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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Expression of CD40 ligand in CD40-positive murine tumors activates transcription of the interleukin-23 subunit genes and produces antitumor responses显示文摘 | Wada A Tada Y Shimozato O | 2004 | Anticancer Res2004，24，5： | 1 |
| 3 | Relationship between two job stress models and coronary risk factors among Japanese part-time female employees of a retail company显示文摘 | Kobayashi Y Hirose T Tada Y ct al | 2005 | J Occup Health2005，47，3： | 1 |
| 4 | Approximate Transformation of an Arbitrary Curved Surface into a Plane Using Dynamic Programming显示文摘 | Shimada T Tada Y | 1991 | Computer - aided Design1991，23，2： | 1 |
| 5 | Differential effects of LPS and TGF-β on the production of IL-6 and IL-12 by langerhans cells,splenic dendritic cells,and macrophages显示文摘 | Tada Y Asahina A Fujita H | | 0，，04： | 1 |
| 6 | Flame retardant tetrabromobisphenol A induced hepatic changes in ICR male mice显示文摘 | Tada Y Fujitanit T Ogata A | 2007 | Environ Toxicol Pharmacology2007，23，2： | 1 |
| 7 | Thermal Conductivityof Polymer Composites With Close-Packed Structure ofNano and Micro Fillers 显示文摘 | Sanada K Tada Y Shindo Y | 2009 | Composites Part A: AppliedScience and Manufacturing2009，40，6： | 1 |
| 8 | Inflammatory pseudotumor of the parapharyngeal space:a case report显示文摘 | Maruya S Miura K Tada Y | 2010 | Auris Nasus Larynx2010，37，3： | 1 |
| 9 | Granulocyte/macrophage colony stimulating factor inhibits IL-12 production of mouse Langerhans cells 显示文摘 | Tada Y Asahina A Nakamura K | 2000 | Journal of Immunology2000，164，10： | 1 |
| 10 | Switching Surge Sparkover Characteristics of Air Gaps and Insulator Strings Under Practical Conditions显示文摘 | Udo T Tada T Watanabe Y | 1968 | IEEE Transactions on Power Apparatus and Systems1968，87，2： | 1 |
| 11 | Correlation of molecular genetic analysis of p53, MDM2, p16, PTEN, and EGFR and survival of patients with anaplastic astrocytoma and glioblastoma 显示文摘 | Ushio Y Tada K Shiraishi S | 2003 | Front Biosci2003，8，2： | 1 |
| 12 | Analysis of gene mutations in three cases of protuberans (DFSP) : ordinary DFSP, DFSP with fibrosarcomatous lesion (DFSP-FS) and lung metastasis of DFSP-FS显示文摘 | Saeki H I-Ioashi T Tada Y | 2003 | J Dermatol Sci2003，33，3： | 1 |
| 13 | The Nationwide GPS Array as an earth observation system 显示文摘 | Miyazaki S Hatanaka Y Sagiya T Tada T | 1998 | Bulletin of Geographical Survey Institute1998，44，： | 1 |
| 14 | Soft gel medium solidified with gellan gum forpreliminary screening for root-associating, free- living nitrogen-fixing bacteria inhabiting the rhizoplane of plants 显示文摘 | HASHIDOKO Y TADA M OSAKI M et aI | 2002 | Biosci Biotechnol Biochem2002，66，： | 1 |
| 15 | Endogenous IL-15 sustains recruitment of IL-2Rbeta and common gamma and IL-2-mediated chemokine production in normal and inflamed human gingival fibroblasts显示文摘 | Ozawa A Tada H Sugawara Y | 2004 | J Immunol2004，173，8： | 1 |
| 16 | A randomized trial comparing adjuvant chemo therapy versus surgery alone for completely resected pN2 non-small cell lung cancer (JCOG9304)显示文摘 | Tada H Tsuchiy R Ichinose Y | 2004 | Lung Cancer2004，4，3： | 1 |
| 17 | Improvement of electrode/organic layer interfafces by the insertion of monolayer-like aluminum oxide film显示文摘 | KUROSAKA Y TADA N OHMORI Y | 1998 | Jpn J Appl Phys1998，37，： | 1 |
| 18 | Tissue-specific light-regulated expression directed by the promoter of a Ca gene, maize pyruvate, orthophosphate dikinase, in a C3 plant, rice 显示文摘 | MATSUOKA M TADA Y FUJIMURA T | 1993 | Proc Natl Acad Sci USA1993，90，20： | 1 |
| 19 | Acid-base bifunctional catalytic surfaces for nucleophilic addition reactions 显示文摘 | MOTOKURA K TADA M IWASAWA Y | 2008 | Chemistry-An Asian Journal2008，3，89： | 1 |
| 20 | A patient of migraine-like headache with amnesia,pleocytosis and transient hypoperfusion of cerebral blood flow显示文摘 | Tada Y Negoro K Abe M | | 0，，： | 1 |
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