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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Effect of lamivudinein in BeAg-positive chronic hepatitis B: Discordant effect on HBeAg and HBV DNA according to pretreatment ALT level显示文摘AIM: To clarify differences in antiviral effect of the drug in patients with different ALT levels, we examined the changes in HBV markers in patients with high or low ALT levels with or without lamivudine treatment. METHODS: Thirty-seven HBeAg-positive patients were studied. Ten patients with ALT levels higher than 200 IU/L (group 1) and 8 patients with ALT below 200 IU/L (group 2) were treated orally with 100 mg/d of lamivudine. As untreated control, 9 patients with ALT above 200 IU/L (group 3) and 10 patients with ALT below 200 IU/L (group 4) were examined. ALT level, HBeAg/HBeAb status, and HBV DNA level were examined monthly for 11.9±0.4 mo.RESULTS: The ALT level normalized in all 10 patients of group 1, 7/8 of group 2, 4/9 of group 3, and 1/10 of group 4 within 6 mo (groups 1 vs 2, P = NS; groups 1 vs 3, P = 0.002; groups 1vs 4, P<0.0001). HBV DNA fell below the detection limit in all 10 patients of group 1, 7/8 of group 2, 0/9 of group 3, and 0/10 of group 4 within 6 mo (groups 1 vs 2, P = NS). HBeAg became seronegative in 7/10 patients of group 1, 1/8 of group 2, 3/9 of group 3, and 0/10 of group 4 within 12 mo (groups 1 vs2, P= 0.02;groups 1 vs 3, P = NS).CONCLUSION: Our data suggest that HBeAg-positive patients with higher ALT levels can be considered good candidates for lamivudine therapy, probably because lamivudine accelerates the natural seroconversion of HBeAg, accompanied by HBV DNA loss, in these patients. | Tomoko Kurihara Fumio Imazeki Osamu Yokosuka Kenichi Fukai Tatsuo Kanda Shigenobu Kawai Hiromitsu Saisho | 2005 | World Journal of Gastroenterology2005，11，22： | 5 |
| 3 | Post-stroke affective or apathetic depression and lesion location: left frontal lobe and bilateral basal ganglia显示文摘 | Seiji Hama Hidehisa Yamashita Masaya Shigenobu Atsuko Watanabe Kaoru Kurisu Shigeto Yamawaki Tamotsu Kitaoka | 2007 | European Archives of Psychiatry and Clinical Neuroscience2007，，3： | 3 |
| 4 | Prediction of pressure-promoted thermal rejuvenation in metallic glasses显示文摘Rejuvenation is the structural excitation of glassy materials,and is a promising approach for improving the macroscopic deformability of metallic glasses.This atomistic study proposes the application of compressive hydrostatic pressure during the glass-forming quenching process and demonstrates highly rejuvenated glass states that have not been attainable without the application of pressure.Surprisingly,the pressure-promoted rejuvenation process increases the characteristic short-and mediumrange order,even though it leads to a higher-energy glassy state.This‘local order’–‘energy’relation is completely opposite to conventional thinking regarding the relation,suggesting the presence of a well-ordered high-pressure glass/high-energy glass phase.We also demonstrate that the rejuvenated glass made by the pressure-promoted rejuvenation exhibits greater plastic performance than as-quenched glass,and greater strength and stiffness than glass made without the application of pressure.It is thus possible to tune the mechanical properties of glass using the pressure-promoted rejuvenation technique. | Narumasa Miyazaki Masato Wakeda Yun-Jiang Wang Shigenobu Ogata | 2016 | npj Computational Materials2016，，1： | 3 |
| 5 | Gene Body CG and CHG Methylation and Suppression of Centromeric CHH Methylation are Mediated by DECREASE IN DNA METHYLATION1 in Rice显示文摘Dear Editor, DECREASE IN DNA METHYLATION1 (DDM1) is a chromatin remodeling protein required for maintenance of cytosine and histone H3K9 methylation in heterochromatin regions in the genome of Arabidopsis thaliana (Gendrel et al.,2002).A ddm 1 mutant also increases the rate of meiotic recombination in euchromatic but not heterochromatic regions of A.thaliana (Melamed-Bessudo and Levy,2012),and changes the state of cytosine methylation of agene flanked by a LINE element located in a region of euchromatin (Saze and Kakutani,2007). | Hisataka Numa Katsushi Yamaguchi Shuji Shigenobu Yoshiki Habu | 2015 | Molecular Plant2015，8，10： | 2 |
| 6 | Salvage Gastrectomy After Intravenous and Intraperitoneal Paclitaxel (PTX) Administration with Oral S-1 for Peritoneal Dissemination of Advanced Gastric Cancer with Malignant Ascites显示文摘 | Joji Kitayama Hironori Ishigami Hironori Yamaguchi Hiroharu Yamashita Shigenobu Emoto Shoich Kaisaki Toshiaki Watanabe | 2014 | Annals of Surgical Oncology2014，，2： | 2 |
| 7 | Clinical significance of CA125 and CA72-4 in gastric cancer with peritoneal dissemination显示文摘 | Shigenobu Emoto Hironori Ishigami Hiroharu Yamashita Hironori Yamaguchi Shoichi Kaisaki Joji Kitayama | 2012 | Gastric Cancer2012，，2： | 2 |
| 8 | Rationale,Biomechanics,and Surgical Indications for Graf Ligamentoplasty显示文摘 | kanayama Hashimoto Shigenobu | 2005 | Orthop Clin N Am2005，36，： | 1 |
| 9 | Correlation-based speckle velocimeter with self-mixing interference in a semiconductor laser diode显示文摘 | Sahin Kaya Ozdemir Satoshi Ito Shigenobu Shinohara | 1999 | Applied Optics1999，38，33： | 1 |
| 10 | Production of L-lactic acid from corncob显示文摘 | Shigenobu Miura Tomohiro Arimura Noriaki Itoda | 2004 | Journal of Bioscience and Bioengineering2004，97，3： | 1 |
| 11 | Attenuating effect of arecoline and physostigmine on an impairment of mealtime- associated activity rhythm in old rats显示文摘 | MICHIKO O YOSHITSUGU M SHIGENOBU S | 1995 | Physiology and Behavior1995，57，1： | 1 |
| 12 | Pitfall of anteriorcervical fusion using titanium mesh and local autograft 显示文摘 | Kanyama M Hashimoto T Shigenobu K | 2003 | J Spine Disord Tech2003，16，6： | 1 |
| 13 | Clinical results ofsingle-leved posterior lumbar interbody fusion using the brantiganI/ F carbon Cage filled with a mixture of local morselized bone andbioaetive ceramic granules显示文摘 | Hashimoto T Shigenobu K Kanayama M | 2002 | Apine2002，27，3： | 1 |
| 14 | Mid-term clinical results of Graf stabilization for lumbar degenerative pathologies:a minimum 2-year follow-up显示文摘 | Hashimoto T Oha F Shigenobu K | 2001 | Spine J2001，1，4： | 1 |
| 15 | Pitfalls of anterior cervical fusion using titanium mesh and local autograft 显示文摘 | Kanayama M Hashimoto T Shigenobu K | 2003 | J Spinal Disord Tech2003，16，6： | 1 |
| 16 | Clinical re- suits of single-level posterior lumbar interbody fusion using the Brantigan I/F carbon cage filled with a mixture of local morselized bone and bioactive ceramic granules 显示文摘 | Hashimoto T Shigenobu K Kanayama M | 2002 | Spine ( Phila Pa 1976)2002，27，3： | 1 |
| 17 | Effects of green tea intake on the development of coronary artery disease 显示文摘 | Junko Sano Shigenobu Inami Koji Seimiya | 2004 | Circ J2004，68，7： | 1 |
| 18 | Adjacent-segment morbidity after Graf ligamentoplasty compared with posterolateral lumbar fusion 显示文摘 | Kanayama M Hashimoto T Shigenobu K | 2001 | J Neurosurg2001，95，1： | 1 |
| 19 | Surgical indications and treatment of mitral valve disease associated with secundum atrial septal defect with special reference to left ventricular geometry and function显示文摘 | Shigenobu M Sano S | 1994 | J Cordiovasc Surg (Torino)1994，35，6： | 1 |
| 20 | Intraperitoneal administration of cisplatin via an in situ cross-linkable hyaluronic acid-based hydrogel for peritoneal dissemination of gastric cancer显示文摘 | Shigenobu Emoto Hironori Yamaguchi Takao Kamei Hironori Ishigami Takashi Suhara Yukimitsu Suzuki Taichi Ito Joji Kitayama Toshiaki Watanabe | 2014 | Surgery Today2014，，5： | 1 |
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