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| 1 | A current perspective of autophagosome biogenesis显示文摘Autophagy 是象滋养的饥饿那样的细胞的压力导致的一个体积降级系统。它的功能依靠泡把 autophagosomes 称为的双膜的形成。不同于看起来稳定地在房间存在的另外的细胞器, autophagosomes 在需求上被形成,并且一旦他们的形成被开始,它很快令人惊讶地继续。这动态 autophagosome 形成怎么并且在哪儿发生在 1990 年代的 Atg 蛋白质的一个长期的问题,而是发现显著地被加速了我们理解 autophagosome 生物的续生说。在这评论,我们将简短介绍每 Atg 在与 autophagosome 生物的续生说的关系的功能的单位,然后与处理这个问题的选择最近的研究的介绍讨论 autophagosomal 膜的起源。 | Shusaku T Shibutani | 2014 | Cell Research2014，24，1： | 41 |
| 2 | Pancreatic carcinoma coexisting with chronic pancreatitis versus tumor-forming pancreatitis:Diagnostic utility of the time-signal intensity curve from dynamic contrast-enhanced MR imaging显示文摘AIM: To evaluate the ability of the time-signal intensity curve (TIC) of the pancreas obtained from dynamic contrast-enhanced magnetic resonance imaging (MRI) for differentiation of focal pancreatic masses, especially pancreatic carcinoma coexisting with chronic pancreatitis and tumor-forming pancreatitis. METHODS: Forty-eight consecutive patients who underwent surgery for a focal pancreatic mass, including pancreatic ductal carcinoma (n = 33), tumor-forming pancreatitis (n = 8), and islet cell tumor (n = 7), were reviewed. Five pancreatic carcinomas coexisted with longstanding chronic pancreatitis. The pancreatic TICs were obtained from the pancreatic mass and the pancreatic parenchyma both proximal and distal to the mass lesion in each patient, prior to surgery, and were classified into 4 types according to the time to a peak: 25 s and 1, 2, and 3 min after the bolus injection of contrast material, namely, type-Ⅰ, Ⅱ, Ⅲ, and Ⅳ, respectively, and were then compared to the corresponding histological pancreatic conditions. RESULTS: Pancreatic carcinomas demonstrated type-Ⅲ (n = 13) or Ⅳ (n = 20) TIC. Tumor-forming pancreatitis showed type-Ⅱ (n = 5) or Ⅲ (n = 3) TIC. All islet cell tumors revealed type-Ⅰ. The type-Ⅳ TIC was only recognized in pancreatic carcinoma, and the TIC of carcinoma always depicted the slowest rise to a peak among the 3 pancreatic TICs measured in each patient, even in patients with chronic pancreatitis.CONCLUSION: Pancreatic TIC from dynamic MRI provides reliable information for distinguishing pancreatic carcinoma from other pancreatic masses, and may enable us to avoid unnecessary pancreatic surgery and delays in making a correct diagnosis of pancreatic carcinoma, especially, in patients with longstanding chronic pancreatitis. | Yoshitsugu Tajima Tamotsu Kuroki Ryuji Tsutsumi Ichiro Isomoto Masataka Uetani Takashi Kanematsu | 2007 | World Journal of Gastroenterology2007，13，6： | 28 |
| 3 | Mechanisms of resistance to spinosad in the western flower thrip, Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae)显示文摘spinosad 抵抗的继承的抗力移转,抗性机制,和模式在西方的花 thrip 被学习, Frankliniella 西方人(Pergande ) 。Spinosad (naturalyte 杀虫药剂) 显示出低抗力移转到 prothiophos (organophosphorus ) , chlorphenapyr (呼吸禁止者) 显示出一些抗力移转到 thiocyclam (沙蚕属毒素) 。信仰神人协力合作说者 PBO ( piperonyl 但是氧化物), DEM ( diethyl 男性吃了),并且 DEF ( s , s , s-tributyl phosphorotrithioate )没在抵抗紧张( ICS )在 spinosad 的毒性上显示出任何协同,显示那新陈代谢调停解毒不为 spinosad 抵抗负责,建议那 spinosad 可以减少目标地点的敏感:烟碱的醋胆素受体和伽马氨基丁酸受体。后面的正反交,剂量反应线和显性比显示 spinosad 抵抗是不完全地主导的,没有母体影响。回交的结果证明 spinosad 抵抗没适合一个单个基因的假设,建议抵抗被几基因影响。 | Shu-Yun Zhang Satoshi Kono Tamotsu Murai Tadashi Miyata | 2008 | Insect Science2008，15，2： | 18 |
| 4 | Visualizing the hepatic vascular architecture using superb microvascular imaging in patients with hepatitis C virus: A novel technique显示文摘AIM: To identify the hepatic vascular architecture of patients with hepatitis C virus(HCV) using superb microvascular imaging(SMI) and investigate the use of SMI in the evaluation of liver fibrosis.METHODS: SMI was performed in 100 HCV patients. SMI images were classified into five types according to the vascular pattern, and these patterns were compared with the fibrosis stage. Moreover, the images were analyzed to examine vascularity by integrating the number of SMI signals in the region of interest ROI [number of vascular trees(VT)]. The number of VT, fibrosis stage, serum parameters of liver function, and CD34 expression were investigated.RESULTS: There was a significant difference between SMI distribution pattern and fibrosis stage(P < 0.001). The mean VT values in each of the fibrosis stages were as follows: 26.69 ± 7.08 in F0, 27.72 ± 9.32 in F1, 36.74 ± 9.23 in F2, 37.36 ± 5.32 in F3, and 58.14 ± 14.08 in F4. The VT showed excellent diagnostic ability for F4 [area under the receiver operator characteristic(AUROC): 0.911]. The VT was significantly correlated with the CD34 labeling index(r = 0.617, P < 0.0001).CONCLUSION: SMI permitted the detailed delineation of the vascular architecture in chronic liver disease. SMI appears to be a reliable tool for noninvasively detecting significant fibrosis or cirrhosis in HCV patients. | Hidekatsu Kuroda Tamami Abe Keisuke Kakisaka Yudai Fujiwara Yuichi Yoshida Akio Miyasaka Kazuyuki Ishida Hideaki Ishida Tamotsu Sugai Yasuhiro Takikawa | 2016 | World Journal of Gastroenterology2016，22，26： | 12 |
| 5 | A NEW HIGH ORDER SCHEME FOR CONVECTION EQUATION AND ITS APPLICATION显示文摘With the undetermined coefficient method, a new high order scheme for convection equation named as HAUC was worke d out. The accuracy of the new scheme was analyzed by comparing the computed res ults with the exact solutions of 1-D pure convection equation and nonlinear con vection equation. The effectiveness of the HAUC was also examined by comparing w ith the results obtained by other schemes. Finally, it was applied to simulate 1 -D dam break flow with differenct ratios of initial upstream water depth to do wnstream one. The results show that the scheme has the ability to simulate both undular bores and moving hydraulic jumps. | Zhang Xiao-feng (Department of River Engineering, Wuhan University, Wuhan 430072, China) Zhang Hong-wu (Department of Hydraulic Engineering, Tsinghua University, Beijing 100084, China) Tamotsu Takahashi, Hajime Nakagawa (Disaster Prevention Research | 2002 | Journal of Hydrodynamics2002，14，1： | 10 |
| 6 | Extrahepatic collaterals and liver damage in embolotherapy for ruptured hepatic artery pseudoaneurysm following hepatobiliary pancreatic surgery显示文摘AIM: To evaluate the effects of extrahepatic collaterals to the liver on liver damage and patient outcome after embolotherapy for the ruptured hepatic artery pseudoa- neurysm following hepatobiliary pancreatic surgery. METHODS: We reviewed 9 patients who underwent transcatheter arterial embolization (TAE) for the ruptured hepatic artery pseudoaneurysm following major hepato- biliary pancreatic surgery between June 1992 and April 2006. We paid special attention to the extrahepatic arte- rial collaterals to the liver which may affect post-TAE liver damage and patient outcome. RESULTS: The underlying diseases were all malignan- cies, and the surgical procedures included hepatopancre- atoduodenectomy in 2 patients, hepatic resection with removal of the bile duct in 5, and pancreaticoduodenec- tomy in 2. A total of 11 pseudoaneurysm developed: 4 in the common hepatic artery, 4 in the proper hepatic artery, and 3 in the right hepatic artery. Successful he- mostasis was accomplished with the initial TAE in all patients, except for 1. Extrahepatic arterial pathways to the liver, including the right inferior phrenic artery, the jejunal branches, and the aberrant left hepatic artery, were identified in 8 of the 9 patients after the completion of TAE. The development of collaterals depended on the extent of liver mobilization during the hepatic resection, the postoperative period, the presence or absence of an aberrant left hepatic artery, and the concomitant arte- rial stenosis adjacent to the pseudoaneurysm. The liver tolerated TAE without significant consequences when at least one of the collaterals from the inferior phrenic ar-tery or the aberrant left hepatic artery was present. One patient, however, with no extrahepatic collaterals died of liver failure due to total liver necrosis 9 d after TAE. CONCLUSION: When TAE is performed on ruptured hepatic artery pseudoaneurysm, reduced collateral path- ways to the liver created by the primary surgical proce- dure and a short postoperative interval may lead to an unfavorable outcome. | Yoshitsugu Tajima Tamotsu Kuroki Ryuji Tsutsumi Ichiro Sakamoto Masataka Uetani Takashi Kanematsu | 2007 | World Journal of Gastroenterology2007，13，3： | 7 |
| 7 | Long‐term outcomes of endoscopic submucosal dissection for early gastric cancer: A single‐center retrospective study显示文摘 | Takashi Kosaka Masaki Endo Yosuke Toya Yukito Abiko Norihiko Kudara Masaaki Inomata Toshimi Chiba Yasuhiro Takikawa Kazuyuki Suzuki Tamotsu Sugai | 2014 | Digestive Endoscopy2014，，2： | 4 |
| 8 | 不溶性基质中天冬氨酸丰富的蛋白在珊瑚的钙质骨片形成中的重要作用显示文摘一般认为,酸性蛋白在控制矿物的形成和发展中发挥重要作用。因此,在不溶性有机基质中鉴定酸性蛋白对于理解珊瑚中个体蛋白的功能是非常重要的一步。在短指多型软珊瑚(Sinularia polydactyla)的可溶性和不溶性基质层中分析蛋白组分表明,在不溶性基质和可溶性基质层中天冬氨酸的含量分别是61%和29%。利用体外分析法发现,基质蛋白诱导碳酸钙形成非晶态析出相先于其形成钙质的结晶态。利用X-射线衍射来鉴定骨片上结晶态的碳酸钙,结果表明钙质的多晶态呈现强反射。傅利叶变换红外光谱分析表明珊瑚基质中富含天冬氨酸的蛋白和多醣的结构。在不溶性基质组分中用钙离子结合分析显示一个分子量为109kD的蛋白质可以与形成骨片的钙离子结合,这一过程对骨片形成非常重要。在对生物钙化过程中起重要作用的碳酸酐酶的分析中显示了此酶的新颖的活性。以上结果显示珊瑚中不溶性基质内的富含天冬氨酸的蛋白在生物矿化调控过程中起重要作用。 | M. Azizur Rahman Tamotsu Oomori | 2008 | 生物工程学报2008，24，12： | 4 |
| 9 | Expression of alpha smooth muscle actin in living donor liver transplant recipients显示文摘Recently,there have been reports from liver biopsies that showed the progression of liver fibrosis in liver transplant patients after the cessation of immunosuppression.Herein,we focused on activated hepatic stellate cells expressing alpha smooth muscle actin(α-SMA)to understand the correlation between immunosuppressant medication and liver fibrosis.The study enrolled two pediatric patients who underwent living donor liver transplantation and ceased immunosuppressant therapy.The number ofα-SMA-positive cells in the specimens obtained by liver biopsy from these two patients showed a three-fold increase compared with the number from four transplanted pediatric patients who were continuing immunosuppressant therapy.In addition,theα-SMA-positive area evaluated using the WinRooF image processing software program continued toincrease over time in three adult transplanted patients with liver fibrosis,and theα-SMA-positive area was increasing even during the pre-fibrotic stage in these adult cases,according to a retrospective review.Therefore,α-SMA could be a useful marker for the detection of early stage fibrosis. | Masataka Hirabaru Kyoko Mochizuki Mitsuhisa Takatsuki Akihiko Soyama Taiichiro Kosaka Tamotsu Kuroki Isao Shimokawa Susmu Eguchi | 2014 | World Journal of Gastroenterology2014，20，22： | 3 |
| 10 | Post-stroke affective or apathetic depression and lesion location: left frontal lobe and bilateral basal ganglia显示文摘 | Seiji Hama Hidehisa Yamashita Masaya Shigenobu Atsuko Watanabe Kaoru Kurisu Shigeto Yamawaki Tamotsu Kitaoka | 2007 | European Archives of Psychiatry and Clinical Neuroscience2007，，3： | 3 |
| 11 | Practical fecal calprotectin cut-off value for Japanese patients with ulcerative colitis显示文摘AIM To determine appropriate fecal calprotectin cut-off values for the prediction of endoscopic and histologic remission in Japanese patients with ulcerative colitis(UC). METHODS We performed a cross-sectional observational study of 131 Japanese patients with UC and measured fecal calprotectin levels by fluorescence enzyme immunoassay. The clinical activity of UC was assessed with the partial Mayo score(PMS). Relapse was defined as increase of PMS by 2 points or more in stool frequency or rectal bleeding subscore. The endoscopic and histologic activities of UC were evaluated in 50 patients within a 2-mo period from fecal sampling. Endoscopic activity was determined by Mayo endoscopic subscore, Rachmilewitz endoscopic index, and ulcerative colitis endoscopic index of severity. The histologic grade of inflammation was evaluated with biopsy specimens obtained from the endoscopically most severely inflamed site, according to the scheme by Matts grade and Riley's score.RESULTS Fecal calprotectin levels varied from 1-20783 μg/g. There was a significant correlation between the partial Mayo score and fecal calprotectin levels(r = 0.548, P < 0.001). In 50 patients who underwent colonoscopy with biopsy, levels were significantly correlated with the Mayo endoscopic subscore(r = 0.574, P < 0.001), Rachmilewitz endoscopic index(r = 0.628, P < 0.001), ulcerative colitis endoscopic index of severity(r = 0.613, P < 0.001), Riley's histologic score(r = 0.400, P = 0.006), and Matts grade(r = 0.586, P < 0.001). Receiver-operating characteristic analyses identified the best cut-off value for the prediction of endoscopic remission as 288 μg/g, with an area under the curve of 0.777 or 0.823, while that for histologic remission was 123 or 125 μg/g, with an AUC of 0.881 or 0918, respectively. Of the 131 study patients, 88 patients in clinical remission were followed up 6 mo. During the follow-up period, 19 patients relapsed. The best fecal calprotectin cut-off value for predicting relapse was 175 μg/g.CONCLUSION Fecal calprotectin is a predictive biomarker for endoscopic and histologic remission in Japanese patients with UC. | Jun Urushikubo Shunichi Yanai Shotaro Nakamura Keisuke Kawasaki Risaburo Akasaka Kunihiko Sato Yosuke Toya Kensuke Asakura Takahiro Gonai Tamotsu Sugai Takayuki Matsumoto | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 12 | Methods in Mammalian Autophagy Research显示文摘 | Noboru Mizushima Tamotsu Yoshimori Beth Levine | 2010 | Cell2010，，3： | 2 |
| 13 | The Role of Atg Proteins in Autophagosome Formation显示文摘 | Noboru Mizushima Tamotsu Yoshimori Yoshinori Ohsumi | 2011 | Annual Review of Cell and Developmental Biology2011，，： | 2 |
| 14 | Vibration Behavior of the Ground and Houses Caused by Monorail Traffic显示文摘 | Katsuya Tanaka Kiyoshi Hayakawa Tamotsu Matsui Hiroaki Fujimoto Jin Watanabe | 2010 | Journal of Civil Engineering and Architecture2010，4，3： | 2 |
| 15 | Morphology and molecular phylogeny of Pleurosira nanjiensis sp. nov., a new marine benthic diatom from the Nanji Islands, China显示文摘A new marine benthic diatom, Pleurosira nanjiensis sp. nov., is described from the rocky intertidal zone of the Xiaochaiyu Island of the Nanji Islands in China. Its morphology was examined with light and scanning electron microscopy. Molecular phylogeny was reconstructed based on SSU rRNA and rbc L gene sequences. Pleurosira nanjiensis differs from congeners in possession of a combination of morphological features including the domed valve with broadly lanceolate, elliptical or circular valve outline, two elevated marginal ocelli, two(rarely three)rimportulae, and radiate striae. | LI Yuhang NAGUMO Tamotsu XU Kuidong | 2018 | Acta Oceanologica Sinica2018，37，10： | 2 |
| 16 | Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer显示文摘 | Yasushi Sato Tetsuji Takayama Tamotsu Sagawa Yasuo Takahashi Hiroyuki Ohnuma Syunichi Okubo Naoaki Shintani Shingo Tanaka Masaya Kida Yasuhiro Sato Hidetoshi Ohta Koji Miyanishi Tsutomu Sato Rishu Takimoto Masayoshi Kobune Koji Yamaguchi Koichi Hirata Yos | 2010 | Cancer Chemotherapy and Pharmacology2010，，4： | 2 |
| 17 | Vitellogenin-immunohistochemistry in the liver and the testis of the medaka,Oryzias latipes,exposed to 17β-estradiol and p-nonylphenol显示文摘 | KOBAYASHI K TAMOTSU S YASUDA K | 2005 | Zoological Science2005，22，4： | 1 |
| 18 | 1,8-cineole inhibits both proliferation and elongation of BY-2 cultured tobacco cells显示文摘 | YOSHIMURA H SAWAI Y TAMOTSU S | 2011 | Journal of Chemical Ecology2011，37，3： | 1 |
| 19 | Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia显示文摘 | Akitoshi Nakashima Mikiko Yamanaka-Tatematsu Naonobu Fujita Keiichi Koizumi Tomoko Shima Toshiko Yoshida Toshio Nikaido Aikou Okamoto Tamotsu Yoshimori Shigeru Saito | 2013 | Autophagy2013，，3： | 1 |
| 20 | Synthesis of a New Degradable Poly urethane glastomer Containing Polyacetal Soft Segments 显示文摘 | Tamotsu Hashimoto | 2004 | Journal of Polymer Science Part A: Polymer Chemistry2004，42，： | 1 |
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