|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | New insights into eutrophication management:Importance of temperature and water residence time显示文摘Eutrophication and harmful cyanobacterial blooms threaten water resources all over the world.There is a great controversy about controlling only phosphorus or controlling both nitrogen and phosphorus in the management of lake eutrophication.The primary argument against the dual nutrients control of eutrophication is that nitrogen fixation can compensate the nitrogen deficits.Thus,it is of great necessary to study the factors that can significantly affect the nitrogen fixation.Due to the difference of climate and human influence,the water quality of different lakes(such as water temperature,N:P ratio and water residence time)is also quite different.Numerous studies have reported that the low N:P ratio can intensify the nitrogen fixation capacities.However,the effects of temperature and water residence time on the nitrogen fixation remain unclear.Thus,30 shallows freshwater lakes in the eastern plain of China were selected to measure dissolved N_(2) and Ar concentrations through N_(2):Ar method using a membrane inlet mass spectrometer to quantify the nitrogen fixation capacities and investigate whether the temperature and water residence time have a great impact on nitrogen fixation.The results have shown that the short lake water residence time can severely inhibit the nitrogen fixation capacities through inhibiting the growth of nitrogenfixing cyanobacteria,changing the N:P ratio and resuspending the solids from sediments.Similarly,lakes with low water temperature also have a low nitrogen fixation capacity,suggesting that controlling nitrogen in such lakes is feasible if the growth of cyanobacteria is limited by nitrogen. | Feng Zhao Xu Zhan Hai Xu Guangwei Zhu Wei Zou Mengyuan Zhu Lijuan Kang Yulong Guo Xingchen Zhao Zicong Wang Wei Tang | 2022 | Journal of Environmental Sciences2022，34，1： | 2 |
| 2 | The Scorpion Venom Peptide Smp76 Inhibits Viral Infection by Regulating Type-Ⅰ Interferon Response显示文摘Dengue virus(DENV) and Zika virus(ZIKV) have spread throughout many countries in the developing world and infect millions of people every year, causing severe harm to human health and the economy. Unfortunately, there are few effective vaccines and therapies available against these viruses. Therefore, the discovery of new antiviral agents is critical.Herein, a scorpion venom peptide(Smp76) characterized from Scorpio maurus palmatus was successfully expressed and purified in Escherichia coli BL21(DE3). The recombinant Smp76(rSmp76) was found to effectively inhibit DENV and ZIKV infections in a dose-dependent manner in both cultured cell lines and primary mouse macrophages. Interestingly,rSmp76 did not inactivate the viral particles directly but suppressed the established viral infection, similar to the effect of interferon(IFN)-b. Mechanistically, rSmp76 was revealed to upregulate the expression of IFN-b by activating interferon regulatory transcription factor 3(IRF3) phosphorylation, enhancing the type-Ⅰ IFN response and inhibiting viral infection.This mechanism is significantly different from traditional virucidal antimicrobial peptides(AMPs). Overall, the scorpion venom peptide Smp76 is a potential new antiviral agent with a unique mechanism involving type-Ⅰ IFN responses,demonstrating that natural AMPs can enhance immunity by functioning as immunomodulators. | Zhenglin Ji Fangfang Li Zhiqiang Xia Xingchen Guo Minjun Gao Fang Sun Yuting Cheng Yingliang Wu Wenxin Li Syed Abid Ali Zhijian Cao | 2018 | Virologica Sinica2018，33，6： | 2 |
| 3 | A lipid-based LMP2-mRNA vaccine to treat nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is a serious and highly invasive epithelial malignancy that is closely associated with Epstein‒Barr virus(EBV).Due to the lack of therapeutic vaccines for NPC,we selected EBV latent membrane protein 2(LMP2)as a preferable targeting antigen to develop a lipid-based LMP2-mRNA(mLMP2)vaccine.Full-length mLMP2 expressing LMP2 was first synthesized using an in vitro transcription method and then encapsulated into(2,3-dioleacyl propyl)trimethylammonium chloride(DOTAP)-based cationic liposomes to obtain the mRNA vaccine(LPX-mLMP2).The cell assays showed that the antigenpresenting cells were capable of highly efficient uptake of LPX-mLMP2 and expression of LMP2.LMP2 could subsequently be presented to form the peptide-major histocompatibility complex(pMHC).Furthermore,LPX-mLMP2 could accumulate in the spleen,express antigens,promote the maturation of dendritic cells and stimulate antigen-specific T-cell responses in vivo.It dramatically inhibited the tumor growth of the LMP2-expressing tumor model after three doses of vaccination.Additionally,the proliferation of antigen-specific T cells in the tumor site made a good sign for the promise of mRNA vaccines in virus-induced cancer.Overall,we provided a newly developed antigen-encoding mRNA vaccine with advantages against NPC.We also demonstrated that mRNA vaccines are attractive candidates for cancer immunotherapy. | Mengran Guo Xing Duan Xingchen Peng Zhaohui Jin Hai Huang Wen Xiao Qian Zheng Yongqi Deng Na Fan Kepan Chen Xiangrong Song | 2023 | Nano Research2023，16，4： | 1 |
| 4 | Supramolecular electrostatic self-assembly of mesoporous thin-walled graphitic carbon nitride microtubes for highly efficient visible-light photocatalytic activities显示文摘For efficient solar energy conversion,the morphology engineering of hollow graphitic carbon nitride(gC3 N4)is one of the promising approachs benefiting from abundant exposed active sites and short photocarrier transport distances,but is difficult to control on account of easy structural collapse.Herein,a facile supramolecular electrostatic self-assembly strategy has been developed for the first time to fabricate mesoporous thin-walled g-C3N4 microtubes(mtw-CNT)with shell thickness of ca.13 nm.The morphological control of g-C3N4 enhances specific surface area by 12 times,induces stronger optical absorption,widens bandgap by 0.18 e V,improves photocurrent density by 2.5 times,and prolongs lifetimes of charge carriers from bulk to surface,compared with those of bulk g-C3N4.As a consequence,the transformed g-C3N4 exhibits the optimum photocatalytic H2-production rate of 3.99 mmol·h^-1·g^-1(λ>420 nm)with remarkable apparent quantum efficiency of 8.7%(λ=420±15 nm)and long-term stability.Moreover,mtw-CNT also achieves high photocatalytic CO2-to-CO selectivity of 96%(λ>420 nm),much better than those on the most previously reported porous g-C3N4 photocatalysts prepared by the conventional hard-templating and soft-templating methods. | Yilin Chen Xingchen He Dongsheng Guo Yanqin Cai Jingling Chen Yun Zheng Bifen Gao Bizhou Lin | 2020 | Journal of Energy Chemistry2020，29，10： | 1 |
| 5 | RING finger 138 deregulation distorts NF-κB signaling and facilities colitis switch to aggressive malignancy显示文摘Prolonged activation of nuclear factor(NF)-кB signaling significantly contributes to the development of colorectal cancer(CRC).New therapeutic opportunities are emerging from targeting this distorted cell signaling transduction.Here,we discovered the critical role of RING finger 138(RNF138)in CRC tumorigenesis through regulating the NF-кB signaling,which is independent of its Ubiquitin-E3 ligase activity involved in DNA damage response.RNF138^(−/−) mice were hyper-susceptible to the switch from colitis to aggressive malignancy,which coincided with sustained aberrant NF-кB signaling in the colonic cells.Furthermore,RNF138 suppresses the activation of NF-кB signaling pathway through preventing the translocation of NIK and IKK-Beta Binding Protein(NIBP)to the cytoplasm,which requires the ubiquitin interaction motif(UIM)domain.More importantly,we uncovered a significant correlation between poor prognosis and the downregulation of RNF138 associated with reinforced NF-кB signaling in clinical settings,raising the possibility of RNF138 dysregulation as an indicator for the therapeutic intervention targeting NF-кB signaling.Using the xenograft models built upon either RNF138-dificient CRC cells or the cells derived from the RNF138-dysregulated CRC patients,we demonstrated that the inhibition of NF-кB signaling effectively hampered tumor growth.Overall,our work defined the pathogenic role of aberrant NF-кB signaling due to RNF138 downregulation in the cascade events from the colitis switch to colonic neoplastic transformation and progression,and also highlights the possibility of targeting the NF-кB signaling in treating specific subtypes of CRC indicated by RNF138-ablation. | Yalan Lu Rong Huang Jianming Ying Xingchen Li Tao Jiao Lei Guo Haitao Zhou Han Wang Amannisa Tuersuntuoheti Jianmei Liu Qichen Chen Yanhong Wang Luying Su Changyuan Guo Fu Xu Ziyi Wang Yan Lu Kai Li Junbo Liang Zhen Huang Xiao Chen Jinjie Yao Hanjie Hu Xiaowen Cheng Yufeng Wan Xinyan Chen Ning Zhang Shiying Miao Jianqiang Cai Linfang Wang Changzheng Liu Wei Song Hong Zhao | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
| 6 | Angle Scattering Method for Soot Concentration Measurement under Ultra-Low Emissions Condition显示文摘Aiming at the problem of soot concentration measurement under ultra-low emission conditions,a forward small angle soot concentration measurement method is proposed.Taking a typical boiler emission of 0.1μm-3.0μm bimodal distribution soot as an object,the particle scatter simulation calculation under different parameters is carried out,and the influence of detection angle and particle size on the angular scatteringmeasurement of ultra-low emission soot is analyzed.The influence of detection angle and particle size on the angular scatteringmeasurement of ultra-lowemission soot is analyzed.Preferably,thewavelength of incident light is 650 nm,and the forward detection angle parameter is 15◦for the design of forward small angle soot concentration measurement system.An experimental system for measuring soot with standard concentration is built.Experiments of particle concentration measurement of 1.0μm and 3.0μm under ultra-low emission conditions are carried out.The results show that the average deviation of soot concentration measurement is less than 0.10 mg/m3 under the condition of ultra-low emission by using 15◦of forward detection,which provides an effective way for monitoring ultra-low emission soot concentration in coal-fired power plants. | Bin Yang Xingchen Zhu Jie Deng Xiaoxu Guo Jinke Han Xiaowei Liu | 2022 | Energy Engineering2022，119，2： | 0 |
| 7 | Patterning of large area nanoscale domains in as-grown epitaxial ferroelectric PbTiO_(3)films显示文摘Effective tuning of nanoscale domain structures provides fundamental basis for controlling and engineering of various functionalities in ferroelectric materials.In this work,we demonstrate the precise patterning of nanoscopic domain structures in as-grown epitaxial PbTiO_(3)(PTO)films by merely introducing an ultrathin pre-patterned doping layer(e.g.,Fe-doped PTO).The doping layer can effectively reverse the interfacial built-in bias,consequent to a reversed initial polarization reorientation in the as-grown film,which makes it possible to transfer the nano-patterns in the doping layer into the domain structure of ferroelectric films.For instance,we have successfully fabricated large area ordered array of nanoscale cylindrical domains(downward polarization)embedded in the matrix domain with opposite polarization(upward polarization)in PTO film.These nanoscale cylinder domains also allow deterministic and reversible erasure and creation induced by biased tip scanning.The results provide an effective pathway for on-demand patterning of large area nanoscale domains in the as-grown films,which may find applications in a wide range of nanoelectronic devices. | Luyong Zhang Guo Tian Wenda Yang Dongfeng Zheng Chuanjie Lin Jianbiao Xian Yihang Guo Xingchen Zhang Xiuqin Qiu Lanping Zhang Zhen Fan Deyang Chen Zhipeng Hou Minghui Qin Jun-Ming Liu Xingsen Gao | 2023 | Journal of Materiomics2023，9，1： | 0 |
| 8 | Creation and erasure of polar bubble domains in PbTiO_(3)films by mechanical stress and light illuminations显示文摘The controllable manipulation of polar topological structures(e.g.skyrmion bubble)in ferroelectric materials have been considered as a cornerstone for future programmable nano-electronics.Here,we present the effective creation and erasure of polar bubble states PbTiO_(3)(PTO)multilayers trigged by mechanical stress and light illumination,respectively.It was found that applying atomic force microscope(AFM)tip force can induced formation of nanoscale bubble domains from the initial monodomain state.Moreover,the created bubble domain can be eliminated by exposure to ultraviolet or infrared light illumination.The above results can be understood by modulation of depolarization screening charges and bias fields,as reflected by scanning Kelvin potential microscopic(SKPM)observations,whereby the flexoelectric effect from the tip force tends to remove the screening charges on top surface and modulate the bias field that favors the formation of bubble state while light illumination tends to recover the screen charges and favor the monodomain state.The results provide a good example for multi-field manipulation of polar topologies,which might create a new avenue towards the immerging new concept electronic devices. | Xingchen Zhang Hongying Chen Guo Tian Wenda Yang Zhen Fan Zhipeng Hou Deyang Chen Min Zeng Minghui Qin Jinwei Gao Xingsen Gao Jun-Ming Liu | 2023 | Journal of Materiomics2023，9，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员