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| 1 | Targeting circular RNAs as a therapeutic approach: current strategies and challenges显示文摘Significant progress has been made in circular RNA(circRNA)research in recent years.Increasing evidence suggests that circRNAs play important roles in many cellular processes,and their dysregulation is implicated in the pathogenesis of various diseases.CircRNAs are highly stable and usually expressed in a tissue-or cell type-specific manner.Therefore,they are currently being explored as potential therapeutic targets.Gain-of-function and loss-of-function approaches are typically performed using circRNA expression plasmids and RNA interference-based strategies,respectively.These strategies have limitations that can be mitigated using nanoparticle and exosome delivery systems.Furthermore,recent developments show that the cre-lox system can be used to knockdown circRNAs in a cell-specific manner.While still in the early stages of development,the CRISPR/Cas13 system has shown promise in knocking down circRNAs with high specificity and efficiency.In this review,we describe circRNA properties and functions and highlight their significance in disease.We summarize strategies that can be used to overexpress or knockdown circRNAs as a therapeutic approach.Lastly,we discuss major challenges and propose future directions for the development of circRNA-based therapeutics. | Alina T.He Jinglei Liu Feiya Li Burton B.Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 5 |
| 2 | The Lobster Eye Imager for Astronomy Onboard the SATech-01 Satellite显示文摘The Lobster Eye Imager for Astronomy(LEIA),a pathfinder of the Wide-field X-ray Telescope of the Einstein Probe mission,was successfully launched onboard the SATech-01 satellite of the Chinese Academy of Sciences on2022 July 27.In this paper,we introduce the design and on-ground test results of the LEIA instrument.Using stateof-the-art Micro-Pore Optics(MPO),a wide field of view of 346 square degrees(18.6°×18.6°)of the X-ray imager is realized.An optical assembly composed of 36 MPO chips is used to focus incident X-ray photons,and four large-format complementary metal-oxide semiconductor(CMOS)sensors,each of size 6 cm×6 cm,are used as the focal plane detectors.The instrument has an angular resolution of 4’-8’(in terms of FWHM)for the central focal spot of the point-spread function,and an effective area of 2-3 cm^(2) at 1 keV in essentially all the directions within the field of view.The detection passband is 0.5-4 keV in soft X-rays and the sensitivity is2-3×10^(-11) erg s^(-1) cm^(-2)(about 1 milliCrab)with a 1000 s observation.The total weight of LEIA is 56 kg and the power is 85 W.The satellite,with a design lifetime of 2 yr,operates in a Sun-synchronous orbit of 500 km with an orbital period of 95 minutes.LEIA is paving the way for future missions by verifying in flight the technologies of both novel focusing imaging optics and CMOS sensors for X-ray observation,and by optimizing the working setups of the instrumental parameters.In addition,LEIA is able to carry out scientific observations to find new transients and to monitor known sources in the soft X-ray band,albeit with limited useful observing time available. | Z.X.Ling X.J.Sun C.Zhang S.L.Sun G.Jin S.N.Zhang X.F.Zhang J.B.Chang F.S.Chen Y.F.Chen Z.W.Cheng W.Fu Y.X.Han H.Li J.F.Li Y.Li Z.D.Li P.R.Liu Y.H.Lv X.H.Ma Y.J.Tang C.B.Wang R.J.Xie Y.L.Xue A.L.Yan Q.Zhang C.Y.Bao H.B.Cai H.Q.Cheng C.Z.Cui Y.F.Dai D.W.Fan H.B.Hu J.W.Hu M.H.Huang Z.Q.Jia C.C.Jin D.Y.Li J.Q.Li H.Y.Liu M.J.Liu Y.Liu H.W.Pan Y.L.Qiu M.Sugizaki H.Sun W.X.Wang Y.L.Wang Q.Y.Wu X.P.Xu Y.F.Xu H.N.Yang X.Yang B.Zhang M.Zhang W.D.Zhang Z.Zhang D.H.Zhao X.Q.Cong B.W.Jiang L.H.Li X.B.Qiu J.N.Sun D.T.Su J.Wang C.Wu Z.Xu X.M.Yang S.K.Zhang Z.Zhang N.Zhang Y.F.Zhu H.Y.Ban X.Z.Bi Z.M.Cai W.Chen X.Chen Y.H.Chen Y.Cui X.L.Duan Z.G Feng Y.Gao J.W.He T.He J.J.Huang F.Li J.S.Li T.J.Li T.T.Li H.Q.Liu L.Liu R.Liu S.Liu N.Meng Q.Shi A.T.Sun Y.M.Wang Y.B.Wang H.C.Wu D.X Xu Y.Q Yang Y.Yang X.S.Yu K.X.Zhang Y.L.Zhang Y.H.Zhang Y.T.Zhang H.Zhou X.C.Zhu J.S.Cheng L.Qin L.Wang Q.L.Wang M.Bai R.L.Gao Z.Ji Y.R.Liu F.L.Ma Y.J.Shi J.Su Y.Y.Tan J.Z.Tong H.T.Xu C.B.Xue G.F.Xue W.Yuan | 2023 | Research in Astronomy and Astrophysics2023，23，9： | 2 |
| 3 | A Reexamination of the Wealth Effect and Uncertainty Effect显示文摘 | Ling T.He Josephp Mcgarrity | | 0，，： | 1 |
| 4 | On the 40-50 day oscillation during the 1979 Northern Hemisphere Summer Part Ⅱ:Heat and moisture budget显示文摘 | Murakami T T.Nakazawa T.He | | 0，，： | 1 |
| 5 | Determinations of strategy responding to COVID-19显示文摘This study explores what determines the selection of strategies by governments responding to COVID-19.To answer the question,we propose concepts of individual utility and societal utility and build a simple model.By applying the model,we predict that countries with an individualist culture would adopt more passive strategies while countries with a collectivist culture would adopt more active strategies.The comparison between strategies adopted in China and in the United Kingdom supports the prediction.Furthermore,as the spread of COVID-19 virus continues,governments’response may change and individualist countries may switch to more active strategies.So we extend our model to incorporate the dynamics of strategy selection,and explain the switch between passive and active strategies.We then predict in particular that facing the unexpected infections and deaths,the countries with an individualist culture would temporally adopt a relatively more active strategy responding to COVID-19.The evidence from Spain shows the dynamic feature of strategy selection as predicted by our model. | Wilson X.B.Li Tina T.He | 2021 | Economic and Political Studies2021，9，2： | 0 |
| 6 | Government involvement in banking systems and economic growth:a comparison across countries显示文摘This study investigates 92 countries of different legal origins,including 25 English origin,44 French origin,11 Scandinavian and German origin,and 12 socialist origin countries.Compared to other countries,China has the highest government ownership of banks,and lies in the middle in terms of official supervisory power over banks,and government efficiency in governance.As regards economic development measured by per capita GDP growth,in the period from 1995 to 2015,China performed significantly better than all the other countries in the sample–countries varying in legal origin,government ownership of banks,level of economic and financial development,supervisory power over banks,and government efficiency.The findings are robust when we examine the country-years with similar per capita GDP as that of China.The regression results show that in some circumstances,higher government ownership of banks is associated with higher economic growth and the positive association is more significant in socialist origin countries.Further discussions suggest that the high government involvement in commercial banks fits in well with the unique characteristics of China–such as a large population,underdeveloped economy,imbalance in resources and development in different areas,as well as the utmost trust placed on the Chinese government and government owned banks–thus may benefit economic growth. | Wilson X.B.Li Tina T.He Stella P.L.Cho | 2019 | Economic and Political Studies2019，7，1： | 0 |
| 7 | MAGNETORESISTANCE EFFECT OBSERVED IN Fe/Mo MULTILAYERS PREPARED BY ELECTRON BEAM EVAPORATION显示文摘The Fe/Mo multilayers were prepared by electron beam evaporation, the microstructure and magnetic properties of the multilayers were studied by X-ray diffraction, vibratingsample magnetometer (VSM) et al. The experimental results revealed that the Fe/Mo multilayers in our experimental conditions behaved magnetoresistance effect with a sharp peak on magnetoresistance (MR) ratio curve, and magnetoresistance is easily saturated at low applied magnetic fields. For [Fe(1.5nm)/Mo(1.0nm)]42 multilayers,MR ratio could arrive to 0.1%. The antiferromagnetic interlayer coupling could be observed in some films at room temperature. The strength of the antiferromagnetic interlayer coupling J in the films is low because of the low saturation field Hs. The relationship between magnetic properties and microstructure was also discussed in this paper. | T.He B.Zhao Y.Gao F.Zeng F.Pan | 2003 | Acta Metallurgica Sinica(English Letters)2003，16，3： | 0 |
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