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| 1 | Prevalence of H elicobacter pylori infection and the effect of its eradication on symptoms of functional dyspepsia in K ashmir, I ndia显示文摘 | Jaswinder Singh Sodhi Gul Javid Showkat Ali Zargar Syed Tufail Altaf Shah Bashir Ahmad Khan Ghulam Nabi Yattoo Ghulam Mohamad Gulzar Mushtaq Ahmad Khan Mohd Iqbal Lone Riyaz u Saif Shaheena Parveen Abid Shoukat | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 2 | The Scorpion Venom Peptide Smp76 Inhibits Viral Infection by Regulating Type-Ⅰ Interferon Response显示文摘Dengue virus(DENV) and Zika virus(ZIKV) have spread throughout many countries in the developing world and infect millions of people every year, causing severe harm to human health and the economy. Unfortunately, there are few effective vaccines and therapies available against these viruses. Therefore, the discovery of new antiviral agents is critical.Herein, a scorpion venom peptide(Smp76) characterized from Scorpio maurus palmatus was successfully expressed and purified in Escherichia coli BL21(DE3). The recombinant Smp76(rSmp76) was found to effectively inhibit DENV and ZIKV infections in a dose-dependent manner in both cultured cell lines and primary mouse macrophages. Interestingly,rSmp76 did not inactivate the viral particles directly but suppressed the established viral infection, similar to the effect of interferon(IFN)-b. Mechanistically, rSmp76 was revealed to upregulate the expression of IFN-b by activating interferon regulatory transcription factor 3(IRF3) phosphorylation, enhancing the type-Ⅰ IFN response and inhibiting viral infection.This mechanism is significantly different from traditional virucidal antimicrobial peptides(AMPs). Overall, the scorpion venom peptide Smp76 is a potential new antiviral agent with a unique mechanism involving type-Ⅰ IFN responses,demonstrating that natural AMPs can enhance immunity by functioning as immunomodulators. | Zhenglin Ji Fangfang Li Zhiqiang Xia Xingchen Guo Minjun Gao Fang Sun Yuting Cheng Yingliang Wu Wenxin Li Syed Abid Ali Zhijian Cao | 2018 | Virologica Sinica2018，33，6： | 2 |
| 3 | Ergonomics of gastrointestinal endoscopies:Musculoskeletal injury among endoscopy physicians,nurses,and technicians显示文摘BACKGROUND Musculoskeletal injuries(MSI)have plagued endoscopists and ancillary staff for decades without any innovative and strong ergonomic guidelines.It has placed a physical and mental strain on our endoscopists and ancillary staff.We have very have limited data supporting this claim in our region and most data is supported by western literature.AIM To document the prevalence of MSI,and awareness and practices of ergonomics by endoscopists and ancillary staff.METHODS This is an observational cross-sectional study,conducted in Karachi,a city that boasts the maximum number of daily endoscopies in the country.An eleven-point self-administered questionnaire was distributed and used to evaluate MSI and ergonomic adjustments amongst three tertiary care setups in Karachi.An onsite survey via a 13-point checklist for endoscopy suite facilities was used to assess the ergonomically friendly conveniences at five tertiary care setups in Karachi.A total of 56 participants replied with a filled survey.RESULTS There were 56 participants in total with 39(69.6%)males.Pain and numbness were documented by 75%of the patients,with pain in the neck(41.1%),lower back(32.1%),shoulder(21.4%),thumb(12.5%),hand(23.2%),elbow(8.9%),and carpal tunnel syndrome(CTS)(7.1%).Of those,33.3%attributed their symptoms to endoscopy, 14.2% said that symptoms were not caused by endoscopy, and 52.4% were notcertain whether endoscopy had caused their symptoms. Twenty-one point four percent of patientshad to take time off their work, while 33.9% took medications for pain. Ergonomic modifications toprevent musculoskeletal injury, including placement of endoscopic monitor at eye level and thecardiac monitor in front, stopping the procedure to move patients, sitting while performingcolonoscopy, and navigating height-adjustable bed were used by 21.4%. Nine out of 13 ergonomicfacilities were not present in all five tertiary care hospitals. Conveniences, such as anti-fatiguemats, height-adjustable computer stations, and time out between patients were not present.CONCLUSIONThree-fourth of our endoscopists reported MSI, of which more than half were not sure orattributed this problem to endoscopy. The prevalence of MSI warrants urgent attention. | Samana Zainab Shah Syed Tabish Rehman Aysha Khan Muhammad Muneeb Hussain Mohsin Ali Sonaila Sarwar Shahab Abid | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，3： | 0 |
| 4 | Current Progress of Phytomedicine in Glioblastoma Therapy显示文摘Glioblastoma multiforme,an intrusive brain cancer,has the lowest survival rate of all brain cancers.The chemotherapy utilized to prevent their proliferation and propagation is limited due to modulation of complex cancer signalling pathways.These complex pathways provide infiltrative and drug evading properties leading to the development of chemotherapy resistance.Therefore,the development and discovery of such interventions or therapies that can bypass all these resistive barriers to ameliorate glioma prognosis and survival is of profound importance.Medicinal plants are comprised of an exorbitant range of phytochemicals that have the broad-spectrum capability to target intrusive brain cancers,modulate anti-cancer pathways and immunological responses to facilitate their eradication,and induce apoptosis.These phytocompounds also interfere with several oncogenic proteins that promote cancer invasiveness and metastasis,chemotherapy resistance and angiogenesis.These plants are extremely vital for promising anti-glioma therapy to avert glioma proliferation and recurrence.In this review,we acquired recent literature on medicinal plants whose extracts/bioactive ingredients are newly exploited in glioma therapeutics,and also highlighted their mode of action and pharmacological profile. | Fahad Hassan Shah Saad Salman Jawaria Idrees Fariha Idrees Syed Turab Ali Shah Abid Ali Khan Bashir Ahmad | 2020 | Current Medical Science2020，40，6： | 0 |
| 5 | A macroscopic traffic model based on weather conditions显示文摘A traffic model based on the road surface conditions during adverse weather is presented. The surface of a road is affected by snow, compacted snow, and ice, which affects the traffic behavior. In this paper, a new macroscopic traffic flow model based on the transition velocity distribution is proposed which characterizes traffic alignment under adverse weather conditions. Two examples are considered to illustrate the effect of the transition velocity behavior on traffic velocity and density. Simulation results are presented which show that this model provides a more accurate characterization of traffic flow behavior than the well known Payne–Whitham model. The proposed model can be used to reduce accidents and improve road safety during adverse weather conditions. | Zawar H.Khan Syed Abid Ali Shah T.Aaron Gulliver | 2018 | Chinese Physics B2018，27，7： | 0 |
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