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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Concordance between functional magnetic resonance imaging and introperative language mapping显示文摘 | MAXIMILIAN I R JONATHAN D V SYED H | 1999 | Stereotact Funct Neurosurg1999，72，4： | 1 |
| 3 | Cross-talk between probiotic bacteria and the bost immune system 显示文摘 | CORTH? SY B GASKINS H R MERCENIER A | 2007 | J Nutr2007，1373，： | 1 |
| 4 | Occurrence of polycyelie aromatic hydrocarbons in the Soan River, Pakistan : Insights into distribution, composition, sources and ecological risk assessment 显示文摘 | Aziz F Syed J H Malik R N | 2014 | Ecotoxicology and Environmental Safety2014，109，： | 1 |
| 5 | Occurrence of polycyclic aromatic hydrocarbons in the Soan River, Pakistan: insights into distribution, composition, sources and ecological risk assessment 显示文摘 | Aziz F Syed J H Malik R N | 2014 | Ecotoxicology and Environmental Safety2014，109，： | 1 |
| 6 | Inhibition of phospholipase Cγ1 by the prenylated flavonoids from Sophora flavescens 显示文摘 | Lee HS Ko H R Ryu SY | 1997 | Planta M edica1997，63，3： | 1 |
| 7 | Organochlorine pesticides in air and soil and estimated air-soil exchange in Punjab, Pakistan显示文摘 | Syed J H Malik R N Liu D | 2013 | Science of the Total Environment2013，444，： | 1 |
| 8 | Losartan reverses glomerularpodocytes injury induced by Angll via stabilizing theexpression of glutl 显示文摘 | Yu SY Qi R Zhao H | 2013 | Mol Biol Rep2013，40，11： | 1 |
| 9 | Biology and behavior of diamond back moth Plutella xylostella (L)显示文摘 | SOOMRO R A SYED T S | 1990 | J Zool1990，24，： | 1 |
| 10 | Thermal diffusivity and conductivity of dense polycrystalline ZrO2 ceramics:a survey显示文摘 | Hasselman D P H Johnson L F Bentsen L D Syed R Lee H L Swain M | 1987 | Am Ceram Soc Bull1987，66，5： | 1 |
| 11 | Effects of clopidogrel therapy on oxidative stress, inflammation, vascular function, and progenitor cells in stable coronary artery disease显示文摘 | Ramadan R Dhawan SS Syed H | 2014 | J Card- iovasc Pharmacol2014，63，4： | 1 |
| 12 | Urological injuries during hysterectomies:a6year review显示文摘 | Gowri D Predid R Syed H | 2007 | Obstet Gynecol2007，30，6： | 1 |
| 13 | Losartan reverses glomerular podocytes injury induced by AnglI via stabilizing the expression of GLUT1 显示文摘 | Yu SY Qi R Zhao H | 2013 | Molecular biology reports2013，40，11： | 1 |
| 14 | Differential impact of Korean banking system reforms on bank productivity显示文摘 | BANKER R D CHANG H LEE SY | 2010 | Journal of Banking & Finance2010，34，： | 1 |
| 15 | Determination of anisotropic deformability parameters from a single standard rock specimen显示文摘 | GONZAGA G G LEITE M H CORTHéSY R | 2008 | International Journal of Rock Mechanics and Mining Sciences2008，45，8： | 1 |
| 16 | Factors Affecting Microbial Degradation of Polycyclic Aromatic Hydrocarbon Phenanthrene in the Caribbean Coastal Water 显示文摘 | Baqar R Zaidi Syed H IMA | 1999 | Marine Pollution Bulletin1999，38，8： | 1 |
| 17 | Fast attack detection using correlation and summarizing of security alerts in grid com- puting networks显示文摘 | Syed R H Pazardzievska J Bourgeois J | 2012 | The Journal of Supereomputing2012，62，2： | 1 |
| 18 | In situ detection of Aspergillus fumigatus显示文摘 | Hanazawa R Murayama SY Yamaguchi H | 2000 | J Med Microbiol2000，49，： | 1 |
| 19 | Daearbazine-based chemotherapy as first-line treatment in noneutaneous metastatic melanoma: multi center, retrospective analysis in Asia显示文摘 | Yi JH Yi SY Lee H R | 2011 | Melanoma Res2011，21，3： | 1 |
| 20 | Effect of organic acids and spices on quality and shelf-life of meats at ambient temperature显示文摘 | SYED Z K SUBBA R H FAIROZE N | 1996 | Journal of Food Science and Technology1996，33，3： | 1 |
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