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| 1 | Endoscopic ultrasound guided radiofrequency ablation,for pancreatic cystic neoplasms and neuroendocrine tumors显示文摘AIM: To outline the feasibility, safety, adverse events and early results of endoscopic ultrasound(EUS)-radiofrequency ablation(RFA) in pancreatic neoplasms using a novel probe. METHODS: This is a multi-center, pilot safety feasibility study. The intervention described was radiofrequency ablation(RF) which was applied with an innovative monopolar RF probe(1.2 mm Habib EUS-RFA catheter) placed through a 19 or 22 gauge fine needle aspiration(FNA) needle once FNA was performed in patients with a tumor in the head of the pancreas. The HabibTM EUSRFA is a 1 Fr wire(0.33 mm, 0.013') with a working length of 190 cm, which can be inserted through the biopsy channel of an echoendoscope. RF power is applied to the electrode at the end of the wire to coagulate tissue in the liver and pancreas.RESULTS: Eight patients [median age of 65(range 27-82) years; 7 female and 1 male] were recruited in a prospective multicenter trial. Six had a pancreatic cysticneoplasm(four a mucinous cyst, one had intraductal papillary mucinous neoplasm and one a microcystic adenoma) and two had a neuroendocrine tumors(NET) in the head of pancreas. The mean size of the cystic neoplasm and NET were 36.5 mm(SD ± 17.9 mm) and 27.5 mm(SD ± 17.7 mm) respectively. The EUSRFA was successfully completed in all cases. Among the 6 patients with a cystic neoplasm, post procedure imaging in 3-6 mo showed complete resolution of the cysts in 2 cases, whilst in three more there was a 48.4% reduction [mean pre RF 38.8 mm(SD ± 21.7 mm) vs mean post RF 20 mm(SD ± 17.1 mm)] in size. In regards to the NET patients, there was a change in vascularity and central necrosis after EUS-RFA. No major complications were observed within 48 h of the procedure. Two patients had mild abdominal pain that resolved within 3 d. CONCLUSION: EUS-RFA of pancreatic neoplasms with a novel monopolar RF probe was well tolerated in all cases. Our preliminary data suggest that the procedure is straightforward and safe. The response ranged from complete resolution to a 50% reduction in size. | Madhava Pai Nagy Habib Hakan Senturk Sundeep Lakhtakia Nageshwar Reddy Vito R Cicinnati Iyad Kaba Susanne Beckebaum Panagiotis Drymousis Michel Kahaleh William Brugge | 2015 | World Journal of Gastrointestinal Surgery2015，7，4： | 23 |
| 2 | Changing spectrum of Budd-Chiari syndrome in India with special reference to non-surgical treatment显示文摘AIM: To evaluate patterns of obstruction, etiological spectrum and non-surgical treatment in patients with Budd-Chiari syndrome in India.METHODS: Forty-nine consecutive cases of Budd-Chiari syndrome (BCS) were prospectively evaluated. All patients with refractory ascites or deteriorating liver function were, depending on morphology of inferior vena cava (IVC) and/or hepatic vein (HV) obstruction, triaged for radiological intervention, in addition to anticoagulation therapy. Asymptomatic patients, patients with diuretic-responsive ascites and stable liver function, and patients unwilling for surgical intervention were treated symptomatically with anticoagulation.RESULTS: Mean duration of symptoms was 41.5 ± 11.2 (range = 1-240) mo. HV thrombosis (HVT) was present in 29 (59.1%), IVC thrombosis in eight (16.3%), membranous obstruction of IVC in two (4%) and both IVC-HV thrombosis in 10 (20.4%) cases. Of 35 cases tested for hypercoagulability, 27 (77.1%) were positive for one or more hypercoagulable states. Radiological intervention was technically successful in 37/38 (97.3%): IVC stenting in seven (18.9%), IVC balloon angioplasty in two (5.4%), combined IVC-HV stenting in two (5.4%), HV stenting in 11 (29.7%), transjugular intrahepatic portosystemic shunt (TIPS) in 13 (35.1%) and combined TIPS-IVC stenting in two (5.4%). Complications encountered in follow-up: death in five, re-stenosis of the stent in five (17.1%), hepatic encephalopathy in two and hepatocellular carcinoma in one patient. Of nine patients treated medically, two showed complete resolution of HVT.CONCLUSION: In our series, HVT was the predominant cause of BCS. In the last five years with the availability of sophisticated tests for hypercoagulability, etiologies weredefined in 85.7% of cases. Non-surgical management was successful in most cases. | Deepak N Amarapurkar Sundeep J Punamiya Nikhil D Patel | 2008 | World Journal of Gastroenterology2008，14，2： | 9 |
| 3 | Per oral cholangiopancreatoscopy in pancreatico biliary diseases- Expert consensus statements显示文摘AIM: To provide consensus statements on the use of per-oral cholangiopancreatoscopy(POCPS).METHODS: A workgroup of experts in endoscopic retrograde cholangiopancreatography(ERCP), endosonography, and POCPS generated consensus statements summarizing the utility of POCPS in pancreaticobiliary disease. Recommendation grades used validated evidence ratings of publications from an extensive literature review.RESULTS: Six consensus statements were generated:(1) POCPS is now an important additional tool during ERCP;(2) in patients with indeterminate biliary strictures, POCS and POCS-guided targeted biopsy are useful for establishing a definitive diagnosis;(3) POCS and POCS-guided lithotripsy are recommended for treatment of difficult common bile duct stones when standard techniques fail;(4) in patients with main duct intraductal papillary mucinous neoplasms(IPMN) POPS may be used to assess extent of tumor to assist surgicalresection;(5) in difficult pancreatic ductal stones,POPS-guided lithotripsy may be useful in fragmentation and extraction of stones; and(6) additional indications for POCPS include selective guidewire placement,unexplained hemobilia, assessing intraductal biliary ablation therapy, and extracting migrated stents. CONCLUSION: POCPS is important in association with ERCP, particularly for diagnosis of indeterminate biliary strictures and for intra-ductal lithotripsy when other techniques failed, and may be useful for preoperative assessment of extent of main duct IPMN, for extraction of difficult pancreatic stones, and for unusua indications involving selective guidewire placement,assessing unexplained hemobilia or intraductal biliary ablation therapy, and extracting migrated stents. | Mohan Ramchandani Duvvur Nageshwar Reddy Sundeep Lakhtakia Manu Tandan Amit Maydeo Thoguluva Seshadri Chandrashekhar Ajay Kumar Randhir Sud Rungsun Rerknimitr Dadang Makmun Christopher Khor | 2015 | World Journal of Gastroenterology2015，21，15： | 8 |
| 4 | Gastric conduit perforation显示文摘As patients with carcinoma of the esophagus live longer, complications associated with the use of a gastric conduit are increasing. Ulcers form in the gastric conduit in 6.6% to 19.4% of patients. There are a few reports of perforation of a gastric conduit in the English literature. Almost all of these were associated with serious complications. We report a patient who developed a tension pneumothorax consequent to spontaneous perforation of an ulcer in the gastric conduit 7 years after the index surgery in a patient with carcinoma of the gastroesophageal junction. He responded well to conservative management. Complications related to a gastric conduit can be because of multiple factors. Periodic endoscopic surveillance of gastric conduits should be considered as these are at a higher risk of ulcer formation than a normal stomach. Long term treatment with proton pump inhibitors may decrease complications. There are no guidelines for the treatment of a perforated gastric conduit ulcer and the management should be individualized. | Nilesh Patil Arvind Kaushal Amit Jain Sundeep Singh Saluja Pramod Kumar Mishra | 2014 | World Journal of Clinical Cases2014，2，8： | 4 |
| 5 | Management of splenic artery aneurysm associated with extrahepatic portal vein obstruction显示文摘BACKGROUND: Splenic artery aneurysms although rare are clinically significant in view of their propensity for spontaneous rupture and life-threatening bleeding. While portal hypertension is an important etiological factor, the majority of reported cases are secondary to cirrhosis of the liver. We report three cases of splenic artery aneurysms associated with extrahepatic portal vein obstruction and discuss their management. METHODS: The records of three patients of splenic artery aneurysm associated with extrahepatic portal vein obstruction managed from 2003 to 2010 were reviewed retrospectively. The clinical presentation, surgical treatment and outcome were analyzed. RESULTS: The aneurysm was >3 cm in all patients. The clinical symptoms were secondary to extrahepatic portal vein obstruction (hematemesis in two, portal biliopathy in two) while the aneurysm was asymptomatic. Doppler ultrasound demonstrated aneurysms in all patients. A proximal splenorenal shunt was performed in two patients with excision of the aneurysm in one patient and ligation of the aneurysm in another one. The third patient had the splenic vein replaced by collaterals and hence underwent splenectomy with aneurysmectomy. All patients had an uneventful post-operative course. CONCLUSIONS: Splenic artery aneurysms are associated with extrahepatic portal vein obstruction. Surgery is the mainstay of treatment. Although technically difficult, it can be safely performed in an experienced center with minimal morbidity and good outcome. | Pramod Kumar Mishra Sundeep Singh Saluja Ashok K Sharma Premanand Pattnaik | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 4 |
| 6 | PGC7, H3K9me2 and Tet3: regulators of DNA methylation in zygotes显示文摘 | Jinsuk Kang Sundeep Kalantry Anjana Rao | 2013 | Cell Research2013，23，1： | 3 |
| 7 | Acute Pancreatitis During Pregnancy显示文摘 | Shou–Jiang Tang Edmundo Rodriguez–Frias Sundeep Singh Marlyn J. Mayo Saad F. Jazrawi Jayaprakash Sreenarasimhaiah Luis F. Lara Don C. Rockey | 2010 | Clinical Gastroenterology and Hepatology2010，，1： | 2 |
| 8 | Self-orthogonality of q-ary Images of qm Codes and Quantum code显示文摘 | Sundeep B Thangaraj A | 2007 | IEEE Trans on Information Theory2007，53，7： | 1 |
| 9 | Hydatid Cyst of Liver Presented as Obstructive Jaundice in Pregnancy; Managed by PAIR: Report of a Common Procedure in a Rare Setting from India显示文摘 | Jayant K. Ghosh Sundeep K. Goyal Manas K. Behera Vinod K. Dixit Ashok K. Jain | 2014 | Journal of Clinical and Experimental Hepatology2014，，： | 1 |
| 10 | Role of Prophylactic Intra-Aortic Balloon Pump in High-Risk Patients Undergoing Percutaneous Coronary Intervention显示文摘 | Sundeep Mishra William W. Chu Rebecca Torguson Roswitha Wolfram Regina Deible William O. Suddath Augusto D. Pichard Lowell F. Satler Kenneth M. Kent Ron Waksman | 2006 | The American Journal of Cardiology2006，，5： | 1 |
| 11 | RANKL and OPG regulation of bone remodeling in health and disease 显示文摘 | Ann E K Sundeep K Paul K | 2008 | Endocrine Reviews2008，29，2： | 1 |
| 12 | Cerebrovascular angioplasty and stenting for the Prevention of stroke显示文摘 | John C. Chaloupka MD John B. Weigele MD PhD Sundeep Mangla MD Walter S. Lesley MD | 2001 | Current Neurology and Neuroscience Reports2001，，1： | 1 |
| 13 | Acute exposure to diesel exhaust increases 11,-8 and GRO-α production in healthy human airways显示文摘 | Sundeep SS Charlotta N Anders B | 2000 | Am J Respir Crit Care Meal2000，161，： | 1 |
| 14 | Acute Pancreatitis During Pregnancy显示文摘 | Shou–Jiang Tang Edmundo Rodriguez–Frias Sundeep Singh Marlyn J. Mayo Saad F. Jazrawi Jayaprakash Sreenarasimhaiah Luis F. Lara Don C. Rockey | 2010 | Clinical Gastroenterology and Hepatology2010，，1： | 1 |
| 15 | Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes显示文摘 | Thierry T Francesca G Sundeep K | | 0，，： | 1 |
| 16 | Cytokine-specific induction of the TGF-β family 显示文摘 | Theresa EH Subramaniam M Sundeep K | 2000 | J Cell Biochem2000，78，： | 1 |
| 17 | In situ nitridation of titanium–molybdenum alloys during laser deposition显示文摘 | Tushar Borkar Sundeep Gopagoni Soumya Nag J. Hwang Peter Collins Rajarshi Banerjee | 2012 | Journal of Materials Science2012，，20： | 1 |
| 18 | Endoscopic or Percutaneous Biliary Drainage for Gallbladder Cancer: A Randomized Trial and Quality of Life Assessment显示文摘 | Sundeep Singh Saluja Manpreet Gulati Pramod Kumar Garg Hemraj Pal Sujoy Pal Peush Sahni Tushar K. Chattopadhyay | 2008 | Clinical Gastroenterology and Hepatology2008，，： | 1 |
| 19 | Analysing the benefits of laparoscopic hernia repair compared to open repair显示文摘 | Sarah AS Sundeep T Sukhmeet SP | 2012 | J Mini Access Surg2012，，： | 1 |
| 20 | Experimental investigations to study the effect of carbon nanotubes reinforced in cement -based matrix composite beams 显示文摘 | Hunashyal A M Sundeep G V Quadri S S | 2011 | Proceedings of the Institution of Mechanical Engineers Part N: Jour- nal of Nanoengineering and Nanosystems2011，225，1： | 1 |
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