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| 1 | 曲马多治疗糖尿病性神经疼痛的双盲随机试验显示文摘目的 :本研究旨在评价曲马多治疗糖尿病性神经痛的有效性和安全性。背景 :糖尿病性神经痛是糖尿病患者的主要症状 ,其治疗和其他的末梢神经病变一样 ,不能令人满意。曲马多是作用于中枢的镇痛剂 ,用于治疗中到重度疼痛。方法 :多中心、门诊病例、随机、双盲、安慰剂做对照、设置平行组的研究 ,包括清洗期 (在此期间停用所有镇痛剂 )和一个为期 42天的双盲治疗期。总共有 1 31名患糖尿病性神经痛的患者按每日 4次接受了曲马多 (n =65)或看上去与曲马多相同的安慰剂胶囊治疗 (n =66)。 42天的治疗结束后或治疗中断后比较曲马多组和安慰剂组平均疼痛强度评分作出主要有效性分析 ;次要有效性分析为疼痛缓解率评分和根据日常活动和睡眠状况作出的对生活质量的评估。结果 :曲马多平均剂量为 2 1 0mg/天 ,治疗糖尿病性神经痛较安慰剂有显著疗效 (P≤ 0 .0 0 1 )。曲马多组患者生理(P =0 .0 2 )和社会功能 (P =0 .0 4 )的评分显著优于安慰剂组。未发现对睡眠有显著治疗作用。曲马多最常见的不良反应是恶心 ,便秘 ,头疼和嗜睡。结论 | Harati Y Gooch C Swenson M Green D Raskin P Donofrio P Cornblath D Sachdeo R Siu CO Kamin M | 2001 | 中国疼痛医学杂志2001，7，1： | 2 |
| 2 | Attracting foreign manufacturing: investment promotion and agglomeration 显示文摘 | Head C K Ries J C Swenson D L | 1999 | Regional Science and Urban Economics1999，29，2： | 1 |
| 3 | Attracting foreign manufacturing:investment promotion and agglomeration 显示文摘 | Head C K Ries J C Swenson D L | 1999 | Regional Science and Urban Economics1999，29，： | 1 |
| 4 | Synthesis and Structures of Mono-and Bis(amidinate)Complexes of Aluminum显示文摘 | Coles M P Swenson D C Jordan R F | 1997 | Organometallics1997，16，： | 1 |
| 5 | Optimized intermolecular potential functions for liquid hydrocarbons显示文摘 | Jorgensen W L Madura J D Swenson C J | 1984 | Journal of the American Chemical Society1984，106，22： | 1 |
| 6 | Electron-impact-ionization Cross-section Measurements for Ti11+ and Cr13+ 显示文摘 | Wang L J Swenson D R | 1990 | Phys Rev1990，41，11： | 1 |
| 7 | ICF ignition capsule neutron, gamma ray, and high energy x-ray images显示文摘 | Bradley P A Wilson D C Swenson F J | 2003 | Rev Sci In- strum2003，74，3： | 1 |
| 8 | On the Determination of Diffusion Coefficients in Multi-phase Ternary Couples显示文摘 | Jan C H Swenson D Zheng X Y | 1991 | Acta Metallurgical Material1991，39，3： | 1 |
| 9 | Fixation of phosphate by iron and aluminum and replacement by organic and inorganic ions 显示文摘 | Swenson R M Cole C V Sieling D H | 1949 | Soil Sci1949，67，： | 1 |
| 10 | Attracting foreign manufacturing:investment promotion and agglomeration显示文摘 | Head K C Ries J C Swenson D L | 1999 | Regional Science and Urban Economics1999，29，2： | 1 |
| 11 | Optimized intermolecular potential functions for liquid hydrocarbons显示文摘 | Jorgensen W L Madura J D Swenson C J | 1984 | Journal of the American Chemical Society1984，106，22： | 1 |
| 12 | The performance and carcass composition responses of finishing swine to arange of porcine somatotropin doses in a 1-week delivery system显示文摘 | KNIGHT C D KASSER T R SWENSON G H | 1991 | J Anim Sci1991，69，10： | 1 |
| 13 | The effect of aging on IgD receptor expression by T cells and its functional implications显示文摘 | Swenson C D Thorbecke G J | 1997 | Immunol Rev1997，160，： | 1 |
| 14 | Infrared spectroscopic studies of N, N-disubstituted amides as models for the peptide bond in hydrogen bonded interactions with water molecules 显示文摘 | HENSON D B SWENSON C A | 1973 | J Phys Chem1973，77，20： | 1 |
| 15 | Human T cell IgD receptors react with O-glycans on both human IgD and IgA1显示文摘 | Swenson C D Patel T Parekh R B | 1998 | Eur J Immunol1998，28，8： | 1 |
| 16 | Simulation of present-day and future permafrost and seasonally frozen ground conditions in CCSM4显示文摘 | LAWRENCE D M SLATER A G SWENSON S C | 2012 | Journal of Climate2012，25，： | 1 |
| 17 | Human T cell IgD receptors react with O-glycans on both human IgD and IgA1 显示文摘 | Swenson C D Patel T Parekh R B | 1998 | Eur J Immunol1998，28，8： | 1 |
| 18 | Climate model biases in sea-sonality of continental water storage revealed by satellitegravimetry显示文摘 | Swenson S C Milly P C D | 2006 | Water Resource Research2006，42，： | 1 |
| 19 | Attracting foreign manufacturing: investment promotion and agglomeration显示文摘 | Head C Ries J Swenson D | 1999 | Regional Science and Urban Economics1999，29，2： | 1 |
| 20 | Optimized Intermolecular Potential Functions for Liquid Hydrocarbons显示文摘 | Jorgensen W L Madura J D Swenson C J | 1984 | J Am Chem Soc1984，106，： | 1 |
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