhou 510070,China | 1992 | 眼科学报1992，8，3： | 0 |
| 11 | A 3D Beam Monitor System for Measuring Beam Distribution and Bragg Curve in Heavy Ion Therapy at IMP显示文摘Heavy ions have a favorable depth-dose profile (Bragg curve) and the narrow Bragg peak can be precisely adjusted to the desired depth by changing the beam energy. The ions as heavy as or heavier than carbon can additionally offer an enhanced biological efficiency in the region around Bragg peak because of the very dense ionization towards the end of the particle tracks. Several heavy ions therapy facilities have | Hu Zhengguo, Xu Zhiguo, Xiao Guoqing, Guo Zhongyan, Xu Hushan, Sun Zhiyu Zhan Wenlong, Wang Jiansong, Qi Huirong, Zhang Xueheng Mao Ruishi, Ding Xianli, Fu Fen and Li Qiang | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 12 | Developing Detector Unit for a Mini Imaging Detector System显示文摘With the development of the heavy ion therapy technique at the Institute Modern Physics, Chinese Academy Sciences, a mini imaging detector system is also developed. The detector system is designed to coincidently measure the two 0. 511 MeVγ-rays oppositely emitted from the annihilation of the positron and electron. The positron is from the decay of the radioactive | Qi Huirong, Xiao Guoqing, Wang Jinchuan, Zhan Wenlong, Guo Zhongyan, Xu Hushan Li Wenjian, Sun Zhiyu, Ding Xianli, Wu Lijie and Xu Zhiguo | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 13 | Dredging hand Yang meridians with deep tissue massage combined with neck movement in stiff-neck syndrome:A randomized controlled trial显示文摘Objective:The objective of this study is to observe the therapeutic effects of dredging hand Yang meridian with deep tissue massage combined with neck movement on stiff-neck syndrome.Materials and Methods:This is a randomized controlled trial.The consecutive patients with the stiff-neck syndrome were randomly allocated into the intervention group and patch group(1:1)according to the random number table.The intervention group was treated with dredging hand Yang meridian with deep tissue massage combined with neck movement once a day for 3 days,while the patch group therapy was treated with a 3-patch therapy and every patch included 24-h patch and 24-h patch-free.A needle electromyogram would be exerted if the patients were at their willingness in different stages.The pain of patients was assessed by Visual Analog Scale in the two groups at every 24 h time point.Results:Finally,212 patients completed the trial,106 in each group.The curative rate in the intervention group was higher than in the patch group(99.06%vs.84.91%,χ^(2)=0.890,P<0.01).Repeated measures of the general linear model showed a significant difference in pain score within the subject-factors(factor of time F=4548.577,P<0.001;factor of time-group F=490.034,P<0.001).There was a significant difference between groups regarding pain score(F=3016.315,P<0.001).Conclusion:Dredging hand Yang meridian with deep tissue massage combined with neck movement is better than patch therapy in stiff-neck syndrome,with a shorter duration and instant effects. | Xueguo SUN Zonghua QI Ying LIU Yan LI Xianli DOU Lingyun ZHANG | 2022 | Journal of Integrative Nursing2022，4，4： | 0 |
| 14 | Performance Test of LASCAR Scintillator Detector Array at RIBLL显示文摘The LASCAR (Large Area Scattering Chamber at PABLL) scintillator detector array is developed to detect neutrons and charged particles from the reaction induced by, the RIBs from RIBLL. It consists of 8 scintillator plus light guide blocks. As shown in Fig.l, each block matches with 49 photomultipliers (PMTs) of 9214SB type from Electron Tubes Limited. Some technical improvements and the latest performance test of the 294 PMTs in 6 blocks of LASCAR are described in this report. | Wang Jinchuan, Xiao Guoqing, Guo Zhongyan, Zhan Wenlong, Qi Huirong, Wu LijieXu Zhiguo, Zhang Li, Ding Xianli, Xu Hushan, Sun Zhiyu, Li Jiaxing, Li ChenWang Meng, Chen Lixin, Hu Zhengguo, Mao Ruishi and Zhao Tiecheng | 2003 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2003，，1： | 0 |
| 15 | Design of Multi-unit Control System of High Voltage Power Supply for LASCAR Scintillator Detector Array显示文摘The power voltages of Photomultipliers (PMTs) at RIBLL LASCAR scintillator detector array are distributed between 900 V and 1 800 V irregularly. 392 CC123 modules are employed to supply high voltage for the PMT array. The CC123 module serves as PMT interface groupware package, and it can transform +12 V DC input voltage to ranges of 0~-2200 V for the PMT power supply corresponding to 0~+5 V output voltage from the control board crate. The relation of PMT power supply with the output voltage of the control crate is shown in Fig.1. | Wu Lijie, Wang Jinchuan, Xiao Guoqing, Guo Zhongyan, Zhan Wenlong, Qi Huirong, Xu ZhiguoZhang Li, Ding Xianli, Xu Hushan, Sun Zhiyu, Li Jiaxing, Li Chen, Wang MengChen Lixin, Hu Zhengguo, Mao Ruishi and Zhao Tiecheng | 2003 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2003，，1： | 0 |
| 16 | Microvascular Changes in the Retrobulbar Optic Nerve in Idiopathic Intracranial Hypertension显示文摘Purpose : To examine the microvascular changes in the retrobulbar optic nerve in idio-pathic intracranial hypertension (PTC).Methods: Both optic nerves from a 29-year-old man with a two year history of PTC were examined histologically and morphometrically. A semi-automated image analysis system and paraphenylenediamine (PPD) stain were employed to resolve sufficiently the microvascular images for counts and measurement.Results: There were 150 vessels distributed in the optic nerves which revealed the following: The average lumen of the vessels in outer sectors were larger than those of the inner sector vessels (168. 17μm2vs. 46. 99μm2; p = 0. 0338;OD; and 251. 96μm2vs. 130.02μm2;p = 0.029;OS) while in the normal control optic nerve the outer and inner area lumens were reversed in size-differential, but this did not show a statistical difference. The thickness of the PTC optic nerve vessel walls in the outer sectors was also greater than that of the walls in the inner sectors (4. 95μm vs. 2. 67μm; | Xinzu Gu, X.H. Lin, H.G. Saddati, Y.Zhong, H.Y.Hsu, A.A.SadunZhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060 , China Department of Ophthalmology, USC School of Medicine , Doheny Eye Institute, Los Angeles , CA 90033 Correspondence: Xinzu Gu, MD, PhD, Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, 54 Xianlie Road, Guangzhou 510060, China | 1999 | 眼科学报1999，15，1： | 0 |
| 17 | Integrated bioremediation techniques in a shrimp farming environment under controlled conditions显示文摘This study investigated the integrated bioremediation techniques for a shrimp culture system to reduce unconsumed feed and the contents of suspended solids(SS), nutrients and organic pollutants using barracuda,clamworm, scallop, large algae and a biofilter. A multi-pool internal circulation system was designed to test the effectiveness of the techniques in the laboratory. The experimental result has shown that Argopecten irradians,Gracilaria lemaneiformis and the biofilter efficiently reduced the contents of SS, dissolved inorganic carbon(DIC)and dissolved organic carbon(DOC) in the breeding wastewater. The amount of unconsumed feed was significantly reduced by barracuda and clamworm, but there was an increase in the contents of SS, DIC and DOC in the water due to disturbance by the barracuda and clamworm. The capacity of macroalgae to extract inorganic nitrogen was insufficient. However, the balance of the nitrogen fixation rate of macroalgae and the biological exhaust nitrogen rate within the system should be fully considered. The use of the biofilter alone was not optimal for the remediation of organic matter in shrimp effluent so that auxiliary foam separation technology is needed to improve the ability of the system to remove macromolecules. This study provides a basis for the further development of remediation techniques to reduce the environmental impact of shrimp aquaculture. | SONG Xianli YANG Qian REN J.Shengmin SUN Yao WANG Xiulin SUN Fuxin | 2016 | Acta Oceanologica Sinica2016，35，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员