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| 1 | Factors determining delay in relaparotomy for anastomotic leakage after colorectal resection显示文摘AIM: To analyze the time interval ('delay') between the first occurrence of clinical parameters associated with anastomotic leakage after colorectal resection and subsequent relaparotomy. METHODS: In 36 out of 289 consecutive patients with colorectal anastomosis, leakage was confirmed at relaparotomy. The medical records of these patients were retrospectively analysed and type and time of appearance of clinical parameters suggestive of anastomotic leakage were recorded. These parameters included heart rate, body temperature, local or generalized peritoneal reaction, leucocytosis, ileus and delayed gastric emptying. Factors influencing delay of relaparotomy and consequences of delayed recognition and treatment were determined. RESULTS: First documentation of at least one of the predefined parameters for anastomotic leakage was after a median interval of 4 ± 1.7 d after the operation. The median number of days between first parameter(s) associated with leakage and relaparotomy was 3.5 ± 5.7 d. The time interval between the first signs of leakage and relaparotomy was significantly longer when a weekend was included (4.2 d vs 2.4 d, P = 0.021) or radiological evaluation proved to be false-negative (8.1 d vs 3.5 d, P = 0.007). No significant association between delay and number of additional relaparotomies, hospital stay or mortality could be demonstrated. CONCLUSION: An intervening weekend and negative diagnostic imaging reports may contribute to a delay in diagnosis and relaparotomy for anastomotic leakage. That delay was more than two days in two-thirds of the patients. | A Doeksen PJ Tanis BC Vrouenraets JJB Lanschot van WF Tets van | 2007 | World Journal of Gastroenterology2007，13，27： | 17 |
| 2 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 3 | Randomized phase II study of gemcitabine and S-1 combination versus gemcitabine alone in the treatment of unresectable advanced pancreatic cancer (Japan Clinical Cancer Research Organization PC-01 study)显示文摘 | Masato Ozaka Yuji Matsumura Hiroshi Ishii Yasushi Omuro Takao Itoi Hisatsugu Mouri Keiji Hanada Yasutoshi Kimura Iruru Maetani Yoshinobu Okabe Masaji Tani Takaaki Ikeda Susumu Hijioka Ryouhei Watanabe Shinya Ohoka Yuki Hirose Masafumi Suyama Naoto Egawa A | 2012 | Cancer Chemotherapy and Pharmacology2012，，5： | 3 |
| 4 | Adaptation to famine: a family of stationary-phase genes revealed by microarray analysis显示文摘 | Tani T H Khodursky A Blumenthal R M | 2002 | Proc NatlAcadSciUSA2002，99，13： | 1 |
| 5 | A Survey of Thresholding Technique显示文摘 | Sahoo P K Tanis S Wong A K C | 1988 | Computer Vision Graphics Image Processing1988，41，2： | 1 |
| 6 | Pancreatic carcinomas deposit laminin-5, preferably adhere to laminin-5, and migrate on the newly deposited basement membrane显示文摘 | TANI T LUMME A LINNALA A | 1997 | Am J Pathol1997，151，5： | 1 |
| 7 | Performance of SVM Controlled Matrix Converter with Input and Output Unbalanced Conditions 显示文摘 | Casadei D Serra G Tani A | 1995 | Proceedings of EPE''951995，2，2： | 1 |
| 8 | Carbamylated erythro-poietin is neuroprotective in an experimental model of traumatic brain injury显示文摘 | Adembri C Massagrande A Tani A | 2008 | Crit Care Med2008，36，3： | 1 |
| 9 | Online analysis of volatile organic compound emissions from Sitka spruce (Picea sitchensis) 显示文摘 | HAYWARD S TANI A OWENS M | 2004 | Tree Physiology2004，24，7： | 1 |
| 10 | Association study of polymorphisrns in the group III metabotropic glutamate receptor genes, G-RM4 and GRM7, with schizophrenia 显示文摘 | Shibata H Tani A Chikuhara T | 2009 | Psycbiatry Res2009，167，12： | 1 |
| 11 | Associations of estrogen and tes- tosterone with insulin resistance in pre-and postmenopausal women with and without hormone therapy 显示文摘 | Matsui S Yasui T Tani A | 2013 | Int J Endocrinol Metab2013，11，2： | 1 |
| 12 | Effect of dipeptidyl pep- tidase-4 inhibitor, vildagliptin on plasminogen activator inhibitor- 1 in patients with diabetes mellitus 显示文摘 | Tani S Takabashi A Nagao K | 2015 | Am J Cardiol2015，115，4： | 1 |
| 13 | Intelligent fuzzy optimal control of building structures 显示文摘 | Tani A Kawamura H Ryu S | 1998 | Eng Struct1998，20，3： | 1 |
| 14 | Trophic state analysis of inlandlakes显示文摘 | Wezemak C T Tanis F J Bajza C A | 1976 | Remote Sensing of Environment1976，5，： | 1 |
| 15 | Rolling contact fatigue of alumina ceramics sprayed on steel roller under pure rolling contact condition 显示文摘 | FUJII M YOSHIDA A MA J B SHIGEMURA S TANI K | 2006 | Tribol Int2006，39，9： | 1 |
| 16 | Expression of functional lung resistance-related protein predicts poor outcome in acute T-cell leukemia 显示文摘 | OHNO N TANI A UOZUMI K | 2001 | Blood2001，98，4： | 1 |
| 17 | Transient Bowel Ischaemia of the Fetus显示文摘 | Ghi T Tani G Carletti A | 2005 | Fetal Diagn Ther2005，20，： | 1 |
| 18 | Role of megalin and the soluble form of its ligand RAP in Cd-metallo- thioneinendocytosis and Cd-metallothionein-induced nephrotoxicity in vivo 显示文摘 | Onodera A Tani M Michigami T | 2012 | Toxicology Letters2012，212，2： | 1 |
| 19 | Theoretical and experimental investigation on the stability of matrix converters 显示文摘 | Casadei D Serra G Tani A | 2005 | IEEE Trans on IE2005，52，5： | 1 |
| 20 | Morbidity related to defunctioning ileostomy closure after ileal pouch-anal anastomosis and low colonic anastomosis显示文摘 | van Westreenen HL Visser A Tanis PJ Bemelman WA | 2012 | Int J Colorectal Dis2012，27，1： | 1 |
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