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| 1 | Neoadjuvant and adjuvant treatment strategies for hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is the most common liver malignancy worldwide and a major cause of cancer-related mortality for which liver resection is an important curative-intent treatment option. However, many patients present with advanced disease and with underlying chronic liver disease and/or cirrhosis, limiting the proportion of patients who are surgical candidates. In addition, the development of recurrent or de novo cancers following surgical resection is common. These issues have led investigators to evaluate the benefit of neoadjuvant and adjuvant treatment strategies aimed at improving resectability rates and decreasing recurrence rates. While high-level evidence to guide treatment decision making is lacking, recent advances in locoregional and systemic therapies, including antiviral treatment and immunotherapy, raise the prospect of novel approaches that may improve the outcomes of patients with HCC. In this review, we evaluate the evidence for various neoadjuvant and adjuvant therapies and discuss opportunities for future clinical and translational research. | Clifford Akateh Sylvester M Black Lanla Conteh Eric D Miller Anne Noonan Eric Elliott Timothy M Pawlik Allan Tsung Jordan M Cloyd | 2019 | World Journal of Gastroenterology2019，25，28： | 16 |
| 2 | Diversification of the RAB Guanosine Triphosphatase Family in Dicots and Monocots显示文摘RAB 海鸟粪正弦 triphosphatases (GTPases ) 是 vesicletrafficking 的关键管理者并且对所有真核细胞的细胞的生长和发展必要。Duringevolution, RAB 家庭在不同模式膨胀了便于不同细胞、发展、生理的改编。酵母有 11 个仅仅家庭成员,而 mammalianRABshave 膨胀了到 18 个 RAB 亚科。植物 RAB 有首先由是复制在内的成员多样化壁炉亚科。植物 RAB 被划分成八个亚科,相应于 mammalianRAB1, RAB2, RABS, RAB6, RAB7, RABS, RAB11 和 RAB18。这些的功能的多样化被 RAB11s 例示,哪个在他们工作在局部性的尖端生长期间搬运泡的植物被划分成唯一的房间分隔空间的 orthologs。同样,在草的 RAB2 家庭多半涉及与墙扩大联系的泡分泌物,作为在表示上异种的 determinedbyanalysis。我们建议 dicots 和单音的简易窄床也在 theirRAB 侧面分叉提供在二个组之间的唯一的细胞的功能。这里我们在场比较米饭,玉米和 Arabidopsis 的 theRAB 亚科的生物信息学分析。这些结果愿望指南未来功能的研究到为亚科的多样化的角色的测试与 dicots 相比的唯一的 tomonocots。 | Jiaming Zhang Daniel R. Hill Anne W. Sylvester | 2007 | Journal of Integrative Plant Biology2007，49，8： | 15 |
| 3 | 近红外激发荧光光谱与拉曼光谱快速鉴别马铃薯品种显示文摘马铃薯是世界上最重要的食物之一,快速无损的进行马铃薯品种鉴别对其在应用中更好的发挥品种优势具有重要作用。研究了以近红外荧光光谱和近红外拉曼光谱的土豆品种鉴别,并对两者进行了比较。实验采用3个品种共98个土豆样本,随机将其分成校正集(74个)和预测集(24个)。首先使用785nm近红外激光激发,采集所有样本的荧光和拉曼混合光谱,然后从混合光谱中分别提取荧光光谱和拉曼光谱,最后对荧光光谱和拉曼光谱进行偏最小二乘判别分析(PLS-DA),PLS-DA模型采用留一法和全交互验证。结果显示,荧光光谱与拉曼光谱都能够对三个马铃薯品种进行鉴别,其中荧光光谱的PLS-DA模型预测Favorita品种效果较好(灵敏度为1,特异性0.86,准确性0.92),但Diamant品种(灵敏度为0.75,特异性0.75,准确性0.75)和Granola品种(灵敏度为0.16,特异性0.89,准确性0.71)预测的效果较差,而拉曼光谱图很好的解释了马铃薯中的主要营养成分,基于拉曼光谱的PLSDA模型的预测效果(三个品种预测灵敏度,特异性,准确性均为1)比荧光光谱判别效果显著提高。 | 代芬 Mads Sylvest Bergholt Arnold Julian Vinoj Benjamin 洪添胜 Zhiwei Huang | 2014 | 光谱学与光谱分析2014，34，3： | 10 |
| 4 | Complementation and Expression Analysis of SoRablA and SoRab2A in Sugarcane Demonstrates Their Functional Diversification显示文摘 | Jia-Ming Zhang Anne W Sylvester Ding-Qin Li Xue-Piao Sun | 2006 | Journal of Integrative Plant Biology2006，48，12： | 6 |
| 5 | Preservation solutions used during abdominal transplantation:Current status and outcomes显示文摘Organ preservation remains an important contributing factor to graft and patient outcomes. During donor organ procurement and transportation, cellular injury is mitigated through the use of preservation solutions in conjunction with hypothermia. Various preservation solutions and protocols exist with widespread variability among transplant centers. In this review of abdominal organ preservation solutions, evolution of transplantation and graft preservation are discussed followed by classification of preservation solutions according to the composition of electrolytes, impermeants, buffers, antioxidants, and energy precursors. Lastly, pertinent clinical studies in the setting of hepatic, renal, pancreas, and intestinal transplantation are reviewed for patient and graft survival as well as financial considerations. In liver transplants there may be some benefit with the use of histidine-tryptophan-ketoglutarate(HTK) over University of Wisconsin solution in terms of biliary complications and potential cost savings. Renal grafts may experience increased initial graft dysfunction with the use of Euro-Collins thereby dissuading its use in support of HTK which can lead to substantial cost savings. University of Wisconsin solution and Celsior are favored in pancreas transplants given the concern for pancreatitis and graft thrombosis associated with HTK. No difference was observed with preservation solutions with respect to graft and patient survival in liver, renal, and pancreas transplants. Studies involving intestinal transplants are sparse but University of Wisconsin solution infused intraluminally in combination with an intra-vascular washout is a reasonable option until further evidence can be generated. Available literature can be used to ameliorate extensive variation across centers while potentially minimizing graft dysfunction and improving associated costs. | Nicholas Latchana Joshua R Peck Bryan A Whitson Mitchell L Henry Elmahdi A Elkhammas Sylvester M Black | 2015 | World Journal of Transplantation2015，5，4： | 5 |
| 6 | Antidiabetic principles of Loranthus micranthus Linn.parasitic on Persea americana显示文摘Objective:To explore antidiabetic principles of the Eastern Nigeria mistletoe,Loranlhus micranthus Linn,parasitic on Persea Americana.Methods:The weakly acidic fraction of the aqueous methanol extract of the leaves of Loranlhus micranthus(Linn.) was isolated and tested for its antidiabetic activities.The isolation of the weakly acidic fraction was carried out following established physico-chemical based procedures.Furthermore,alloxan-induced diabetic rats were treated intraperitoneally(ip) with 250 mg/kg and 400 mg/kg of the weakly acidic fraction, glibenclamide 10 mg/kg(positive control) and 2 mg/kg of 3%v/v tween 20(negative control).The sugar levels of the treated and untreated animals were determined by withdrawing the blood at regular intervals and testing them with an automated glucometer.The phytochemical analysis of the acidic fraction was carried out using standard procedures.Chromatographic techniques were employed in the subsequent isolation and purification of the constituents of the weakly acidic fraction.Results:It was shown that the maximum effect of the weakly acidic fraction was obtained at 24 hours after administration and was found to be statistically comparable with that of the positive control.The phytochemical analysis revealed the presence of steroids,terpenoids, alkaloids,flavonoids,glycosides,carbohydrates,saponins,and acidic compounds in the crude extract and carbohydrates,flavonoids.terpenoids and oil in the weakly acidic fraction.Further purification of the weakly acidic fraction of the methanol extract using thin layer chromatography shows that toluene:methanol:diethyl amine(3:1:1) and chloroform:methanol:diethyl amine (9:1:1) are the best solvent system for the isolation of the various components of the weakly acidic fraction of the crude methanol extract of Loranlhus micranthus.Conclusions:The present study has led to the conclusion that the weakly acidic fraction of the plant under study has the potent antidiabetic activity and that the various components can be isolated using basic chromatographic techniques. | Patience Ogoamaka Osadebe Edwin Ogechukwu Omeje Sylvester Chukwuemeka Nworu Charles Okechukwu Esimone Philip Felix Uzor Ernest kenechukwu David John Uchechukwu Uzoma | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，8： | 4 |
| 7 | 为在尼日利亚的平淡的诊断上面的胃肠的内视镜检查法的镇静惯例显示文摘 AIM:To determine the sedation practices and preferences of Nigerian endoscopists for routine diagnostic upper gastrointestinal endoscopy.METHODS:A structured questionnaire containing questions related to sedation practices and safety procedures was administered to Nigerian gastrointestinal endoscopists at the 2011 annual conference of the Society for Gastroenterology and Hepatology in Nigeria which was held at Ibadan,June 23-35,2011.RESULTS:Of 35 endoscopists who responded,17(48.6%) used sedation for less than 25% of procedures,while 14(40.0%) used sedation for more than 75% of upper gastrointestinal endoscopies.The majority of respondents(22/35 or 62.9%) had less than 5 years experience in gastrointestinal endoscopy.The sedative of choice was benzodiazepine alone in the majority of respondents(85.7%).Opioid use(alone or in combination with benzodiazepines) was reported by only 5 respondents(14.3%).None of the respondents had had any experience with propofol.Non-anaesthesiologist-directed sedation was practiced by 91.4% of endoscopists.Monitoring of oxygen saturation during sedation was practiced by only 57.1% of respondents.Over half of the respondents(18/35 or 51.4%) never used supplemental oxygen for diagnostic upper gastrointestinal endoscopy.CONCLUSION:Sedation for routine diagnostic upper gastrointestinal endoscopy in Nigeria is characterized by lack of guidelines,and differs markedly from that in developed countries. | Sylvester Chuks Nwokediuko Olive Obienu | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，6： | 3 |
| 8 | Animal models of ex vivo lung perfusion as a platform for transplantation research显示文摘Ex vivo lung perfusion(EVLP) is a powerful experimental model for isolated lung research. EVLP allows for the lungs to be manipulated and characterized in an external environment so that the effect of specific ventilation/perfusion variables can be studied independent of other confounding physiologic contributions. At the same time,EVLP allows for normal organ level function and real-time monitoring of pulmonary physiology and mechanics. As a result,this technique provides uniqueadvantages over in vivo and in vitro models. Small and large animal models of EVLP have been developed and each of these models has their strengths and weaknesses. In this manuscript,we provide insight into the relative strengths of each model and describe how the development of advanced EVLP protocols is leading to a novel experimental platform that can be used to answer critical questions in pulmonary physiology and transplant medicine. | Kevin Nelson Christopher Bobba Samir Ghadiali Don Hayes Jr Sylvester M Black Bryan A Whitson | 2014 | World Journal of Experimental Medicine2014，4，2： | 2 |
| 9 | Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: a randomised trial显示文摘 | GHJ Mickisch A Garin H van Poppel L de Prijck R Sylvester | 2001 | The Lancet . 2001 (9286)2001，，： | 2 |
| 10 | Trends and outcomes of transarterial chemoembolization in hepatocellular carcinoma:a national survey显示文摘BACKGROUND:Transarterial chemoembolization(TACE) is a palliative procedure frequently used in patients with advanced hepatocellular carcinoma(HCC). We examined the national inpatient trends of TACE and related outcomes in the United States over the last decade.METHODS:We utilized the National Inpatient Sample(2002 to 2012) and performed trend analyses of TACE for HCC in all adult patients(age >18 years). Multivariate analyses for the outcomes of in-hospital 'procedure-related complications'(PRCs) and 'post-procedure complications'(PPCs) were performed. We also compared early(2002 to 2006) and late(2007 to 2012) eras by multivariate analyses to identify predictors of complications, healthcare resource utilization and mortality.RESULTS:Overall, 19058 patients underwent TACE for HCC where PRCs and PPCs were seen in 24.2% and 17.6% of patients, respectively. The overall trends in the use of TACE(P<0.001) and associated PRCs(P=0.006) were observed to be increasing. There was less mortality [adjusted Odds ratio(a OR):0.58; 95% CI:0.41, 0.82], reduced length of hospital stay(-1.87 days; 95% CI:-2.77,-0.97) and increased hospital charges($19232; 95% CI:11013, 27451) in the late era. Additionally, there was increased mortality(a OR:4.07; 95% CI:2.96, 5.59), PRCs(a OR:3.21; 95% CI:2.56, 4.02), and PPCs(a OR:2.70; 95% CI:2.11, 3.46) among patients with coagulopathy.CONCLUSIONS:There is an increasing trend of TACE utilization in HCC. However, the outcomes are worse in patients with coagulopathy. Although PRCs have increased, mortality has decreased in recent years. These findings should be considered during TACE evaluation in patients with HCC. | Khalid Mumtaz Nishi Patel Rohan M Modi Vihang Patel Alice Hinton James Hanje Sylvester M Black Somashaker Krishna | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，6： | 2 |
| 11 | miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection显示文摘 | Qi-Jing Li Jacqueline Chau Peter J.R. Ebert Giselle Sylvester Hyeyoung Min Gwen Liu Ravi Braich Muthiah Manoharan Juergen Soutschek Petra Skare Lawrence O. Klein Mark M. Davis Chang-Zheng Chen | 2007 | Cell2007，，1： | 2 |
| 12 | Oxidation of hydrogen sulfide by mixed cultures of Thiobacillus denitrificans and heterotrophs 显示文摘 | SUBLETTE K L SYLVESTER N D | 1987 | Biotechnol Bioeng1987，29，： | 2 |
| 13 | Oxidation of hydrogen sulfide by continuous cultures of thiobacillus denitrificans显示文摘 | SUBLETTE K L SYLVESTER N D | 1987 | Biotechnoiogy and Bioengineering1987，29，： | 2 |
| 14 | Predicting Recurrence and Progression in Individual Patients with Stage Ta T1 Bladder Cancer Using EORTC Risk Tables: A Combined Analysis of 2596 Patients from Seven EORTC Trials 显示文摘 | Richard J. Sylvester Adrian P.M. van der Meijden Willem Oosterlinck J. Alfred Witjes Christian Bouffioux Louis Denis Donald W.W. Newling Karlheinz Kurth | 2006 | European Urology2006，，3： | 2 |
| 15 | Identification and machine learning prediction of knee-point and knee-onset in capacity degradation curves of lithium-ion cells显示文摘High-performance batteries greatly benefit from accurate,early predictions of future capacity loss,to advance the management of the battery and sustain desirable application-specific performance characteristics for as long as possible.Li-ion cells exhibit a slow capacity degradation up to a knee-point,after which the degradation ac-celerates rapidly until the cell’s End-of-Life.Using capacity degradation data,we propose a robust method to identify the knee-point within capacity fade curves.In a new approach to knee research,we propose the concept‘knee-onset’,marking the beginning of the nonlinear degradation,and provide a simple and robust identifica-tion mechanism for it.We link cycle life,knee-point and knee-onset,where predicting/identifying one promptly reveals the others.On data featuring continuous high C-rate cycling(1C–8C),we show that,on average,the knee-point occurs at 95%capacity under these conditions and the knee-onset at 97.1%capacity,with knee and its onset on average 108 cycles apart.After the critical identification step,we employ machine learning(ML)techniques for early prediction of the knee-point and knee-onset.Our models predict knee-point and knee-onset quantitatively with 9.4% error using only information from the first 50 cycles of the cells’life.Our models use the knee-point predictions to classify the cells’expected cycle lives as short,medium or long with 88–90% accuracy using only information from the first 3–5 cycles.Our accuracy levels are on par with existing literature for End-of-Life prediction(requiring information from 100-cycles),nonetheless,we address the more complex problem of knee prediction.All estimations are enriched with confidence/credibility metrics.The uncertainty regarding the ML model’s estimations is quantified through prediction intervals.These yield risk-criteria insurers and manufacturers of energy storage applications can use for battery warranties.Our classification model provides a tool for cell man-ufacturers to speed up the validation of cell production techniques. | Paula Fermin-Cueto Euan McTurk Michael Allerhand Encarni Medina-Lopez Miguel F.Anjos Joel Sylvester Goncalo dos Reis | 2020 | Energy and AI2020，1，1： | 2 |
| 16 | A SINGLE IMMEDIATE POSTOPERATIVE INSTILLATION OF CHEMOTHERAPY DECREASES THE RISK OF RECURRENCE IN PATIENTS WITH STAGE Ta T1 BLADDER CANCER: A META-ANALYSIS OF PUBLISHED RESULTS OF RANDOMIZED CLINICAL TRIALS显示文摘 | RICHARD J. SYLVESTER WILLEM OOSTERLINCK ADRIAN P.M. van der MEIJDEN | 2004 | The Journal of Urology2004，，6： | 2 |
| 17 | Combining electroacupuncture and transcranial direct current stimulation as an adjuvant therapy enhances spontaneous conversation and naming in subacute vascular aphasia:A retrospective analysis显示文摘Objective:Emerging evidence shows the effectiveness of speech and language therapy(SLT);however,precise therapeutic parameters remain unclear.Evidence for the use of adjunctive transcranial direct current stimulation(t DCS)to treat post-stroke aphasia(PSA)is promising;however,the utility of combining t DCS and electroacupuncture(EA)has not yet been analyzed.This study assessed the therapeutic consequences of EA and t DCS coupled with SLT in subacute PSA patients who were also undergoing hyperbaric oxygen therapy(HBOT).Methods:A retrospective analysis was conducted on subacute(<6 months)PSA patients who were divided into three groups:patients who received EA plus t DCS(acupuncture group),patients who underwent t DCS(t DCS group),and patients who experienced conventional therapy(HBOT+SLT).All subjects underwent 21 days of treatment and also received conventional treatment.The aphasia battery of Chinese(ABC)was used to score pre-and post-intervention status.Results:The analysis comprised 238 patients.Cerebral infarction was the most frequent stroke type(137[57.6%]),while motor(66[27.7%])and global aphasia(60[25.2%])were the most common types of aphasia.After 21 days of intervention,the ABC scores of all patients were improved.The acupuncture group had the highest ABC scores,but only repetition,naming,and spontaneous speech were statistically improved(P<0.01).Post-hoc tests revealed significant improvement in word retrieval in the acupuncture and t DCS groups(P<0.01,P=0.037),while the acupuncture group had additional significant improvement in spontaneous conversation(P<0.01).Conclusion:Combining acupuncture and t DCS as an adjuvant therapy for subacute PSA led to significant spontaneous speech and word retrieval improvements.Future prospective,multi-ethnic,multi-center trials are warranted. | Samwel Sylvester Msigwa Yan Li Xiang-lin Cheng Fen Cao | 2022 | Journal of Integrative Medicine2022，20，3： | 2 |
| 18 | Performance and yield stability of maize hybrids in stress-prone environments in eastern Africa显示文摘Identification and deployment of high-yielding and stress-tolerant maize hybrids adapted to stress-prone agro-ecologies is important for improving the food security and livelihoods of smallholder farmers in eastern Africa.The objectives of this study were to(i)assess the performance of maize hybrids under well-watered and drought stress conditions;(ii)evaluate grain yield stability of 65 intermediate-maturing and 55 early-maturing hybrids in 24 well-watered locations and seven drought stress locations;and(iii)identify representative and/or discriminative testing locations for increasing genetic gains for the target traits.There were significant differences for grain yield among early-and intermediatematuring hybrids tested under well-watered and drought stress environments.Among the early-maturing hybrids,the top 10 hybrids produced 46.8%–73.9%and 31.2%–42.1%higher mean grain yields than the best commercial check under drought and well-watered conditions,respectively.Among the intermediate-maturing hybrids,the top 10 hybrids produced 25.2%–47.7%and 8.5%–13.5%higher grain yield than commercial checks under drought stress and well-watered conditions,respectively,suggesting improvement in the levels of drought tolerance in both early-and intermediate-maturing hybrids.GGE biplot analysis and a bi-segmented regression linear method identified specific early-maturing and intermediate-maturing hybrids that performed well under both well-watered and drought stress conditions.These hybrids could be recommended for commercial production in eastern Africa.Kakamega in Kenya was found to be the most representative and highly discriminating site among well-watered testing locations,while Kabuku in Tanzania was the least representative of test locations.For testing under drought stress conditions,Kiboko in Kenya was identified as the most representative location.This information could be useful for allocating resources and streamlining CIMMYT maize hybrid testing in eastern Africa. | Wender Santos Rezende Yoseph Beyene Stephen Mugo Eric Ndou Manje Gowda Julius Pyton Sserumaga Godfrey Asea Ismail Ngolinda McDonald Jumbo Sylvester O.Oikeh Michael Olsen Aluízio Borém Cosme Damião Cruz Boddupalli M.Prasanna | 2020 | The Crop Journal2020，8，1： | 2 |
| 19 | Early enteral feeding versus 'nil by mouth′after gastrointestinal surgery:systematic review and meta-analysis of controlled trials显示文摘 | Lewis SJ Egger M Sylvester PA | 2001 | BMJ2001，323，7316： | 1 |
| 20 | A bead-based activity screen for small-molecule inhibitors of signal transduetion in chronic myelogenous leukemia cells显示文摘 | Sylvester JE Kron SJ | 2010 | Mol Cancer Ther2010，9，5： | 1 |
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