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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 3 | Determination of neutral and cationic herbicides in water by micellar electrokinetic capillary chromatography显示文摘 | ACEDO -VALENZUELA M I TERESA G D NIELENE M D ANTONIO S R | 2004 | Anal Chim Acta2004，519，： | 1 |
| 4 | Hepatocyte growth factor and its receptor Met are induced in crescentic glomerulonephritis显示文摘 | Teresa R Marilena G Giovanni C | 2005 | Nephrol Dial Transplant2005，20，： | 1 |
| 5 | Cooperative Research and Rising Expectations:Lessons from NSF's Industry/University Cooperative Research Centers显示文摘 | WILLIAM A H TERESA R G DENIS O G | 1989 | Technology in Society1989，11，3： | 1 |
| 6 | In vitro growth inhibition of Curvularia gudauskasii by Bacillus subtilis显示文摘 | TERESA O R ZENIA G G MANUEL S D | 2012 | Annals of Microbiology2012，62，2： | 1 |
| 7 | Hepatocyte growth factor and its receptor met are induced in crescentic glomerulonephritis 显示文摘 | TERESA R MARILENA G GIOVANNI C | 2005 | Nephrol Dial Transplant2005，20，： | 1 |
| 8 | Methods to measure g-protein-coupled receptor activity for the identification of inverse agonists 显示文摘 | BARREDA-GOMEZ G TERESA GM RODRIGUEZ-PUERTAS R | 2010 | Methods Enzymol2010，485，： | 1 |
| 9 | Elastic wave propagation in cylindrical bar after brittle failures:application to spalling tests显示文摘 | TERESA G D R JESUS R P | 2007 | International Journal of Impact Engineering2007，34，2： | 1 |
| 10 | Fitness costs and sta- bility of a high level ciprofloxacin resistance phenotype in Sal- monella enterica serotype enteritidis reduced infectivity associ- ated with decreased expression of Salmonella pathogenicity island 1 genes显示文摘 | EEL R TERESA Q JONATHAN G F | 2010 | Antimicrob Agents Chemother2010，54，1： | 1 |
| 11 | Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer 显示文摘 | Teresa G Ileana VA Beth R | 2008 | Biochim Biophys Acta2008，1782，4： | 1 |
| 12 | Inhibitory effect of liposomal solutions of grape seed extract on the formation of heterocyclic aromatic amines显示文摘 | DANIELA N MONIKA G MARIA TERESA R E | 2014 | Food Chemistry2014，62，1： | 1 |
| 13 | In vitro growth inhibition of Curvularia gudauskasii by Bacillus subtilis显示文摘 | Teresa () R Zenia G G Manuel S D | | 0，，02： | 1 |
| 14 | Differential behavioral effect of the TRPM8/TRPA1 channel agonist icilin(AG-3-5) 显示文摘 | Scott M R Teresa G Zhe D | 2007 | European Journal of Pharmacology2007，576，： | 1 |
| 15 | Risk-taking behavior and ownership in the banking industry:The Spanish evidence 显示文摘 | TERESA G DOLORES R | 2008 | Journal of Economics and Business2008，60，4： | 1 |
| 16 | Shivering post epidural an-aesthe-sia different doses of intravenous elonidine显示文摘 | Teresa V G Carmon R E | 2002 | Can J Anesth2002，49，： | 1 |
| 17 | Gold glyconanoparticles:Synthetic polyvalent ligands mimicking glycocalyx-like surfaces as tools for glycobiological studies显示文摘 | Africa G B Jesus M F Teresa C R | | 0，，： | 1 |
| 18 | Lactobacillus acidophilus La-5 increases lactacin B production when it senses live target bacteria显示文摘 | Raquel T Tom6s G C Teresa R | 2009 | International Journal of Food Microbiology2009，132，： | 1 |
| 19 | Performance of different systems for the composting of the source-selected organic fraction of municipal solid waste 显示文摘 | LUZ R TERESA G MARISOL M | 2008 | Biosystems Engineering2008，101，： | 1 |
| 20 | Mesenehymal stromal cells improve renal injury in anti-Thy 1 nephritis by modulating inflammatory cytokines and scatter factors显示文摘 | Teresa R Marilena G Giulia B | | 0，，： | 1 |
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